Xiaochun Chen

Summary

Publications

  1. doi request reprint Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
    Xiaochun Chen
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Brain Res 1200:99-106. 2008
  2. ncbi request reprint Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cells
    Xiaochun Chen
    Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, PR China
    J Gerontol A Biol Sci Med Sci 63:253-64. 2008
  3. ncbi request reprint [Diverse components of voltage-gated calcium channel currents in primary cultured hippocampal neurons]
    Zhi Ying Lin
    Department of Neurology, the Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, China
    Sheng Li Xue Bao 64:687-94. 2012
  4. pmc Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
    Xiao Dong Pan
    Department of Neurology, Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, 350001, China
    Mol Neurodegener 6:45. 2011
  5. ncbi request reprint [Involvement of protein kinase C in NMDAR-dependent long-term potentiation in rat amygdala.]
    Ai Qin Chen
    Department of Physiology and Pathophysilology, Fujian Medical University, Fuzhou, China
    Sheng Li Xue Bao 60:737-42. 2008
  6. pmc Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis
    Qinyong Ye
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, China
    BMC Neurosci 13:156. 2012
  7. pmc Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway
    Qinyong Ye
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, China
    Mar Drugs 11:1019-34. 2013
  8. pmc Ginsenoside Rg1 attenuates oligomeric Aβ(1-42)-induced mitochondrial dysfunction
    Tianwen Huang
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Curr Alzheimer Res 9:388-95. 2012
  9. ncbi request reprint Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice
    Kunmu Zheng
    Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian, 350001, People s Republic of China
    Mol Neurobiol . 2016
  10. ncbi request reprint APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice
    Meng Zhou
    Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
    Curr Alzheimer Res 13:1048-55. 2016

Collaborators

  • Yuan Gui Zhu
  • Jing Zhang
  • Meng Zhou
  • Nan Lin
  • Hui Shen
  • Fang Fang
  • Qin Yong Ye
  • Wei Wang
  • Tianwen Huang
  • Kunmu Zheng
  • Xiaoman Dai
  • Yuqi Zeng
  • Zhi Ying Lin
  • Xiao Dong Pan
  • Gongcheng Lu
  • Zhewei Ye
  • Ai Qin Chen
  • Xiaoyi V Hu
  • Ping Hao
  • Jiang Chen
  • Nai An Xiao
  • Yali Xiong
  • Xilin Wu
  • Min Fan
  • Wenting Fang
  • Zhen Wei
  • Xiaodong Pan
  • Jianping Lu
  • Zhiying Lin
  • Raoli He
  • Shirley ShiDu Yan
  • Tian Wen Huang
  • Limin Chen
  • Hua Pin Huang
  • Rui xiang Zhou
  • Kee Chung Han
  • Albert S Mildvan
  • Jun O Liu
  • Longjie Gu
  • Huaizhen Geng
  • Fuqing Zeng
  • Shuhua Yang

Detail Information

Publications20

  1. doi request reprint Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
    Xiaochun Chen
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Brain Res 1200:99-106. 2008
    ..The present study suggests that Ca(2+), calpain, and p25 in CDK5 pathway may play important roles in Abeta(25-35)-induced tau hyperphosphorylation...
  2. ncbi request reprint Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cells
    Xiaochun Chen
    Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, PR China
    J Gerontol A Biol Sci Med Sci 63:253-64. 2008
    ..These data indicate that ginsenoside Rg1 has an anti-aging effect on t-BHP-induced premature senescence in WI-38 cells. This effect may be mediated by regulating cell cycle proteins and enhancing mitochondrial functioning...
  3. ncbi request reprint [Diverse components of voltage-gated calcium channel currents in primary cultured hippocampal neurons]
    Zhi Ying Lin
    Department of Neurology, the Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, China
    Sheng Li Xue Bao 64:687-94. 2012
    ....
  4. pmc Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
    Xiao Dong Pan
    Department of Neurology, Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, 350001, China
    Mol Neurodegener 6:45. 2011
    ..However, the role of the different Aβ forms in microglial phagocytosis, induction of inflammation and oxidation, and subsequent regulation of phagocytic receptor system, remain unclear...
  5. ncbi request reprint [Involvement of protein kinase C in NMDAR-dependent long-term potentiation in rat amygdala.]
    Ai Qin Chen
    Department of Physiology and Pathophysilology, Fujian Medical University, Fuzhou, China
    Sheng Li Xue Bao 60:737-42. 2008
    ..These results indicate that LTP is NMDAR-dependent and PKC is involved in the induction and early maintenance of LTP in BLA...
  6. pmc Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis
    Qinyong Ye
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, China
    BMC Neurosci 13:156. 2012
    ..Astaxanthin (ATX), a carotenoid with antioxidant properties, is 100-1000 times more effective than vitamin E. The present study investigated the neuroprotective effects of ATX on MPP(+)-induced oxidative stress in PC12 cells...
  7. pmc Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway
    Qinyong Ye
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, China
    Mar Drugs 11:1019-34. 2013
    ..To investigate astaxanthin (ATX) neuroprotection, and its mechanism, on a 1-methyl-4-phenyl-pyridine ion (MPP+)-induced cell model of Parkinson's disease...
  8. pmc Ginsenoside Rg1 attenuates oligomeric Aβ(1-42)-induced mitochondrial dysfunction
    Tianwen Huang
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Curr Alzheimer Res 9:388-95. 2012
    ..This finding suggests that ginsenoside Rg1 may attenuate Aβ-induced neuronal death through the suppression of intracellular mitochondrial oxidative stress and may rescue neurons in AD...
  9. ncbi request reprint Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice
    Kunmu Zheng
    Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian, 350001, People s Republic of China
    Mol Neurobiol . 2016
    ..These findings suggest that curcumin is a potential candidate for AD treatment...
  10. ncbi request reprint APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice
    Meng Zhou
    Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
    Curr Alzheimer Res 13:1048-55. 2016
    ..These results suggest that the APOE4 genotype contributes to increased site-specific tau phosphorylation via activation of the calpain-CDK5 signaling pathway. ..
  11. ncbi request reprint [Possible effect of N-Acetyl-L-cysteine on Aβ(25-35)-induced tau hyperphosphorylation]
    Tianwen Huang
    Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou 350001, China
    Zhonghua Yi Xue Za Zhi 95:2701-4. 2015
    ..To investigate the possible effect and mechanism of N-Acetyl-L-cysteine (NAC) on fibrillar Aβ(25-35)-induced tau hyperphosphorylation...
  12. doi request reprint Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease
    Yuqi Zeng
    Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China Key Laboratory of Brain Aging and Neurodegenerative Disease, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China
    J Neurochem 133:38-52. 2015
    ..Taken together, our findings identify T4 as a potent negative regulator of brain Aβ levels and show that it significantly ameliorates synaptic degeneration and cognitive deficits in a mouse model of AD...
  13. doi request reprint Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice
    Jing Zhang
    Key Laboratory of Brain Aging and Neurodegenerative Disease, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, China Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China Electronic address
    Neurobiol Aging 35:655-68. 2014
    ....
  14. pmc Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
    Qinyong Ye
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, China
    BMC Complement Altern Med 12:82. 2012
    ..Therefore, research of the protective mechanism of EGCG in PC12 cells damaged by -methyl-4-phenyl-pyridine (MMP+) may provide a new insight into protect against and treatment of Parkinson's disease...
  15. doi request reprint Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons
    Qinyong Ye
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian, 350001, China
    Mol Neurobiol 53:3756-70. 2016
    ..The overexpression of PGC-1α can inhibit MPP(+)-induced mitochondrial damage in SH-SY5Y cells, and PGC-1α may realize the neuroprotective effects via the ERRα, PPARγ, and NRF-1 pathway. ..
  16. ncbi request reprint Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases
    Xiaoyi V Hu
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Biochemistry 46:12833-43. 2007
    ..Together, these results suggest that human MetAP1 is distinct from other members of the MetAP superfamily in the number of metal ions employed and likely mechanism of catalysis...
  17. pmc Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity
    Xiaochun Chen
    Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:14548-53. 2006
    ..These results suggest that PfMetAP1b is a promising target and XC11 is an important lead compound for the development of novel antimalarial drugs...
  18. ncbi request reprint Expression and implication of hypoxia inducible factor-1alpha in prostate neoplasm
    Ping Hao
    Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 24:593-5. 2004
    ..01). Overexpression of HIF-1alpha is the preliminary event of the formation of Pca, which may induce carcinoma into malignant phenotype. Thus it may serve as an early diagnosis marker and the novel target for Pca treatment...
  19. ncbi request reprint Expression of mouse telomerase catalytic subunit mTERT gene in testis of SD rats and its significance
    Zhewei Ye
    Department of Orthopedics, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 23:288-90. 2003
    ..Type A spermatogonia expressed the highest level of telomerase mTERT mRNA. Our results suggest that the expression of mTERT gene in the testis of SD rats is of lifetime and coincide with the telomerase activity...
  20. ncbi request reprint Expression of telomerase gene mTR in the testis of SD rats and its significance
    Min Fan
    Department of Urology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
    J Huazhong Univ Sci Technolog Med Sci 23:173-5. 2003
    ..Type A spermatogonia expressed the highest level of telomerase mTR mRNA. It was suggested that the expression of mTR gene in the testis of SD rats is of lifetime and coincides with the telomerase activity...