Naibedya Chattopadhyay

Summary

Publications

  1. ncbi The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Biochem Pharmacol 74:438-47. 2007
  2. ncbi Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing
    Naibedya Chattopadhyay
    Division of Endocrinology, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India
    Mol Genet Metab 89:189-202. 2006
  3. ncbi Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 292:E523-32. 2007
  4. pmc A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts
    Gaurav Swarnkar
    Division of Endocrinology, CSIR Central Drug Research Institute, Chattar Manzil, Lucknow, India
    Br J Pharmacol 165:1526-42. 2012
  5. doi A novel flavonoid isolated from the steam-bark of Ulmus wallichiana planchon stimulates osteoblast function and inhibits osteoclast and adipocyte differentiation
    Gaurav Swarnkar
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow, India
    Eur J Pharmacol 658:65-73. 2011
  6. doi Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect
    Kunal Sharan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Menopause 17:393-402. 2010
  7. doi A novel flavonoid, 6-C-beta-d-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats
    Kunal Sharan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, Lucknow, India
    Menopause 17:577-86. 2010
  8. ncbi High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Growth Factors 23:117-23. 2005
  9. doi Quercetin-6-C-β-D-glucopyranoside isolated from Ulmus wallichiana planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats
    Jawed A Siddiqui
    Division of Endocrinology, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India
    Menopause 18:198-207. 2011
  10. ncbi Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Beth Israel Seaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 145:3451-62. 2004

Collaborators

Detail Information

Publications64

  1. ncbi The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Biochem Pharmacol 74:438-47. 2007
    ..In conclusion, Sr(2+) is a full CaR agonist in HEK-CaR and POB, and, therefore, the anabolic effect of Sr(2+) on bone in vivo could be mediated, in part, by the CaR...
  2. ncbi Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing
    Naibedya Chattopadhyay
    Division of Endocrinology, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India
    Mol Genet Metab 89:189-202. 2006
    ..Calcimimetics are also an effective element in the treatment of secondary hyperparathyroidism, particularly in dialysis patients, by virtue of reducing plasma levels of PTH, calcium and phosphate...
  3. ncbi Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 292:E523-32. 2007
    ..We conclude that the CaR may be a novel regulator of GnRH neuronal migration likely involving, in part, MCP-1...
  4. pmc A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts
    Gaurav Swarnkar
    Division of Endocrinology, CSIR Central Drug Research Institute, Chattar Manzil, Lucknow, India
    Br J Pharmacol 165:1526-42. 2012
    ..Naringenin and its derivatives have been assessed in bone health for their oestrogen-'like' effects but low bioavailability impedes clinical potential. This study was aimed at finding a potent form of naringenin with osteogenic action...
  5. doi A novel flavonoid isolated from the steam-bark of Ulmus wallichiana planchon stimulates osteoblast function and inhibits osteoclast and adipocyte differentiation
    Gaurav Swarnkar
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow, India
    Eur J Pharmacol 658:65-73. 2011
    ..AG exhibited no estrogenic/antiestrogenic effect. Together, our data show that AG has potent osteogenic, anti-osteoclastogenic and anti-adipogenic effects, which may translate to a better skeletal outcome in postmenopausal osteoporosis...
  6. doi Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect
    Kunal Sharan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Menopause 17:393-402. 2010
    ....
  7. doi A novel flavonoid, 6-C-beta-d-glucopyranosyl-(2S,3S)-(+)-3',4',5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats
    Kunal Sharan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, Lucknow, India
    Menopause 17:577-86. 2010
    ....
  8. ncbi High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Growth Factors 23:117-23. 2005
    ..In conclusion, the calcium activates the EGFR, possibly through the CaR, to regulate downstream signaling events and important biological functions in a model of HHM...
  9. doi Quercetin-6-C-β-D-glucopyranoside isolated from Ulmus wallichiana planchon is more potent than quercetin in inhibiting osteoclastogenesis and mitigating ovariectomy-induced bone loss in rats
    Jawed A Siddiqui
    Division of Endocrinology, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India
    Menopause 18:198-207. 2011
    ..The aim of this study was to determine the skeletal effect of quercetin-6-C-β-D-glucopyranoside (QCG) isolated from the extract of Ulmus wallichiana and compare this effect with quercetin (Q) in a rat model of postmenopausal bone loss...
  10. ncbi Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Beth Israel Seaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 145:3451-62. 2004
    ..Our data, therefore, show that the parathyroid/kidney CaR expressed in rat calvarial OBs exerts a mitogenic effect that involves activation of the JNK pathway and up-regulation of several mitogenic genes...
  11. doi In vivo efficacy studies of layer-by-layer nano-matrix bearing kaempferol for the conditions of osteoporosis: a study in ovariectomized rat model
    Avinash Kumar
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, India
    Eur J Pharm Biopharm 82:508-17. 2012
    ..Treatment post-withdrawal sustenance of formulated kaempferol could become a strategy to enhance bioavailability of flavanoids...
  12. doi Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling
    Biju Bhargavan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, Lucknow, Uttar Pradesh, India
    J Cell Biochem 108:388-99. 2009
    ..To the best of our knowledge, this work represents the first attempt to elucidate structure-activity relationship between the two methoxylated isoflavones regarding their effects in osteoblasts and bone formation...
  13. doi [6]-Gingerol induces bone loss in ovary intact adult mice and augments osteoclast function via the transient receptor potential vanilloid 1 channel
    Kainat Khan
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, India
    Mol Nutr Food Res 56:1860-73. 2012
    ..6]-Gingerol, a major constituent of ginger, is considered to have several health beneficial effects. The effect of 6-gingerol on bone cells and skeleton of mice was investigated...
  14. doi Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor β-mediated osteogenic action of medicarpin
    Biju Bhargavan
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow, India
    J Nutr Biochem 23:27-38. 2012
    ..In addition, given its excellent oral bioavailability, Med can be potential osteogenic agent...
  15. doi 8,8''-Biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: Osteoprotective action of 8,8''-biapigeninyl in ovariectomized mice
    Jawed A Siddiqui
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow 226001, India
    Mol Cell Endocrinol 323:256-67. 2010
    ..BA exhibited no uterine estrogenicity. From these data, we conclude that BA exerts osteoprotective effect in OVx mice by multiple beneficial effects on bone cells...
  16. doi Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction
    Rashmi Pandey
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Menopause 17:602-10. 2010
    ....
  17. doi Prunetin signals via G-protein-coupled receptor, GPR30(GPER1): Stimulation of adenylyl cyclase and cAMP-mediated activation of MAPK signaling induces Runx2 expression in osteoblasts to promote bone regeneration
    Kainat Khan
    Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226021, India
    J Nutr Biochem 26:1491-501. 2015
    ..We conclude that prunetin promotes osteoinduction in vivo and the mechanism is defined by signaling through GPR30 resulting in the up-regulation of the key osteogenic gene Runx2 that in turn up-regulates GPR30. ..
  18. doi Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats
    Ritu Trivedi
    Division of Endocrinology, Central Drug Research Institute, Chattar Manzil, Lucknow, India
    Mol Cell Endocrinol 289:85-93. 2008
    ..Together we show that K is non-estrogenic in vivo and exerts bone anabolic activity with attendant inhibition of bone marrow adipogenesis...
  19. doi Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats
    Abnish K Gautam
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow, India
    J Nutr Biochem 22:318-27. 2011
    ..To the best of our knowledge, this is the first attempt to elucidate structure-activity relationship between the methoxylated forms of daidzein and their osteogenic effects...
  20. doi Synthetic analogs of daidzein, having more potent osteoblast stimulating effect
    Dinesh K Yadav
    Medicinal and Process Chemistry Division, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow 226 001, India
    Bioorg Med Chem Lett 21:677-81. 2011
    ..Unlike daidzein, 3c did not inhibit osteoclastogenesis. Collectively, we demonstrate osteogenic activity of daidzein analogs at significantly lower concentrations than daidzein...
  21. doi A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action
    Kunal Sharan
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, India
    J Bone Miner Res 26:2096-111. 2011
    ..Based on these preclinical data, clinical evaluation of GTDF as a potential bone anabolic agent is warranted...
  22. doi A standardized phytopreparation from an Indian medicinal plant (Dalbergia sissoo) has antiresorptive and bone-forming effects on a postmenopausal osteoporosis model of rat
    Vikram Khedgikar
    Division of Endocrinology, Council of Scientific and Industrial Research Central Drug Research Institute, Chattar Manzil Palace, Lucknow, India
    Menopause 19:1336-46. 2012
    ..The aim of this study was to evaluate the skeletal effects of an extract made from the leaves and pods of Dalbergia sissoo (butanol-soluble standardized fraction [BSSF]) on ovariectomized rats, a model for postmenopausal osteopenia...
  23. ncbi Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:4222-31. 2004
    ..Finally, regulation of its expression has glioma-specific features and is selectively regulated by promalignant cytokines including EGFR ligands and HGF...
  24. ncbi 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells
    Naibedya Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 284:E219-27. 2003
    ..The known antiproliferative effect of 1,25(OH)(2)D(3) on MG-63 cells can be accounted for by the concomitant 1,25(OH)(2)D(3)-induced inhibition of HGF production...
  25. ncbi PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation
    R John Macleod
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 284:E435-42. 2003
    ..We conclude that CaR specifically mediates the effect of increasing [Ca(2+)](o) on PTHrP synthesis and secretion and that activated MEK1/2 and p38 MAP kinases are determinants of the CaR's stimulation of PTHrP secretion...
  26. ncbi Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase
    Chian Ping Ye
    Division of Endocrinology, Hypertension and Diabetes and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 75:491-8. 2004
    ..Large-conductance CAKCs play an important role in the regulation of cellular volume, so our results have important implications for glioma cell volume regulation...
  27. ncbi Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Membrane Biology Program, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 288:E1206-13. 2005
    ..In conclusion, high calcium upregulates the levels of iNOS mRNA and protein as well as NO production in H-500 cells, and the effect of Cao2+ on iNOS expression is mediated by the CaR...
  28. doi Amino acids derived benzoxazepines: design, synthesis and antitumor activity
    Shailendra Kumar Dhar Dwivedi
    Division of Endocrinology, CSIR Central Drug Research Institute, 10 Janakipuram Extension, Sitapur Road, Lucknow 226031, UP, India
    Bioorg Med Chem Lett 23:6816-21. 2013
    ..Compound 15a also significantly reduced the growth of MCF-7 xenograft tumors in athymic nude mice. Together, 15a could serve as a base for the development of a new group of effective breast cancer therapeutics. ..
  29. doi Anti-osteoporotic constituents from Indian medicinal plants
    Manmeet Kumar
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, M G Road, Lucknow 226001, Uttar Pradesh, India
    Phytomedicine 17:993-9. 2010
    ..Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine...
  30. pmc Parathyroid hormone ablation alters erythrocyte parameters that are rescued by calcium-sensing receptor gene deletion
    Jose R Romero
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Eur J Haematol 91:37-45. 2013
    ..Our results demonstrate that Ca2+ -sensing receptor and parathyroid hormone are functionally coupled to maintain erythrocyte homeostasis...
  31. pmc Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis
    Abdul M Tyagi
    Division of Endocrinology, Central Drug Research Institute, Council of Scientific and Industrial Research, Chattar Manzil, Lucknow, India
    PLoS ONE 7:e44552. 2012
    ..IL-17 thus plays a critical causal role in Ovx-induced bone loss and may be considered a potential therapeutic target in pathogenesis of post menopausal osteoporosis...
  32. ncbi Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation
    Shozo Yano
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Bone 35:664-72. 2004
    ..This transactivation is most likely mediated by activation of MMP and cleavage of proheparin-binding EGF (proHB-EGF) to HB-EGF...
  33. doi Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol
    Ritu Trivedi
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, Lucknow, India
    Mol Cell Endocrinol 302:86-91. 2009
    ..These results show for the first time that oral administration of Egb 761 restores bone mass in aged OVx rats...
  34. ncbi Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts
    Shozo Yano
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 146:2324-35. 2005
    ..Furthermore, RANTES secreted from osteoclasts induces osteoblast chemotaxis. Therefore, expression of RANTES and its receptors in both osteoblasts and osteoclasts could enable this chemokine to act in autocrine/paracrine modes...
  35. doi Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice
    Naibedya Chattopadhyay
    Department of Medicine and Membrane Biology Program, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurosci Res 86:2159-67. 2008
    ..We conclude that the CaR may be a novel regulator of oligodendroglial development and function...
  36. doi Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative
    Bandana Chakravarti
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Lucknow, India
    Mol Cell Endocrinol 338:68-78. 2011
    ..We suggest that interfering with the IGF-1R signaling by the benzoxazepine THBP offers a novel and selective therapeutic strategy for estrogen receptor-positive, postmenopausal breast cancer patients...
  37. doi Investigational anabolic therapies for osteoporosis
    Ritu Trivedi
    Central Drug Research Institute Council of Scientific and Industrial Research, Division of Endocrinology, Lucknow, India
    Expert Opin Investig Drugs 19:995-1005. 2010
    ..Anabolic therapy, or stimulating the function of bone-forming osteoblasts, is the preferred pharmacological intervention for osteoporosis...
  38. doi Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice
    Abdul M Tyagi
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow, India
    Mol Cell Endocrinol 325:101-9. 2010
    ..Medicarpin exhibited no uterine estrogenicity. Our findings point towards direct and indirect inhibitory effects of medicarpin on osteoclastogenesis in vitro that contribute to its bone sparing effect in OVx mice...
  39. pmc Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
    Kamini Srivastava
    Endocrinology Division and The Center for Research on Anabolic Skeletal Targets in Health and Illness ASTHI, CSIR, Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226021, India
    Evid Based Complement Alternat Med 2013:519387. 2013
    ..ASF supplementation during skeletal growth could maximize bone accrual and could confer increased resistance to post-OVx osteopenia despite treatment withdrawal...
  40. doi Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer
    Krishnananda Samanta
    Endocrinology, Central Drug Research Institute, Lucknow 226 001, UP, India
    Bioorg Med Chem Lett 20:283-7. 2010
    ..The identified most active compounds of the series have specific advantages as anti-cancer agent in breast cancer than tamoxifen...
  41. doi Signaling through the extracellular calcium-sensing receptor (CaSR)
    Bandana Chakravarti
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, India
    Adv Exp Med Biol 740:103-42. 2012
    ..g., the cytoskeleton). Thus CaSR signaling likely does not take place randomly throughout the cell, but is compartmentalized and organized so as to facilitate the interaction of the receptor with its various signaling pathways...
  42. pmc The emerging role of pituitary tumor transforming gene in tumorigenesis
    Jacob Tfelt-Hansen
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Med Res 4:130-7. 2006
    ..Here, we review the current knowledge of the biological and pathophysiological roles of PTTG...
  43. doi Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents
    Atul Kumar
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, India
    Bioorg Med Chem 19:5409-19. 2011
    ..Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity...
  44. ncbi Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells
    Jian L Pang
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Biochem Pharmacol 71:818-26. 2006
    ....
  45. ncbi Calcium-sensing receptor in the brain
    Shozo Yano
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Cell Calcium 35:257-64. 2004
    ..e. water homeostasis). Furthermore, the expression of the CaR in all three types of glial cells indicates potential roles in the maintenance of local ionic homeostasis as well as in disease processes such as glioma...
  46. ncbi Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Rm 205, Boston, MA 02115, USA
    Brain Res Mol Brain Res 121:146-50. 2004
    ..Because interfering with TbetaR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy...
  47. ncbi Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer
    Jacob Tfelt-Hansen
    Endocrine Hypertension Division, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 144:5188-93. 2003
    ..22-fold. In conclusion, we show for the first time that a GPCR, the CaR, stimulates the synthesis of PTTG mRNA in a nonmetastasizing model for humoral hypercalcemia of malignancy and, in the process, might induce angiogenesis via VEGF...
  48. doi Calcium-sensing receptor in cancer: good cop or bad cop?
    Bandana Chakravarti
    Division of Endocrinology, Central Drug Research Institute, Chattar Manzil, Lucknow, India
    Endocrine 35:271-84. 2009
    ....
  49. ncbi The calcium-sensing receptor in human disease
    Jacob Tfelt-Hansen
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC room 205, Boston, MA 02115, USA
    Front Biosci 8:s377-90. 2003
    ..In renal secondary hyperparathyroidism, a drug that stimulates the receptor (calcimimetic) shows great promise as a medical treatment for this condition...
  50. doi Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents
    Uma Sharan Singh
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
    Bioorg Med Chem 16:8482-91. 2008
    ..5% of the ovariectomized group. Further, screening of anti-leishmanial activity, four compounds 24-25 and 27-28 showed more than 80% inhibition against both the promastigote and amastigote stages of the Leishmania parasite...
  51. doi Association of interleukin-4 and interleukin-1 receptor antagonist gene polymorphisms and risk of benign prostatic hyperplasia
    Rituraj Konwar
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Urology 71:868-72. 2008
    ..The purpose of this study was to investigate the genetic association of polymorphisms of important cytokine genes (IL-4 and IL-1Ra) with the risk of BPH in a case-control study of a North Indian population...
  52. doi Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia
    Mohd Parvez Khan
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, Uttar Pradesh, India
    Diabetes 64:2609-23. 2015
    ..We conclude that PGC-1α upregulation in osteoblasts could reverse type 2 diabetes-associated deterioration in skeletal health...
  53. ncbi A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA
    Sanghamitra Bandyopadhyay
    Neurochemistry Laboratory, Genetics and Aging Research Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA, USA, and School of Biological and Environmental Science, University College Dublin, Belfield, Ireland
    J Biomol Screen 11:469-80. 2006
    ..The hits obtained from this robust, specific, and highly quantitative HTS will be characterized to identify agents that may be developed into useful future therapeutic agents to limit APP translation and Abeta production for AD...
  54. ncbi Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India
    Phytother Res 21:1105-8. 2007
    ..The antiproliferative activity of 13-epi-sclareol is comparable to Tamoxifen in terms of IC50 and also showed concentration dependent increased apoptotic changes in the breast cancer cell line, MCF-7...
  55. doi Genetic polymorphism and pathogenesis of benign prostatic hyperplasia
    Rituraj Konwar
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    BJU Int 102:536-44. 2008
  56. ncbi Recent updates on the calcium-sensing receptor as a drug target
    Ritu Trivedi
    Division of Endocrinology, Central Drug Research Institute, Chattar Manzil, Lucknow, India
    Curr Med Chem 15:178-86. 2008
    ..Antagonism of the CaSR has the potential to yield an anabolic therapy for osteoporosis that awaits clinical validation...
  57. ncbi Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy
    Naibedya Chattopadhyay
    Div of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 290:E761-70. 2006
    ..Finally, I raise several necessary questions to demonstrate the roles of the receptor in promoting tumors and metastases that will enable consideration of the CaR as a potential antagonizing/neutralizing target for the treatment of HHM...
  58. doi Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase
    Preeti Rawat
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India
    Bioorg Med Chem Lett 19:4684-7. 2009
    ..Compounds 1-3 and 5 significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity...
  59. ncbi Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharma-cokinetic studies
    Kunal Sharan
    Division of Endocrinology, Central Drug Research Institute, Chattar Manzil, P O Box 173, Lucknow 226001, India
    Curr Med Chem 16:1138-57. 2009
    ....
  60. ncbi PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells
    Naibedya Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Brain Res Mol Brain Res 102:73-82. 2002
    ....
  61. ncbi Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons
    Sanghamitra Bandyopadhyay
    Neurochemistry Laboratory, Department of Psychiatry and Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02115, USA
    J Neurosci Res 85:882-95. 2007
    ..These results implicate CaR as an important regulator of GnRH neuron function in vivo by stimulating secretion of heretofore unsuspected cytokines, i.e., CXCL10 and MCP-3...
  62. ncbi Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism
    Ravinder Goswami
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110029, India
    Eur J Endocrinol 150:9-18. 2004
    ....
  63. ncbi Attenuation of osteoclastogenesis and osteoclast function by apigenin
    Sanghamitra Bandyopadhyay
    Genetics and Aging Research Unit, Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Biochem Pharmacol 72:184-97. 2006
    ..In all instances, a structurally related compound, flavone had no significant effect. These data suggest that apigenin has multiple effects on all three bone cells that could prevent bone loss in vivo...
  64. doi Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells
    Sanghamitra Bandyopadhyay
    Developmental Toxicology, Indian Institute of Toxicology Research, Lucknow, India
    Mol Cell Endocrinol 287:57-64. 2008
    ..Taken together, our results demonstrate that K and Q activate an immune response in the prostate cancer cells by stimulating GM-CSF production, which in turn could result in the recruitment of DCs to the tumor site...