Carlo Castellani

Summary

Publications

  1. doi request reprint Cystic fibrosis: a clinical view
    Carlo Castellani
    Verona Cystic Fibrosis Centre, Piazzale Stefani 1, 37126, Verona, Italy
    Cell Mol Life Sci 74:129-140. 2017
  2. doi request reprint Newborn screening for cystic fibrosis
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata, Verona, Italy Electronic address
    Lancet Respir Med 4:653-61. 2016
  3. doi request reprint CFTR2: How will it help care?
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Paediatr Respir Rev 14:2-5. 2013
  4. doi request reprint Benchmarks for cystic fibrosis carrier screening: a European consensus document
    Carlo Castellani
    Verona Cystic Fibrosis Centre, Italy
    J Cyst Fibros 9:165-78. 2010
  5. doi request reprint Emerging issues in cystic fibrosis newborn screening
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Curr Opin Pulm Med 16:584-90. 2010
  6. doi request reprint An interactive computer program can effectively educate potential users of cystic fibrosis carrier tests
    Carlo Castellani
    Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Am J Med Genet A 155:778-85. 2011
  7. doi request reprint Association between carrier screening and incidence of cystic fibrosis
    Carlo Castellani
    Cystic Fibrosis Center, Verona Hospital, Piazzale Stefani 1, 37126 Verona, Italy
    JAMA 302:2573-9. 2009
  8. doi request reprint Cystic fibrosis carrier screening effects on birth prevalence and newborn screening
    Carlo Castellani
    Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Genet Med 18:145-51. 2016
  9. ncbi request reprint Cystic fibrosis carriers have higher neonatal immunoreactive trypsinogen values than non-carriers
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Med Genet A 135:142-4. 2005
  10. ncbi request reprint The genetic background of osteoporosis in cystic fibrosis: association analysis with polymorphic markers in four candidate genes
    Carlo Castellani
    Cystic Fibrosis Center, Pediatric Department, Azienda Ospedaliera, Verona, Italy
    J Cyst Fibros 5:229-35. 2006

Detail Information

Publications20

  1. doi request reprint Cystic fibrosis: a clinical view
    Carlo Castellani
    Verona Cystic Fibrosis Centre, Piazzale Stefani 1, 37126, Verona, Italy
    Cell Mol Life Sci 74:129-140. 2017
    ..Research is focusing on new drugs restoring CFTR function, some already available and with good clinical impact, others showing promising preliminary results that need to be confirmed in phase III clinical trials...
  2. doi request reprint Newborn screening for cystic fibrosis
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata, Verona, Italy Electronic address
    Lancet Respir Med 4:653-61. 2016
    ..In the future, research should focus on the rationalisation and optimisation of existing programmes, with particular attention to bioethical implications such as unwanted detection of carriers and inconclusive diagnoses. ..
  3. doi request reprint CFTR2: How will it help care?
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Paediatr Respir Rev 14:2-5. 2013
    ..Data originated by CFTR2 may be valuable in several facets of CF care, including diagnosis, newborn screening, carrier testing, genotype/phenotype correlation and mutation-specific therapeutics...
  4. doi request reprint Benchmarks for cystic fibrosis carrier screening: a European consensus document
    Carlo Castellani
    Verona Cystic Fibrosis Centre, Italy
    J Cyst Fibros 9:165-78. 2010
    ..The consensus statement also aims to establish the benchmarks for communicating with health care providers, the general public and potential and actual participants before and after the genetic test...
  5. doi request reprint Emerging issues in cystic fibrosis newborn screening
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Curr Opin Pulm Med 16:584-90. 2010
    ..In light of the emerging issues of NBS, new algorithms have been implemented and are reviewed here...
  6. doi request reprint An interactive computer program can effectively educate potential users of cystic fibrosis carrier tests
    Carlo Castellani
    Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Am J Med Genet A 155:778-85. 2011
    ..The computer program under evaluation can successfully educate individuals considering genetic testing for CF...
  7. doi request reprint Association between carrier screening and incidence of cystic fibrosis
    Carlo Castellani
    Cystic Fibrosis Center, Verona Hospital, Piazzale Stefani 1, 37126 Verona, Italy
    JAMA 302:2573-9. 2009
    ..A downward trend in cystic fibrosis (CF) birth incidence has been reported in some areas...
  8. doi request reprint Cystic fibrosis carrier screening effects on birth prevalence and newborn screening
    Carlo Castellani
    Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Genet Med 18:145-51. 2016
    ....
  9. ncbi request reprint Cystic fibrosis carriers have higher neonatal immunoreactive trypsinogen values than non-carriers
    Carlo Castellani
    Cystic Fibrosis Centre, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Med Genet A 135:142-4. 2005
    ..Heterozygotes had higher IRT levels than their controls (mean 35.32 vs. 27.58 microg/L, P<0.001). Even within normal trypsinogen range, the probability of being a CF carrier increases with neonatal IRT concentration...
  10. ncbi request reprint The genetic background of osteoporosis in cystic fibrosis: association analysis with polymorphic markers in four candidate genes
    Carlo Castellani
    Cystic Fibrosis Center, Pediatric Department, Azienda Ospedaliera, Verona, Italy
    J Cyst Fibros 5:229-35. 2006
    ..Reduced Bone Mass Density (BMD) is frequent in Cystic Fibrosis (CF). Potentially, other genes than the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene may contribute to the bone phenotype variability in CF patients...
  11. doi request reprint Inconclusive cystic fibrosis neonatal screening results: long-term psychosocial effects on parents
    Sandra Perobelli
    Verona Cystic Fibrosis Centre, Ospedale Civile Maggiore, Verona, Italy
    Acta Paediatr 98:1927-34. 2009
    ..Cystic Fibrosis (CF) Newborn Screening occasionally identifies neonates where a CF diagnosis can neither be confirmed nor excluded. To assess how parents of these infants cope with this ambiguous situation...
  12. doi request reprint European best practice guidelines for cystic fibrosis neonatal screening
    Carlo Castellani
    Verona Cystic Fibrosis Centre, Italy
    J Cyst Fibros 8:153-73. 2009
    ..When establishing a NBS programme for CF, attention should be given to ensuring timely and appropriate processing of results, to minimise potential stress for families...
  13. pmc Pancreatic phenotype in infants with cystic fibrosis identified by mutation screening
    Marco Cipolli
    Cystic Fibrosis Centre, Azienda Ospedaliera di Verona, Verona, Italy
    Arch Dis Child 92:842-6. 2007
    ..To determine the pancreatic phenotype of infants with cystic fibrosis (CF) diagnosed in the first week of life by a combined immunoreactive trypsin/mutation screening program...
  14. doi request reprint Sweat chloride and immunoreactive trypsinogen in infants carrying two CFTR mutations and not affected by cystic fibrosis
    Carlo Castellani
    Cystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Arch Dis Child . 2016
    ..This study found that newborns with these characteristics and normal IRT have lower sweat chloride values than those with raised IRT (p=0.007)...
  15. ncbi request reprint Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients
    Macarena Gomez-Lira
    Section of Biology and Genetics, Department of Mother and Child, Biology and Genetics, University of Verona, Verona, Italy
    Eur J Hum Genet 11:543-6. 2003
    ..The association of SPINK1 with CFTR gene mutations in IP patients is statistically significant (3/32 IP cases and 0/100 control individuals carrying mutations in both genes; Fisher's exact test P=0.01)...
  16. ncbi request reprint Epidemiology and survival analysis of cystic fibrosis in an area of intense neonatal screening over 30 years
    Baroukh M Assael
    Cystic Fibrosis Center, Verona, Italy
    Am J Epidemiol 156:397-401. 2002
    ..They could not conclude that neonatal screening improves long-term survival if compared with diagnosis by symptoms in early infancy...
  17. doi request reprint Genotypes and phenotypes in cystic fibrosis and cystic fibrosis transmembrane regulator-related disorders
    Cristina Bombieri
    Section of Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
    Semin Respir Crit Care Med 36:180-93. 2015
    ..This might change with the development of treatments targeting specific mutations and possibly capable of changing the natural history of the disease. ..
  18. ncbi request reprint Evidence for newborn screening for cystic fibrosis
    Carlo Castellani
    Cystic Fibrosis Centre, Ospedale Civile Maggiore, Azienda Ospedaliera, Piazzale Stefani 1, 37126 Verona, Italy
    Paediatr Respir Rev 4:278-84. 2003
    ..Disadvantages of neonatal screening for CF include the detection of heterozygotes and the discovery of mild forms of disease...
  19. doi request reprint Hemodynamic predictors of long term survival in end stage cystic fibrosis
    Roberto Scarsini
    Department of Medicine, Section of Cardiology, University of Verona, Verona, Italy Electronic address
    Int J Cardiol 202:221-5. 2016
    ..The aim of this study is to investigate whether PAC is a predictor of long-term prognosis in a population of CF patients affected by advanced lung disease...
  20. pmc Why women do not ask for information on preconception health? A qualitative study
    Renata Bortolus
    Office for Research Promotion, Department of the Hospital Management, Verona University Hospital, Verona, Italy
    BMC Pregnancy Childbirth 17:5. 2017
    ..The aim of this study was to investigate attitudes and behaviours of Italian women of childbearing age and healthcare professionals regarding preconception health...