Yong Gu

Summary

Country: China

Publications

  1. doi request reprint Elderly patients with acute kidney injury (AKI): clinical features and risk factors for mortality
    Yu Gong
    Division of Nephrology, Huashan Hospital, Fudan University, 12 Wulumuqi Road middle, Shanghai 200040, China
    Arch Gerontol Geriatr 54:e47-51. 2012
  2. pmc Effects of angiogenic factors, antagonists, and podocyte injury on development of proteinuria in preeclampsia
    Guixiang Chen
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, China
    Reprod Sci 20:579-88. 2013
  3. doi request reprint Upregulation of nestin in proximal tubules may participate in cell migration during renal repair
    Donghai Wen
    Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan Univ, Shanghai, China
    Am J Physiol Renal Physiol 303:F1534-44. 2012
  4. pmc Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells
    Weiwei Qi
    Nephrology Department, Shanghai Fifth People s Hospital, Fudan University, Shanghai, 200240, China
    Cell Stress Chaperones 19:105-14. 2014
  5. pmc Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway
    Qiaojing Qin
    Department of Nephrology, Shanghai Fifth People s Hospital, Fudan University, Shanghai 200240, China
    Cardiovasc Diabetol 12:37. 2013
  6. pmc Effects and safety of calcimimetics in end stage renal disease patients with secondary hyperparathyroidism: a meta-analysis
    Qian Zhang
    Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 7:e48070. 2012
  7. doi request reprint Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction of elderly patients with acute kidney injury
    Yu Gong
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    Aging Clin Exp Res 24:74-8. 2012
  8. pmc The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury
    Qionghong Xie
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
    BMC Nephrol 12:30. 2011
  9. pmc Nitrotyrosine level was associated with mortality in patients with acute kidney injury
    Jing Qian
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e79962. 2013
  10. pmc Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
    Lingyun Lai
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e64964. 2013

Collaborators

Detail Information

Publications46

  1. doi request reprint Elderly patients with acute kidney injury (AKI): clinical features and risk factors for mortality
    Yu Gong
    Division of Nephrology, Huashan Hospital, Fudan University, 12 Wulumuqi Road middle, Shanghai 200040, China
    Arch Gerontol Geriatr 54:e47-51. 2012
    ..The clinical features and risk factors predicting poor outcomes of these patients are not known. The aim of this study is to investigate the clinical features and risk factors affecting mortality in elderly patients with AKI...
  2. pmc Effects of angiogenic factors, antagonists, and podocyte injury on development of proteinuria in preeclampsia
    Guixiang Chen
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, China
    Reprod Sci 20:579-88. 2013
    ..We considered that the dysregulation of angiogenic factors and its subsequent podocyte injury may contribute to the mechanism of proteinuria development in preeclampsia...
  3. doi request reprint Upregulation of nestin in proximal tubules may participate in cell migration during renal repair
    Donghai Wen
    Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan Univ, Shanghai, China
    Am J Physiol Renal Physiol 303:F1534-44. 2012
    ....
  4. pmc Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells
    Weiwei Qi
    Nephrology Department, Shanghai Fifth People s Hospital, Fudan University, Shanghai, 200240, China
    Cell Stress Chaperones 19:105-14. 2014
    ..Our data demonstrate that GA could induce NRK-52E cell line EMT through oxidative stress. This effect could be attenuated by A-IV via regulation of the impaired redox balance. ..
  5. pmc Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway
    Qiaojing Qin
    Department of Nephrology, Shanghai Fifth People s Hospital, Fudan University, Shanghai 200240, China
    Cardiovasc Diabetol 12:37. 2013
    ..However, virtually nothing is presently known the role of HPA during macrophage migration exposed to AGEs involving signal pathway...
  6. pmc Effects and safety of calcimimetics in end stage renal disease patients with secondary hyperparathyroidism: a meta-analysis
    Qian Zhang
    Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 7:e48070. 2012
    ..We performed a meta-analysis to determine the effect and safety of cinacalcet in SHPT patients receiving dialysis...
  7. doi request reprint Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction of elderly patients with acute kidney injury
    Yu Gong
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    Aging Clin Exp Res 24:74-8. 2012
    ....
  8. pmc The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury
    Qionghong Xie
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
    BMC Nephrol 12:30. 2011
    ..No study examined whether the combination of inflammatory and nutritional markers could predict the mortality of AKI patients...
  9. pmc Nitrotyrosine level was associated with mortality in patients with acute kidney injury
    Jing Qian
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e79962. 2013
    ..To examine the characteristics of oxidative stress in patients with acute kidney injury (AKI) and investigate the association between plasma nitrotyrosine levels and 90-day mortality in patients with AKI...
  10. pmc Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
    Lingyun Lai
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e64964. 2013
    ..However, in patients with acute kidney injury (AKI), whether vitamin D deficiency occurs and is a potential contributor to worse early outcomes at the time of AKI diagnosis remains unclear...
  11. doi request reprint 2D-speckle tracking echocardiography contributes to early identification of impaired left ventricular myocardial function in patients with chronic kidney disease
    Ping Yan
    Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, PR China
    Nephron Clin Pract 118:c232-40. 2011
    ....
  12. doi request reprint Chronic inhibition of nuclear factor kappa B attenuates aldosterone/salt-induced renal injury
    Wei Ding
    Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, 12 Wulumuqi Road, Shanghai 200040, China
    Life Sci 90:600-6. 2012
    ..This study investigated whether NF-κB inhibition attenuates progressive renal damage in aldosterone/salt-induced renal injury and its mechanisms...
  13. doi request reprint Upregulation of nestin protects podocytes from apoptosis induced by puromycin aminonucleoside
    Donghai Wen
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    Am J Nephrol 34:423-34. 2011
    ..Nestin is also highly expressed in the glomerular podocyte, a type of terminally differentiated epithelial cell. Little is known about the significance of nestin in podocytes...
  14. doi request reprint Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients
    Haiming Li
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    Blood Purif 31:33-40. 2011
    ..To evaluate the effects of short-term restriction of dietary protein intake (DPI) supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis (MHD) patients...
  15. doi request reprint Efficacy of cytokine removal by plasmadiafiltration using a selective plasma separator: in vitro sepsis model
    Mingxin Li
    Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    Ther Apher Dial 15:98-108. 2011
    ..1 at first and then decreased to 0.05 after 1 hour of therapy. Plasmadiafiltration with Evacure 2A plasma separator can effectively remove almost all of the inflammatory mediators with low albumin loss...
  16. doi request reprint Effect of serum fibroblast growth factor-23, matrix Gla protein and Fetuin-A in predicting osteoporosis in maintenance hemodialysis patients
    Qing Wu
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, China
    Ther Apher Dial 18:427-33. 2014
    ..Its sensitivity/specificity was 71%/77.8%. The incidence of osteoporosis is high in MHD patients. Serum Fetuin-A level is closely correlated with osteoporosis and it may serve as a predictor of osteoporosis...
  17. doi request reprint Angiotensin-(1-7) attenuates damage to podocytes induced by preeclamptic serum through MAPK pathways
    Jimei Tian
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, P R China
    Int J Mol Med 34:1057-64. 2014
    ..Thus, our data suggest that Ang-(1-7) plays a protective role in PE through the downregulation of MAPK phosphorylation. ..
  18. doi request reprint Contributions of endoplasmic reticulum stress and reactive oxygen species to renal injury in aldosterone/salt-induced rats
    Chengyan Xu
    Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, Shanghai, China
    Nephron Exp Nephrol 126:25-32. 2014
    ..This study was performed to test the hypothesis that reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress contribute to the pathogenesis of Aldo- and salt-induced renal injury...
  19. pmc Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD
    Qian Zhang
    Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, People s Republic of China
    J Am Soc Nephrol 22:664-72. 2011
    ..In conclusion, COX2 promotes the pathogenesis of hyperparathyroidism in ESRD, suggesting that inhibiting the COX2 pathway could be a potential therapeutic target...
  20. doi request reprint Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells
    Weiwei Qi
    Nephrology Department, Shanghai Fifth People s Hospital, Fudan University, Shanghai 200240, China
    Mol Cell Endocrinol 405:74-83. 2015
    ..This effect is instrumental to renal damage and disease progression in patients with DN. ..
  21. doi request reprint Double filtration plasmapheresis benefits myasthenia gravis patients through an immunomodulatory action
    Lei Zhang
    Department of Nephrology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China
    J Clin Neurosci 21:1570-4. 2014
    ..05). DFPP treatment more effectively lowers sICAM-1 and increases Treg cell expression, consequently benefiting MG patients. ..
  22. doi request reprint Study on the clinical significance and related factors of thirst and xerostomia in maintenance hemodialysis patients
    Wei Feng Fan
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, China
    Kidney Blood Press Res 37:464-74. 2013
    ..To analyse the clinical significance and related factors of thirst and xerostomia and to find methods to alleviate thirst and xerostomia in maintenance hemodialysis (MHD) patients...
  23. pmc Resveratrol attenuates diabetic nephropathy via modulating angiogenesis
    Donghai Wen
    Department of Internal Medicine, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e82336. 2013
    ..Taken together, the present study demonstrated that resveratrol may attenuate DN via modulating angiogenesis. ..
  24. ncbi request reprint [Expression of nestin in human kidney and its clinical significance]
    Wei Su
    Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Zhonghua Bing Li Xue Za Zhi 37:309-12. 2008
    ..To study the expression and significance of nestin (a type of cytoskeletal protein) in normal and diseased human kidneys...
  25. doi request reprint Mannitol is an independent risk factor of acute kidney injury after cerebral trauma: a case-control study
    Lv Fang
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, PR China
    Ren Fail 32:673-9. 2010
    ..We concluded that AKI was a common complication in patients with cerebral trauma. SOFA score and the accumulative doses of torsemide and mannitol were independent risk factors of AKI following cerebral trauma...
  26. doi request reprint Association between two genetic polymorphisms of the renin-angiotensin-aldosterone system and diabetic nephropathy: a meta-analysis
    Wei Ding
    Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, Wulumuqi Road, Shanghai 200040, China
    Mol Biol Rep 39:1293-303. 2012
    ..AA model and dominant model (CC vs. AA: OR = 3.31, 95% CI: 1.21-9.08; dominant model: OR = 3.50, 95% CI: 1.41-8.69). This study suggests that the AGTR1 A1166C polymorphism may contribute to DN development, particularly in T2DM patients...
  27. doi request reprint Tempol, a Superoxide Dismutase-Mimetic Drug, Ameliorates Progression of Renal Disease in CKD Mice
    Wei Ding
    Division of Nephrology, Shanghai Ninth People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Cell Physiol Biochem 36:2170-82. 2015
    ..We investigate the beneficial effect of Tempol, a superoxide dismutase-mimetic drug, on progression of disease in a mouse model of CKD...
  28. doi request reprint Involvement of Endoplasmic Reticulum Stress in Uremic Cardiomyopathy: Protective Effects of Tauroursodeoxycholic Acid
    Wei Ding
    Division of Nephrology, Shanghai Ninth People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Cell Physiol Biochem 38:141-52. 2016
    ..Uremic cardiomyopathy (UCM) is a complication in chronic kidney disease. We investigated if endoplasmic reticulum stress (ERS) is involved in UCM, and determined the efficacy of tauroursodeoxycholic acid (TUDCA) in UCM prevention...
  29. doi request reprint Effect of serum FGF-23, MGP and fetuin-A on calcium-phosphate metabolism in maintenance hemodialysis patients
    Dong Mei Xiao
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, China Division of Internal Medicine, Ningbo First Hospital, Medical School of Ningbo University, Ningbo, China
    Hemodial Int 17:483-92. 2013
    ..Different combinations of serum FGF-23 and fetuin-A in parallel or in series effectively boosted the identification of CAC. The incidence of CAC is high in MHD patients. Serum FGF-23 and fetuin-A levels are closely correlated with CAC...
  30. doi request reprint Endothelial bioreactor ameliorates endotoxemia sepsis in swine
    Qionghong Xie
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, PR China
    Blood Purif 29:252-8. 2010
    ..Central to this process is an alteration of endothelial cell function. Therefore, we investigated whether an endothelial bioreactor (EBR) would provide a new therapeutic approach to this clinical disorder...
  31. doi request reprint Angiopoietin-1 inhibits mouse glomerular endothelial cell senescence via Tie2 receptor-modulated ERK1/2 signaling
    Min Yang
    Huashan Hospital, Institute of Nephrology, Fudan University, Shanghai, China
    Am J Nephrol 31:490-500. 2010
    ..In this study, we examined the role of angiopoietin-1 (Ang1) in H(2)O(2)-induced senescence in mouse glomerular endothelial cells (MGECs) and the signaling pathway involved...
  32. doi request reprint Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy
    Mingxin Li
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    J Ethnopharmacol 133:412-9. 2011
    ..In modern medicine, Astragalus shows significant renal protective effect in DN. We aimed to systematically review the randomized and semi-randomized control trials to ascertain its role in the treatment of DN...
  33. doi request reprint Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells
    Wei Ding
    Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, 12 Wulumuqi Road, Shanghai 200040, China
    Biochem Biophys Res Commun 418:451-6. 2012
    ..NAC also could inhibit Aldo-induced expression of GRP78 and CHOP. Altogether, these observations suggest that Aldo induces apoptosis via ROS-mediated, CHOP-dependent activation in renal tubular epithelial cells...
  34. doi request reprint Urinary proteomics analysis for renal injury in hypertensive disorders of pregnancy with iTRAQ labeling and LC-MS/MS
    Guixiang Chen
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, P R China
    Proteomics Clin Appl 5:300-10. 2011
    ..The purpose of the present study was to find differential proteins among women with preeclampsia, gestational hypertension and normal pregnancy, and to screen potential biomarkers for the early diagnosis of preeclampsia...
  35. doi request reprint Gender differences in the association between hyperuricemia and diabetic kidney disease in community elderly patients
    Mei Guo
    Fifth People s Hospital, Fudan University, No 128 Ruili Road, Minhang District, Shanghai 200240, China
    J Diabetes Complications 29:1042-9. 2015
    ..To investigate gender differences of the associations between hyperuricemia and diabetic kidney disease (DKD) in elderly patients with type 2 diabetes mellitus (T2DM) based on electronic health records (EHR)...
  36. doi request reprint The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients
    Hong Na Wang
    Department of Nephrology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China
    Clin Immunol 160:342-8. 2015
    ..Clinical remission was significantly related to higher exposure of 4OHCTX (P=0.038). In conclusion, LN patients with GSTA1*A heterozygous genotypes had poor CTX treatment remission due to less exposure to activated metabolites of CTX. ..
  37. doi request reprint Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia
    Jing Xiao
    Division of Nephrology, The Fifth People s Hospital of Shanghai, Fudan University, Shanghai, People s Republic of China
    Hypertens Pregnancy 32:439-49. 2013
    ..To identify novel potential biomarkers and evaluate combined biomarkers for diagnosing kidney injury with considerable accuracy in preeclampsia...
  38. doi request reprint Rapamycin attenuates aldosterone-induced tubulointerstitial inflammation and fibrosis
    Bin Wang
    Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, Shanghai, China
    Cell Physiol Biochem 35:116-25. 2015
    ..The aim of this study was to evaluate the regulatory role of rapamycin (Rap) in Aldo-induced tubulointerstitial inflammation and fibrosis...
  39. doi request reprint Protective effects of angiotensin-(1-7) administrated with an angiotensin-receptor blocker in a rat model of chronic kidney disease
    Chengyan Xu
    Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, Shanghai, China
    Nephrology (Carlton) 18:761-9. 2013
    ..This study observed the effects of Ang-(1-7), on its own or in combination with losartan, an angiotensin-receptor blocker, on five-sixths nephrectomized rats...
  40. doi request reprint Astragalus embranaceus extract activates immune response in macrophages via heparanase
    Qiaojing Qin
    Department of Nephrology, Shanghai Fifth People s Hospital, Fudan University, Shanghai 200240, China
    Molecules 17:7232-40. 2012
    ..This suggests that AME may increase the release of immune response mediator and cell migration via HPA to activate immune response in macrophages...
  41. doi request reprint Meta-analysis comparing sevelamer and calcium-based phosphate binders on cardiovascular calcification in hemodialysis patients
    Qian Zhang
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, PR China
    Nephron Clin Pract 115:c259-67. 2010
    ....
  42. doi request reprint Aqueous extract of Astragali Radix ameliorates proteinuria in adriamycin nephropathy rats through inhibition of oxidative stress and endothelial nitric oxide synthase
    Huaizhou You
    Division of Nephrology, Huashan Hospital, Fudan University, 12 Wulumuqi Road middle, Shanghai 200040, China
    J Ethnopharmacol 134:176-82. 2011
    ..To investigate the effects of aqueous extract of Astragali Radix (ARE) on the oxidative stress status and endothelial nitric oxide synthase level in adriamycin (ADR) nephropathy rats...
  43. doi request reprint An iatrogenic complication of internal jugular vein catheterization for hemodialysis
    Yu Gong
    Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
    Ir J Med Sci 181:135-7. 2012
    ..Few cases of such complication of uremic patients on hemodialysis have been reported in the literature...
  44. doi request reprint The role of Na+-H+ exchanger isoform 1 in aldosterone-induced glomerulosclerosis in vivo
    Minmin Zhang
    Department of Nephrology, Huashan Hospital, Institute of Nephrology, Fudan University, Shanghai, China
    Ren Fail 31:726-35. 2009
    ..The present study suggested that NHE1 contributed to aldosterone-induced-glomerulosclerosis and could be a potential therapeutic target for chronic kidney disease...
  45. doi request reprint Comparing the autoantibody levels and clinical efficacy of double filtration plasmapheresis, immunoadsorption, and intravenous immunoglobulin for the treatment of late-onset myasthenia gravis
    Jun Feng Liu
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    Ther Apher Dial 14:153-60. 2010
    ..6107, P < 0.01). Both DFPP and IA showed better short-term clinical effectiveness than immunoglobulin transfusion, rapidly and effectively clearing the pathogenic antibodies in late-onset MG patients, especially for Titin-ab...
  46. doi request reprint Intima-media thickness of the carotid artery and its correlation factors in maintenance hemodialysis patients: a cross-sectional study
    Dingwei Kuang
    Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, PR China
    Blood Purif 28:181-6. 2009
    ..To investigate the relationship between the intima-media thickness of the carotid artery (CA-IMT) and its major risk factors in maintenance hemodialysis (MHD) patients...