Oswaldo Castro

Summary

Publications

  1. ncbi Frequent and prolonged hospitalizations: a risk factor for early mortality in sickle cell disease patients
    Patricia Houston-Yu
    Department of Pediatrics and Child Health, Howard University, Washington, DC 20060, USA
    Am J Hematol 72:201-3. 2003
  2. ncbi Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management
    Oswaldo Castro
    Howard University College of Medicine, Center for Sickle Cell Disease, Washington, DC 20001, USA
    Hematol Oncol Clin North Am 19:881-96, vii. 2005
  3. ncbi Predicting the effect of transfusing only phenotype-matched RBCs to patients with sickle cell disease: theoretical and practical implications
    Oswaldo Castro
    Department of Internal Meidicine, Howard University College of Medicine, Washington, DC, USA
    Transfusion 42:684-90. 2002
  4. ncbi Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival
    Oswaldo Castro
    Center for Sickle Cell Disease and Division of Cardiology, Department of Medicine, Howard University College of Medicine, Washington, DC 20059, USA
    Blood 101:1257-61. 2003
  5. pmc Hepatitis C virus in sickle cell disease
    Mohamed Hassan
    Division of Gastroenterology, Howard University Hospital, Washington, DC, USA
    J Natl Med Assoc 95:939-42. 2003
  6. pmc Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia
    Deepika S Darbari
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Pediatr 160:286-90. 2012
  7. ncbi Circumstances of death in adult sickle cell disease patients
    Deepika S Darbari
    Center for Sickle Cell Disease, Howard University, Washington, DC, USA
    Am J Hematol 81:858-63. 2006
  8. ncbi Long-term outcomes in patients with sickle cell disease and frequent vaso-occlusive crises
    Rajinder Prasad
    Center for Sickle Cell Disease, Howard University, College of Medicine, Washington DC 20060, USA
    Am J Med Sci 325:107-9. 2003
  9. pmc Prospective echocardiography assessment of pulmonary hypertension and its potential etiologies in children with sickle cell disease
    Niti Dham
    Department of Cardiology, Children s National Medical Center, Washington, District of Columbia, USA
    Am J Cardiol 104:713-20. 2009
  10. pmc Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia
    Deepika S Darbari
    Division of Haematology, Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC, USA Department of Paediatrics, The George Washington University Medical Center, Washington, DC, USA
    Eur J Haematol 92:341-5. 2014

Collaborators

Detail Information

Publications36

  1. ncbi Frequent and prolonged hospitalizations: a risk factor for early mortality in sickle cell disease patients
    Patricia Houston-Yu
    Department of Pediatrics and Child Health, Howard University, Washington, DC 20060, USA
    Am J Hematol 72:201-3. 2003
    ..40, P < 0.000008) and were also more depressed than those who survived (mean score 17.8 vs. 11.9, P = 0.031). Frequent and prolonged hospitalizations are a risk factor for early mortality in patients with SCD...
  2. ncbi Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management
    Oswaldo Castro
    Howard University College of Medicine, Center for Sickle Cell Disease, Washington, DC 20001, USA
    Hematol Oncol Clin North Am 19:881-96, vii. 2005
    ..Newer agents such as sildenafil and bosentan have demonstrated efficacy in other forms of pulmonary hypertension, and future clinical trials may prove them helpful in sickle cell patients...
  3. ncbi Predicting the effect of transfusing only phenotype-matched RBCs to patients with sickle cell disease: theoretical and practical implications
    Oswaldo Castro
    Department of Internal Meidicine, Howard University College of Medicine, Washington, DC, USA
    Transfusion 42:684-90. 2002
    ..Transfusing only phenotype-matched RBCs has been recommended to reduce the incidence of alloimmunization to blood group antigens in patients with sickle cell disease (SCD)...
  4. ncbi Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival
    Oswaldo Castro
    Center for Sickle Cell Disease and Division of Cardiology, Department of Medicine, Howard University College of Medicine, Washington, DC 20059, USA
    Blood 101:1257-61. 2003
    ..044, Breslow-Gehan log-rank test). Our findings suggest that PHTN in patients with SCD shortened their survival...
  5. pmc Hepatitis C virus in sickle cell disease
    Mohamed Hassan
    Division of Gastroenterology, Howard University Hospital, Washington, DC, USA
    J Natl Med Assoc 95:939-42. 2003
    ..To determine the prevalence of hepatitis C virus antibodies (anti-HCV) in patients with sickle cell disease...
  6. pmc Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia
    Deepika S Darbari
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Pediatr 160:286-90. 2012
    ....
  7. ncbi Circumstances of death in adult sickle cell disease patients
    Deepika S Darbari
    Center for Sickle Cell Disease, Howard University, Washington, DC, USA
    Am J Hematol 81:858-63. 2006
    ..In this proportional mortality study of adults with SCD, PHT was the leading finding at the time of death. Thromboembolism was associated with PHT, and iron overload was associated with cirrhosis...
  8. ncbi Long-term outcomes in patients with sickle cell disease and frequent vaso-occlusive crises
    Rajinder Prasad
    Center for Sickle Cell Disease, Howard University, College of Medicine, Washington DC 20060, USA
    Am J Med Sci 325:107-9. 2003
    ..The frequency of vaso-occlusive crises correlates with mortality in patients with sickle cell disease (SCD). We examined the degree to which a high number of hospitalization days for these events affected survival...
  9. pmc Prospective echocardiography assessment of pulmonary hypertension and its potential etiologies in children with sickle cell disease
    Niti Dham
    Department of Cardiology, Children s National Medical Center, Washington, District of Columbia, USA
    Am J Cardiol 104:713-20. 2009
    ..In conclusion, children with SCD had mildly increased TRV that was correlated with increased cardiac output and left ventricular filling pressures. Hemoglobin-adjusted analysis also suggested a contribution of primary vascular changes...
  10. pmc Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia
    Deepika S Darbari
    Division of Haematology, Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC, USA Department of Paediatrics, The George Washington University Medical Center, Washington, DC, USA
    Eur J Haematol 92:341-5. 2014
    ..Alpha-thalassaemia is a known modifier of SCA. Studies on the efficacy of HU in SCA patients with α-thalassaemia have yielded varying results...
  11. ncbi Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease
    Deepika S Darbari
    Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC, USA
    J Natl Med Assoc 100:948-51. 2008
    ..We conclude that corticosteroids should be used with caution in patients with SCD...
  12. pmc Low cobalamin levels in African Americans with and without sickle cell disease
    Padma Kamineni
    Howard University Hospital, Washington, DC 20060, USA
    J Natl Med Assoc 98:352-6. 2006
    ..92, nonsignificant) Our data suggest that cobalamin levels are lower in SCD patients than in subjects without SCD, and low-cobalamin SCD patients are younger and more likely to be males...
  13. pmc HCV in sickle cell disease
    Mohamed Hassan
    Division of Gastroenterology, Howard University Hospital, 2041 Georgia Avenue NW, Washington, DC 20060, USA
    J Natl Med Assoc 95:864-7, 872-4. 2003
    ..This review explores the impact of HCV in sickle cell patients and the possible therapeutic options available to them...
  14. pmc Depression in sickle cell disease
    Syed Parwez Hasan
    Center for Sickle Cell Disease, Howard University Hospital, Washington, DC 20059, USA
    J Natl Med Assoc 95:533-7. 2003
    ....
  15. ncbi Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene
    Victor R Gordeuk
    Howard University College of Medicine, Washington, DC 20059, USA
    Blood Cells Mol Dis 31:299-304. 2003
    ..We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading...
  16. ncbi Fluorescence measurements of the labile iron pool of sickle erythrocytes
    Deepika Darbari
    Center for Sickle Cell Disease, Department of Biophysics and Physiology, University Hospital, Howard University College of Medicine, 2121 Georgia Avenue NW, Washington, DC 20060, USA
    Blood 102:357-64. 2003
    ..We conclude that cytosolic labile iron is not elevated in hemoglobin SS erythrocytes and that elemental membrane iron is present in only trace amounts...
  17. ncbi Central retinal vein occlusion in sickle cell disease
    Syed Hasan
    Department of Medicine, Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    South Med J 97:202-4. 2004
    ..The search for risk factors for central retinal vein occlusion in this young patient revealed protein S deficiency and a history of iron deficiency. He was treated with anticoagulation therapy, and his vision improved gradually...
  18. ncbi Effects of hydroxyurea treatment on cerebral oxygenation in adult patients with sickle cell disease: an open-label pilot study
    Fatemeh Tavakkoli
    Department of Anesthesiology, College of Medicine, Howard University, Washington, DC 20059, USA
    Clin Ther 27:1083-8. 2005
    ..In patients with sickle cell disease (SCD), cerebral oxygen saturation (rSO(2)) has been reported to be below normal and to increase after red blood cell transfusion...
  19. pmc The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up
    Martin H Steinberg
    Department of Medicine, Boston University School of Medicine, Boston Medical Center, Massachusetts, USA
    Am J Hematol 85:403-8. 2010
    ..Our results, while no longer the product of a randomized study because of the ethical concerns of withholding an efficacious treatment, suggest that long-term use of hydroxyurea is safe and might decrease mortality...
  20. doi Hydroxycarbamide treatment in sickle cell disease: estimates of possible leukaemia risk and of hospitalization survival benefit
    Oswaldo Castro
    Center for Sickle Cell Disease, Howard University, Washington, DC, USA
    Br J Haematol 167:687-91. 2014
    ..If such a risk is eventually proven, it will probably be lower than that for drugs with known AML association. By contrast, HC treatment appears to confer a survival benefit. ..
  21. pmc Arterialization of peripheral venous blood in sickle cell disease
    Masoud Nahavandi
    Department of Anesthesiology, Howard University College of Medicine and Hospital, Washington, DC 20059, USA
    J Natl Med Assoc 94:320-6. 2002
    ..Therefore, the venous O2Hb saturation may be a useful biochemical marker for the arteriovenous shunting and hemodynamic adaptations associated with sickle cell disease...
  22. ncbi Nitric oxide and cyclic GMP levels in sickle cell patients receiving hydroxyurea
    Masoud Nahavandi
    Department of Anaesthesiology, and Center For Sickle Cell Disease, College of Medicine, Howard University, Washington, DC 20060, USA
    Br J Haematol 119:855-7. 2002
    ..Recently it was shown that HbF production was stimulated by cGMP-dependent protein kinase. Our results suggest that NO stimulates cGMP production, which then activates a protein kinase and increases the production of HbF...
  23. pmc Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension
    Roberto F Machado
    Vascular Therapeutics Section, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA
    Br J Haematol 130:445-53. 2005
    ..No episodes of priapism occurred in the three men in the study; two of them were on chronic exchange transfusions and one had erectile dysfunction...
  24. pmc Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease
    Vandana Sachdev
    Cardiovascular Branch, Echocardiography Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1454, USA
    J Am Coll Cardiol 49:472-9. 2007
    ..The goal of this study was to characterize left ventricular diastolic function in the sickle cell disease (SCD) population and to relate echocardiographic measures of dysfunction with pulmonary hypertension and mortality...
  25. ncbi N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease
    Roberto F Machado
    Vascular Medicine Branch, Clinical Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    JAMA 296:310-8. 2006
    ..Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) provide such information in patients with idiopathic pulmonary arterial hypertension...
  26. pmc Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease
    James G Taylor
    Vascular Medicine Branch, NHLBI, NIH, Bethesda, Maryland 20892 1476, USA
    Am J Hematol 83:6-14. 2008
    ..Despite this protective association, patients with SC who did develop pulmonary hypertension remained at significant risk for death during 49 months of follow-up (Hazard Ratio=8.20, P=0.0057)...
  27. ncbi Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    Mark T Gladwin
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1662, USA
    N Engl J Med 350:886-95. 2004
    ..The prevalence of pulmonary hypertension in adults with sickle cell disease, the mechanism of its development, and its prospective prognostic significance are unknown...
  28. ncbi Hydroxyurea treatment of sickle cell anemia in hospital-based practices
    Robert P Ferguson
    The Union Memorial Hospital, Baltimore, Maryland, USA
    Am J Hematol 70:326-8. 2002
    ..We conclude that hydroxyurea therapy of SCA applied in community settings leads to declining admissions and transfusion rates in many individuals for 4 years or more...
  29. ncbi Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease
    Martin H Steinberg
    Boston University School of Medicine, Room 211, 88 E Newton Street, Boston, MA 02118, USA
    Am J Hematol 72:121-6. 2003
    ..Our results provide additional evidence that some elements that regulate HbF expression are linked to the beta-globin gene cluster...
  30. ncbi Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment
    Martin H Steinberg
    Boston University School of Medicine, Center of Excellence in Sickle Cell Disease, Boston Medical Center, Boston, Mass 02118, USA
    JAMA 289:1645-51. 2003
    ..Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidity and mortality...
  31. pmc Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study
    James C Barton
    Southern Iron Disorders Center, 2022 Brookwood Medical Center Drive, Birmingham, AL 35209, USA
    Thyroid 18:831-8. 2008
    ..We evaluated thyroid-stimulating hormone (TSH) and free thyroxine (T4) in white participants of the primary care-based Hemochromatosis and Iron Overload Screening (HEIRS) Study...
  32. pmc Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    Christine E McLaren
    Department of Epidemiology, University of California, Irvine, California, USA
    Transl Res 151:97-109. 2008
    ..This approach can identify populations in which hereditary or acquired factors influence metabolism measurement...
  33. doi Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia
    Kenneth I Ataga
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, CB no 7305, 3009 Old Clinic Bldg, Chapel Hill, NC 27599 7305, USA
    Blood 111:3991-7. 2008
    ..This study is registered at http://clinicaltrials.gov as NCT00040677...
  34. ncbi Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening study
    Christine E McLaren
    Department of Epidemiology, University of California, Irvine, California 92697, USA
    Am J Hematol 82:898-905. 2007
    ..2 g/dL higher in women with C282Y/C282Y than in controls. Greater mean MCV in C282Y homozygosity reflects increased mean TfSat and mean SF in men and women; an additional effect of genotype on MCV and Hb was detected in women...
  35. pmc Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review
    Jane A Little
    Vascular Medicine Branch, National Heart Lung and Blood Institute, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1476, USA
    Haematologica 91:1076-83. 2006
    ..Furthermore EPO appears to be safe in SCD, particularly when used in conjunction with HU. We outline our current therapeutic strategy for EPO use in SCD...
  36. ncbi Case 17-2005: acute chest syndrome and ARDS
    Oswaldo Castro
    N Engl J Med 353:1529-30; author reply 1529-30. 2005