Bin Wang

Summary

Affiliation: China Agricultural University
Country: China

Publications

  1. pmc Increasing a robust antigen-specific cytotoxic T lymphocyte response by FMDV DNA vaccination with IL-9 expressing construct
    Qiang Zou
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100193, China
    J Biomed Biotechnol 2010:562356. 2010
  2. pmc Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells
    Shuang Geng
    Key laboratory of Medical Molecular Virology of MOH and MOE, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 7:e33015. 2012
  3. pmc Praziquantel facilitates IFN-γ-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice
    Qiang Zou
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 6:e25525. 2011
  4. ncbi request reprint Synergistic effects of adjuvants interferon-gamma and levamisole on DNA vaccination against infection with Newcastle disease virus
    Jiangmei Yin
    State Key Laboratory for Agro Biotechnology, Key Laboratory of Agro Microbial Resource, and Application of MOA, College of Biology, China Agricultural University, Beijing, China
    Viral Immunol 20:288-99. 2007
  5. ncbi request reprint Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants
    Chong Xiao
    State Key Laboratory for Agro Biotechnology and the Key Laboratory of Agro Microbial Resources and Applications of MOA, China Agricultural University, Beijing 100094, China
    Antiviral Res 76:11-20. 2007
  6. doi request reprint Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus
    Xiao Wang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Vaccine 26:5135-44. 2008
  7. doi request reprint Enhancement of humoral and cellular responses to HBsAg DNA vaccination by immunization with praziquantel through inhibition TGF-beta/Smad2,3 signaling
    Qiang Zou
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100193, China
    Vaccine 28:2032-8. 2010
  8. doi request reprint Protein transfer enhances cellular immune responses to DNA vaccination against SARS-CoV
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    Viral Immunol 22:417-22. 2009
  9. ncbi request reprint Co-inoculation of DNA and protein vaccines induces antigen-specific T cell suppression
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Biochem Biophys Res Commun 353:1034-9. 2007
  10. ncbi request reprint The adjuvant effects of co-stimulatory molecules on cellular and memory responses to HBsAg DNA vaccination
    Xiaogang Du
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100094, China
    J Gene Med 9:136-46. 2007

Collaborators

  • Yang Yu
  • Xiaogang Du
  • Guoxing Zheng
  • Jin Jin
  • Rong Wang
  • Junpeng Wang
  • Aoshuang Chen
  • Ruiping She
  • Shuang Geng
  • Xiaolin Li
  • Xilong Wang
  • Bing Chen
  • Gang Yu
  • Bing Wu
  • Jun Huang
  • Lin Zhao
  • Youmin Kang
  • Huali Jin
  • Chong Xiao
  • Qiang Zou
  • Gan Zhao
  • Yanxin Hu
  • Wenjuan Zhang
  • Zheng Ding
  • Guoliang Xia
  • Jingyao Zhang
  • Jiangmei Yin
  • Jinyao Li
  • Yuan Gao
  • Baowei Su
  • Wenxue Zhao
  • Suowei Wu
  • Wenjuan Gao
  • Congcong Feng
  • Hu Liu
  • Yongliang Zhang
  • Qifa Xie
  • Hanqian Xu
  • Jianwu Dai
  • Zhifeng Xiao
  • Yannan Zhao
  • Ping Tai
  • Fuchun Zhang
  • Lvzhen Huang
  • Guofeng Shen
  • Dao Zhen Xu
  • Ming Wang
  • Kaichun Zhu
  • Chunxiu Wang
  • Xuan Chen
  • Can Zhang
  • Yong Zhou
  • Bo Zhou
  • Jialin Yu
  • Dawei Li
  • Guanping Mao
  • Chenggui Han
  • Wei Luo
  • Pengxiu Cao
  • Wenjie Sun
  • Qianqian Han
  • Hang Lin
  • Fengge Wang
  • Chunjiang Ye
  • Weihua Li
  • Zhanwang Yu
  • Jiuran Zhao
  • Jun Li
  • Fu Yang
  • Qinghong Zhu
  • Xiaoying Zhang
  • Chun Jiang Zhou
  • Xinyu Zhang
  • Yijie Ma
  • Chiea Chuen Khor
  • Jia Xue
  • Chunfang Zhang
  • Fei Yang
  • Yaoyao Sun
  • Xiaoxu Fan
  • Mingwei Zhao
  • Wenzhen Yu
  • Yingjie Li
  • Yujing Bai
  • Shicheng Guo
  • Shanshan Li
  • Min Zhao
  • Wen Xiang Huang
  • Miao Xue
  • Huizhong Shen

Detail Information

Publications62

  1. pmc Increasing a robust antigen-specific cytotoxic T lymphocyte response by FMDV DNA vaccination with IL-9 expressing construct
    Qiang Zou
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100193, China
    J Biomed Biotechnol 2010:562356. 2010
    ..Thus, the IL-9 may be utilized as a potent Tc1 adjuvant for DNA vaccines...
  2. pmc Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells
    Shuang Geng
    Key laboratory of Medical Molecular Virology of MOH and MOE, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 7:e33015. 2012
    ..Thus, amiloride is a facilitator for DNA transduction into host cells which in turn enhances the efficiency of the immune responses...
  3. pmc Praziquantel facilitates IFN-γ-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice
    Qiang Zou
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 6:e25525. 2011
    ..DNA vaccination, a novel therapeutic strategy for chronic virus infection, has been shown to induce CTL responses. However, accumulated data have shown that CTLs could not be effectively induced by HBV DNA vaccination...
  4. ncbi request reprint Synergistic effects of adjuvants interferon-gamma and levamisole on DNA vaccination against infection with Newcastle disease virus
    Jiangmei Yin
    State Key Laboratory for Agro Biotechnology, Key Laboratory of Agro Microbial Resource, and Application of MOA, College of Biology, China Agricultural University, Beijing, China
    Viral Immunol 20:288-99. 2007
    ..This study demonstrates that the synergistic effects of provax-chIFN-gamma plus LMS as the adjuvants in NDV DNA vaccination could be used to improve protective efficacy in chickens...
  5. ncbi request reprint Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants
    Chong Xiao
    State Key Laboratory for Agro Biotechnology and the Key Laboratory of Agro Microbial Resources and Applications of MOA, China Agricultural University, Beijing 100094, China
    Antiviral Res 76:11-20. 2007
    ....
  6. doi request reprint Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus
    Xiao Wang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Vaccine 26:5135-44. 2008
    ..Taken together, the results demonstrated that intranasal delivery of IL-15 as a mucosal adjuvant can enhance the antigen-specific mucosal and systemic immune responses, which may provide a protection against the FMDV initial infection...
  7. doi request reprint Enhancement of humoral and cellular responses to HBsAg DNA vaccination by immunization with praziquantel through inhibition TGF-beta/Smad2,3 signaling
    Qiang Zou
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100193, China
    Vaccine 28:2032-8. 2010
    ..Together, these results suggest that PZQ can enhance humoral and cellular responses to HBsAg DNA vaccination through inhibition TGF-beta/Smad2,3 signaling...
  8. doi request reprint Protein transfer enhances cellular immune responses to DNA vaccination against SARS-CoV
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    Viral Immunol 22:417-22. 2009
    ..Results of our study suggest, for the first time, that muscle cells may be modified in situ, at the DNA injection site, into APC-like cells to allow direct priming of CD8(+) T cells and thereby improve the efficacy of DNA vaccines...
  9. ncbi request reprint Co-inoculation of DNA and protein vaccines induces antigen-specific T cell suppression
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Biochem Biophys Res Commun 353:1034-9. 2007
    ..Our study thus shows for the first time that co-administration of antigen-matched DNA and protein vaccines can generate this type of adaptive regulatory T cells...
  10. ncbi request reprint The adjuvant effects of co-stimulatory molecules on cellular and memory responses to HBsAg DNA vaccination
    Xiaogang Du
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing 100094, China
    J Gene Med 9:136-46. 2007
    ..This approach may lead to an effective therapeutic vaccine for chronic hepatitis B virus (HBV) infection...
  11. ncbi request reprint DNA prime followed by protein boost enhances neutralization and Th1 type immunity against FMDV
    Huali Jin
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Viral Immunol 18:539-48. 2005
    ..This study suggests that the prime-boost strategy significantly improves the effective immunity and may provide a longer protection against FMDV infection...
  12. doi request reprint CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination
    Hanqian Xu
    State Key Laboratories for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    J Gene Med 12:97-106. 2010
    ..Because the CD40 ligand-CD40 interaction plays a major role in initiating immune responses, we sought to develop a molecular adjuvant targeting this interaction...
  13. doi request reprint The effects of IL-6 and TNF-alpha as molecular adjuvants on immune responses to FMDV and maturation of dendritic cells by DNA vaccination
    Baowei Su
    State Key Laboratories of Agro biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Vaccine 26:5111-22. 2008
    ..Together, the results demonstrate that IL-6 and TNF-alpha used as molecular adjuvants can enhance the antigen-specific cell-mediated responses elicited by VP1 DNA vaccine...
  14. ncbi request reprint Protective immune responses against foot-and-mouth disease virus by vaccination with a DNA vaccine expressing virus-like particles
    Huali Jin
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    Viral Immunol 20:429-40. 2007
    ..Thus, immunization with chimeric VLP induces higher efficacy and provides an attractive DNA vaccine strategy for controlling FMDV infection in future...
  15. doi request reprint PyNTTTTGT prototype oligonucleotide IMT504, a novel effective adjuvant of the FMDV DNA vaccine
    Gan Zhao
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing, China
    Viral Immunol 22:131-8. 2009
    ..At this point, the PyNTTTTGT prototype IMT504 ODN can reasonably be predicted to be a good adjuvant for FMDV DNA vaccine in small animals, but its efficacy in larger animals remains to be explored...
  16. ncbi request reprint Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells
    Junpeng Wang
    State Key Laboratories of Agro biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Biochem Biophys Res Commun 372:491-6. 2008
    ..Collectively these findings suggest that CIM enhances the immune responses of HBV DNA vaccine through the stimulation of pro-inflammatory and inhibition of anti-inflammatory cytokine expression patterns...
  17. doi request reprint Levamisole is a potential facilitator for the activation of Th1 responses of the subunit HBV vaccination
    Wenjuan Zhang
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, 2 Yuanmingyuan Xi Road, Beijing 100094, China
    Vaccine 27:4938-46. 2009
    ....
  18. doi request reprint Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin
    Wenxue Zhao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    J Mol Med (Berl) 86:1127-38. 2008
    ..This provides a potential approach to improve therapeutic neovascularization and wound repair...
  19. doi request reprint Protein/DNA vaccine-induced antigen-specific Treg confer protection against asthma
    Huali Jin
    State Key Laboratory for Agro Biotechnology and College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Eur J Immunol 38:2451-63. 2008
    ....
  20. ncbi request reprint Induction of adaptive T regulatory cells that suppress the allergic response by coimmunization of DNA and protein vaccines
    Huali Jin
    State Key Laboratory for Agro Biotechnology, China Agricultural University, Beijing 100094, China
    J Immunol 180:5360-72. 2008
    ..Exploitation of these cellular regulators and understanding their induction provides a basis for the possible development of novel therapies against allergic and related disorders in humans and animals...
  21. ncbi request reprint Association between insulin receptor gene polymorphism and the metabolic syndrome in Han and Yi Chinese
    Chunxiu Wang
    Department of Evidence Based Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China
    Asia Pac J Clin Nutr 21:457-63. 2012
    ..These findings contribute to our better understanding on the genetic basis of MS...
  22. ncbi request reprint Effects of chronic heat stress on immune responses of the foot-and-mouth disease DNA vaccination
    Yanxin Hu
    Department of Veterinary Pathology, College of Veterinary Medicine, China Agricultural University, Beijing, China
    DNA Cell Biol 26:619-26. 2007
    ..It suggests that vaccination in animals is affected by the changes of ambient temperature...
  23. doi request reprint Development of Tobacco necrosis virus A as a vector for efficient and stable expression of FMDV VP1 peptides
    Yongliang Zhang
    State Key Laboratory of Agro Biotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China
    Plant Biotechnol J 8:506-23. 2010
    ..And when inoculated nasally, CVPs could induce systemic and mucosal immune responses in mice...
  24. doi request reprint Oral administration of plant-based rotavirus VP6 induces antigen-specific IgAs, IgGs and passive protection in mice
    Bo Zhou
    State Key Laboratory of Agro Biotechnology, College of Biological Sciences, China Agricultural University, No 2 Yuanmingyuan West Road, Beijing 100193, PR China
    Vaccine 28:6021-7. 2010
    ..These results suggested that it is feasible to induce lactogenic immunity against an enteric pathogen through oral vaccination, by using the antigen produced in a new BBSV-based plant protein expression system...
  25. doi request reprint Tolerogenic DNA vaccine for prevention of autoimmune ovarian disease
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, Key Laboratory of Microbiological Resources and Applications of the Ministry of Agriculture, College of Biological Science, China Agricultural University, Beijing 100193, China
    Immunol Invest 41:249-60. 2012
    ..Significantly, the immunization also protected the animals from experimentally induced autoimmune ovarian disease. These results suggest that DNA vaccination in the presence of FK506 may be used to induce Treg cells and prevent AOD...
  26. doi request reprint The protective efficacy against Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice
    Xiao Wang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, 2 Yuanmingyuan Xi Road, Beijing 100094, China
    Vaccine 26:1832-45. 2008
    ....
  27. ncbi request reprint The adjuvant effect of levamisole on killed viral vaccines
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, Department of Physiology, College of Biology, China Agricultural University, Beijing 100094, China
    Vaccine 23:5543-50. 2005
    ..These results establish that LMS can be used to induce Th1-biased immune responses when combined with killed-virus-based antiviral vaccines and that such adjuvant effect depends on the optimal LMS dosage...
  28. doi request reprint Identification and characterization of a novel adenine phosphoribosyltransferase gene (ZmAPT2) from maize (Zea mays L.)
    Suowei Wu
    The State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People s Republic of China
    DNA Seq 19:357-65. 2008
    ..Southern blot analysis indicated that at least three APRT genes existed in maize genome. These results confirmed that the novel maize ZmAPT2 gene was truly identified, and its potential role in maize growth and development was discussed...
  29. pmc Efficient induction of CD25- iTreg by co-immunization requires strongly antigenic epitopes for T cells
    Shuang Geng
    State Key Laboratory for Agro Biotechnology China Agricultural University, Beijing 100193, China
    BMC Immunol 12:27. 2011
    ..However, it was unclear how to choose the antigen sequence to maximize tolerogenic antigen presentation and, consequently, CD25- iTreg induction...
  30. doi request reprint An immunotherapeutic treatment against flea allergy dermatitis in cats by co-immunization of DNA and protein vaccines
    Jin Jin
    State Key Laboratory for Agro Biotechnology, China Agricultural University, Beijing 100094, China
    Vaccine 28:1997-2004. 2010
    ..This study demonstrates that a co-immunization approach as described can be used to treat flea-induced allergic disease in animals, thus implicating its potential for a practical clinical application...
  31. ncbi request reprint Different hereditary contribution of the CFH gene between polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese Han people
    Lvzhen Huang
    Department of Ophthalmology, Peking University People s Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 55:2534-8. 2014
    ..To investigate whether 11 variants in complement factor H gene contributed differently in patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) of Chinese descent...
  32. doi request reprint Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells
    Yuan Gao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People s Republic of China
    Stem Cells Dev 19:53-60. 2010
    ..Immunofluorescence assay demonstrates that NgR and its ligand Nogo-A/B exist on mouse blastocysts and cultured ES cells, suggesting NgR might play a role in early embryo development...
  33. ncbi request reprint Efficacy of modified levamisole adjuvant on inactivated virus vaccine
    Jiangmei Yin
    State Key Laboratory for Agro Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
    Viral Immunol 19:525-35. 2006
    ..These results demonstrated that modified LMS+ adjuvant could be used to improve both humoral and cell-mediated responses for inactivated viral vaccines and its development as an effective inactivated viral vaccine is warranted...
  34. ncbi request reprint Cloning and characterization of a second form of the rice adenine phosphoribosyl transferase gene (OsAPT2) and its association with TGMS
    Chun Jiang Zhou
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Plant Mol Biol 60:365-76. 2006
    ..These data suggest that OsAPT2 is likely to be involved in TGMS in the rice line 'Annong S-1'...
  35. ncbi request reprint Treatment of autoimmune ovarian disease by co-administration with mouse zona pellucida protein 3 and DNA vaccine through induction of adaptive regulatory T cells
    Jinyao Li
    Department of Microbiology and Immunology, State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    J Gene Med 10:810-20. 2008
    ..Autoimmune ovarian disease (AOD) caused by auto-reactive T cells is considered a major reason for human premature ovarian failure, which affects 5% of women worldwide...
  36. ncbi request reprint Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection
    Huali Jin
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    J Cell Biochem 102:980-91. 2007
    ....
  37. ncbi request reprint Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines
    Huali Jin
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing
    Virology 337:183-91. 2005
    ..Hence, co-immunization with DNA- and protein-based vaccines may represent a novel means for inducing active suppression against untoward immunity...
  38. ncbi request reprint Induction of regulatory T cells by physiological level estrogen
    Ping Tai
    State Key Laboratories of Agro biotechnology, College of Biological Science, China Agricultural University, Beijing, People s Republic of China
    J Cell Physiol 214:456-64. 2008
    ..This supports that E2 may directly act on CD4+CD25- T cells via ER(s). We conclude that E2 is a potential physiological regulatory factor for the peripheral development of CD4+CD25+ Treg cells during the implantation period in mice...
  39. ncbi request reprint Dexamethasone suppresses cochlear Hes1 expression after noise exposure
    Bin Wang
    Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
    Acta Otolaryngol 133:233-8. 2013
    ..Dexamethasone provides protection against noise-induced hearing loss (NIHL) possibly by suppressing cochlear Hes1 expression via a glucocorticoid receptor (GR)-dependent mechanism...
  40. pmc Helminth protein vaccine induced follicular T helper cell for enhancement of humoral immunity against Schistosoma japonicum
    Jingyao Zhang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100193, China
    Biomed Res Int 2013:798164. 2013
    ..Our results suggest that helminth protein vaccine combined with FK506 induces Tfh cell for stimulating humoral immune responses and inducing long-lived humoral immunity. ..
  41. doi request reprint Cimetidine augments Th1/Th2 dual polarized immune responses to recombinant HBV antigens
    Wenjuan Zhang
    State Key Laboratories of Agro biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Vaccine 29:4862-8. 2011
    ..These results suggest that CIM may be a better adjuvant for therapeutic vaccines against chronic viral infection, such as the HBV infection, where dual polarization should allow more effective elimination of infected host cells...
  42. doi request reprint Hemokinin-1 as an adjuvant molecule enhancing humoral and memory responses to HBsAg DNA vaccination
    Xuan Chen
    State Key Laboratory for Agro Biotechnology, Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing, China
    Viral Immunol 25:289-96. 2012
    ..Therefore, HK-1 may lead to the development of a novel humoral-biased molecular adjuvant for an HBsAg DNA vaccine against hepatitis B infection...
  43. doi request reprint Protective response against type 1 diabetes in nonobese diabetic mice after coimmunization with insulin and DNA encoding proinsulin
    Wenjuan Zhang
    State Key Laboratory for Agro Biotechnology and College of Biological Science, China Agricultural University, Beijing, China
    Hum Gene Ther 21:171-8. 2010
    ..A strategy based on co-immunization to induce a protective response against the onset of diabetes in NOD mice may lead to the development of an immunotherapeutic/preventive protocol against T1D in humans...
  44. ncbi request reprint An association study of SNP + 45 T > G of the AdipoQ gene with type 2 diabetes in Yi and Han people in China
    Bin Wang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    Int J Vitam Nutr Res 81:392-7. 2011
    ..This study was designed to identify genetic variants of the AdipoQ gene that contribute to the development of T2D in Yi and Han people...
  45. doi request reprint Distribution and sources of mercury in soils from former industrialized urban areas of Beijing, China
    Wei Luo
    State Key Lab of Urban and Regional Ecology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China
    Environ Monit Assess 158:507-17. 2009
    ..The greater concentration of SigmaHg in most soils could have been due in part to combustion of coal and leakage from industrial processes...
  46. ncbi request reprint CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection
    Qiang Zou
    Key laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, Shanghai, China State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    Eur J Immunol 44:103-14. 2014
    ....
  47. doi request reprint FK506 as an adjuvant of tolerogenic DNA vaccination for the prevention of experimental autoimmune encephalomyelitis
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    J Gene Med 11:1064-70. 2009
    ..DNA vaccination is a strategy that has been developed primarily to elicit protective immunity against infection and cancer...
  48. doi request reprint Characterization of multiple cold induced genes from Ammopiptanthus mongolicus and functional analyses of gene AmEBP1
    Pengxiu Cao
    The State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Plant Mol Biol 69:529-39. 2009
    ....
  49. ncbi request reprint Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice
    Huali Jin
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Biochem Biophys Res Commun 328:979-86. 2005
    ..The highest immune responses were generated by the construct encoding the nucleocapsid protein. The results suggest that the N, M, and E genes could be used as the targets to prevent SARS-CoV infection in the DNA vaccine development...
  50. pmc Children's vaccines do not induce cross reactivity against SARS-CoV
    Yang Yu
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    J Clin Pathol 60:208-11. 2007
    ..The results showed no marked cross reactivity against SARS-CoV, which implies that the reduced symptoms among children infected by SARS-CoV may be caused by other factors...
  51. ncbi request reprint An automated process to extract plasmid DNA by alkaline lysis
    Xiaolin Li
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, 100094, China
    Appl Microbiol Biotechnol 75:1217-23. 2007
    ..Using this procedure, plasmid can be extracted and purified from 1 l of Escherichia coli cultures at an OD600 nm of 50 in less than 45 min. The plasmid yields are approximately 90 mg/l culture...
  52. pmc Treg cell resistance to apoptosis in DNA vaccination for experimental autoimmune encephalomyelitis treatment
    Youmin Kang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing, China
    PLoS ONE 7:e49994. 2012
    ..Here we examined the therapeutic effect of DNA vaccine in conjunction with FK506 on EAE...
  53. pmc Emission characteristics for polycyclic aromatic hydrocarbons from solid fuels burned in domestic stoves in rural china
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
    Environ Sci Technol 47:14485-94. 2013
    ..For source diagnosis, high molecular weight isomers are more informative than low molecular weight ones and multiple ratios could be used together whenever possible. ..
  54. doi request reprint Human basic fibroblast growth factor fused with Kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis
    Wenxue Zhao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Tissue Eng Part A 15:991-8. 2009
    ..Moreover, the regenerative tissues were integrated well with the fibrin scaffolds, suggesting its good biocompatibility. In summary, targeted delivery of K4bFGF could potentially improve therapeutic angiogenesis...
  55. doi request reprint A continuous process to extract plasmid DNA based on alkaline lysis
    Xiaolin Li
    State Key Laboratory for Agro Biotechnology and the Key Laboratory of Agro Microbial Resources and Applications of MOA, China Agricultural University, Beijing 100094, China
    Nat Protoc 3:176-80. 2008
    ..Using this procedure, plasmid can be extracted and purified from 4 l of Escherichia coli culture at an OD 600 nm of 50 in <90 min. The plasmid yields are approximately 80-90 mg l(-1) culture...
  56. ncbi request reprint Cloning, characterization, and transformation of the phosphoethanolamine N-methyltransferase gene (ZmPEAMT1) in maize (Zea mays L.)
    Suowei Wu
    The State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
    Mol Biotechnol 36:102-12. 2007
    ..These data indicated that ZmPEAMT1 maybe involved in maize root development and stress resistance, and maybe having a potential application in maize genetic engineering...
  57. ncbi request reprint A rodent model for allergic dermatitis induced by flea antigens
    Lin Zhao
    College of Biological Science, China Agricultural University, Beijing 100094, China
    Vet Immunol Immunopathol 114:285-96. 2006
    ....
  58. pmc GM-CSF and IL-2 as adjuvant enhance the immune effect of protein vaccine against foot-and-mouth disease
    Can Zhang
    College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
    Virol J 8:7. 2011
    ..In this study, we investigated the effects of GM-CSF and IL-2 as adjuvant on the immune responses of VP1 recombinant protein as a model antigen for foot and mouth disease...
  59. doi request reprint Cell absorption induced desorption of hydrophobic organic contaminants from digested soil residue
    Bin Wang
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, China
    Chemosphere 83:1461-6. 2011
    ..7-2.8 times higher than those without the residue. This supported the hypothesis that the cell absorption of dissolved HOCs induces desorption of the sorbed fraction from digestive residue, and the desorbed HOCs can be absorbed as well...
  60. doi request reprint Sesquiterpenoid and phenolic glucoside gallates from Lagerstroemia balansae
    Yong Zhou
    State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China
    Planta Med 77:1944-6. 2011
    ..Their structures were elucidated on the basis of chemical and spectroscopic evidences...
  61. doi request reprint Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings
    Dao Zhen Xu
    Beijing Ditan Hospital, Capital Medical University, Beijing, People s Republic of China
    J Hepatol 59:450-6. 2013
    ..A double-blind, placebo-controlled, phase II B clinical trial of YIC has been reported previously, and herein we present the results of the phase III clinical trial of 450 patients...
  62. doi request reprint Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice
    Guanping Mao
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100193, China
    Endocrinology 151:5477-88. 2010
    ..Together, the present results demonstrate that P4 is an important regulator of systemic and local CD4(+)CD25(+) Treg cells, which are involved in maintaining maternal-fetal immune tolerance during midterm pregnancy...