Huanzhang Zhu

Summary

Affiliation: Fudan University
Country: China

Publications

  1. ncbi request reprint Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone
    Xian Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Curr HIV Res 14:484-490. 2016
  2. pmc Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
    Hao Ying
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 7:e48832. 2012
  3. pmc Mutational analysis of highly conserved residues in the phage phiC31 integrase reveals key amino acids necessary for the DNA recombination
    Shaohui Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e8863. 2010
  4. pmc CCL3L1 copy number variation and susceptibility to HIV-1 infection: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e15778. 2010
  5. ncbi request reprint Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    Huanzhang Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetic, School of Life Sciences, Fudan University, Shanghai 200433, China
    Exp Mol Pathol 76:44-50. 2004
  6. doi request reprint Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells
    Hao Yin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Mol Biol Rep 38:5071-8. 2011
  7. pmc Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China andKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
    Nucleic Acids Res 41:7771-82. 2013
  8. doi request reprint HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells
    Shiguan Lin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Curr HIV Res 9:202-8. 2011
  9. pmc The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb
    Panpan Lu
    State Key Laboratory of Genetic Engineering, and Key Laboratory of Medical Molecular Virology of Ministry of Education Health, School of Life Sciences, Fudan University, Shanghai, China
    Sci Rep 6:24100. 2016
  10. pmc Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter
    Haiyan Ji
    State Key Laboratory of Genetic Engineering, and Key Laboratory of Medical Molecular Virology of Ministry of Education Health, School of Life Sciences, Fudan University, Shanghai, China
    Mol Ther 24:508-21. 2016

Collaborators

  • Xin Zhou
  • Zheng Fu
  • Lin Li
  • Lin Liu
  • Yan Chen
  • Wei Wang
  • Feng Zhang
  • Li Ma
  • Jie Wu
  • Jianhua Wang
  • Yun Wang
  • Xiying Qu
  • Pengfei Wang
  • Sijie Liu
  • Xiaohui Wang
  • Panpan Lu
  • Hanxian Zeng
  • Junxiao Deng
  • Haiyan Ji
  • Donglin Ding
  • Xiaoli Zhu
  • Hao Ying
  • Xinyi Yang
  • Shiguan Lin
  • Shaohui Liu
  • Xian Li
  • Zhishuo Song
  • Chuijin Kong
  • Yuhao Zhang
  • Zhengtao Jiang
  • Yinzhong Shen
  • Hongzhou Lu
  • Gongmin Zhang
  • Daru Lu
  • Hao Yin
  • DengMin Feng
  • Yuanzhe Fu
  • Hanyu Pan
  • Chuan Li
  • Pinyi Zhen
  • Lu Lin
  • Wenbo Yu
  • Shijun Zha
  • Zhongjun Ma
  • Huabiao Chen
  • Haibo Wang
  • Qingting Xin
  • Jinfang Ma
  • Lei Yao
  • Maoxiang Zhang
  • Siman Peng
  • Rongxiu Li
  • Jinzhong Chen
  • Jinglun Xue
  • William WeiGuo Jia
  • YangBo Yue

Detail Information

Publications22

  1. ncbi request reprint Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone
    Xian Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Curr HIV Res 14:484-490. 2016
    ..The "shock and kill" strategy is a promising approach to eliminate the viral reservoir. However, there are various limits existing in current latency-reversing agents, searching for new activators are urgently needed...
  2. pmc Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
    Hao Ying
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 7:e48832. 2012
    ..However, little is known about the effects and action mechanism of M344 in inducing HIV expression in latently infected cells...
  3. pmc Mutational analysis of highly conserved residues in the phage phiC31 integrase reveals key amino acids necessary for the DNA recombination
    Shaohui Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e8863. 2010
    ..Until now, no system mutational or biochemical studies have been carried out to assess the roles of these conserved residues in the recombination of phiC31 integrase...
  4. pmc CCL3L1 copy number variation and susceptibility to HIV-1 infection: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e15778. 2010
    ..Therefore, we performed a meta-analysis using two models to generate a more robust estimate of the association between CCL3L1 CNV and susceptibility to HIV-1 infection...
  5. ncbi request reprint Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis
    Huanzhang Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetic, School of Life Sciences, Fudan University, Shanghai 200433, China
    Exp Mol Pathol 76:44-50. 2004
    ..Taken together, our results suggest that HBx gene expression alone is not sufficient for carcinogenesis, but may act as a promoter for malignant transformation...
  6. doi request reprint Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells
    Hao Yin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Mol Biol Rep 38:5071-8. 2011
    ..Taken together, our results suggest that the histone acetylation plays an important role in regulating HIV-1 LTR gene expression, and Oxamflatin has potential as drug candidates as antilatency therapies...
  7. pmc Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China andKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
    Nucleic Acids Res 41:7771-82. 2013
    ....
  8. doi request reprint HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells
    Shiguan Lin
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Curr HIV Res 9:202-8. 2011
    ..Our research reveals a potent activator for reactivating latent HIV-1 and shows promise for HIV-1 therapy...
  9. pmc The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb
    Panpan Lu
    State Key Laboratory of Genetic Engineering, and Key Laboratory of Medical Molecular Virology of Ministry of Education Health, School of Life Sciences, Fudan University, Shanghai, China
    Sci Rep 6:24100. 2016
    ..Our results suggest that the BET inhibitor OTX015 may be a candidate for anti-HIV-1-latency therapies. ..
  10. pmc Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter
    Haiyan Ji
    State Key Laboratory of Genetic Engineering, and Key Laboratory of Medical Molecular Virology of Ministry of Education Health, School of Life Sciences, Fudan University, Shanghai, China
    Mol Ther 24:508-21. 2016
    ..Taken together, our data demonstrated dCas9-SunTag-VP64 system can effectively and specifically reactivate latent HIV-1 transcription, suggesting that this strategy could offer a novel approach to anti-HIV-1 latency. ..
  11. doi request reprint Zinc finger nuclease: a new approach for excising HIV-1 proviral DNA from infected human T cells
    Xiying Qu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Genetics, Fudan University, Shanghai, 200433, China
    Mol Biol Rep 41:5819-27. 2014
    ..This method to delete full length HIV-1 in human genome can therefore provide a novel approach to cure HIV-infected individuals in the future...
  12. doi request reprint Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation
    Donglin Ding
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Virology 440:182-9. 2013
    ..GLP knockdown by small interfering RNA clearly induced HIV-1 LTR expression. Results suggest that GLP may play a significant role in the maintenance of HIV-1 latency by catalyzing dimethylation of H3K9...
  13. doi request reprint Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency
    Pengfei Wang
    State Key Laboratory of Genetic Engineering, and Key Laboratory of Medical Molecular Virology of Ministry of Education Health, School of Life Sciences, Fudan University, Shanghai, China
    Virology 486:228-38. 2015
    ..Our study emphasizes the role of cellular miRNAs in HIV-1 latency regulation, and it suggests that inhibitors of miR-196b and miR-1290 could be used to activate latent HIV-1. ..
  14. pmc Designed transcription activator-like effector proteins efficiently induced the expression of latent HIV-1 in latently infected cells
    Xiaohui Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    AIDS Res Hum Retroviruses 31:98-106. 2015
    ..Taken together, our data demonstrated that TALE1-VP64 can specifically and effectively reactivate latent HIV-1 transcription, suggesting that this strategy may provide a novel approach for anti-HIV-1 latency therapy in the future...
  15. doi request reprint Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation
    Xiaoli Zhu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biochem Biophys Res Commun 450:202-7. 2014
    ..Our results indicated that Oxaliplatin could be a potential drug candidate for anti-latency therapies. ..
  16. doi request reprint Dilazep synergistically reactivates latent HIV-1 in latently infected cells
    Hanxian Zeng
    School of Life Sciences, Institute of Genetics, Fudan University, Shanghai, 200433, China
    Mol Biol Rep 41:7697-704. 2014
    ..We also found that dilazep activates viral latency without inducing cell surface activation markers CD25 and CD69 activation. In summary, dilazep, alone or in combination with VPA, could be useful in future eradication strategies. ..
  17. doi request reprint TRIM5α H43Y Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis
    Junxiao Deng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    AIDS Res Hum Retroviruses 31:1213-8. 2015
    ..This polymorphism may act as a protective factor against HIV-1 infection, especially in Asians. ..
  18. pmc Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    PLoS ONE 7:e35020. 2012
    ..However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility...
  19. ncbi request reprint Association between polymorphism of SDF1 (CXCL12) gene and HIV-1 susceptibility: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China
    Curr HIV Res 9:112-9. 2011
    ..In conclusion, no statistically significant association between SDF1 genotype and HIV-1 susceptibility was detected in any models. Our data suggested that SDF1 genotype might have limited effect on HIV-1 susceptibility...
  20. ncbi request reprint In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus
    Lin Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China
    Curr HIV Res 10:572-7. 2012
    ..These data demonstrated that the envelope of CRF07_BC from China has the capability of resulting in infection to CD34+ HPCs, which may serve as a mechanism for long-term latency of HIV-1 infection in vivo...
  21. ncbi request reprint A 16bp Rep binding element is sufficient for mediating Rep-dependent integration into AAVS1
    DengMin Feng
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
    J Mol Biol 358:38-45. 2006
    ..These findings added new information on the mechanism of Rep-dependent AAV genome insertion at the AAVS1 site and may be helpful in developing new high efficiency vectors for site-specific transgene integration...
  22. ncbi request reprint Histone deacetylase inhibitor MC1293 induces latent HIV-1 reactivation by histone modification in vitro latency cell lines
    Xiying Qu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P R China
    Curr HIV Res 11:24-9. 2013
    ..The results suggest that the acetylation of histone plays an important role in regulating HIV-1 LTR gene expression, and MC1293 is potential drug candidate for antilatency therapies...