Peng Huang

Summary

Country: China

Publications

  1. pmc Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma
    Peng Huang
    Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, China
    World J Gastroenterol 14:3903-7. 2008
  2. pmc A single posterior approach for multilevel modified vertebral column resection in adults with severe rigid congenital kyphoscoliosis: a retrospective study of 13 cases
    Yan Wang
    Department of Orthopaedics, Chinese PLA General Hospital, Fuxing Road 28, Beijing 100853, China
    Eur Spine J 17:361-72. 2008
  3. ncbi request reprint Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
    Steffan T Nawrocki
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11658-66. 2005
  4. ncbi request reprint Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response
    Yan Zhou
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharmacol 61:222-9. 2002
  5. ncbi request reprint GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor
    Chongguang Chen
    Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 281:7983-93. 2006
  6. ncbi request reprint Anticancer activities of novel chalcone and bis-chalcone derivatives
    Aneta Modzelewska
    Division of Chemical Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Bioorg Med Chem 14:3491-5. 2006
  7. ncbi request reprint Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia
    Zhihong Zeng
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3737-46. 2006
  8. ncbi request reprint Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
    Steffan T Nawrocki
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3773-81. 2006
  9. ncbi request reprint A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome
    Geetha Achanta
    Department of Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Pharmacol 70:426-33. 2006
  10. pmc Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells
    Peng Huang
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, United States
    Biochem Pharmacol 73:534-49. 2007

Collaborators

  • S R Khan
  • Chun You Wang
  • Yonggang Zhang
  • Yan Wang
  • D J McConkey
  • Chun Li
  • Julie G Izzo
  • Kenneth Wang
  • Jaffer Ajani
  • F J Giles
  • Rui Hua Xu
  • Douglas B Evans
  • Steffan T Nawrocki
  • Jennifer S Carew
  • Helene Pelicano
  • Geetha Achanta
  • Jinsong Liu
  • Yan Zhou
  • James L Abbruzzese
  • Aneta Modzelewska
  • Yumin Hu
  • Li Feng
  • Kenneth Dunner
  • Paul J Chiao
  • Michael J Keating
  • Chia Jui Yen
  • Janet A Houghton
  • John L Cleveland
  • Jerome Alexandre
  • Chongguang Chen
  • Weiqin Lu
  • Zhihong Zeng
  • Zeev Estrov
  • Maria S Pino
  • Ralph A Highshaw
  • Xiaojun Liu
  • Chenyi Zhou
  • Elizabeth Oldham Hileman
  • Ning Ning Zhou
  • Andrew P Mone
  • Shuichi Fujioka
  • William Plunkett
  • Feng Cheng
  • Xiaoxia Wen
  • Loning Fu
  • Jung Mao Hsu
  • Yongkun Wei
  • Hui Lung Sun
  • Sushovan Guha
  • Tsung Teh Wu
  • Hsu Ping Kuo
  • Dung Fang Lee
  • Navtej S Buttar
  • Chao Kai Chou
  • Chun Te Chen
  • James F Courage
  • Kirsteen H Maclean
  • Mien Chie Hung
  • Linda Chung
  • Hui Zhang
  • Chunying Yang
  • Charissa N Kahue
  • Michael Andreeff
  • Olga Frolova
  • Yong Chen
  • Nancy E Davidson
  • Ashutosh Pal
  • Weiguo Zhang
  • Marina Konopleva
  • Wenjing Chen
  • Steven M Kornblau
  • David Harris
  • Ismael J Samudio
  • Catherine Pettit
  • Gordon B Mills
  • Henry Xiong
  • Yiling Lu
  • Robert H I Andtbacka
  • Lee Yuan Liu-Chen
  • Jian Guo Li
  • Numsen Hail
  • William G Bornmann
  • Wensheng Yu
  • Yexiong Li
  • Changgang Lou
  • Zhendong Jin
  • Ying Kang
  • Gong Yang
  • Akira Matsuda
  • David M Harris

Detail Information

Publications28

  1. pmc Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma
    Peng Huang
    Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan, China
    World J Gastroenterol 14:3903-7. 2008
    ..To explore the method of isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma cell line PANC-1...
  2. pmc A single posterior approach for multilevel modified vertebral column resection in adults with severe rigid congenital kyphoscoliosis: a retrospective study of 13 cases
    Yan Wang
    Department of Orthopaedics, Chinese PLA General Hospital, Fuxing Road 28, Beijing 100853, China
    Eur Spine J 17:361-72. 2008
    ..MVCR technique through a single posterior approach is an effective procedure for the surgical treatment of severe congenital rigid kyphoscoliosis in adults...
  3. ncbi request reprint Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
    Steffan T Nawrocki
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11658-66. 2005
    ..Taken together, our data establish that bortezomib sensitizes pancreatic cancer cells to ER stress-induced apoptosis and show that bortezomib strongly enhances the anticancer activity of cisplatin...
  4. ncbi request reprint Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response
    Yan Zhou
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharmacol 61:222-9. 2002
    ..We conclude that the incorporated FMdC nucleotide profoundly disrupts DNA synthesis and resists excision by exonucleases, and that incorporation of this analog into DNA is a key molecular event responsible for the drug's cytotoxicity...
  5. ncbi request reprint GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor
    Chongguang Chen
    Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 281:7983-93. 2006
    ..This is the first report on biological functions of GEC1 and the first demonstration that a GPCR interacts with a protein of the MAP family. The interaction is important for trafficking of the receptor in the biosynthesis pathway...
  6. ncbi request reprint Anticancer activities of novel chalcone and bis-chalcone derivatives
    Aneta Modzelewska
    Division of Chemical Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Bioorg Med Chem 14:3491-5. 2006
    ..Furthermore, bis-chalcone 8 exhibited a more potent inhibition of colon cancer cells expressing wild-type p53 than of an isogenic cell line that was p53-null...
  7. ncbi request reprint Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia
    Zhihong Zeng
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3737-46. 2006
    ..Taken together, our results show that the simultaneous inhibition of critical prosurvival kinases by KP372-1 leads to mitochondrial dysfunction and apoptosis of AML but not normal hematopoietic progenitor cells...
  8. ncbi request reprint Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
    Steffan T Nawrocki
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3773-81. 2006
    ....
  9. ncbi request reprint A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome
    Geetha Achanta
    Department of Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Pharmacol 70:426-33. 2006
    ....
  10. pmc Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells
    Peng Huang
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, United States
    Biochem Pharmacol 73:534-49. 2007
    ..Cholesterol-dependent association of caveolin-1 with and the resulting inhibition of G proteins may be a contributing factor...
  11. pmc Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance
    Jennifer S Carew
    Departments of Biochemistry, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 110:313-22. 2007
    ..Our data suggest that, when combined with HDAC inhibitors, agents that disrupt autophagy are a promising new strategy to treat imatinib-refractory patients who fail conventional therapy...
  12. ncbi request reprint Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species
    Jerome Alexandre
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Cancer Res 67:3512-7. 2007
    ..This may contribute to the potent anticancer activity of paclitaxel and provide a novel basis to improve the clinical use of this important drug...
  13. pmc Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma
    Chia Jui Yen
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:2632-40. 2008
    ..In addition, Bay 11-7082 and rapamycin may potentially be chemopreventive drugs against Barrett's esophagus-associated EAC...
  14. ncbi request reprint Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells
    Steffan T Nawrocki
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11510-9. 2005
    ..Taken together, the results show that bortezomib induces a unique type of ER stress compared with other ER stress agents characterized by an absence of eif2alpha phosphorylation, ubiquitylated protein accumulation, and proteotoxicity...
  15. ncbi request reprint OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action
    Yan Zhou
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1781-5. 2005
    ..The promising anticancer activity of OSW-1 and its unique mechanism of action make this compound worthy of further investigation for its potential to overcome drug resistance...
  16. ncbi request reprint The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
    Loning Fu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 111:41-50. 2002
    ..Our studies suggest that the mPer2 gene functions in tumor suppression by regulating DNA damage-responsive pathways...
  17. pmc Mitochondrial defects in cancer
    Jennifer S Carew
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Cancer 1:9. 2002
    ....
  18. ncbi request reprint [Relationship between the expression of IL-10 and liver regeneration following reduced-size orthotopic liver transplantation in rats]
    Feng Cheng
    Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Gan Zang Bing Za Zhi 11:552-4. 2003
    ..To explore the relationship between the expression of IL-10 and liver regeneration following reduced-size orthotopic liver transplantation in rats...
  19. ncbi request reprint Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity
    Elizabeth Oldham Hileman
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Cancer Chemother Pharmacol 53:209-19. 2004
    ..The purpose of the current study was to investigate the biochemical basis for such selective anticancer activity...
  20. ncbi request reprint Improved radiolabeling of PEGylated protein: PEGylated annexin V for noninvasive imaging of tumor apoptosis
    Xiaoxia Wen
    Division of Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Biother Radiopharm 18:819-27. 2003
    ..The PEGylated, radiolabeled annexin V may be useful in the noninvasive imaging of apoptosis...
  21. ncbi request reprint Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells
    Andrew P Mone
    Division of Hematology Oncology, The Ohio State University, Columbus 43210, USA
    Blood 103:1846-54. 2004
    ..These data suggest that Hu1D10 ligation in CLL cells induces death and survival signals for which combination therapies may be designed to greatly enhance efficiency of both Hu1D10 and other class II antibodies in development...
  22. ncbi request reprint Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB
    Shuichi Fujioka
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:27549-59. 2004
    ..Thus, these findings reveal a mechanism of NF-kappaB-regulated proapoptotic signaling...
  23. ncbi request reprint 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells
    Ning Ning Zhou
    Cancer Center, Sun Yat Sen University, Guangzhou, China
    Acta Pharmacol Sin 25:1515-20. 2004
    ..To investigate 2-methoxyestradiol induced apoptosis and its mechanism of action in CNE2 cell lines...
  24. ncbi request reprint Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation
    Xiaojun Liu
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:6874-81. 2005
    ..These findings provide a mechanistic rationale for the design of new strategies, combining CNDAC with inhibitors of cell cycle checkpoint regulation in the therapy of hematologic malignancies...
  25. pmc Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma
    Geetha Achanta
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 24:3482-92. 2005
    ..This study provides a mechanistic explanation for the accelerating genetic instability and increased ROS stress in cancer cells associated with loss of p53...
  26. ncbi request reprint The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells
    Chenyi Zhou
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Biochem Biophys Res Commun 336:952-60. 2005
    ..These results suggest that the carboxyl-terminal of BRCA1 is required for the cisplatin-induced recruitment of RAD51 to the DNA-damage site, which may contribute to cisplatin resistance...
  27. ncbi request reprint Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress
    Yumin Hu
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:39485-92. 2005
    ....
  28. pmc Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA
    Steffan T Nawrocki
    The Institute for Drug Development, Cancer Therapy and Research Center at The University of Texas Health Science Center at San Antonio, USA
    Blood 112:2917-26. 2008
    ..These data suggest that MM patients with elevated Myc activity may be particularly sensitive to the BZ + SAHA combination...