Xiao Xin Yan

Summary

Affiliation: Central South University
Country: China

Publications

  1. pmc Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China
    PLoS ONE 7:e48782. 2012
  2. pmc BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Exp Neurol 235:228-37. 2012
  3. pmc Chronic lead exposure reduces doublecortin-expressing immature neurons in young adult guinea pig cerebral cortex
    Jufang Huang
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, China
    BMC Neurosci 13:82. 2012
  4. pmc Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients
    Xiaoxin Jiang
    The First Affiliated Hospital, Nanhua University, Hengyang, China
    BMC Immunol 13:62. 2012
  5. pmc β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Eur J Neurosci 32:1223-38. 2010
  6. doi request reprint Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs
    Aihua Pan
    Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Neurosci Res 91:249-61. 2013
  7. pmc BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology
    Yan Cai
    Department of Human Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Neurotox Res 21:160-74. 2012
  8. pmc Layer I as a putative neurogenic niche in young adult guinea pig cerebrum
    Kun Xiong
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Mol Cell Neurosci 45:180-91. 2010
  9. pmc Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    PLoS ONE 7:e37599. 2012
  10. pmc γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ
    Fei Liu
    Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
    Eur J Neurosci 37:1714-25. 2013

Collaborators

Detail Information

Publications21

  1. pmc Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China
    PLoS ONE 7:e48782. 2012
    ....
  2. pmc BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Exp Neurol 235:228-37. 2012
    ..These findings suggest that BACE1 is involved in aberrant limbic axonal sprouting in a model of temporal lobe epilepsy, warranting further investigation into the role of BACE1 in physiological vs. pathological neuronal plasticity...
  3. pmc Chronic lead exposure reduces doublecortin-expressing immature neurons in young adult guinea pig cerebral cortex
    Jufang Huang
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, China
    BMC Neurosci 13:82. 2012
    ..Using young adult guinea pigs as an experimental model, the present study explored if chronic Pb exposure affects cortical DCX + immature neurons and those around the subventricular and subgranular zones (SVZ, SGZ)...
  4. pmc Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients
    Xiaoxin Jiang
    The First Affiliated Hospital, Nanhua University, Hengyang, China
    BMC Immunol 13:62. 2012
    ..Cells infected by microbiological pathogens may release sMICA, whereas less is known whether and to what extent serum sMICA levels may change in infectious diseases...
  5. pmc β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Eur J Neurosci 32:1223-38. 2010
    ..The data provide a mechanistic explanation for why senile plaques are present preferentially near the cerebral vasculature...
  6. doi request reprint Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs
    Aihua Pan
    Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Neurosci Res 91:249-61. 2013
    ..These findings point to potential therapeutic targets for improving neuronal recovery in clinical management of EDH...
  7. pmc BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology
    Yan Cai
    Department of Human Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Neurotox Res 21:160-74. 2012
    ....
  8. pmc Layer I as a putative neurogenic niche in young adult guinea pig cerebrum
    Kun Xiong
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Mol Cell Neurosci 45:180-91. 2010
    ....
  9. pmc Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    PLoS ONE 7:e37599. 2012
    ..This novel neuronal alteration indicates that impairments in membrane protein metabolism, possibly due to neuronal calcium mishandling and/or enhancement of calcium sensitive proteolysis, occur during aging and in transgenic AD mice...
  10. pmc γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ
    Fei Liu
    Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
    Eur J Neurosci 37:1714-25. 2013
    ..The CP appears to be a previously unrecognised non-neuronal contributor to CSF Aβ, probably at reduced levels in AD...
  11. pmc Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain
    Zhi Qin Xue
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, Hunan, 410013, China
    BMC Neurol 15:71. 2015
    ..Also being considered a part of CAA is the Aβ deposition in leptomeninge. The cellular origin of angiopathic Aβ and the pathogenic course of CAA remain incompletely understood...
  12. pmc Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum
    Jian Ming Li
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, Hunan, China
    Oncotarget 6:10772-85. 2015
    ..These experimental data suggest that microvascular injury can induce multisystem neuritic pathology associated with an enhanced amyloidogenic potential in wild-type mammalian brain. ..
  13. pmc Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex
    Chao Liu
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science Changsha, China Department of Neurology, The First Hospital of Changsha Changsha, China
    Front Neuroanat 9:11. 2015
    ..The data also suggest that type II nitrinergic neurons may undergo a period of development/differentiation, for over 1 month, before being NADPH-d reactive...
  14. pmc Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex
    Yan Yang
    Department of Anatomy and Neurobiology, Central South University School of Basic Medicine Changsha, China Department of Nursing in Internal Medicine, Xiangtan Vocational and Technical College Xiangtan, China
    Front Neuroanat 9:109. 2015
    ..Our data also show an earlier establishment of the basic lamination in the piriform relative to neocortical areas in guinea pigs...
  15. pmc Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury
    Jian Ming Li
    Neuroscience Research Center, Changsha Medical University, Changsha, 410219, Hunan, China
    Neurotox Res 24:1-14. 2013
    ..Spinal neuritic plaque formation is enhanced after peripheral axotomy, suggesting a retrograde transneuronal modulation on pathogenesis...
  16. pmc Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response
    Ju fang Huang
    Department of Anatomy and Neurobiology, Central South University, Changsha, Hunan, China
    BMC Neurosci 14:16. 2013
    ..Evidence suggests that necroptosis may be a mode of neuronal death in the retina...
  17. doi request reprint Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease
    Hai xia Zhu
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, Hunan 410013, China Department of Neurology, Central South University, The Third Affiliated Hospital of Xiangya School of Medicine, Changsha, Hunan 410013, China
    Exp Gerontol 69:43-52. 2015
    ..These results confirm an age-related intraneuronal SBDP120 accumulation in the human cerebrum that is enhanced in AD. This neuronal change appears to occur independent of amyloid deposition, tau pathology and overt neuronal death. ..
  18. pmc Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China
    J Alzheimers Dis 38:705-18. 2014
    ..Finally, we propose pharmacological inhibition of excessive BACE1 activity as an option to mitigate early axonal pathology occurring in AD and other neurological disorders. ..
  19. doi request reprint [(3) H]-L685,458 binding sites are abundant in multiple peripheral organs in rats: implications for safety assessment of putative γ-secretase targeting drugs
    Zhi Ying Yang
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, China Department of Pharmacy, Changsha Health Vocational College, Changsha, China
    Basic Clin Pharmacol Toxicol 115:518-26. 2014
    ..The development of γ-secretase inhibitors/modulators for AD and cancer therapy should include close monitoring of toxicological panels for hepatic, gastrointestinal, endocrinal and reproductive functions. ..
  20. pmc Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan 410013, China
    Exp Neurol 216:342-56. 2009
    ..These data suggest that immature neurons persist into adulthood in many cortical areas in cats and primates, and that these cells appear to undergo development and differentiation to become functional subgroups of GABAergic interneurons...
  21. doi request reprint Somal and dendritic development of human CA3 pyramidal neurons from midgestation to middle childhood: a quantitative Golgi study
    Dahua Lu
    Department of Anatomy and Neurobiology, Central South University, Xiangya School of Medicine, Changsha, Hunan, China
    Anat Rec (Hoboken) 296:123-32. 2013
    ..Spine development and likely synaptogenesis on CA3 pyramidal cells progress during the third prenatal trimester and may continue throughout childhood...