Zhang Jun

Summary

Country: China

Publications

  1. doi request reprint Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway
    Jun Zhang
    Institute of Molecular Medicine and Oncology, Chongqing Medical University, Chongqing 400016, China Electronic address
    Cell Signal 27:1703-12. 2015
  2. ncbi request reprint Preliminarily investigating the polymorphism of self-organized actin filament in vitro by atomic force microscope
    Jun Zhang
    Key Lab of Biomechanics and Tissue Engineering, Chongqing University, Chongqing 400044, China
    Acta Biochim Biophys Sin (Shanghai) 36:637-43. 2004
  3. doi request reprint The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line
    Jun Zhang
    Department of Cell Biology and Genetics, Chongqing University of Medical Sciences, Chongqing, People s Republic of China
    Cancer Invest 26:456-63. 2008
  4. doi request reprint Single-photon atomic force microscopy
    Zhang Jun
    Department of Cell Biology and Genetics, Chongqing University of Medical Sciences, Chongqing 400016, China
    Anal Bioanal Chem 397:987-90. 2010
  5. ncbi request reprint [The relationship between intracellular actin distribution and morphology and cell adherence]
    Chao Cheng
    Key Lab of Biomechanics and Tissue Engineering under Ministry Education, College of Biology Engineering, Chongqing University, Chongqing 400044, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24:226-9. 2007
  6. ncbi request reprint [Interspecific interaction between Moina mongolica and Brachionus plicatilis]
    Taoying Chen
    Laboratory of Aquatic Ecology and Fish Nutrition, Shanghai Fisheries University, Shanghai 200090, China
    Ying Yong Sheng Tai Xue Bao 15:1253-6. 2004
  7. ncbi request reprint [Effect of continuous blood purification for management of multiple organ failure with acute renal failure]
    Lu Chen
    Department of Nephrology, Shenzhen Sixth People s Hospital, Shenzhen 518052, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:896-7. 2008
  8. ncbi request reprint Effect of pharmacologic preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver
    Zhongmin Liu
    Department of General Surgery and Organ Transplantation, The Second Affiliated Hospital, Shantou University Medical College, Dongxiabeilu, Shantou, 515041 Guangdong, People s Republic of China
    World J Surg 28:620-4. 2004
  9. ncbi request reprint [A diffusion tensor magnetic resonance imaging for studying white matter changes in patients with mild cognitive impairment.]
    Jin Qun Guan
    Department of Nanlou Neurology, Chinese PLA General Hospital, Beijing 100853, China Email
    Zhonghua Nei Ke Za Zhi 49:107-10. 2010
  10. ncbi request reprint [Treatment of lumbar disc herniation by modified transforaminal lumbar interbody fusion with a pedicle screw system]
    Li Ming Fang
    Department of Orthopedics, Second Hospital of Peking Armed Police, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 90:3339-42. 2010

Collaborators

Detail Information

Publications74

  1. doi request reprint Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway
    Jun Zhang
    Institute of Molecular Medicine and Oncology, Chongqing Medical University, Chongqing 400016, China Electronic address
    Cell Signal 27:1703-12. 2015
    ....
  2. ncbi request reprint Preliminarily investigating the polymorphism of self-organized actin filament in vitro by atomic force microscope
    Jun Zhang
    Key Lab of Biomechanics and Tissue Engineering, Chongqing University, Chongqing 400044, China
    Acta Biochim Biophys Sin (Shanghai) 36:637-43. 2004
    ....
  3. doi request reprint The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line
    Jun Zhang
    Department of Cell Biology and Genetics, Chongqing University of Medical Sciences, Chongqing, People s Republic of China
    Cancer Invest 26:456-63. 2008
    ....
  4. doi request reprint Single-photon atomic force microscopy
    Zhang Jun
    Department of Cell Biology and Genetics, Chongqing University of Medical Sciences, Chongqing 400016, China
    Anal Bioanal Chem 397:987-90. 2010
    ....
  5. ncbi request reprint [The relationship between intracellular actin distribution and morphology and cell adherence]
    Chao Cheng
    Key Lab of Biomechanics and Tissue Engineering under Ministry Education, College of Biology Engineering, Chongqing University, Chongqing 400044, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24:226-9. 2007
    ..It is obvious that the relationship between the mechanism of cell adhering to the matrix and the morphology & distribution of actins needs more attention...
  6. ncbi request reprint [Interspecific interaction between Moina mongolica and Brachionus plicatilis]
    Taoying Chen
    Laboratory of Aquatic Ecology and Fish Nutrition, Shanghai Fisheries University, Shanghai 200090, China
    Ying Yong Sheng Tai Xue Bao 15:1253-6. 2004
    ..plicatilis survived after 144 h of food deprivation. The relatively strong capacity of B. plicatilis in tolerating starvation may be one of the important reasons for it wins the competition against M. mongolica...
  7. ncbi request reprint [Effect of continuous blood purification for management of multiple organ failure with acute renal failure]
    Lu Chen
    Department of Nephrology, Shenzhen Sixth People s Hospital, Shenzhen 518052, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:896-7. 2008
    ..To evaluate the effect of continuous blood purification (CBP) for treatment of multiple organ failure (MOF) with acute renal failure (ARF)...
  8. ncbi request reprint Effect of pharmacologic preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver
    Zhongmin Liu
    Department of General Surgery and Organ Transplantation, The Second Affiliated Hospital, Shantou University Medical College, Dongxiabeilu, Shantou, 515041 Guangdong, People s Republic of China
    World J Surg 28:620-4. 2004
    ..The simultaneous decrease of both lipid peroxide generation and polymorphonuclear neutrophil infiltration in the ischemic liver may explain the acquisition of tolerance following administration of TET...
  9. ncbi request reprint [A diffusion tensor magnetic resonance imaging for studying white matter changes in patients with mild cognitive impairment.]
    Jin Qun Guan
    Department of Nanlou Neurology, Chinese PLA General Hospital, Beijing 100853, China Email
    Zhonghua Nei Ke Za Zhi 49:107-10. 2010
    ....
  10. ncbi request reprint [Treatment of lumbar disc herniation by modified transforaminal lumbar interbody fusion with a pedicle screw system]
    Li Ming Fang
    Department of Orthopedics, Second Hospital of Peking Armed Police, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 90:3339-42. 2010
    ..To evaluate the outcomes of modified transforaminal lumbar interbody fusion in patients with lumbar disc herniation...
  11. ncbi request reprint [Preliminary study of apoptosis of human hepatocarcinoma cell line HepG2 induced by topotecan]
    Jun Zhang
    Department of Biology, Institute of Basic Medical Sciences, Chongqing University of Medical Sciences, Chongqing 400016, P R China
    Ai Zheng 21:1305-9. 2002
    ..The inducing effect of topotecan on apoptosis of hepatocarcinoma cell line HepG2 and its cytotoxicity on HepG2 were studied in this paper...
  12. ncbi request reprint Atomic force microscopy of actin
    Jun Zhang
    Key Lab for Biomechanics Tissue Engineering under the State Ministry of Education, Chongqing University, Chongqing 400044, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:489-94. 2003
    ....
  13. ncbi request reprint Changes in circulating immunosuppressive cytokine levels of cancer patients after high intensity focused ultrasound treatment
    Qiang Zhou
    Clinical Center for Tumor Therapy of the 2nd Affiliated Hospital and Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, Chongqing, China
    Ultrasound Med Biol 34:81-7. 2008
    ..This change may lessen tumor-induced immunosuppression and renew antitumor immunity after HIFU in cancer patients...
  14. doi request reprint HCV core protein interacts with Dicer to antagonize RNA silencing
    Weixian Chen
    The Institute for Viral Hepatitis, Key Laboratory of Molecular Biology on Infectious Diseases of the Ministry of Education, Chongqing Medical University, Chongqing, 400016, China
    Virus Res 133:250-8. 2008
    ..This anti-Dicer ability of core protein may contribute to the persistent viral infection and pathogenesis of HCV...
  15. ncbi request reprint Potent and specific inhibition of SARS-CoV antigen expression by RNA interference
    Peng Tao
    The Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China
    Chin Med J (Engl) 118:714-9. 2005
    ....
  16. doi request reprint Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion
    Zhi You Cai
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China
    Neurosci Bull 24:305-13. 2008
    ....
  17. ncbi request reprint [The promoter activity of the DNA sequence corresponding to HCV 5'UTR in HepG2]
    Wei xian Chen
    Key Laboratory of Infectious Diseases, Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China
    Zhonghua Gan Zang Bing Za Zhi 13:897-9. 2005
    ..To study the promoter activity in HepG2 cells of the DNA sequence corresponding to the HCV 5'UTR...
  18. ncbi request reprint [Radiofrequency ablation therapy of hepatic neoplasms]
    Jun Zhang
    Department of General Surgery, First College of Clinical Medicine and First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
    Zhonghua Gan Zang Bing Za Zhi 11:760-2. 2003
  19. doi request reprint A common polymorphism is associated with body mass index in Uyghur population
    Jun Zhang
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Diabetes Res Clin Pract 81:e11-3. 2008
    ..47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age...
  20. ncbi request reprint Specific CD8(+ )T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination
    Hua gang Zhang
    Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xue Yuan Road, Beijing, 100083, People s Republic of China
    Cancer Immunol Immunother 56:1945-54. 2007
    ..The responsive CD8(+ )T cells to both NY-ESO-1 and MAGE-A3 antigens provide a rationale for the application of a bivalent vaccine in HCC patients with tumors expressing both antigens...
  21. ncbi request reprint Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection
    Jun Zhang
    Department of Physiology, Cardiovascular Research Laboratories, Suite 1619 MRL Bldg, 675 Charles E Young Dr, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 287:H2364-6. 2004
    ..These findings indicate that a novel type of PKC-tyrosine kinase module (involving Bmx) is formed in the heart and may be involved in pharmacological cardioprotection by NO donors...
  22. ncbi request reprint Analysis of apoptosis and cell proliferation after high intensity-focused ultrasound ablation combined with microbubbles in rabbit livers
    Wen Luo
    Department of Ultrasound in Xijing Hospital, Fourth Military Medical University, 17th Changle Xilu, Xi an, China
    Eur J Gastroenterol Hepatol 19:962-8. 2007
    ..To analyze apoptosis and expression of proliferating cell nuclear antigen (PCNA) sequentially in the rabbit liver tissue after high-intensity focused ultrasound (HIFU) ablation combined with microbubbles...
  23. ncbi request reprint [Effect of inhibiting survivin expression with antisense oligodeoxynucleotides on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to adriamycin]
    De Jian Dai
    Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P R China
    Ai Zheng 24:951-7. 2005
    ..This study was to investigate the effect of inhibiting survivin expression with ASODN on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to Adriamycin (ADM)...
  24. ncbi request reprint Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 19:1646-53. 2005
    ....
  25. ncbi request reprint Study of sequential histopathologic changes, apoptosis, and cell proliferation in rabbit livers after high-intensity focused ultrasound ablation
    Wen Luo
    Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Ultrasound Med 26:477-85. 2007
    ....
  26. ncbi request reprint Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5
    Jun Zhang
    Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA
    J Biochem Mol Toxicol 21:206-15. 2007
    ..The results revealed unique features for mFMO5, suggesting possible impact on the functional significance of this abundantly expressed FMO5 isoform in both human and mouse liver...
  27. pmc The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity
    Parvaneh Espandiari
    Center for Drug Evaluation and Research, Silver Spring, Maryland 20993, USA
    Toxicol Sci 99:637-48. 2007
    ....
  28. ncbi request reprint Adenovirus-mediated small hairpin RNA targeting Bcl-XL as therapy for colon cancer
    Hongbo Zhu
    Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Zhejiang, China
    Int J Cancer 121:1366-72. 2007
    ..Together, our results support the feasibility of using adenovirus-mediated RNA interference therapy targeting Bcl-XL against colon cancers and warrant further studies of its safety and efficacy...
  29. ncbi request reprint In vitro and in vivo toxicity of CdTe nanoparticles
    Yongbin Zhang
    Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Nanosci Nanotechnol 7:497-503. 2007
    ....
  30. ncbi request reprint Comparative analysis of the protein profiles from primary gastric tumors and their adjacent regions: MAWBP could be a new protein candidate involved in gastric cancer
    Jun Zhang
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing Airport Industrial Zone B 6, Shunyi, Beijing, China 101318
    J Proteome Res 6:4423-32. 2007
    ..On the basis of all the results, we concluded that MAWBP could be a new GC-related protein even though its physiological roles remain unexplored...
  31. ncbi request reprint Endothelial nitric oxide synthase gene intron 4, 27 bp repeat polymorphism and essential hypertension in the Kazakh Chinese population
    Fengmei Deng
    West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610044, China
    Acta Biochim Biophys Sin (Shanghai) 39:311-6. 2007
    ..However, a positive association between plasma eNOS activity and essential hypertension has been revealed...
  32. ncbi request reprint Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma
    Youlei Zhang
    Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200433, China
    Biochem Biophys Res Commun 358:124-9. 2007
    ..Our results suggest that genetic downregulation of the expression of heparanase may serve as an efficient cancer therapeutic for human HCC...
  33. ncbi request reprint Age-related differences in susceptibility to toxic effects of valproic acid in rats
    Parvaneh Espandiari
    FDA, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA
    J Appl Toxicol 28:628-37. 2008
    ..In conclusion, this study showed that the vulnerability profile of each age group was different indicating that a multi-age pediatric animal model is appropriate to assess more completely age-dependent changes in drug toxicity...
  34. ncbi request reprint Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries
    Long Gang Niu
    Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, PR China
    Eur J Pharmacol 580:169-74. 2008
    ....
  35. ncbi request reprint [Screening of highly effective siRNA sequence targeting to HIV-1 vif and the lentiviral-mediated antiviral research in vitro]
    Tao Zhang
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361005, China
    Bing Du Xue Bao 24:88-95. 2008
    ..These results showed that RNAi has great potential as an antiviral gene therapy approach and supports the efforts to develop treatment for HIV-1-infected individuals...
  36. pmc Long-term outcome of esophageal myotomy for achalasia
    Jun Feng Liu
    Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
    World J Gastroenterol 10:287-91. 2004
    ..This study was to objectively assess the long-term outcomes of esophageal myotomy for achalasia using esophageal manometry, 24-hour pH monitoring, esophageal scintigraphy and fiberoptic esophagoscopy...
  37. pmc Altered proteome biology of cardiac mitochondria under stress conditions
    Jun Zhang
    Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Proteome Res 7:2204-14. 2008
    ....
  38. pmc Closing two doors of viral entry: intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1
    Erhard Kopetzki
    1Pharmaceuticals Division, Roche Penzberg, Penzberg, Germany
    Virol J 5:56. 2008
    ....
  39. doi request reprint Increasing prevalence and low awareness, treatment and control of diabetes mellitus among Chinese adults: the InterASIA study
    Dongsheng Hu
    Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China
    Diabetes Res Clin Pract 81:250-7. 2008
    ..To estimate the prevalence rates of impaired fasting glucose (IFG) and diabetes mellitus (DM) and to evaluate the awareness, treatment, and control of DM in the Chinese adult population...
  40. ncbi request reprint Experimental studies with foot-and-mouth disease virus type Asia-1, responsible for the 2005 epidemic in China
    Qiang Zhang
    Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu 730046, PR China
    Res Vet Sci 85:368-71. 2008
    ..The result showed that this strain is not host restricted, and could not only cause FMD in cattle and sheep but also in pigs by either inoculation or direct contact...
  41. ncbi request reprint Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists
    Rama Kondru
    Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Mol Pharmacol 73:789-800. 2008
    ..The fully mapped binding pocket of CCR5 is being used for structure-based design and lead optimization of novel anti-HIV CCR5 inhibitors with improved potency and better resistance profile...
  42. ncbi request reprint [Effect on mouse S180 MDR tumour cell expression correlated factorial matter by 70% ethanol with Huanglian Jiedu Tang]
    Gui Hai Li
    Shandong Academy of Chinese of Medicine, Jinan 250014, China
    Zhongguo Zhong Yao Za Zhi 32:1906-8. 2007
    ..To observe the effect on P170, LRP, TOPO II of S180 tumour MDR mice for matter by 70% ethanol with Huanglian Jiedu Tang, and then discuss the molecular biology base for clinic...
  43. doi request reprint Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway
    Bin Kang
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing Airport Industrial Zone B 6, Shunyi District, Beijing, China
    J Proteome Res 7:3507-15. 2008
    ..And the HM occurrence of RKO cell (4/5) was dramatically higher than that of HT29 cell (1/5). Therefore, the protein signature derived from PI3K/AKT pathway is likely a promising multiplex biomarker for HM of CRC...
  44. ncbi request reprint Enhancing effects of SonoVue, a microbubble sonographic contrast agent, on high-intensity focused ultrasound ablation in rabbit livers in vivo
    Wen Luo
    Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Ultrasound Med 26:469-76. 2007
    ..The purpose of this study was to explore the enhancing biological effects of SonoVue (Bracco SpA, Milan, Italy), a sulfur hexafluoride sonographic contrast agent, on high-intensity focused ultrasound (HIFU) ablation in vivo...
  45. ncbi request reprint Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    Jun Zhang
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:1478-86. 2007
    ..Vascular endothelial growth factor (VEGF) is a critical proangiogenic factor in solid tumors. However, its expression and role in human neuroendocrine tumor development and progression remains unclear...
  46. ncbi request reprint Drug-induced vascular injury--a quest for biomarkers
    William Kerns
    Pharma Consulting Inc
    Toxicol Appl Pharmacol 203:62-87. 2005
  47. ncbi request reprint Cystatin m: a novel candidate tumor suppressor gene for breast cancer
    Jun Zhang
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Cancer Res 64:6957-64. 2004
    ..Immunohistochemical studies confirmed that expression of cystatin M in IDCs was partially or completely lost. We propose cystatin M as a novel candidate tumor suppressor gene for breast cancer...
  48. ncbi request reprint [Construction and expression of single-chain antibody of neutralizing monoclonal antibody 13D8 against hepatitis E virus]
    Li feng Li
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:556-9. 2004
    ..To weaken the immunogenicity of the neutralizing monoclonal antibody (mAb) 13D8 against hepatitis E virus and express its scFv...
  49. ncbi request reprint The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
    Jun Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:49517-22. 2004
    ..These results define a central role for CAR in LCA detoxification and show that CAR and PXR function coordinately to regulate both xenobiotic and bile acid metabolism...
  50. ncbi request reprint Distribution and sources of polynuclear aromatic hydrocarbons in Mangrove surficial sediments of Deep Bay, China
    Jun Zhang
    Key Laboratory of Marine Environmental Science Xiamen University, Ministry of Education, Environmental Science Research Center, Xiamen University, Xiamen, 361005, China
    Mar Pollut Bull 49:479-86. 2004
    ..Principal component analysis (PCA) was applied to further investigate the source of PAHs. The PAH sources of Deep Bay mangrove swamp were suggested to be primarily combustion of fossil fuel, especially leaded-gasoline exhaust...
  51. ncbi request reprint Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 18:2402-8. 2004
    ..These results demonstrate that a single compound can induce opposite xenobiotic responses via orthologous receptors in rodents and humans...
  52. ncbi request reprint PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
    Jun Zhang
    National Jewish Medical and Research Center, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    FEBS Lett 570:97-101. 2004
    ..Furthermore, PIASy also inhibits IRF-3, IRF-7 and Sendai virus-induced ISRE activation. Our results suggest that PIASy is an inhibitor of TRIF-induced ISRE and NF-kappaB activation but not apoptosis...
  53. ncbi request reprint [Effects of chronic alcohol administration on the activities of the key glycolytic enzymes of rats]
    Hong Pang
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Wei Sheng Yan Jiu 33:195-7. 2004
    ..They can also be one of the mechanisms of diabetes mellitus relating to alcohol because of the high blood sugar and the disturbed blood sugar regulation...
  54. ncbi request reprint [Inhibition of invasiveness of human mammary carcinoma cell line MDA435 by heparanase antisense oligodeoxynucleotide]
    You Lei Zhang
    Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhonghua Yi Xue Za Zhi 83:204-7. 2003
    ..To evaluate the inhibitory effect of heparanase antisense oligodeoxynucleotide (AS-ODN) on the invasiveness of human mammary carcinoma cell line MDA435...
  55. ncbi request reprint Quantitative analysis of tumor-derived methylated p16INK4a sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients
    Ivy H N Wong
    Department of Biochemistry, Faculty of Medicine Building, Laboratory Block, The University of Hong Kong, Hong Kong, People s Republic of China
    Clin Cancer Res 9:1047-52. 2003
    ....
  56. ncbi request reprint [Acute aging model induced by gamma-ray irradiation]
    Yun Li
    School of Public Health, West China University of Medical Sciences, Chengdu 610041, China
    Wei Sheng Yan Jiu 31:290-1. 2002
    ..The results from this investigation indicate that an acute aging model can be induced by gamma-ray irradiating on rats...
  57. ncbi request reprint Mouse T cells receive costimulatory signals from LIGHT, a TNF family member
    Guixiu Shi
    Laboratory of Transplantation Immunology, Research Center, Centre hospitalier de l Universite de Montreal CHUM Notre Dame Hospital, Pavilion DeSeve, 1560 Sherbrooke Street E, Montreal, Quebec H2L 4M21, Canada
    Blood 100:3279-86. 2002
    ..Indeed, LIGHT cross-linking enhanced p44/42 mitogen-activated protein kinase activation after TCR ligation. This study reveals a new function and signaling event of LIGHT...
  58. ncbi request reprint Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    Jun Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 298:422-4. 2002
    ..These results suggest an innovative therapeutic approach for treating the adverse effects of acetaminophen and potentially other hepatotoxic agents...
  59. ncbi request reprint Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense CIITA
    Gang Cai
    Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, 174 Changhai Avenue, Shanghai 200433, China
    J Mol Cell Cardiol 38:593-605. 2005
    ..It indicates the therapeutic potential of blocking T cells activation by gene-transfer in myocarditis...
  60. ncbi request reprint Cross-inhibition to heterologous foot-and-mouth disease virus infection induced by RNA interference targeting the conserved regions of viral genome
    Mingqiu Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Virology 336:51-9. 2005
    ..These results suggested that siRNAs directed to several conserved regions of the FMDV genome could inhibit FMDV replication in a cross-resistance manner, providing a strategy candidate to treat high genetic variability of FMDV...
  61. ncbi request reprint Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51)
    Qing Yan Sun
    Department of Organic Chemistry, College of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai 200433, People s Republic of China
    Eur J Med Chem 42:1226-33. 2007
    ..albicans as voriconazole (with the MIC value of 0.0152microg/mL). Compounds 3, 6, and 7 showed higher activity against C. parapsilosis than all five positive controls...
  62. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
    ..These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo...
  63. ncbi request reprint Neogenesis and proliferation of beta-cells induced by human betacellulin gene transduction via retrograde pancreatic duct injection of an adenovirus vector
    Yae Tokui
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5, Yamadaoka, Suita City, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 350:987-93. 2006
    ....
  64. ncbi request reprint VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients
    Yingshuang Zhang
    Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100083, China
    Amyotroph Lateral Scler 7:119-22. 2006
    ....
  65. ncbi request reprint Trends in the rates of resistance of Ureaplasma urealyticum to antibiotics and identification of the mutation site in the quinolone resistance-determining region in Chinese patients
    Xinyou Xie
    Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
    FEMS Microbiol Lett 259:181-6. 2006
    ..urealyticum and the emergence of quinolone resistance. Analysis of the gene sequence of topoisomerase IV and DNA gyrase suggested a role for the topoisomerase IV ParE subunit in fluoroquinolone-resistant U. urealyticum...
  66. ncbi request reprint Swine as a principal reservoir of hepatitis E virus that infects humans in eastern China
    Yingjie Zheng
    Department of Epidemiology, School of Public Health, The Key Laboratory on Public Health Safety, Ministry of Education, Fudan University, Shanghai, China
    J Infect Dis 193:1643-9. 2006
    ..To study the relationship between the human and swine reservoirs, we estimated their respective viral burden, analyzed the genetic makeup of the virus populations, and assessed the risk of infection associated with swine farming...
  67. ncbi request reprint Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 312:233-6. 2006
    ..FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth...
  68. ncbi request reprint Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat
    Jun Zhang
    Division of Applied Pharmacology Research HFD 910, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 34:152-63. 2006
    ....
  69. ncbi request reprint [Studies on the resources survey methods of Panax notogingseng based on remote sensing]
    Ying qun Zhou
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Chinese Peking Union Medical College, Beijing 100094, China
    Zhongguo Zhong Yao Za Zhi 30:1902-5. 2005
    ..To explore the survey methods for the cultivated medicinal plant resources such as Panax notogingseng based on remote sensing...
  70. ncbi request reprint A rare Cu/Zn superoxide dismutase mutation causing familial amyotrophic lateral sclerosis with variable age of onset and incomplete penetrance in China
    Huagang Zhang
    Department of Neurology, Peking University Third Hospital, Haidian District, Beijing, China
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:234-8. 2005
    ..It is concluded that the S105L mutation in exon 4 of the Cu/Zn SOD gene is pathogenic. The phenotype is characterized by relatively variable clinical symptoms, with incomplete penetrance...
  71. ncbi request reprint Development of a novel dual CCR5-dependent and CXCR4-dependent cell-cell fusion assay system with inducible gp160 expression
    Changhua Ji
    Roche Palo Alto, 3411 Hillview Avenue, Palo Alto, CA 94304, USA
    J Biomol Screen 11:65-74. 2006
    ..1% or 0.5% DMSO. This assay system has been successfully used for the identification and characterization of thousands of CCR5 inhibitors...
  72. ncbi request reprint Quantitative analysis of FMO gene mRNA levels in human tissues
    Jun Zhang
    Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA
    Drug Metab Dispos 34:19-26. 2006
    ..e., FMO1 in kidney, FMO2 in lung, FMO3 and FMO5 in adult liver), FMO4 mRNA was observed more broadly at relatively comparable levels in liver, kidney, lung, and small intestine...
  73. ncbi request reprint Expression and function of inducible costimulator on peripheral blood T cells in patients with systemic lupus erythematosus
    Jia Hui Yang
    Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, P R China
    Rheumatology (Oxford) 44:1245-54. 2005
    ..To investigate the role of inducible costimulator (ICOS) in the pathogenesis of SLE, we assessed its expression on peripheral blood CD4 and CD8 T cells and functional roles in patients with systemic lupus erythematosus (SLE)...
  74. ncbi request reprint Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection
    Christopher P Baines
    Department of Physiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Circ Res 90:390-7. 2002
    ..Furthermore, formation of mitochondrial PKCepsilon-ERK modules appears to play a role in PKCepsilon-mediated cardioprotection, in part by the phosphorylation and inactivation of Bad...