Tao Chen

Summary

Country: China

Publications

  1. pmc Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice
    Xiang yao Li
    Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi an Jiaotong University, Xi an 710054, China
    Mol Pain 8:53. 2012
  2. pmc Spinal microglial motility is independent of neuronal activity and plasticity in adult mice
    Tao Chen
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 6:19. 2010
  3. doi Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
  4. pmc Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011
  5. doi Cortical GluK1 kainate receptors modulate scratching in adult mice
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, University of Toronto Center for the Study of Pain, Toronto, Ontario, Canada
    J Neurochem 126:636-50. 2013
  6. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
  7. doi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
  8. pmc Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
  9. pmc Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 7:47. 2011
  10. pmc Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:32. 2009

Detail Information

Publications16

  1. pmc Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice
    Xiang yao Li
    Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi an Jiaotong University, Xi an 710054, China
    Mol Pain 8:53. 2012
    ..Our studies provide the first report characterizing the electrophysiological properties of neurons in LI of the ACC from adult mice...
  2. pmc Spinal microglial motility is independent of neuronal activity and plasticity in adult mice
    Tao Chen
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 6:19. 2010
    ....
  3. doi Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
    ..Our study thus shows that AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain...
  4. pmc Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011
    ....
  5. doi Cortical GluK1 kainate receptors modulate scratching in adult mice
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, University of Toronto Center for the Study of Pain, Toronto, Ontario, Canada
    J Neurochem 126:636-50. 2013
    ..In addition, we found that inhibiting GluK1-containing KA receptors in the ACC also reduced behavioral nociceptive responses induced by formalin. Our results reveal a new role of the cortex in pruritogen-induced scratching...
  6. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
    ..These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders...
  7. doi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  8. pmc Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
    ....
  9. pmc Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 7:47. 2011
    ..Our results will help to understand the neuronal mechanism of itch and aid future treatment for patients with pruritic disease...
  10. pmc Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:32. 2009
    ..Moreover, reciprocal connections exist in all four types of paired neurons. Our results provide the first key evidence of functional excitatory and inhibitory connections in the ACC...
  11. pmc In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 6:62. 2010
    ..Our studies provide the first in vivo characterization of ACC neurons in adult mice, and demonstrate that ACC neurons are indeed nociceptive. These findings support the critical roles of ACC in nociception, from mice to humans...
  12. ncbi Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, Medical Science Building, Room no 3342, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    J Mol Med (Berl) 89:847-55. 2011
    ..We propose that targeting PKMζ, or its up- or downstream signaling proteins, in the ACC may provide novel clinical treatment for chronic pain...
  13. doi Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex
    Kohei Koga
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:1988-98. 2012
    ..These data suggest that both GluK1 and GluK2 play functional roles in the IC. Our study may provide the synaptic basis for the physiology and pathology of KA receptors in the IC-related functions...
  14. pmc Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
    Xiao Yan Cao
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 5:73. 2009
    ....
  15. pmc Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mol Brain 3:27. 2010
    ..Our results reveal in the first time a transcription- and translation-dependent component of early synaptic LTP in adult ACC synapses, and demonstrate that CaMKIV enhances early synaptic potentiation by activating new protein synthesis...
  16. pmc DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Brain 3:3. 2010
    ..By contrast, sensory responses to noxious stimuli were not affected. Our results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory...