Yue Fang

Summary

Affiliation: China Medical University
Country: China

Publications

  1. pmc A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis
    Yue Fang
    Department of Pharmacology, School of Pharmaceutical Sciences, China Medical University, Shenyang, China
    Antimicrob Agents Chemother 56:1949-59. 2012
  2. doi request reprint Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast
    Yue Fang
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 14:759-71. 2009
  3. pmc A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast
    Tomonori Takami
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e49004. 2012
  4. pmc Studies on the roles of clathrin-mediated membrane trafficking and zinc transporter Cis4 in the transport of GPI-anchored proteins in fission yeast
    Wurentuya Jaiseng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e41946. 2012
  5. ncbi request reprint Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis
    Kiwamu Imagawa
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 55:E30-5. 2009
  6. pmc E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast
    Yue Fang
    Department of Biopharmaceutics, School of Pharmacy, China Medical University, Shenyang, China Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 9:e85238. 2014
  7. ncbi request reprint Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism
    Xibo Zhang
    Division of Pharmacology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Kobe J Med Sci 61:E54-63. 2015
  8. pmc Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeast
    Yue Fang
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 19:1295-303. 2008
  9. doi request reprint Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil
    Lingling Hu
    Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110112, China Division of Pharmacology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Fungal Genet Biol 93:17-24. 2016
  10. pmc The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast
    Hirofumi Takada
    Laboratory of Molecular Pharmacogenomics, Laboratory of Molecular and Cellular Biology, and Laboratory of Bioinformatics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, 577 8502, Japan
    Mol Biol Cell 21:674-85. 2010

Collaborators

Detail Information

Publications12

  1. pmc A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis
    Yue Fang
    Department of Pharmacology, School of Pharmaceutical Sciences, China Medical University, Shenyang, China
    Antimicrob Agents Chemother 56:1949-59. 2012
    ....
  2. doi request reprint Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast
    Yue Fang
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 14:759-71. 2009
    ..These data suggest that the pleiotropic phenotypes reflect the integrated effects of the reduced availability of ergosterol and various intermediates of the mevalonate pathway...
  3. pmc A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast
    Tomonori Takami
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e49004. 2012
    ....
  4. pmc Studies on the roles of clathrin-mediated membrane trafficking and zinc transporter Cis4 in the transport of GPI-anchored proteins in fission yeast
    Wurentuya Jaiseng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 7:e41946. 2012
    ....
  5. ncbi request reprint Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis
    Kiwamu Imagawa
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 55:E30-5. 2009
    ....
  6. pmc E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast
    Yue Fang
    Department of Biopharmaceutics, School of Pharmacy, China Medical University, Shenyang, China Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 9:e85238. 2014
    ..Altogether, our findings reveal a novel role for Pub1 in endocytosis of Ecm33 and regulation of cell wall integrity in fission yeast. ..
  7. ncbi request reprint Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism
    Xibo Zhang
    Division of Pharmacology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Kobe J Med Sci 61:E54-63. 2015
    ....
  8. pmc Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeast
    Yue Fang
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 19:1295-303. 2008
    ..These results suggest that Cis4 forms a heteromeric functional complex with Zrg17 and that Cis4 is implicated in Golgi membrane trafficking through the regulation of zinc homeostasis in fission yeast...
  9. doi request reprint Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil
    Lingling Hu
    Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110112, China Division of Pharmacology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Fungal Genet Biol 93:17-24. 2016
    ..Altogether, our findings revealed the first evidence that 5-FU influences membrane trafficking as the potential underlying mechanism of the drug action. ..
  10. pmc The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast
    Hirofumi Takada
    Laboratory of Molecular Pharmacogenomics, Laboratory of Molecular and Cellular Biology, and Laboratory of Bioinformatics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, 577 8502, Japan
    Mol Biol Cell 21:674-85. 2010
    ..Our results suggest that Ecm33 is involved in the negative feedback regulation of Pmk1 cell integrity signaling and is linked to cellular Ca(2+) signaling...
  11. pmc A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe
    Xin Zhou
    Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, China
    PLoS ONE 8:e65904. 2013
    ..Altogether, our findings provide useful information for new potential drug combinations in the treatment of fungal infections...
  12. doi request reprint Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast
    Lingling Hu
    Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
    Genes Cells 20:695-705. 2015
    ..Collectively, these results suggest that azoles activate stress-activated MAP kinase pathway, thereby facilitating Atf1-mediated transcription for antifungal effects. ..