ALEJANDRO ROBERTO CHADE

Summary

Publications

  1. pmc Renal Therapeutic Angiogenesis Using a Bioengineered Polymer-Stabilized Vascular Endothelial Growth Factor Construct
    Alejandro R Chade
    Department of Physiology and Biophysics, Department of Medicine, Department of Radiology
    J Am Soc Nephrol 27:1741-52. 2016
  2. pmc Endothelin-a receptor antagonism after renal angioplasty enhances renal recovery in renovascular disease
    Alejandro R Chade
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, Department of Medicine, and Department of Radiology, University of Mississippi Medical Center, Jackson, Mississippi
    J Am Soc Nephrol 26:1071-80. 2015
  3. pmc Renal vascular structure and rarefaction
    Alejandro R Chade
    The Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Compr Physiol 3:817-31. 2013
  4. pmc Angiogenic cytokines in renovascular disease: do they have potential for therapeutic use?
    Alejandro R Chade
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    J Am Soc Hypertens 7:180-90. 2013
  5. pmc Renoprotective effects of hepatocyte growth factor in the stenotic kidney
    Nicholas Stewart
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Renal Physiol 304:F625-33. 2013
  6. pmc Early superoxide scavenging accelerates renal microvascular rarefaction and damage in the stenotic kidney
    Silvia Kelsen
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 303:F576-83. 2012
  7. pmc Reversal of renal dysfunction by targeted administration of VEGF into the stenotic kidney: a novel potential therapeutic approach
    Alejandro R Chade
    Dept of Physiology and Biophysics, Dept of Medicine, Univ of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 302:F1342-50. 2012
  8. pmc Renal microvascular disease determines the responses to revascularization in experimental renovascular disease
    Alejandro R Chade
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Circ Cardiovasc Interv 3:376-83. 2010
  9. pmc Renovascular disease, microcirculation, and the progression of renal injury: role of angiogenesis
    Alejandro R Chade
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, and University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 300:R783-90. 2011
  10. pmc Microvascular disease precedes the decline in renal function in the streptozotocin-induced diabetic rat
    Christine Maric-Bilkan
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 302:F308-15. 2012

Collaborators

  • Silvia Kelsen
  • Nicholas Stewart
  • Christine Maric-Bilkan
  • Xiaochen He
  • Elizabeth R Flynn
  • John E Hall

Detail Information

Publications12

  1. pmc Renal Therapeutic Angiogenesis Using a Bioengineered Polymer-Stabilized Vascular Endothelial Growth Factor Construct
    Alejandro R Chade
    Department of Physiology and Biophysics, Department of Medicine, Department of Radiology
    J Am Soc Nephrol 27:1741-52. 2016
    ..Recovery of the stenotic kidney in RVD after ELP-VEGF therapy may be driven by restoration of renal angiogenic signaling and attenuated fibrogenic activity, which ameliorates MV rarefaction and improves renal function. ..
  2. pmc Endothelin-a receptor antagonism after renal angioplasty enhances renal recovery in renovascular disease
    Alejandro R Chade
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, Department of Medicine, and Department of Radiology, University of Mississippi Medical Center, Jackson, Mississippi
    J Am Soc Nephrol 26:1071-80. 2015
    ..Using clinically available compounds and techniques, our results could contribute to both refinement and design of new therapeutic strategies in chronic RVD. ..
  3. pmc Renal vascular structure and rarefaction
    Alejandro R Chade
    The Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Compr Physiol 3:817-31. 2013
    ..This overview will also attempt to discuss the potential renoprotective mechanisms of the therapeutic targeting of the renal microcirculation...
  4. pmc Angiogenic cytokines in renovascular disease: do they have potential for therapeutic use?
    Alejandro R Chade
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    J Am Soc Hypertens 7:180-90. 2013
    ..Such interventions may potentially constitute a sole strategy to preserve renal function and/or a co-adjuvant tool to improve the success of current therapeutic approaches in renovascular disease...
  5. pmc Renoprotective effects of hepatocyte growth factor in the stenotic kidney
    Nicholas Stewart
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Renal Physiol 304:F625-33. 2013
    ..Furthermore, these effects imply plasticity of the stenotic kidney to recuperate its function and underscore the importance of MV integrity in the progression of renal injury in RAS...
  6. pmc Early superoxide scavenging accelerates renal microvascular rarefaction and damage in the stenotic kidney
    Silvia Kelsen
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 303:F576-83. 2012
    ..These results suggest that a tight balance of the renal redox status is necessary for a normal MV repair response to injury, at least at the early stage of RVD, and raise caution regarding antioxidant strategies in RAS...
  7. pmc Reversal of renal dysfunction by targeted administration of VEGF into the stenotic kidney: a novel potential therapeutic approach
    Alejandro R Chade
    Dept of Physiology and Biophysics, Dept of Medicine, Univ of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 302:F1342-50. 2012
    ....
  8. pmc Renal microvascular disease determines the responses to revascularization in experimental renovascular disease
    Alejandro R Chade
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Circ Cardiovasc Interv 3:376-83. 2010
    ..However, renal function recovers in only 30% of the cases. The causes of these poor outcomes are still unknown. We hypothesized that preserving the renal microcirculation distal to RAS will improve the responses to PTRA...
  9. pmc Renovascular disease, microcirculation, and the progression of renal injury: role of angiogenesis
    Alejandro R Chade
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, and University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 300:R783-90. 2011
    ....
  10. pmc Microvascular disease precedes the decline in renal function in the streptozotocin-induced diabetic rat
    Christine Maric-Bilkan
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 302:F308-15. 2012
    ..This study suggests a novel concept of MV disease as an early instigator of diabetic kidney disease that may precede and likely promote the decline in renal function...
  11. pmc Endothelin-A receptor blockade slows the progression of renal injury in experimental renovascular disease
    Silvia Kelsen
    Dept of Physiology and Biophysics, Dept of Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 301:F218-25. 2011
    ..These results support a role for ET-1/ET-A as a potential therapeutic target in chronic RVD...