Jun Guo

Summary

Affiliation: Nanjing Medical University
Country: China

Publications

  1. pmc Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
    Lize Gu
    Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Neuroinflammation 10:109. 2013
  2. pmc PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus
    Jianxi Zhu
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, 210029, People s Republic of China
    BMC Neurosci 14:1. 2013
  3. doi Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells
    Shan Shan Chen
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, PR China Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, PR China
    Biochem Biophys Res Commun 443:814-20. 2014
  4. doi Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2+/CaM-dependent ERK activation in cerebral ischemia
    Jie Zhao
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    J Neurosci Res 86:2733-45. 2008
  5. pmc Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia
    Xiaohan Hu
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 210029, PR China
    BMC Neurosci 10:74. 2009
  6. doi Palmitate-induced inhibition of insulin gene expression in rat islet β-cells involves the ceramide transport protein
    Jun Guo
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, PR China
    Cell Physiol Biochem 26:717-28. 2010
  7. doi Elevated toll-like receptor 3 inhibits pancreatic β-cell proliferation through G1 phase cell cycle arrest
    Yi Wang
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 210029, PR China
    Mol Cell Endocrinol 377:112-22. 2013
  8. pmc Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells
    Lili Gao
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, People s Republic of China
    Mol Med 21:154-66. 2015
  9. ncbi N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia
    Hui Wen Wu
    Morphological Laboratory, Nanjing Medical University, Nanjing 210029, China
    Neurosci Bull 23:107-12. 2007
  10. doi Role of transcription factors in neurogenesis after cerebral ischemia
    Cuiling Zhang
    Laboratory Center for Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China
    Rev Neurosci 22:457-65. 2011

Collaborators

Detail Information

Publications13

  1. pmc Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
    Lize Gu
    Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Neuroinflammation 10:109. 2013
    ..Ceramide accumulation is considered a contributing factor to neuronal dysfunction and damage. However, the underlying mechanisms that occur following ischemic insult are still unclear...
  2. pmc PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus
    Jianxi Zhu
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, 210029, People s Republic of China
    BMC Neurosci 14:1. 2013
    ..The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases...
  3. doi Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells
    Shan Shan Chen
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, PR China Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, PR China
    Biochem Biophys Res Commun 443:814-20. 2014
    ..These findings indicate that the anti-proliferative actions of PKR on pancreatic β-cells may contribute to the pathogenesis of T2DM. ..
  4. doi Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2+/CaM-dependent ERK activation in cerebral ischemia
    Jie Zhao
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    J Neurosci Res 86:2733-45. 2008
    ....
  5. pmc Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia
    Xiaohan Hu
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 210029, PR China
    BMC Neurosci 10:74. 2009
    ..This study examined the molecular mechanisms by which Src activates ERK cascade through protein phosphatases following cerebral ischemia...
  6. doi Palmitate-induced inhibition of insulin gene expression in rat islet β-cells involves the ceramide transport protein
    Jun Guo
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, PR China
    Cell Physiol Biochem 26:717-28. 2010
    ....
  7. doi Elevated toll-like receptor 3 inhibits pancreatic β-cell proliferation through G1 phase cell cycle arrest
    Yi Wang
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 210029, PR China
    Mol Cell Endocrinol 377:112-22. 2013
    ..These results support a role for TLR3 in β-cell mass loss in metabolic surplus and raise the possibility that TRIF/p38 signaling may be involved in G1 phase cycle arrest through ubiquitin/proteasome-dependent degradation of cyclin D...
  8. pmc Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells
    Lili Gao
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, People s Republic of China
    Mol Med 21:154-66. 2015
    ..Therapeutic opportunities for type 2 diabetes may arise when its kinase catalytic function, but not its protein-binding function, is downregulated. ..
  9. ncbi N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia
    Hui Wen Wu
    Morphological Laboratory, Nanjing Medical University, Nanjing 210029, China
    Neurosci Bull 23:107-12. 2007
    ..Extracellular signal-regulated kinases (ERKs) can be activated by calcium signals. In this study, we investigated whether calcium-dependent kinases were involved in ERKs cascade activation after global cerebral ischemia...
  10. doi Role of transcription factors in neurogenesis after cerebral ischemia
    Cuiling Zhang
    Laboratory Center for Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, China
    Rev Neurosci 22:457-65. 2011
    ..This review article gives a brief overview of some transcription factors (NF-κB, Hes, STAT3, AP-1, CREB, HIF1, Pax6, Tcf/Lef, Gli, Sox2, Olig2, Dlx2, TLX, Bmi-1) in ischemia-induced neurogenesis...
  11. ncbi [Relationship between neuroinflammation and neurodegenerative diseases]
    Ao Wang Qiu
    The Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China
    Sheng Li Ke Xue Jin Zhan 42:353-8. 2011
    ..The anti-inflammatory cytokines synthesized by regulatory T cells and neuropeptides secreted by neurons protect the neurons against neuroinflammation, through which neurodegenerative diseases are alleviated...
  12. doi [Advance in research on regulatory mechanism and functions of neutral sphingomyelinse 2]
    Lan Zhang
    Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 35:581-5. 2013
    ..In the review, recent research advances in the structure and function of nSMase2 and its underlying mechanisms are summarized...
  13. ncbi [Advances in the study on anti-HIV lignan compounds]
    Hao Qin
    Laboratory Center for Basic Medical Science, Nanjing Medical University, Nanjing 210029, China
    Bing Du Xue Bao 28:577-83. 2012
    ..Lignan is divided into four categories based on different anti-HIV detection methods. In this paper, we summarize the advance in the study on anti-HIV lignan compounds in last two decades...