- Novel ultrasound-targeted microbubble destruction mediated short hairpin RNA plasmid transfection targeting survivin inhibits gene expression and induces apoptosis of HeLa cellsZhiyi Chen
Department of Medical Ultrasound, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China
Mol Biol Rep 36:2059-67. 2009..This novel method for RNA interference represents a powerful, promising non-viral technology that can be used in the tumor gene therapy and research...
- Induced apoptosis with ultrasound-mediated microbubble destruction and shRNA targeting survivin in transplanted tumorsZhi Yi Chen
Department of Medical Ultrasound, The Third Affiliated Hospital of Guangzhou Medical College, Guangdong, 510150, China
Adv Ther 26:99-106. 2009..This study was designed to evaluate the consequences of survivin down-modulation on tumor growth in a nude mice model combined with short hairpin RNA recombinant vector (shRNA) and ultrasound-mediated microbubble destruction (UMMD)...
- Enhancement of survivin gene downregulation and cell apoptosis by a novel combination: liposome microbubbles and ultrasound exposureZhiyi Chen
Department of Medical Ultrasound, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, 510150, China
Med Oncol 26:491-500. 2009..We concluded that this nonviral technique would be valuable in the gene transfection of shRNA and Survivin gene downregulation would lead to apparent cell apoptosis...
- Targeted gene delivery in tumor xenografts by the combination of ultrasound-targeted microbubble destruction and polyethylenimine to inhibit survivin gene expression and induce apoptosisZhi Yi Chen
Department of Medical Ultrasound, the Third Affiliated Hospital of Guangzhou Medical University, PR China
J Exp Clin Cancer Res 29:152. 2010....