Claudia Altamirano

Summary

Country: Chile

Publications

  1. ncbi request reprint Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture
    C Altamirano
    Departament d Enginyeria Quimica, Escola Tecnica Superior d Enginyeria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Biotechnol Prog 17:1032-41. 2001
  2. ncbi request reprint Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium
    C Altamirano
    Escuela de Ingeniería Bioquímica, Facultad de Ingenieria, Universidad Catolica de Valparaiso, Av Brasil 2147, Valparaiso, Chile
    J Biotechnol 110:171-9. 2004
  3. ncbi request reprint Considerations on the lactate consumption by CHO cells in the presence of galactose
    Claudia Altamirano
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Chile
    J Biotechnol 125:547-56. 2006
  4. pmc Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
    Mauricio Vergara
    Institute of Chemistry, Pontificia Universidad Catolica de Valparaiso, Av Universidad 330, Curauma, Chile
    PLoS ONE 10:e0144224. 2015
  5. doi request reprint Relationship between tissue plasminogen activator production and specific growth rate in Chinese hamster ovary cells cultured in mannose at low temperature
    Julio Berrios
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2147, Casilla, 4059, Valparaiso, Chile
    Biotechnol Lett 31:1493-7. 2009
  6. ncbi request reprint Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control
    C Altamirano
    , , , 08193 Bellaterra, Barcelona, Spain
    Biotechnol Bioeng 76:351-60. 2001
  7. doi request reprint A comparative study of glycerol and sorbitol as co-substrates in methanol-induced cultures of Pichia pastoris: temperature effect and scale-up simulation
    Julio Berrios
    School of Biochemical Engineering, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2085, Valparaiso, Chile
    J Ind Microbiol Biotechnol . 2016
  8. doi request reprint Batch production of coenzyme Q10 by recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Sphingomonas baekryungensis
    IRENE MARTINEZ
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2085, Valparaiso, Chile
    J Ind Microbiol Biotechnol 42:1283-9. 2015
  9. pmc Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture
    Mauricio Vergara
    School of Biochemical Engineering, Pontificia Universidad Católica de Valparaiíso, Valparaiso, Chile
    PLoS ONE 9:e93865. 2014
  10. doi request reprint Alginate production and alg8 gene expression by Azotobacter vinelandii in continuous cultures
    Alvaro Díaz-Barrera
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catόlica de Valparaíso, Av Brasil 2147, Casilla 4059, Valparaiso, Chile
    J Ind Microbiol Biotechnol 39:613-21. 2012

Collaborators

  • Alvaro Díaz-Barrera
  • Ramon Gonzalez
  • Juan G Reyes
  • Andres Illanes
  • Julio Berrios
  • IRENE MARTINEZ
  • Mauricio Vergara
  • Pablo Fuentealba
  • Christian Canales
  • Mirtha Henríquez
  • Pau Ferrer
  • Yesenia Latorre
  • Camila Aros
  • Sergio Marshall
  • Joan Albiol
  • Zaida Cabrera
  • María Olga Flores
  • Claudia Mendez
  • Cristian Acevedo
  • Silvana Becerra
  • Nelson Osses
  • María Rodríguez-Moyá
  • Fernando A Gómez
  • Ernesto Gonzalez
  • Sergio H Marshall
  • Vitalia Henriquez
  • Consuelo Bazán

Detail Information

Publications14

  1. ncbi request reprint Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture
    C Altamirano
    Departament d Enginyeria Quimica, Escola Tecnica Superior d Enginyeria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Biotechnol Prog 17:1032-41. 2001
    ..It is, therefore, the combination of growth rate and carbon and energy source availability that determines the level of t-PA production in continuous culture...
  2. ncbi request reprint Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium
    C Altamirano
    Escuela de Ingeniería Bioquímica, Facultad de Ingenieria, Universidad Catolica de Valparaiso, Av Brasil 2147, Valparaiso, Chile
    J Biotechnol 110:171-9. 2004
    ..This allowed an increase in cell growth and cell viability with respect to a fed-batch culture in which only glucose was used in the fed stage...
  3. ncbi request reprint Considerations on the lactate consumption by CHO cells in the presence of galactose
    Claudia Altamirano
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Chile
    J Biotechnol 125:547-56. 2006
    ..This metabolic behavior is further investigated by using metabolic flux analysis, suggesting that the lactate produced is not used in the oxidative metabolism through the TCA cycle. Metabolic fate of the lactate consumed is discussed...
  4. pmc Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
    Mauricio Vergara
    Institute of Chemistry, Pontificia Universidad Catolica de Valparaiso, Av Universidad 330, Curauma, Chile
    PLoS ONE 10:e0144224. 2015
    ..However, little information is available on the effect of culture temperature on the folding and degradation processes of recombinant proteins that takes place in the endoplasmic reticulum...
  5. doi request reprint Relationship between tissue plasminogen activator production and specific growth rate in Chinese hamster ovary cells cultured in mannose at low temperature
    Julio Berrios
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2147, Casilla, 4059, Valparaiso, Chile
    Biotechnol Lett 31:1493-7. 2009
    ....
  6. ncbi request reprint Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control
    C Altamirano
    , , , 08193 Bellaterra, Barcelona, Spain
    Biotechnol Bioeng 76:351-60. 2001
    ..The use of this metabolic shift enables the generation of biphasic processes, with a first phase with cell growth on glucose and a second stationary phase on galactose, which is particularly suited to perfusion systems...
  7. doi request reprint A comparative study of glycerol and sorbitol as co-substrates in methanol-induced cultures of Pichia pastoris: temperature effect and scale-up simulation
    Julio Berrios
    School of Biochemical Engineering, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2085, Valparaiso, Chile
    J Ind Microbiol Biotechnol . 2016
    ..Therefore, glycerol rises as a better option than sorbitol in ROL production...
  8. doi request reprint Batch production of coenzyme Q10 by recombinant Escherichia coli containing the decaprenyl diphosphate synthase gene from Sphingomonas baekryungensis
    IRENE MARTINEZ
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2085, Valparaiso, Chile
    J Ind Microbiol Biotechnol 42:1283-9. 2015
    ..Therefore, the results obtained in the present work are a valuable contribution for the optimization of CoQ10 production processes using recombinant E. coli strains...
  9. pmc Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture
    Mauricio Vergara
    School of Biochemical Engineering, Pontificia Universidad Católica de Valparaiíso, Valparaiso, Chile
    PLoS ONE 9:e93865. 2014
    ..Interestingly, reduction of metabolism could not be associated with a decrease in culture temperature, but rather with a decrease in specific growth rate...
  10. doi request reprint Alginate production and alg8 gene expression by Azotobacter vinelandii in continuous cultures
    Alvaro Díaz-Barrera
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catόlica de Valparaíso, Av Brasil 2147, Casilla 4059, Valparaiso, Chile
    J Ind Microbiol Biotechnol 39:613-21. 2012
    ....
  11. doi request reprint Genome-scale metabolic reconstruction for the insidious bacterium in aquaculture Piscirickettsia salmonis
    Pablo Fuentealba
    Doctorado en Biotecnología, Pontificia Universidad Católica de Valparaíso Universidad Federico Santa María, Valparaiso, Chile Laboratorio of Cultivos Celulares, Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile
    Bioresour Technol 223:105-114. 2017
    ..salmonis LF-89 strain obtained in this research provides a baseline that describes the metabolic capacities of the bacterium and is the basis for developing improvements to its cultivation for vaccine formulation...
  12. doi request reprint Effect of dilution rate and methanol-glycerol mixed feeding on heterologous Rhizopus oryzae lipase production with Pichia pastoris Mut(+) phenotype in continuous culture
    Christian Canales
    School of Biochemical Engineering, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2085, Valparaiso, Chile
    Biotechnol Prog 31:707-14. 2015
    ..It is concluded that despite the effect of dilution rate on ROL yield, mixed feeding strategy is a proper process option to be applied to P. pastoris Mut(+) phenotype for heterologous protein production...
  13. pmc A novel liquid medium for the efficient growth of the salmonid pathogen Piscirickettsia salmonis and optimization of culture conditions
    Mirtha Henríquez
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile
    PLoS ONE 8:e71830. 2013
    ..Therefore, these results represent a breakthrough regarding P. salmonis research in order to optimize pure P. salmonis growth in liquid blood and serum free medium. ..
  14. doi request reprint Production of alginate by Azotobacter vinelandii grown at two bioreactor scales under oxygen-limited conditions
    Alvaro Díaz-Barrera
    Escuela de Ingeniería Bioquímica, Pontificia Universidad Catolica de Valparaiso, Av Brasil 2147, 4059, Casilla, Valparaiso, Chile
    Bioprocess Biosyst Eng 37:1133-40. 2014
    ..These findings open the possibility of using [Formula: see text] instead of OTRmax as a scaling criterion to produce polymers with similar molecular weights during fermentation...