- Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic heartsGuozhen Chen
Department of Cardiology, The Children s Hospital of Chongqing Medical University, Chongqing, PR China
J Biomed Sci 16:24. 2009..The expression of p300 is earlier and more predominate, suggesting that p300 may play a more important role in embryonic heart development especially during cardiac precursor cell induction and interventricular septum formation...
- Ethanol and its metabolites induce histone lysine 9 acetylation and an alteration of the expression of heart development-related genes in cardiac progenitor cellsLilin Zhong
Department of Cardiology, The Children s Hospital of Chongqing Medical University, 136 Zhong Shan Er Road, Yu Zhong District, 400014 Chongqing, People s Republic of China
Cardiovasc Toxicol 10:268-74. 2010..The altered histone H3 acetylation at lysine 9 has an important impact on the expression of the heart development-related genes, which may be one of the mechanisms underlying the alcohol-induced CHD...
- Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytesHuichao Sun
Heart Centre, Children s Hospital of Chongqing Medical University, Chongqing, PR China
Life Sci 87:707-14. 2010..In this study, we investigated the relationship between histone hypo-acetylation and the expression of cardiac-specific genes to explore the underlying mechanisms...