Zengqiang Yuan

Summary

Affiliation: Institute of Biophysics
Country: China

Publications

  1. pmc Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway
    Weizhe Liu
    Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, China
    PLoS ONE 7:e36562. 2012
  2. pmc Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120
    Zengqiang Yuan
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 285:3815-24. 2010
  3. pmc E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors
    Qi Xie
    From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 289:34205-13. 2014
  4. doi request reprint Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury
    Siqi Zhao
    Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Brain Behav Immun 55:236-48. 2016
  5. pmc Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death
    Qi Xie
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    EMBO Rep 13:371-7. 2012
  6. pmc One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system
    Xianlong Wang
    State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Sci Rep 6:20620. 2016
  7. doi request reprint The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death
    Lei Xiao
    State Key Laboratory of Brain and Cognitive Sciences, Beijing 100101, China
    J Neurosci 31:9611-9. 2011
  8. pmc MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
    Fang Yuan
    State Key Laboratory of Brain and Cognitive Sciences, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 286:6940-5. 2011
  9. doi request reprint YAP/TEAD-mediated transcription controls cellular senescence
    Qi Xie
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Cancer Res 73:3615-24. 2013
  10. pmc YAP enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation
    Qinghe Song
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
    PLoS ONE 10:e0120790. 2015

Collaborators

Detail Information

Publications30

  1. pmc Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway
    Weizhe Liu
    Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, China
    PLoS ONE 7:e36562. 2012
    ..Previously we reported that protein kinase c-Abl mediates oxidative stress-induced neuronal cell death through phosphorylating MST1 at Y433, which is not conserved among mammalian MST2, Drosophila Hippo and C.elegans cst-1/2...
  2. pmc Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120
    Zengqiang Yuan
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 285:3815-24. 2010
    ..These findings indicate that the phosphorylation of MST1-Thr(120) by Akt could be a major mechanism of regulation of the Hippo/MST1 pathway by cell survival signaling...
  3. pmc E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors
    Qi Xie
    From the State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 289:34205-13. 2014
    ..We speculate that drugs and/or therapies that inhibit this physical interaction might be good candidates for reducing cellular senescence and increasing longevity. ..
  4. doi request reprint Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury
    Siqi Zhao
    Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Brain Behav Immun 55:236-48. 2016
    ..Together with our previous work demonstrating that MST1 is important for oxidative stress-induced neuronal cell death, our results indicate that MST1 could represent a potent therapeutic target for ischemic stroke. ..
  5. pmc Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death
    Qi Xie
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    EMBO Rep 13:371-7. 2012
    ..Collectively, these findings define a novel modification of FOXO3 and show that lysine methylation negatively regulates FOXO3-mediated transcription and neuronal apoptosis...
  6. pmc One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system
    Xianlong Wang
    State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Sci Rep 6:20620. 2016
    ..Our results demonstrate that the simplicity, efficiency, and power of the CRISPR/Cas9 system to allow for the modification of multiple genes in pigs and yield results of high medical value. ..
  7. doi request reprint The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death
    Lei Xiao
    State Key Laboratory of Brain and Cognitive Sciences, Beijing 100101, China
    J Neurosci 31:9611-9. 2011
    ..The identification of the c-Abl tyrosine kinase as a novel upstream activator of MST1 suggests that the c-Abl-MST1 signaling cascade plays an important role in cellular responses to oxidative stress...
  8. pmc MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
    Fang Yuan
    State Key Laboratory of Brain and Cognitive Sciences, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 286:6940-5. 2011
    ....
  9. doi request reprint YAP/TEAD-mediated transcription controls cellular senescence
    Qi Xie
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Cancer Res 73:3615-24. 2013
    ..Taken together, our findings define the critical role of YAP in the regulation of cellular senescence and provide a novel insight into a potential chemotherapeutic avenue for tumor suppression...
  10. pmc YAP enhances autophagic flux to promote breast cancer cell survival in response to nutrient deprivation
    Qinghe Song
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
    PLoS ONE 10:e0120790. 2015
    ..Collectively, our data reveal a role for YAP in promoting breast cancer cell survival upon ND stress and uncover an unappreciated function of YAP/TEAD in the regulation of autophagy. ..
  11. pmc Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop
    Jinbo Cheng
    The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Sci Rep 6:20158. 2016
    ..Altogether, our findings suggest that MCU and TNFR1 are involved in the regulation of RIG-I-like receptors (RLR) signaling. ..
  12. doi request reprint DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis
    Jun Ma
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Biochem J 462:489-97. 2014
    ..Taken together, the DJ-1-RACK1 complex protects neurons from oxidative stress-induced apoptosis, with the implication that DJ-1 and RACK1 might be novel targets in the treatment of neurodegenerative diseases. ..
  13. pmc Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression
    Junbing Wu
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Protein Cell 3:470-80. 2012
    ..In sum, we found that mouse Calhm1 was of rare abundance in brain tissues. So it might not be suitable to utilize the knockout murine model to explore biological function of Calhm1 in the pathogenesis of AD...
  14. pmc PP1A-mediated dephosphorylation positively regulates YAP2 activity
    Pei Wang
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 6:e24288. 2011
    ..However, the dephosphorylation of YAP2 is not fully appreciated...
  15. doi request reprint HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death
    Shengyi Peng
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, Center of Alzheimer s Disease, Beijing Institute for Brain Disorders, Beijing, 100069, China, and College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
    J Neurosci 35:1250-9. 2015
    ..Our study reveals the novel regulation of FOXO3a-mediated selective gene transcription via epigenetic modification in the process of oxidative stress-induced cell death, which could be exploited therapeutically. ..
  16. doi request reprint Methylation-mediated regulation of E2F1 in DNA damage-induced cell death
    Qi Xie
    Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    J Recept Signal Transduct Res 31:139-46. 2011
    ..The identification of the methylation/demethylation of E2F1 by Set9/LSD1 suggests that E2F1 is dynamically regulated by epigenetic enzymes in response to DNA damage...
  17. doi request reprint Post-translational regulation of FOXO
    Qi Xie
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Acta Biochim Biophys Sin (Shanghai) 44:897-901. 2012
    ..FOXO proteins are subject to several post-translational modifications, which are closely related to their activity. In this paper, we review the post-translational modifications of FOXOs and their biological functions...
  18. ncbi request reprint DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection
    Qiang Zhang
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Biochem J 447:261-9. 2012
    ....
  19. doi request reprint Vps35-dependent recycling of Trem2 regulates microglial function
    Jie Yin
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Traffic 17:1286-1296. 2016
    ..Our study suggests that Vps35/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to AD...
  20. pmc Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death
    Yajin Liao
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Protein Cell 6:434-42. 2015
    ..This finding demonstrates that MCU-VDAC1 complex regulates mitochondrial Ca(2+) uptake and oxidative stress-induced apoptosis, which might represent therapeutic targets for oxidative stress related diseases. ..
  21. doi request reprint Ezh2 regulates adult hippocampal neurogenesis and memory
    Juan Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China, University of Chinese Academy of Sciences, Beijing 100049, China, and Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Neurosci 34:5184-99. 2014
    ..Our findings demonstrate the essential role of Ezh2 in the proliferation of progenitor cells, thus providing insight into the molecular mechanisms of adult neurogenesis in preserving cognitive functions. ..
  22. pmc MST1, a key player, in enhancing fast skeletal muscle atrophy
    Bin Wei
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Beijing 100101, China
    BMC Biol 11:12. 2013
    ..MST1 has been shown to mediate phosphorylation of FOXO3a at Ser207. Whether this MST1-FOXO signaling cascade exerts any functional consequence on cellular homeostasis remains to be investigated...
  23. doi request reprint c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice
    Rong Wu
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China
    Diabetologia . 2017
    ..Hence, we sought to address the role of c-Abl in diet-induced obesity and obesity-associated insulin resistance...
  24. pmc Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress
    Peng Zhang
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Sci Rep 6:19418. 2016
    ..Taken together, this study reveals a previously unknown Golgi-to-ER retrograde route of Wg, and elucidates a correlation between Wnt secretion and ER stress during development. ..
  25. doi request reprint Hippo signaling in stress response and homeostasis maintenance
    Beibei Mao
    State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Acta Biochim Biophys Sin (Shanghai) 47:2-9. 2015
    ..The purpose of this review is to summarize the recent findings and discuss how Hippo pathway responds to cellular stress and regulates early development events, tissue homeostasis as well as tumorigenesis. ..
  26. pmc c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82
    Wenzhi Bi
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 285:6259-64. 2010
    ..Collectively, these findings define the novel feedback regulation of MST1 kinase activation by its putative substrate, JNK, with implication for our understanding of the signaling mechanism during cell death...
  27. doi request reprint The function of NOD-like receptors in central nervous system diseases
    Xiangxi Kong
    The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    J Neurosci Res . 2016
    ..In this review, we mainly focus on the role of NLRs and the underlying signaling pathways in central nervous system (CNS) diseases. © 2016 Wiley Periodicals, Inc...
  28. doi request reprint Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule
    Jinqi Ren
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Biochem J 468:133-44. 2015
    ....
  29. doi request reprint Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs
    Ye Zhu
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Signal 27:606-13. 2015
    ..Together, we showed that Brm functions as a critical regulator of Hippo signaling during tissue growth and plays an important role in the feedback loop between Crb and Yki. ..
  30. pmc Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs
    Jing Yao
    1 State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, P R China, 100101 2 Beijing Farm Animal Research Center, Institute of Zoology, Chinese Academy of Sciences, P R China, 100101
    Sci Rep 4:6926. 2014
    ..These DJ-1 KO pigs will provide valuable information for studying Parkinson's disease. ..