- Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
J Immunol 177:6930-9. 2006
..However, a fraction of BCL6+ diffuse large B cell lymphomas express IRF4 bearing the MUM1 epitope, indicative of a posttranscriptional modification of IRF4 not seen in the normal counterpart...
- Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
Institute for Cancer Genetics, Department of Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
Nat Immunol 7:773-82. 2006
..These results identify IRF4 as a crucial transcriptional 'switch' in the generation of functionally competent plasma cells...
- Tracking CD40 signaling during germinal center development
Institute for Cancer Genetics, Department of Pathology and Genetics and Development, Joint Centers for Systems Biology, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
Blood 104:4088-96. 2004
..Together, these results show that GC expansion occurs in the absence of CD40 signaling, which may act only in the initial and final stages of the GC reaction...
- Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
Cancer Cell 7:445-55. 2005
..These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease...
- Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6
Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
Leuk Lymphoma 44:S5-12. 2003
..These studies also indicate a novel mechanism by which acetylation promotes transcription, not only by modifying histones and activating transcriptional activators, but also by inhibiting transcriptional repressors...
- PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
J Pathol 206:76-86. 2005
..Infiltrating T-cells in PRDM1- B-cell lymphomas expressed PRDM1. In conclusion, PRDM1 staining is a reliable and informative assay to define plasma cell commitment and differentiation in human normal and neoplastic B-cell lineages...
- Gene expression dynamics during germinal center transit in B cells
Institute for Cancer Genetics, Columbia University, Departments of Pathology and Genetics and Development, New York, New York 10032, USA
Ann N Y Acad Sci 987:166-72. 2003
- Identification of rare Epstein-Barr virus infected memory B cells and plasma cells in non-monomorphic post-transplant lymphoproliferative disorders and the signature of viral signaling
Department of Pathology, Columbia University Medical Center, Columbia University, New York, NY 10032, USA
Haematologica 91:1313-20. 2006
- Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Science 316:860-6. 2007
..We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage...
- Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
Institute for Cancer Genetics and the Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA
Cancer Res 69:8686-92. 2009
..The high incidence of DLBCL in S1P(2)(-/-) mice, its onset at old age, and the relative lack of other neoplasms identify these mice as a novel, and potentially valuable, model for this highly prevalent and aggressive human malignancy...
- Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Immunol 176:3958-65. 2006
..These findings suggest Dok-1 and SHIP function in pathways that influence regulatory T cell development...
- BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells
Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
J Exp Med 198:211-21. 2003
..In addition, these findings imply that T-B cell interactions may be disrupted in B cell lymphoma expressing deregulated BCL6 genes...
- Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 112:1809-20. 2003
..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers...
- CD117 expression in diffuse large B-cell lymphomas: fact or fiction?
Department of Pathology, Columbia University, New York, NY, USA
Pathol Int 55:716-23. 2005
- Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells
Institute for Cancer Genetics, 1150 St Nicholas Avenue, Russ Berrie Science Pavilion, Rm 301, Columbia University, New York, NY 10032, USA
Blood 107:3967-75. 2006
..The distribution of nuclear AID is consistent with the topography of SHM and CSR inside the GC and in extrafollicular activated B cells...
- Essential role of Plzf in maintenance of spermatogonial stem cells
Jose A Costoya
Cancer Biology and Genetics Program, Department of Pathology Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nat Genet 36:653-9. 2004
..These results identify Plzf as a spermatogonia-specific transcription factor in the testis that is required to regulate self-renewal and maintenance of the stem cell pool...
- Dominant negative retinoic acid receptor initiates tumor formation in mice
Tara S Kupumbati
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Cancer 5:12. 2006
..This begs the question of whether chronic physiological RAR activation by endogenous retinoids is likewise anti-tumorigenic...
- Transcriptional analysis of the B cell germinal center reaction
Institute for Cancer Genetics and Department of Pathology, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:2639-44. 2003
..These results provide insights into the dynamics of the GC reaction and represent the basis for the analysis of B cell malignancies...
- Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
Department of Pathology, Columbia University, New York, NY 10032, USA
Hum Immunol 64:389-401. 2003
..Taken together these findings indicate that IBP is a novel type of GEF, which participates in the activation of Rho GTPases in lymphoid tissues...
- Novel relational database for tissue microarray analysis
Department of Pathology, New York Presbyterian Hospital, New York, NY, USA
Arch Pathol Lab Med 127:492-4. 2003
- Flow cytometric analysis of normal and reactive spleen
Adriana I Colovai
Department of Pathology, Columbia University, New York, NY 10032, USA
Mod Pathol 17:918-27. 2004
..These results will facilitate an accurate interpretation of the flow cytometric analysis of human spleen lymphocytes...
- The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development
David H Chang
Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
Mech Dev 117:305-9. 2002
..Finally, Blimp-1 is expressed in the migrating primordial germ cells...
- Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development
Department of Human Genetics, Memorial Sloan Kettering Cancer Center, New York, USA
Eur J Immunol 32:2607-16. 2002
..Thus, GPI-linked proteins are not required for lymphocyte development but they are required for normal lymphocyte function and for maintaining normal peripheral lymphoid homeostasis...
- A rare cause of nephrotic syndrome
Department of Pathology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
Am J Kidney Dis 39:892-5. 2002
- Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Blood 103:1862-8. 2004
..Nonetheless, these data indicate that DLBCLs are heterogeneous with respect to REL and thus nuclear factor-kappaB (NF-kappaB) activity...
- BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 110:2067-74. 2007
..Taken together, these results show that BCL6 regulates distinct transcriptional programs through the SMRT/N-CoR and MTA3 corepressors, respectively, and provides a basis for combinatorial therapeutic targeting of BCL6...
- NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
Blood 106:1392-9. 2005
..In this large series of primary MLBCLs and DLBCLs, NFkappaB activation was not associated with amplification of the cREL locus, suggesting alternative pathogenetic mechanisms...
- Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling
Institute for Genetics, and Department of Internal Medicine I, University of Cologne, Cologne, Germany
J Clin Invest 111:529-37. 2003
..The newly identified HL-specific genes may play important roles in the pathogenesis of HL, potentially represent novel diagnostic markers, and can be considered for therapeutic targeting...
- Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)
Institute of Hematology, University of Perugia, 06122 Perugia, Italy
Blood 102:3684-92. 2003
..Collectively, these results suggest a role of IRTA1 in the immune function of B cells within epithelia...
- Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting
CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:7396-401. 2006
..To expedite the genetic analysis of GC B cells, we have established Cgamma1-cre F(1) embryonic stem cells, allowing further rounds of gene targeting and the cloning of compound mutants by tetraploid embryo complementation...
- Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
B Belinda Ding
Departments of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 111:1515-23. 2008
- AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies
Comprehensive Cancer Center, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Cancer Cell 13:167-80. 2008
- The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
Kerry J Savage
Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
Blood 102:3871-9. 2003
..In almost all cases, c-REL was localized to the nucleus, consistent with activation of the NF-kappa B pathway. These studies identify a molecular link between MLBCL and cHL and a shared survival pathway...