Fu Chu He

Summary

Affiliation: Beijing Institute of Radiation Medicine
Country: China

Publications

  1. pmc Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26
    Ying Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Nucleic Acids Res 38:6544-54. 2010
  2. pmc Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine
    Xiaoping Chen
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, Beijing, China
    Environ Health Perspect 117:1541-8. 2009
  3. pmc Regular patterns for proteome-wide distribution of protein abundance across species
    Fan Zhong
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    PLoS ONE 7:e32423. 2012
  4. pmc Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles
    Yuanbiao Guo
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    PLoS ONE 4:e7641. 2009
  5. doi request reprint Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver
    Yunfei Zuo
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Gut 62:1169-78. 2013
  6. pmc A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population
    Yang Zhang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    BMC Med 9:106. 2011
  7. pmc The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
    Man Wai Ng
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 7:50. 2007
  8. pmc Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma
    Ye Lu
    Department of Chemistry, Fudan University, Shanghai, China
    BMC Gastroenterol 10:115. 2010
  9. pmc Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs
    Zhongyang Liu
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    BMC Evol Biol 11:133. 2011
  10. pmc A miniaturized sandwich immunoassay platform for the detection of protein-protein interactions
    Qiongming Liu
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    BMC Biotechnol 10:78. 2010

Collaborators

Detail Information

Publications36

  1. pmc Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26
    Ying Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Nucleic Acids Res 38:6544-54. 2010
    ..Overexpression of RPL26 results in activating of p53, inhibits cell proliferation and induces a p53-dependent cell cycle arrest. These results provide a novel regulatory mechanism of RPL26 to activate p53 by inhibiting HDM2...
  2. pmc Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine
    Xiaoping Chen
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, Beijing, China
    Environ Health Perspect 117:1541-8. 2009
    ..Functional variants in the CYP3A locus may have undergone a selective sweep in response to various environmental conditions...
  3. pmc Regular patterns for proteome-wide distribution of protein abundance across species
    Fan Zhong
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    PLoS ONE 7:e32423. 2012
    ..Thus, protein abundance is intrinsically related to the protein's inherent characters of evolution, structure, and function...
  4. pmc Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles
    Yuanbiao Guo
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    PLoS ONE 4:e7641. 2009
    ..5-E15.5 and thereafter, and the depression of the key pathways attributes to build the hematopoietic microenvironment. These findings signal hematopoiesis emigration is the key to open the door of liver maturation...
  5. doi request reprint Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver
    Yunfei Zuo
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Gut 62:1169-78. 2013
    ..This study aimed to determine the role of liver sinusoidal endothelial cell lectin (LSECtin) in colon carcinoma metastasis to the liver...
  6. pmc A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population
    Yang Zhang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    BMC Med 9:106. 2011
    ..We examined whether the functional MNS16A was related to the risk of occurrence or progression of NPC in the Chinese population...
  7. pmc The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese
    Man Wai Ng
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 7:50. 2007
    ..Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)...
  8. pmc Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma
    Ye Lu
    Department of Chemistry, Fudan University, Shanghai, China
    BMC Gastroenterol 10:115. 2010
    ..The aim of this study was to identify biomarkers for early diagnosis of HBV related liver fibrosis...
  9. pmc Evidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs
    Zhongyang Liu
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    BMC Evol Biol 11:133. 2011
    ..How the proteins were added to the protein interaction network during its growth is a basic and important issue. Network motifs represent the simplest building blocks of cellular machines and are of biological significance...
  10. pmc A miniaturized sandwich immunoassay platform for the detection of protein-protein interactions
    Qiongming Liu
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    BMC Biotechnol 10:78. 2010
    ..To overcome this problem, we developed a miniaturized sandwich immunoassay platform (MSIP) by combining antibody array technology and coIP methods...
  11. pmc Computational identification of rare codons of Escherichia coli based on codon pairs preference
    Xianming Wu
    School of Biological Science and Technology, Shenyang Agricultural University, Shenyang, PR China
    BMC Bioinformatics 11:61. 2010
    ..Here we focus on the patterns of rarely-used synonymous codons. A novel method was introduced to identify the rare codons merely by codon pair bias in Escherichia coli...
  12. pmc SigFlux: a novel network feature to evaluate the importance of proteins in signal transduction networks
    Wei Liu
    College of Mechanical and Electronic Engineering and Automatization, National University of Defense Technology, Changsha, China
    BMC Bioinformatics 7:515. 2006
    ..However, there are relatively few methods to evaluate the importance of proteins in signaling networks...
  13. pmc A nonparametric model for quality control of database search results in shotgun proteomics
    Jiyang Zhang
    College of Mechanical and Electronic Engineering and Automatization, National University of Defense Technology, Changsha, 410073, China
    BMC Bioinformatics 9:29. 2008
    ..However, a consequent problem is the ignorance of how to combine different database search scores to improve the sensitivity of randomized database methods...
  14. pmc A novel parametric approach to mine gene regulatory relationship from microarray datasets
    Wanlin Liu
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    BMC Bioinformatics 11:S15. 2010
    ..And few of them are able to offer intuitive parameters. We wonder whether some simple but basic characteristics of microarray datasets can be found to identify the potential gene regulatory relationship...
  15. ncbi request reprint Human liver proteome project: plan, progress, and perspectives
    Fuchu He
    Beijing National Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Mol Cell Proteomics 4:1841-8. 2005
    ....
  16. ncbi request reprint CNHUPO: pioneer and vigorous roles for proteomics investigation in China
    Fuchu He
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Mol Cell Proteomics 7:1186-7. 2008
  17. ncbi request reprint Protein product encoded by a human novel gene E9730 enhances AP-1 activity through interacting with Jab1
    Zhao Qing Wang
    Department of System Biology, Beijing Institute of Radiation Medicine, Chinese Human National Center at Beijing, Beijing 100850, China
    Acta Biochim Biophys Sin (Shanghai) 36:11-5. 2004
    ..Furthermore, the data indicated that E9730 appeared to enhance Jab1-induced AP-1 activity in a concentration-dependent manner and Jab1 may be involved in the intracellular signaling transduction from E9730 to AP-1...
  18. ncbi request reprint [Transcriptional regulation of gamma- and epsilon-globin genes by basic Krüppel-like factor]
    Xiao Yun Ma
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:271-6. 2003
    ..These results suggest that gamma- and epsilon-globin genes may be transcriptional targets of BKLF, providing evidence for further studies on the role of BKLF in participating the transcriptional regulation of haemocyte-specific genes...
  19. ncbi request reprint [Subcellular localization of basic Krüppel-like factor]
    Xiao Yun Ma
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:255-60. 2003
    ..These results provided a basis for further clarifying the function of BKLF...
  20. ncbi request reprint [Isolation and characterization of a novel transcript of hepatopoietin]
    Jun Lu
    Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:225-30. 2002
    ..The similar result was observed by FACS technique. Therefore, our results suggest that the HPO-205 has activity to stimulate proliferation of liver derived cells, and this activity may be stronger than HPO...
  21. ncbi request reprint [Identification, modeling and simulation of key pathways underlying certain cancers]
    Hao Guo
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan 33:809-19. 2011
    ..In this paper, firstly we review the recent development of these algorithms and models; then list the related software and data sources; and finally discuss the existence problems and perspectives in this field...
  22. ncbi request reprint [Chemical probe in the proteomics]
    Yun Wei Hao
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan 29:779-84. 2007
    ..To investigate these variations, proteomic technology provided powerful tools. In this article, chemical probe in quantitative and modification study is discussed in details...
  23. ncbi request reprint [KAP-1, a scaffold protein in transcription regulation]
    Dong Yang
    Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Yi Chuan 29:131-6. 2007
    ..It is reported that KAP-1 related transcription regulation complexes exert functions essential for spermiogenesis and early embryo development. This regulation is one pattern of epigenetic regulations...
  24. ncbi request reprint [cDNA cloning, subcellular localization and tissue expression of a new human Krüppel-like transcription factor: human basic Krüppel-like factor (hBKLF)]
    Mang Ju Wang
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan Xue Bao 30:1-9. 2003
    ..Taken together, in this paper we have successfully cloned the full length cDNA of hBKLF. Expression study suggests it may have broad functions in vivo, especially the functions in hematopoietic tissues...
  25. ncbi request reprint [Technique progress in the study of protein/peptide phosphorylation]
    Xin Yu Deng
    State Key Laboratory of Proteomics Beijing Proteome Research Center Beijing Institute of Radiation Medicine, Beijing, China
    Yi Chuan 29:1163-6. 2007
    ....
  26. ncbi request reprint [Recent development of metabonomics and its applications in clinical research]
    Hao Li
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China
    Yi Chuan 30:389-99. 2008
    ..Finally, the role of metabonomics in elucidating the function of the unknown or novel enzyme is mentioned...
  27. ncbi request reprint [Bioinformatics advances in protein ubiquitination]
    Liang Lu
    Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Yi Chuan 35:17-26. 2013
    ..Some potential perspectives are also discussed...
  28. ncbi request reprint [The application of large-scale yeast two-hybrid to study protein--protein interaction]
    Zhi Hao Wu
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan 28:1627-32. 2006
    ....
  29. ncbi request reprint [Constructing gene regulatory network from microarray data]
    Wan Lin Liu
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan 29:1434-42. 2007
    ..In this paper, we review the development of these algorithms, with a particular emphasis on their improvement of theory and method. At last, we present the available software and platform and discuss the development trends in this field...
  30. ncbi request reprint [Research advances in expression profiling of mitochondrial proteins]
    Ai Hua Sun
    Beijing Institute of Radiation Medicine, Beijing Proteome Research Center, Beijing 100850, China
    Yi Chuan 28:1311-5. 2006
    ..This article reviews the most recent studies in the significance, technological aspects, problems and future prospects of expression profiling of mitochondrial proteins...
  31. ncbi request reprint [Association of human microRNA related genetic variations with cancer]
    Pei Yao Li
    Department of Genomics and Proteomics, State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan 33:870-8. 2011
    ..In this review, we focus on the miRNA-related genetic variations and cancer susceptibility and progression...
  32. ncbi request reprint [Gene prediction and function research of SARS-CoV(BJ01)]
    Ting Gui Chen
    Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Yi Chuan Xue Bao 30:773-80. 2003
    ..In the end, we discuss the results and analyse the reasons...
  33. ncbi request reprint A putative NES mediates cytoplasmic localization of Apoptin in normal cells
    Qing Ming Wang
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China
    Acta Biochim Biophys Sin (Shanghai) 36:817-23. 2004
    ..On the other hand, the pNES was also proved to be necessary for Apoptin multimerization. Mutants lacking the pNES did not form obviously visible globular aggregates in normal or tumor cells...
  34. ncbi request reprint [Effect of the new human transcription factor hBKLF on the proliferation, differentiation of K562 cell line and hemoglobin synthesis]
    Mang Ju Wang
    Department of Hematology, Peking University First Hospital, Beijing 100034, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:1083-8. 2006
    ..It is concluded that hBKLF can inhibit hematopoietic cell proliferation and hemoglobin synthesis. It is suggested that hBKLF plays an important role in the proliferation and differentiation of hematopoietic cells...
  35. ncbi request reprint [Progress in human disease proteomics]
    Fu Chu He
    Department of Genomics and Proteomics, Institute of Radiation Medicine, Beijing 100850, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:219-22. 2002
    ..In this article, we have made a concise discussion on the current status, existing problems and future development in the research of human disease proteomics both in and out of China...
  36. pmc Identification and characterization of a novel isoform of hepatopoietin
    Jun Lu
    Institute of Infectious Disease, First Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 310003, China
    World J Gastroenterol 8:353-6. 2002
    ..To isolate a novel isoform of human HPO (HPO-205) from human fetal liver Marathon-ready cDNA and characterize its primary biological function...