Yan Li

Summary

Country: China

Publications

  1. ncbi request reprint Prognostic significance of tumor-associated macrophages density in gastric cancer: a systemic review and meta-analysis
    Jiu Y Liu
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China
    Minerva Med 107:314-21. 2016
  2. pmc Long term follow up and retrospective study on 533 gastric cancer cases
    Wei Juan Zeng
    Departments of Oncology and Pathology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, China
    BMC Surg 14:29. 2014
  3. pmc Quantum dots for cancer research: current status, remaining issues, and future perspectives
    Min Fang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, China
    Cancer Biol Med 9:151-63. 2012
  4. pmc Collagen as a double-edged sword in tumor progression
    Min Fang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan, 430071, China
    Tumour Biol 35:2871-82. 2014
  5. pmc Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity
    Li Tang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169, Donghu Road, Wuhan 430071, China
    Mol Cancer 13:44. 2014
  6. ncbi request reprint A clinical database of breast cancer patients reveals distinctive clinico-pathological characteristics: a study from central China
    Lin Wei Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China E mail
    Asian Pac J Cancer Prev 15:1621-6. 2014
  7. pmc Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study
    Qun Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, 430071 Wuhan, P, R, China
    J Transl Med 11:192. 2013
  8. pmc Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
    Jinxuan Hou
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105, USA
    J Transl Med 9:64. 2011
  9. pmc The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
    Wen Qing Hu
    Department of Surgery, Heji Hospital Affiliated to Changzhi Medical College, Changzhi 046011, PR China
    J Exp Clin Cancer Res 28:144. 2009
  10. doi request reprint Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: an experimental study
    Li Hua Shao
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China
    Cancer 118:2986-96. 2012

Collaborators

  • Chun Wei Peng
  • Chuang Chen
  • Dai Wen Pang
  • Xiao jun Yang
  • Min Fang
  • Juan Tao
  • Yutaka Yonemura
  • Zhao You Tang
  • Wei Wang
  • Gui Fang Yang
  • Li Li
  • Ding Ma
  • Jun Peng
  • Jing Yang
  • Jing Ping Yuan
  • Lin Wei Wang
  • Yan Jun Zhong
  • Shao Ping Liu
  • Jia Mei Chen
  • Chao Qun Huang
  • Long Wu
  • Ming Bai Hu
  • Li Tang
  • Ji Ma
  • Hao Xu
  • Liang Dong Chen
  • Qing Ming Xiang
  • Xiaofei Qin
  • Yan Hua Zhang
  • Jin Zheng
  • Jin Xuan Hou
  • Juan Liu
  • Ai Ping Qu
  • Ze xin Tao
  • Ninu Maskey
  • Wei Li
  • Raymond A Firestone
  • Ya Ping Hong
  • Li Hua Shao
  • Peng Cheng
  • Wenchao Liu
  • Yan Xue
  • Zhengli Shi
  • Jun Yu
  • Mincai Li
  • Yao Liu
  • Hai Yan Wang
  • Yang Yu
  • Wen biao Duan
  • Min Hu
  • Fang Yang
  • Xi hui Li
  • Sheng rong Sun
  • Peng cheng Li
  • Fang Yu
  • Shixuan Wang
  • Hui Wang
  • Qing Wu
  • Hui Gao
  • Han Lin Wu
  • Ming Wang
  • Hong Wu Tang
  • Zhi Ling Zhang
  • Xingyi Ge
  • Xiu li Liu
  • Libo Yao
  • Yunzhi Zhang
  • Dujuan Li
  • Qiurong Ruan
  • Lie Jun Mei
  • Xijuan Xia
  • Yaxian Zhao
  • Xingru Zhao
  • Lei Feng
  • Mi Tian
  • Xiaobai Xu
  • Zhanfen Qin
  • Ai Qiang Xu
  • Qing Ying Fan
  • Guanxin Shen
  • Li Zhi Song
  • Gui fang Liu
  • Jiu Y Liu
  • Jian Hua Sun
  • Zhanguo Chen
  • Wen Lou Liu
  • Ling Hu
  • Chang Hong Wang
  • Shuxin Ye
  • Fang Zheng

Detail Information

Publications172 found, 100 shown here

  1. ncbi request reprint Prognostic significance of tumor-associated macrophages density in gastric cancer: a systemic review and meta-analysis
    Jiu Y Liu
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China
    Minerva Med 107:314-21. 2016
    ..Tumor-associated macrophages (TAM) play a dual role in the development of gastric cancer (GC). This study aims to analyze the prognostic value of TAM density in GC patients...
  2. pmc Long term follow up and retrospective study on 533 gastric cancer cases
    Wei Juan Zeng
    Departments of Oncology and Pathology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, China
    BMC Surg 14:29. 2014
    ..The aim of the research is to study the prognostic factors of gastric cancer patients who had curative intent or palliative resection, completed clinical database and follow-up...
  3. pmc Quantum dots for cancer research: current status, remaining issues, and future perspectives
    Min Fang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, China
    Cancer Biol Med 9:151-63. 2012
    ..This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives...
  4. pmc Collagen as a double-edged sword in tumor progression
    Min Fang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan, 430071, China
    Tumour Biol 35:2871-82. 2014
    ..In this work, we discuss how collagen can be a double-edged sword in tumor progression, both inhibiting and promoting tumor progression at different stages of cancer development. ..
  5. pmc Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity
    Li Tang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169, Donghu Road, Wuhan 430071, China
    Mol Cancer 13:44. 2014
    ..This work aimed to synthesize a cathepsin B (CTSB)-cleavable tumor-targeting prodrug peptide doxorubicin (PDOX) and study the in vivo efficacy and toxicities on an animal model of gastric peritoneal carcinomatosis (PC)...
  6. ncbi request reprint A clinical database of breast cancer patients reveals distinctive clinico-pathological characteristics: a study from central China
    Lin Wei Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China E mail
    Asian Pac J Cancer Prev 15:1621-6. 2014
    ..Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China...
  7. pmc Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study
    Qun Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, 430071 Wuhan, P, R, China
    J Transl Med 11:192. 2013
    ..This study was to investigate the effects and safety of cathepsin B-cleavable doxorubicin (DOX)-prodrug (PDOX) for targeting therapy of metastatic human hepatocellular carcinoma (HCC) using DOX as a positive control drug...
  8. pmc Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
    Jinxuan Hou
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105, USA
    J Transl Med 9:64. 2011
    ..In this study, we investigated the role of c-Met in rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be a potential therapeutic target for RMS...
  9. pmc The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
    Wen Qing Hu
    Department of Surgery, Heji Hospital Affiliated to Changzhi Medical College, Changzhi 046011, PR China
    J Exp Clin Cancer Res 28:144. 2009
    ....
  10. doi request reprint Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: an experimental study
    Li Hua Shao
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China
    Cancer 118:2986-96. 2012
    ..The authors examined the antitumor effect and toxicities of Ac-Phe-Lys-PABC-ADM against gastric cancer peritoneal carcinomatosis...
  11. pmc Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial
    Xiao jun Yang
    Department of Oncology, Hubei Cancer Clinical Study Center and Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan, China
    Ann Surg Oncol 18:1575-81. 2011
    ..This randomized phase III study was to evaluate the efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of peritoneal carcinomatosis (PC) from gastric cancer...
  12. pmc Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation
    Long Wu
    Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumor Biological Behaviors, Wuchang District, 430071 Wuhan, PR China
    J Exp Clin Cancer Res 29:17. 2010
    ..To better search for potential markers for hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify potential metastasis biomarkers associated with HCC...
  13. pmc Quantum dot-based quantitative immunofluorescence detection and spectrum analysis of epidermal growth factor receptor in breast cancer tissue arrays
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory on Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, People s Republic of China
    Int J Nanomedicine 6:2265-73. 2011
    ..The present study was undertaken to investigate the prognostic value of EGFR in breast cancer using quantum dot-based quantitative spectral analysis...
  14. doi request reprint [Increased coronin-1C expression is related to hepatocellular carcinoma invasion and metastasis]
    Long Wu
    Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan 430071, China
    Zhonghua Gan Zang Bing Za Zhi 18:516-9. 2010
    ..To search for hepatocellular carcinoma (HCC) invasion related biomarkers using the cell membrane proteomics approaches, and to validate the markers using experimental and clinical specimens...
  15. doi request reprint Quantum dots-based double-color imaging of HER2 positive breast cancer invasion
    Xiu li Liu
    Department of Oncology, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biochem Biophys Res Commun 409:577-82. 2011
    ..Moreover, HER2 (3+) BC cells also show direct invasion into the blood vessels. This novel imaging method provides direct observable evidence to support the theory that the HER2 expression level is directly related to BC invasion...
  16. ncbi request reprint Value of tumor markers in diagnosing and monitoring colorectal cancer and strategies for further improvement: analysis of 130 cases
    Chuang Chen
    Department of Oncology, Zhongnan Hospital Cancer Center, Wuhan University, Wuhan, Hubei, 430071, PR China
    Ai Zheng 26:1221-6. 2007
    ..Measurement of blood tumor markers is the most widely used and convenient method for the diagnosis of colorectal cancer(CRC). This study was to evaluate the diagnostic value of a biochip diagnostic system C12 in the diagnosis of CRC...
  17. doi request reprint Recognition and capture of metastatic hepatocellular carcinoma cells using aptamer-conjugated quantum dots and magnetic particles
    Fu Bing Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biomaterials 34:3816-27. 2013
    ..These studies demonstrated that this HCC specific aptamer LY-1 could be a promising molecular probe to recognize metastatic HCC cells...
  18. pmc Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study
    Li Tang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P R China
    J Transl Med 9:53. 2011
    ..Results from experimental animal model study could help provide reliable information. This study was to investigate the safety and efficacy of CRS + HIPEC to treat gastric cancer with PC in a rabbit model...
  19. pmc Combined features based on MT1-MMP expression, CD11b + immunocytes density and LNR predict clinical outcomes of gastric cancer
    Chun Wei Peng
    Department of Oncology, Zhongnan Hospital of Wuhan University, NO, 169 Donghu Road, Wuchang District Wuhan 430071, People s Republic China
    J Transl Med 11:153. 2013
    ..The objective of this study was to evaluate the prognostic role of combined features including conventional pathology, proteinase and immune data in GC...
  20. doi request reprint Patterns of cancer invasion revealed by QDs-based quantitative multiplexed imaging of tumor microenvironment
    Chun Wei Peng
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biomaterials 32:2907-17. 2011
    ..This quantum dots based multiplexed technology could help gain new insight into the complex process of tumor invasion, and formulate new anti-cancer strategies...
  21. doi request reprint Prevalence and genetic diversity of adeno-associated viruses in bats from China
    Yan Li
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences CAS, Wuhan, PR China
    J Gen Virol 91:2601-9. 2010
    ..3%. Co-presence of multiple distinctive genotypes of bat AAV within an individual sample was also observed. These results demonstrated that diverse AAVs might be widely distributed in bat populations...
  22. pmc NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression
    Jin Zheng
    State Key Discipline of Cell Biology, Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    BMC Cancer 11:251:1-9. 2011
    ..Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The role of CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate tumor suppressor gene, has not yet been explored in HCC...
  23. doi request reprint The quantitative detection of total HER2 load by quantum dots and the identification of a new subtype of breast cancer with different 5-year prognosis
    Chuang Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biomaterials 31:8818-25. 2010
    ..Furthermore, this mode integrating macro- and micro-pathological indicators might help gain new insights into invasive BC biological behaviors...
  24. doi request reprint Quantum dots-based molecular classification of breast cancer by quantitative spectroanalysis of hormone receptors and HER2
    Chuang Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, PR China
    Biomaterials 32:7592-9. 2011
    ....
  25. ncbi request reprint Bicluster and pathway enrichment analysis of HCV-induced cirrhosis and hepatocellular carcinoma
    Peng Cheng
    Department of Oncology, PLA general hospital of Chengdu Commond, Clinical Medical College of the Third Medical Military University, Chengdu, China
    Asian Pac J Cancer Prev 13:3741-5. 2012
    ..However, while it is associated frequently with hepatitis C virus (HCV) there is only an elementary understanding of its molecular pathogenesis...
  26. doi request reprint The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis
    Liang Dong Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, No 169 Donghu Road, Wuchang District, Wuhan 430071, China
    Biomaterials 29:4170-6. 2008
    ..The results in vitro and in vivo indicate that our QD-based probes have good stability, specificity and biocompatibility for ultrasensitive fluorescence imaging of molecular targets in our liver cancer model system...
  27. doi request reprint Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy to treat gastric cancer with ascites and/or peritoneal carcinomatosis: Results from a Chinese center
    Xiao jun Yang
    Department of Oncology, Zhongnan Hospital Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuchang District, Wuhan, Hubei Province, China
    J Surg Oncol 101:457-64. 2010
    ..This work was to evaluate cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gastric cancer (GC)...
  28. doi request reprint Anticancer effects of Ac‑Phe‑Lys‑PABC‑doxorubicin via mitochondria‑centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC‑803 cells
    Yan Jun Zhong
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, Hubei 430071, P R China
    Oncol Rep 30:1681-6. 2013
    ..PDOX and DOX have different mechanisms of action, particularly the mitochondria‑centered intrinsic apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway...
  29. doi request reprint CXCR4+ progenitors derived from bone mesenchymal stem cells differentiate into endothelial cells capable of vascular repair after arterial injury
    Mincai Li
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Cell Reprogram 12:405-15. 2010
    ....
  30. doi request reprint Quantum dots-based in situ molecular imaging of dynamic changes of collagen IV during cancer invasion
    Min Fang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biomaterials 34:8708-17. 2013
    ....
  31. ncbi request reprint Multivariate survival and outcome analysis of 154 patients with gastric cancer at a single Chinese institution
    Han Lin Wu
    Department of Oncology, Wuhan University, Wuhan, China
    Asian Pac J Cancer Prev 12:3341-5. 2011
    ..Implementation of standardized radical surgery and reasonable adjuvant therapy could improve survival and prognosis of GC patients...
  32. doi request reprint Evaluation of the staging systems for gastric cancer
    Chun Wei Peng
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, PR China
    J Surg Oncol 108:93-105. 2013
    ..This study evaluated the overall performance of these systems for GC...
  33. doi request reprint Carbohydrate antigen 242 highly consists with carbohydrate antigen 19-9 in diagnosis and prognosis of colorectal cancer: study on 185 cases
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory on Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, 430071 Wuhan, China
    Med Oncol 29:1030-6. 2012
    ..Both CA19-9 and CA242 had strong consistencies in diagnosis and prognosis for predicting 5-year RFS. CA242 demonstrated superior value to CA19-9 in CRC...
  34. ncbi request reprint Serum CYFRA 21-1 level reflects hepatocellular carcinoma metastasis: study in nude mice model and clinical patients
    Yan Li
    Department of Oncology, Zhongnan Hospital of Wuhan University and Cancer Center of Wuhan University, No 169 Donghu Road, Wuhan, 430071, China
    J Cancer Res Clin Oncol 132:515-20. 2006
    ..2%, 13/24) than in CYFRA 21-1 normal cases (21.4%, 18/84) (x2=9.776, P < 0.005). These results suggest that CK19 may play an important role in HCC metastasis...
  35. ncbi request reprint Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study
    Yi shan Xie
    Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    Oncol Rep 24:1613-20. 2010
    ..No animal death was observed, although 2 nude mice in rAd-p53 group developed liver toxicity and 1 nude mouse in EPI group developed cardiac toxicity. rAd-p53 and EPI have synergistic tumor inhibition effect on gastric cancer cells...
  36. doi request reprint Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma
    Yan Li
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    Gynecol Oncol 124:112-8. 2012
    ..This study investigated the clinic-pathological significance of twist homolog 2 (TWIST2), a basic helix-loop-helix transcription factor, and correlated TWIST2 and E-cadherin expression in cervical cancer...
  37. doi request reprint Impact of neoadjuvant chemotherapy on lymphocytes and co-inhibitory B7-H4 molecule in gastric cancer: low B7-H4 expression associates with favorable prognosis
    Ninu Maskey
    Department of Pathology, Zhongnan Hospital, Wuhan University, Donghu Road 169, Wuchang District, Wuhan, 430071, People s Republic of China
    Tumour Biol 35:11837-43. 2014
    ..031). The study findings suggest that low expression of B7-H4 could serve as a candidate biomarker for predicting response to NACT and could provide favorable prognostic information in GC. ..
  38. pmc New breast cancer prognostic factors identified by computer-aided image analysis of HE stained histopathology images
    Jia Mei Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, China
    Sci Rep 5:10690. 2015
    ..The TNs feature, TNs cell nuclei feature, TNs cell density, and stromal cell structure feature could be new prognostic factors...
  39. doi request reprint Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78
    Wei Li
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P R China
    Oncol Rep 31:2525-34. 2014
    ..In conclusion, GRP78 may have anti-senescence effects on ovarian cancer cells involving multiple mechanisms. Intervention against GRP78 may reduce cisplatin resistance in ovarian cancer. ..
  40. ncbi request reprint Effects of perioperative cimetidine administration on peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: results of a randomized controlled clinical trial
    Yan Li
    Institute of Oncology of Wuhan University and Department of Oncology, Mid South Hospital of Wuhan University, Wuhan City, Hubei Province, 430071, China
    Hepatogastroenterology 52:504-8. 2005
    ....
  41. doi request reprint Hantavirus outbreak associated with laboratory rats in Yunnan, China
    Yunzhi Zhang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    Infect Genet Evol 10:638-44. 2010
    ..Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages...
  42. doi request reprint Quantum-dots based simultaneous detection of multiple biomarkers of tumor stromal features to predict clinical outcomes in gastric cancer
    Chun Wei Peng
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biomaterials 33:5742-52. 2012
    ....
  43. ncbi request reprint Preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory on Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China
    Hepatogastroenterology 58:377-82. 2011
    ..Tumor markers (TM) play an important role in the management of colorectal cancer (CRC). This study evaluates the predictive and prognostic value of preoperative serum carbohydrate antigen 242 (CA242) in CRC...
  44. doi request reprint Coevolution of the tumor microenvironment revealed by quantum dot-based multiplexed imaging of hepatocellular carcinoma
    Min Fang
    Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Number 169 Donghu Road, Wuchang District, Wuhan, 430071, PR China
    Future Oncol 9:1029-37. 2013
    ..This study aimed to provide new insights into the mechanisms of hepatocellular carcinoma (HCC) invasion by simultaneously imaging tumor cells and major components of the tumor microenvironment...
  45. doi request reprint Evaluation of the bioconjugation efficiency of different quantum dots as probes for immunostaining tumor-marker proteins
    Hao Xu
    Key Laboratory of Analytical Chemistry for Biology and Medicine Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China
    Appl Spectrosc 64:847-52. 2010
    ..The results demonstrate that it is possible to maintain uniform bioconjugation efficiencies with different QD bioconjugation processes in order to obtain accurate and reliable results in biomedical analysis and cancer diagnosis...
  46. doi request reprint Down-regulation of alphav integrin by retroviral delivery of small interfering RNA reduces multicellular resistance of HT29
    Jian Ming He
    Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China
    Cancer Lett 284:182-8. 2009
    ..Since force, including adhesion, can activate alphav integrin, cell-cell contact may contribute to activation of alphav integrin, through which increasing phosphorylated p65 and decreasing phosphorylated JNK2 takes part in MCR...
  47. pmc Application of multispectral imaging in quantitative immunohistochemistry study of breast cancer: a comparative study
    Wen Lou Liu
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430071, China
    Tumour Biol 37:5013-24. 2016
    ..It may become an optimal IHC digital imaging system used in quantitative pathology. ..
  48. pmc Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy to Treat Advanced/Recurrent Epithelial Ovarian Cancer: Results from a Retrospective Study on Prospectively Established Database
    Jian Hua Sun
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430071, P R China Department of Gastrointestinal Surgery, Enshi Autonomous Prefecture Hospital, Enshi, Hubei, 445000, P R China
    Transl Oncol 9:130-8. 2016
    ..Recently, CRS plus hyperthermic intraperitoneal chemotherapy (HIPEC) has been developed to treat peritoneal carcinomatosis (PC). This study was to evaluate the efficacy and safety of CRS+HIPEC to treat PC from advanced/recurrent EOC...
  49. doi request reprint Restoration of the expression of transports associated with antigen processing in human malignant melanoma increases tumor-specific immunity
    Juan Tao
    Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Invest Dermatol 128:1991-6. 2008
    ....
  50. doi request reprint Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival in selected patients with peritoneal carcinomatosis from abdominal and pelvic malignancies: results of 21 cases
    Xiao jun Yang
    Department of Oncology, Zhongnan Hospital, Cancer Center of Wuhan University, Hubei Cancer Clinical Study Center, Wuchang District, China
    Ann Surg Oncol 16:345-51. 2009
    ..5 months). Eleven patients died, three survived with tumor, and seven survived free of tumor. CRS + HIPEC was well tolerated in our selected patients with PC, some of whom had improved survival...
  51. pmc Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer
    Lie Jun Mei
    Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, 430071, China
    BMC Cancer 10:124. 2010
    ..This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2 tumor, and analyze the clinico-pathological features...
  52. pmc Quantum dots-based quantitative and in situ multiple imaging on ki67 and cytokeratin to improve ki67 assessment in breast cancer
    Jing Ping Yuan
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, Hubei, China
    PLoS ONE 10:e0122734. 2015
    ..This study was to develop a fluorescent spectrum-based quantitative analysis of Ki67 expression by quantum-dots (QDs) multiple imaging technique...
  53. ncbi request reprint Study on the inhibitory effect of tyroserleutide on tumor growth and metastasis in nude mice model of human hepatocellular carcinoma metastasis
    Peng cheng Li
    Department of Oncology, Zhongnan Hospital of Wuhan University and Cancer Center of Wuhan University Wuhan, China
    Hepatogastroenterology 54:1359-63. 2007
    ..This study was designed to test the effect of tyroserleutide on tumor growth and metastasis in a nude mice model of human hepatocellular carcinoma (HCC) metastasis...
  54. ncbi request reprint Evaluation of tumor markers biochip C12 system in the diagnosis of gastric cancer and the strategies for improvement: analysis of 100 cases
    Chuang Chen
    Department of Oncology, Zhongnan Hospital and Cancer Center of Wuhah University, Wuhan, China
    Hepatogastroenterology 55:991-7. 2008
    ..A C12 biochip system using 12 tumor markers has been developed in China for serum diagnosis of common cancers. This work is to evaluate this C12 system in the diagnosis of gastric cancer...
  55. ncbi request reprint [Proteasome inhibitors sensitize ovarian cancer cells to cisplatin]
    Yan Li
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Zhonghua Fu Chan Ke Za Zhi 45:445-8. 2010
    ..To explore the sensitivity and the molecular mechanism of cisplatin-resistance ovarian cancer cell line C13 to proteasome inhibitors and the combination with cisplatin...
  56. pmc Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in China
    Xingyi Ge
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
    J Virol 86:4620-30. 2012
    ..This study provides the first preliminary understanding of the virome of some bat populations in China, which may guide the discovery and isolation of novel viruses in the future...
  57. pmc Proteomics analysis of normal and senescent NG108-15 cells: GRP78 plays a negative role in cisplatin-induced senescence in the NG108-15 cell line
    Wei Li
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P R China
    PLoS ONE 9:e90114. 2014
    ..GRP78 plays an important role in cisplatin-induced senescence in NG108-15 cells, mainly through its regulation of P53 expression and ER calcium efflux. ..
  58. doi request reprint Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP
    Wei Wang
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Apoptosis 16:55-66. 2011
    ..This suggests a novel mechanism for deregulation of cervical epithelial cell growth upon HPV-induced transformation, which is of great significance in developing therapeutic strategies for intervention of cervical carcinogenesis...
  59. doi request reprint Hadamard transform spectral microscopy for single cell imaging using organic and quantum dot fluorescent probes
    Hao Xu
    College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, PR China
    Analyst 134:504-11. 2009
    ..The preliminary biomedical applications indicate the great potential of the Hadamard imaging system as a useful tool in biomedicine...
  60. doi request reprint Stepwise discriminant function analysis for rapid identification of acute promyelocytic leukemia from acute myeloid leukemia with multiparameter flow cytometry
    Zhanguo Chen
    Department of Clinical Laboratory, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, Hubei, China
    Int J Hematol 103:306-15. 2016
    ..The established SDFA based on MFC with seven variables can precisely and rapidly differentiate APL and non-APL AML, which may contribute to the urgent initiation of all-trans-retinoic acid-based APL therapy...
  61. ncbi request reprint Application of C12 multi-tumor marker protein chip in the diagnosis of gastrointestinal cancer: results of 329 surgical patients and suggestions for improvement
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center and Hubei Key Laboratory on Tumor Biological Behaviors, Wuhan, 430071, China
    Hepatogastroenterology 56:1388-94. 2009
    ..Serum tumor markers (TMs) are frequently used in the diagnosis of GI cancer. This study was to assess value of C12 multi-tumor marker protein chip diagnostic system developed in China in GI cancer...
  62. doi request reprint Overexpression of the chemokine receptor CXCR3 and its correlation with favorable prognosis in gastric cancer
    Min Hu
    Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, People s Republic of China
    Hum Pathol 46:1872-80. 2015
    ..023). In conclusion, our study suggested a potential use of CXCR3 overexpression as a prognostic marker for GC and involvement of the up-regulation of CXCR3-B in favorable prognosis of GC patients. ..
  63. ncbi request reprint The expression of endothelin receptor B in melanoma cells A375 and Sk-mel-1 and the proliferative effects of endothelin 3 on A375 cells
    Nengxing Lin
    Department of Dermatology, Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:611-3. 2007
    ..ET3 had stronger ability to enhance the proliferation of A375 cells in vitro in a concentration-dependent manner. It was suggested that ET3/ETR-B might play an important proliferative role in MM...
  64. ncbi request reprint NDRG2 expression regulates CD24 and metastatic potential of breast cancer cells
    Jin Zheng
    Department of Oncology, Xijing Hospital, China
    Asian Pac J Cancer Prev 11:1817-21. 2010
    ..In conclusion, the data from the current study indicated that NDRG2, the product of a tumor suppressor gene, can regulate CD24 expression to decrease the metastatic potential of breast cancer cells...
  65. ncbi request reprint [In-vivo targeted imaging of hepatocellular carcinoma in nude mice using quantum dot probes]
    Liang Dong Chen
    Zhongnan Hospital of Wuhan University and Cancer Center of Wuhan University, Wuhan 430071, China
    Zhonghua Bing Li Xue Za Zhi 36:394-9. 2007
    ..To explore in-vivo targeted imaging techniques for liver cancer detection using quantum dots (QDs) labeled probes in a nude mouse model of human hepatocellular carcinoma...
  66. ncbi request reprint [Study on the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) and susceptibility to breast cancer in Chinese women]
    Ming Bai Hu
    Oncology Department of Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 27:351-5. 2006
    ..To investigate the relationship between polymorphisms of genes (CYP17, CYP19 and SULT1A1) involved in estrogen metabolism and susceptibility to breast cancer in Chinese women...
  67. ncbi request reprint High Ki-67 expression is a poor prognostic indicator of 5-year recurrence free survival in patients with invasive breast cancer
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory on Tumor Biological Behavior and Hubei Cancer Clinical Study Center, Wuhan, China
    Asian Pac J Cancer Prev 12:3101-5. 2011
    ..Despite a clear understanding of the protein's structure and properties, its functional role remains elusive. We conducted the present study to assess the prognostic value of Ki-67 in breast cancer (BC)...
  68. ncbi request reprint Screening the gastric cancer related tumor markers from multi-tumor markers protein chip with kappa coefficient and cost-effectiveness analysis
    Jin Xuan Hou
    Department of Oncology, Zhongnan Hospital, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, China
    Hepatogastroenterology 58:632-6. 2011
    ....
  69. pmc Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population
    Chang Hong Wang
    Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University Psychiatric hospital of Henan province, China, Xinxiang, 453002, Henan, China
    Behav Brain Funct 12:30. 2016
    ..The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population...
  70. pmc Integrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer
    Ling Hu
    Department of Anesthesiology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China
    Oncotarget 7:8441-54. 2016
    ..Therefore, we conduct to systematically identify miRNAs related to NSCLC, and their target genes expression changes using microarray data sets...
  71. doi request reprint Skin healing and collagen changes of rats after fractional erbium:yttrium aluminum garnet laser: observation by reflectance confocal microscopy with confirmed histological evidence
    Jing Yang
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology HUST, 1277 Jiefang Avenue, Wuhan, 430022, China
    Lasers Med Sci 31:1251-60. 2016
    ..05). In conclusion, RCM is a reliable technique for observing and evaluating skin healing and collagen expression after laser irradiation. ..
  72. ncbi request reprint Postoperative recurrence in gastric cancer: analysis of 59 cases
    Chun Wei Peng
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan City, Hubei Province, China
    Hepatogastroenterology 57:663-7. 2010
    ..This study was aimed to find out the relationship of cancer recurrence with major clinico-pathological factors, with special attention focused on time of recurrence...
  73. pmc Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (Review)
    Yan Jun Zhong
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P R China
    Int J Oncol 42:373-83. 2013
    ..In this review, we focused on Cat B-cleavable DOX prodrugs and discussed the efficacy of these prodrugs, demonstrated by preclinical and clinical developments...
  74. doi request reprint Expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features
    Xiangjie An
    Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Dermatol 41:76-83. 2014
    ..05). Overexpression of HIF-1α and VEGF, as well as the decreased expression of PHD2, may play important roles in the development of cutaneous SCC. ..
  75. pmc Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from colorectal cancer: a case-control study from a Chinese center
    Chao Qun Huang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center and Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, P R China
    J Surg Oncol 109:730-9. 2014
    ..This case-control study was to compare the efficacy and safety of cytoreductive surgery (CRS) versus CRS plus hyperthermic intraperitoneal chemotherapy (HIPEC) in Chinese patients with CRC PC...
  76. pmc Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis
    Hassan Alaa Hammed Al-Shammaa
    Department of Oncology, Zhongnan Hospital of Wuhan University, Cancer Center of Wuhan University, and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China
    World J Gastroenterol 14:1159-66. 2008
    ..This review summarizes the current status and possible progress in future...
  77. doi request reprint Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry
    Yuxuan Hou
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences CAS, Wuhan, Hubei, China
    Arch Virol 155:1563-9. 2010
    ..This calls for continuation and expansion of field surveillance studies among different bat populations to eventually identify the true natural reservoir of SARS-CoV...
  78. doi request reprint Role of endogenous estrogen on the incidence of coronary heart disease in men
    Hongyun Zheng
    Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
    Angiology 63:591-6. 2012
    ..05), total cholesterol/HDL-C (P < .05), CRP (P < .01), and d-dimer (P < .01). In conclusion, serum E2 and T levels affect coronary heart disease risk factors in males...
  79. doi request reprint Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditions
    Ji Ma
    Department of Oncology, Xijing Hospital, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi an, China
    Cancer 118:4105-16. 2012
    ....
  80. doi request reprint Tapping the potential of quantum dots for personalized oncology: current status and future perspectives
    Chuang Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University and Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Nanomedicine (Lond) 7:411-28. 2012
    ..In addition, the major challenges in translating quantum dot-based nanotechnology into clinical application and promising future directions in personalized oncology are also discussed...
  81. doi request reprint Patient distress and emotional disclosure: a study of Chinese cancer patients
    Dong Wei
    Department of Oncology, PLA General Hospital of Chengdu Military Region, Chengdu, China
    J Cancer Educ 28:346-51. 2013
    ..Cultural traits should be integrated into supportive cancer care research...
  82. ncbi request reprint Comparison of the gene expression profiles between smokers with and without lung cancer using RNA-Seq
    Peng Cheng
    Department of Oncology, PLA general hospital of Chengdu Commond, Clinical Medical College of Third Medical Military University, Chengdu, China
    Asian Pac J Cancer Prev 13:3605-9. 2012
    ..Our study provided detail expression profiles and expression changes between smokers with and without lung cancer...
  83. ncbi request reprint Preoperative serum carcinoembryonic antigen, carbohydrate antigen19-9 and carbohydrate antigen 125 as prognostic factors for recurrence-free survival in colorectal cancer
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory on Tumor Biological Behavior and Hubei Cancer Clinical Study Center, Wuhan, China
    Asian Pac J Cancer Prev 12:1251-6. 2011
    ....
  84. doi request reprint Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells
    Xiaoyuan Xu
    Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Int J Dermatol 48:186-92. 2009
    ..To investigate the effect of a Chinese traditional medicine, gambogic acid (GA), on human malignant melanoma (MM) A375 cells and to study the mechanism of apoptosis induced by GA...
  85. doi request reprint Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer
    Xue Qin Yang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center and Hubei Key Laboratory on Tumor Biological Behaviors, No 169 Donghu Road, 430071, Wuhan, China
    Med Oncol 28:789-95. 2011
    ..The simultaneously positive serum CA19-9, CEA, and CA125 was the most dismal predicting factor for OS of patients with CRC. Preoperative serum CA125 status and stage were independent prognostic factors for OS of CRC...
  86. pmc Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival for patients with peritoneal carcinomatosis from colorectal cancer: a phase II study from a Chinese center
    Chao Qun Huang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center and Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, P R China
    PLoS ONE 9:e108509. 2014
    ..This phase II study was to further investigate the efficacy and adverse events of CRS+HIPEC for Chinese patients with CRC PC...
  87. doi request reprint KGM-based magnetic carbon aerogels matrix for the uptake of methylene blue and methyl orange
    Shuxin Ye
    College of Food Science and Technology, Huazhong Agriculture University, Wuhan, 430070, China
    Int J Biol Macromol 92:1169-1174. 2016
    ..Moreover, Mag-CA with dyes (MO or MB) were successfully regenerated by ethanol and then easily separated from aqueous solution by applying magnetic field...
  88. doi request reprint Foxc2 overexpression enhances benefit of endothelial progenitor cells for inhibiting neointimal formation by promoting CXCR4-dependent homing
    Dujuan Li
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Vasc Surg 53:1668-78. 2011
    ..CXCR4 plays a critical role in regulating EPCs homing. Here, we studied the effect of Foxc2 overexpression on CXCR4 expression and the homing capacity of EPCs as well as the EPCs-mediated therapeutic benefit after artery injury...
  89. pmc Computer-based image studies on tumor nests mathematical features of breast cancer and their clinical prognostic value
    Lin Wei Wang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, Hubei Province, China
    PLoS ONE 8:e82314. 2013
    ..Useful information on cancer invasiveness hidden within tumor nests could be extracted and analyzed by computer image processing and big data analysis...
  90. doi request reprint Quantum dot-based multispectral fluorescent imaging to quantitatively study co-expressions of Ki67 and HER2 in breast cancer
    Qing Ming Xiang
    Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan City, Hubei Province, China
    Exp Mol Pathol 99:133-8. 2015
    ..493 vs. 1.481). This study demonstrated that QD-based fluorescent imaging technique could help the quantitative study on the co-expressions of Ki67 and HER2 in BC, and Ki67 has a greater negative impact on BC prognosis than HER2...
  91. doi request reprint Metastatic factors for Krukenberg tumor: a clinical study on 102 cases
    Li Qiu
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
    Med Oncol 28:1514-9. 2011
    ..Multivariate analysis confirmed that invasion depth was the only significant metastatic factor (Relative Risk: 3.2, P=0.004). Primary carcinomas T stage is the most important predictor of Krukenberg tumor from GI cancer...
  92. doi request reprint Rapid identification of Staphylococcus aureus directly from positive blood culture media using quantum dots as fluorescence probes
    Qing Wu
    Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
    APMIS 121:348-52. 2013
    ..5% (19/21) sensitivity and 100% (52/52) specificity for S. aureus. These results suggest that this immunofluorescence assay allows the rapid identification of S. aureus directly from specimens...
  93. doi request reprint IGF-1R and ErbB3/HER3 contribute to enhanced proliferation and carcinogenesis in trastuzumab-resistant ovarian cancer model
    Yanhan Jia
    Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China
    Biochem Biophys Res Commun 436:740-5. 2013
    ..These results suggest that IGF-1R and HER3 differentially regulate trastuzumab resistance and could be promising targets for trastuzumab therapy in ovarian cancer. ..
  94. doi request reprint Analysis of cancer marker in tissues with Hadamard transform fluorescence spectral microscopic imaging
    Hao Xu
    Key Laboratory of Analytical Chemistry for Biology and Medicine Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China
    J Fluoresc 25:397-402. 2015
    ....
  95. ncbi request reprint Intraperitoneal chemotherapy with hydroxycamptothecin reduces peritoneal carcinomatosis: results of an experimental study
    Peng cheng Li
    Department of Oncology, Zhongnan Hospital and Cancer Center of Wuhan University, 169 Donghu Road, Wuhan 430071, Hubei Province, China
    J Cancer Res Clin Oncol 134:37-44. 2008
    ..We studied the efficacy and safety of intraperitoneal chemotherapy with hydroxycamptothecin (HCPT) for the treatment of peritoneal carcinomatosis in animal model...
  96. doi request reprint Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer
    Chuang Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuchang District, PR China
    Biomaterials 30:2912-8. 2009
    ..Compared to conventional immunohistochemistry techniques, this method provided a superior accurate and sensitive method for the detection of HER2 in clinical breast cancer diagnosis...
  97. ncbi request reprint Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study
    Fang Zheng
    Department of Oncology, Zhongnan Hospital of Wuhan University and Cancer Center of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan, 430071, China
    Life Sci 80:388-96. 2007
    ..TMCO-60%/pDNA nanoparticles had better in vitro and in vivo transfection activity than the other two, and with minimal toxicity, which made it a desirable non-viral vector for gene therapy via oral administration...
  98. ncbi request reprint Carcinoembryonic antigen level is related to tumor invasion into the serosa of the stomach: study on 166 cases and suggestion for new therapy
    Yan Hua Zhang
    Department of Oncology, Zhongnan Hospital of Wuhan University, No 169, Donghu Road, Wuhan 430071, China
    Hepatogastroenterology 56:1750-4. 2009
    ..The present study aim is to study the significance of serum tumor markers in predicting tumor progression and clinical outcomes in gastric cancer (GC)...
  99. doi request reprint Lack of association between the unique LMP2 gene polymorphism and the outcome of lung cancer in a population of Chinese Han nationality
    Bangwei Cao
    Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Hum Immunol 73:580-4. 2012
    ..05). These results suggest that the polymorphic site is unique in the Chinese population of Han nationality at the LMP2 codon 60 loci (Arg60Cys), but a lack of association with lung cancer exists...
  100. doi request reprint In vitro invasive pattern of hepatocellular carcinoma cell line HCCLM9 based on three-dimensional cell culture and quantum dots molecular imaging
    Min Fang
    Department of Oncology and Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China
    J Huazhong Univ Sci Technolog Med Sci 33:520-4. 2013
    ....