Genomes and Genes
Affiliation: Novartis Institute
Location: Cambridge, USA
Ph.D in Molecular Genetics.
-drug discovery and development experience in top pharmaceutical company
-Extensive experience in oncology drug discovery, focused on cancer signaling pathways and targeted cancer therapeutics.
-Managed and coordinated internal and external groups for drug formulation, DM/PK, in vivo animal efficacy and PD.
-Expertise in clinical drug response and resistance, patient stratification, biomarker evaluation and development.
Jian Chen*, Qiong Shen, Mark Labow, and Larry A. Gaither*. (2011). Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Research, 71 (12): 4280-4291. (*Corresponding Author)
Jian Chen, Xiaoying Shi, Ranjani Padmanabhan, Qiong Wang, Zhidan Wu, Susan C. Stevenson, Marc Hild, Dan Garza, and Hao Li. (2008). Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Research, 18: 123-136.
Biao Wang, Jason Goode, Jennifer Best, Jodi Meltzer, Pablo E. Schilman, Jian Chen, Dan Garza, John B. Thomas, and Marc Montminy. (2008). The Insulin-Regulated CREB Coactivator TORC Promotes Stress Resistance in Drosophila. Cell Metabolism, 7: 434-444.
Alarco, A-M., Marcil, A., Chen, J., Suter, B., Thomas, DY., Whiteway, M. (2004). Immune deficient Drosophila melanogaster: A model for the innate immune response to human fungal pathogens. J. Immunology, 172: 5622-5628.
Jian Chen, St
- Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogensAnne Marie Alarco
Genetics Group, Biotechnology Research Institute National Research Council, Montreal, Quebec, Canada
J Immunol 172:5622-8. 2004..The genetic systems available in both host and pathogen will enable the identification of host-specific components and C. albicans genes involved in the host-fungal interplay...
- Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogasterJian Chen
Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
Genome Res 18:123-36. 2008....
- The insulin-regulated CREB coactivator TORC promotes stress resistance in DrosophilaBiao Wang
Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
Cell Metab 7:434-44. 2008..As disruption of insulin signaling also augmented TORC activity in adult flies, our results illustrate the importance of an insulin-regulated pathway that functions in the brain to maintain energy balance...