Wenxing Chen

Summary

Publications

  1. pmc Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
    Wenxing Chen
    School of Pharmacy, Nanjing University of Chinese Medicine, No 138, Xianlin Avenue, Nanjing, Jiangsu Province, 210023, China
    BMC Cancer 17:34. 2017
  2. pmc Molecular evidence of cryptotanshinone for treatment and prevention of human cancer
    Wenxing Chen
    College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China
    Anticancer Agents Med Chem 13:979-87. 2013
  3. doi request reprint Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    J Ethnopharmacol 133:220-6. 2011
  4. doi request reprint Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Highway, 210046 Nanjing, China
    Cancer Chemother Pharmacol 67:799-808. 2011
  5. pmc Prophylaxis of Diallyl Disulfide on Skin Carcinogenic Model via p21-dependent Nrf2 stabilization
    Yunlong Shan
    Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    Sci Rep 6:35676. 2016
  6. doi request reprint Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats
    Liang Zhou
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Reprod Toxicol 37:62-9. 2013
  7. pmc Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells
    Yang Zhao
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    PLoS ONE 8:e56557. 2013
  8. pmc Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin
    Li Tao
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    PLoS ONE 8:e81945. 2013
  9. doi request reprint Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR
    Zhijie Zhu
    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
    Mol Carcinog 55:1399-410. 2016
  10. doi request reprint TRPM8: a potential target for cancer treatment
    Zhaoguo Liu
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, Jiangsu, People s Republic of China
    J Cancer Res Clin Oncol 142:1871-81. 2016

Collaborators

Detail Information

Publications17

  1. pmc Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells
    Wenxing Chen
    School of Pharmacy, Nanjing University of Chinese Medicine, No 138, Xianlin Avenue, Nanjing, Jiangsu Province, 210023, China
    BMC Cancer 17:34. 2017
    ..However, its concrete molecular mechanism about how CPT inhibits mTORC1 signaling pathway is unclear...
  2. pmc Molecular evidence of cryptotanshinone for treatment and prevention of human cancer
    Wenxing Chen
    College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China
    Anticancer Agents Med Chem 13:979-87. 2013
    ..Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms. ..
  3. doi request reprint Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    J Ethnopharmacol 133:220-6. 2011
    ....
  4. doi request reprint Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Highway, 210046 Nanjing, China
    Cancer Chemother Pharmacol 67:799-808. 2011
    ..It was to assess antiangiogenic effect of β-elemene in vitro and in vivo, and it was involved in inhibiting melanoma growth and metastasis, as well as to elucidate its intrinsic mechanism...
  5. pmc Prophylaxis of Diallyl Disulfide on Skin Carcinogenic Model via p21-dependent Nrf2 stabilization
    Yunlong Shan
    Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    Sci Rep 6:35676. 2016
    ..Based on the results, we concluded that DADS was a promising cancer chemoprevention agent and suggested a garlic-rich diet might be beneficial to reduce the cancer risk in our daily life...
  6. doi request reprint Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats
    Liang Zhou
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Reprod Toxicol 37:62-9. 2013
    ..Our results suggest that the reproductive toxicity of C. zedoaria may be caused by sesquiterpenoids in the essential oil blocking VEGF-mediated angiogenesis...
  7. pmc Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells
    Yang Zhao
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    PLoS ONE 8:e56557. 2013
    ..Consequently, hGAG exerts a dual function in the inhibition of metastasis and coagulation activity in mouse melanoma B16F10 cells. Our studies suggest hGAG to be a promising therapeutic agent for metastatic cancer treatment...
  8. pmc Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin
    Li Tao
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    PLoS ONE 8:e81945. 2013
    ..Thus, the discovery of xanthatin, which has ability to simultaneously orchestrate two independent signaling cascades, may have important implications for screening promising drugs in cancer therapies. ..
  9. doi request reprint Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR
    Zhijie Zhu
    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
    Mol Carcinog 55:1399-410. 2016
    ..Based on the abilities of CT in targeting tumor cells, inhibiting angiogenesis, and destroying tumor vasculature, CT is worthy of further investigation for preventive, and therapeutic purposes in cancer. © 2015 Wiley Periodicals, Inc. ..
  10. doi request reprint TRPM8: a potential target for cancer treatment
    Zhaoguo Liu
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, Jiangsu, People s Republic of China
    J Cancer Res Clin Oncol 142:1871-81. 2016
    ....
  11. doi request reprint Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells
    Zhiqiang Yue
    College of Pharmacy, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, Jiangsu, China
    Mol Cell Biochem 410:143-54. 2015
    ..In conclusion, hGAG has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis...
  12. doi request reprint Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis
    Wenhui Qian
    Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    J Vasc Res 52:197-209. 2015
    ....
  13. pmc Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways
    Yuping Liu
    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
    PLoS ONE 10:e0123781. 2015
    ..Molecular mechanisms underlying the anticancer effects of DATS were further investigated...
  14. doi request reprint Chemomodulatory efficacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcinoma in mice
    Cunsi Shen
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China
    Food Funct 5:1422-31. 2014
    ..Collectively, these results indicated that lycopene exerts a protective effect against DMBA/TPA-induced cutaneum carcinoma through antioxidant defence. ..
  15. doi request reprint Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity
    Li Chen
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    Chem Biol Interact 206:76-82. 2013
    ..These data collectively indicated that SSD induced apoptosis by interrupting PDGF-βR/p38 pathway in LO2 hepatocytes...
  16. ncbi request reprint [Effect of danshensu on redox state and relevant nuclear transcription factors in non-small cell lung cancer A549 cells]
    Li Tao
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Zhongguo Zhong Yao Za Zhi 37:1265-8. 2012
    ....
  17. doi request reprint Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells
    Junshan Ruan
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, PR China
    Mol Med Rep 6:232-8. 2012
    ..Since integrin β1 and FAK signaling are closely related to EMT formation, these results suggest that luteolin inhibits hypoxia-induced EMT, at least in part, by inhibiting the expression of integrin β1 and FAK...