Dirce Maria Carraro

Summary

Publications

  1. pmc Ductal carcinoma in situ of the breast: morphological and molecular features implicated in progression
    Dirce M Carraro
    Laboratory of Genomics and Molecular Biology, International Center of Research, A C Camargo Cancer Center, Sao Paulo, SP 01509 900, Brazil
    Biosci Rep 34:. 2014
  2. pmc Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients
    Felipe C Silva
    Laboratory of Genomics and Molecular Biology, CIPE A, C, Camargo Cancer Center, Sao Paulo, Brazil
    BMC Med Genet 15:55. 2014
  3. pmc Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset
    M Maschietto
    Laboratory of Genomics and Molecular Biology, CIPE AC Camargo Hospital, Sao Paulo, SP, Brasil
    Cell Death Dis 2:e224. 2011
  4. pmc Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil
    Dirce Maria Carraro
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, Brazil
    PLoS ONE 8:e57581. 2013
  5. pmc Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries
    Erika Maria Monteiro Santos
    Graduation Program, AC Camargo Hospital, Sao Paulo, Brazil
    BMC Cancer 12:64. 2012
  6. pmc Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients
    Giovana Tardin Torrezan
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, SP, Brazil
    Orphanet J Rare Dis 8:54. 2013
  7. doi request reprint Role of rare germline copy number variation in melanoma-prone patients
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Future Oncol 12:1345-57. 2016
  8. doi request reprint Linear mRNA amplification approach for RNAseq from limited amount of RNA
    Elisa Napolitano Ferreira
    International Research Center, A C Camargo Cancer Center, Rua Taguá, 440 1 andar, Liberdade, Sao Paulo, SP 01508 010, Brazil
    Gene 564:220-7. 2015
  9. doi request reprint Upregulated genes at 2q24 gains as candidate oncogenes in hepatoblastomas
    Tatiane Cristina Rodrigues
    Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Future Oncol 10:2449-57. 2014
  10. pmc Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Tumour Biol 36:1835-48. 2015

Collaborators

  • Helena Brentani
  • Elisa Napolitano Ferreira
  • Gustavo Cardoso Guimaraes
  • Jose Vassallo
  • Samuel Aguiar
  • Glauco Baiocchi
  • Sabrina Daniela da Silva
  • Laura Sterian Ward
  • Lucas Leite Cunha
  • Carla Rosenberg
  • C Torres
  • Giovana T Torrezan
  • Edgard Graner
  • Maria Aparecida Nagai
  • Sandro José Conde
  • Fernando Augusto Soares
  • Felipe Fidalgo
  • Isabela Werneck da Cunha
  • Ana Cristina Victorino Krepischi
  • Rafael Malagoli Rocha
  • Maria Mitzi Brentani
  • Tatiane Cristina Rodrigues
  • Maria Lucia Hirata Katayama
  • Maria Aparecida Azevedo Koike Folgueira
  • Felipe Carneiro da Silva
  • Bianca Costa Soares de Sá
  • Erika Maria Monteiro Santos
  • Elen Pereira Bastos
  • Patricia Bortman Rozenchan
  • Louise De Brot
  • Alice Muglia Thomaz da Silva Amancio
  • Simone Maistro
  • Amanda Gonçalves Silva
  • Victor Piana de Andrade
  • João Pedreira Duprat
  • Andréia Cristina de Melo
  • Alexandre Leon Ribeiro de Ávila
  • Nancy Bueno Figueiredo
  • Maria Isabel Waddington Achatz
  • Mariana Rezende Alves
  • Felipe C Silva
  • Luciana Facure Moredo
  • Ademar Lopes
  • Erica Sara Souza de Araújo
  • Eloísa Ribeiro Olivieri
  • Benedito Mauro Rossi
  • Wilson Toshihiko Nakagawa
  • Ligia Petrolini de Oliveira
  • Maria do Socorro Maciel
  • Julia Pinheiro Chagas da Cunha
  • Marjory Alana Marcello
  • Antônio Hugo José Fróes Marques Campos
  • Carolina Sens-Abuázar
  • Mariana Petaccia Macedo
  • Rosângela Portilho Costa Santos
  • M Maschietto
  • Maria Isabel Achatz
  • Roberto Marques Ribeiro
  • José Ivanildo Neves
  • Larissa Garcia Cabral
  • Stenio Cassio Zequi
  • Ana Carolina Ribeiro Chaves de Gouvêa
  • Marcos Venício Alves Lima
  • Sabrina Teixeira Moretti
  • Maria do Perpétuo Socorro Saldanha da Cunha
  • Vivian Dionisio Tavares Niewiadonski
  • Bruno Pellegrini
  • Nelson Gaburo Junior
  • Francisco Paulo da Fonseca
  • Luciana Facure
  • Antonio Leopoldo Cubilla
  • Roger Chammas
  • Geertruida Hendrika De Bock
  • Natalia Teixeira
  • Maria del Pilar Estevez Diz
  • Ester Cerdeira Sabino
  • Giselly Encinas
  • Josiane da Silva Quetz
  • Márcia Cristina Pena Figueiredo
  • Rafael Canfield Brianese
  • José Roberto de Oliveira Ferreira
  • Mabel Pinilla
  • Vanessa Karen de Sá
  • Samuel Aguiar-Junior
  • Cinthya Sternberg
  • Haynna Kimie Pimenta Inada
  • Alexandre Todorovic Fabro
  • Milton José de Barros e Silva
  • Evandro Sobrosa de Mello
  • Carlos Gil Ferreira

Detail Information

Publications35

  1. pmc Ductal carcinoma in situ of the breast: morphological and molecular features implicated in progression
    Dirce M Carraro
    Laboratory of Genomics and Molecular Biology, International Center of Research, A C Camargo Cancer Center, Sao Paulo, SP 01509 900, Brazil
    Biosci Rep 34:. 2014
    ..The knowledge gained in recent years might allow the development of tailored clinical management for women with DCIS in the future...
  2. pmc Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients
    Felipe C Silva
    Laboratory of Genomics and Molecular Biology, CIPE A, C, Camargo Cancer Center, Sao Paulo, Brazil
    BMC Med Genet 15:55. 2014
    ....
  3. pmc Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset
    M Maschietto
    Laboratory of Genomics and Molecular Biology, CIPE AC Camargo Hospital, Sao Paulo, SP, Brasil
    Cell Death Dis 2:e224. 2011
    ..Taken together, this study reveals new genes candidate for triggering WT onset and for therapeutic treatment targets...
  4. pmc Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil
    Dirce Maria Carraro
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, Brazil
    PLoS ONE 8:e57581. 2013
    ..Additionally, the data revealed molecular factors that potentially trigger the tumor development in young patients...
  5. pmc Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries
    Erika Maria Monteiro Santos
    Graduation Program, AC Camargo Hospital, Sao Paulo, Brazil
    BMC Cancer 12:64. 2012
    ..This study aims to evaluate sensitivity and specificity of five predictive models for germline mutations in repair genes in a sample of individuals with suspected Lynch syndrome...
  6. pmc Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients
    Giovana Tardin Torrezan
    Laboratory of Genomics and Molecular Biology, A C Camargo Hospital, Sao Paulo, SP, Brazil
    Orphanet J Rare Dis 8:54. 2013
    ..The spectrum of mutations as well as the genotype-phenotype correlations in polyposis syndromes present clinical impact and can be population specific, making important to obtain genetic and clinical data from different populations...
  7. doi request reprint Role of rare germline copy number variation in melanoma-prone patients
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Future Oncol 12:1345-57. 2016
    ..This work evaluates a possible causative role for germline copy number variants (CNVs) in melanoma predisposition...
  8. doi request reprint Linear mRNA amplification approach for RNAseq from limited amount of RNA
    Elisa Napolitano Ferreira
    International Research Center, A C Camargo Cancer Center, Rua Taguá, 440 1 andar, Liberdade, Sao Paulo, SP 01508 010, Brazil
    Gene 564:220-7. 2015
    ..Altogether, we established a robust protocol for assessing the polyadenylated transcriptome derived from limited amounts of total RNA that is applicable to all NGS platforms. ..
  9. doi request reprint Upregulated genes at 2q24 gains as candidate oncogenes in hepatoblastomas
    Tatiane Cristina Rodrigues
    Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Future Oncol 10:2449-57. 2014
    ..High-resolution cytogenetics may provide clues to hepatoblastoma tumorigenesis and indicate markers with clinical significance...
  10. pmc Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Tumour Biol 36:1835-48. 2015
    ..The data has shed some light on the molecular players involved in two highly relevant prognostic factors and may further add to the understanding of the mechanisms of breast cancer aggressiveness...
  11. doi request reprint Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix
    Louise De Brot
    Department of Pathology, A C Camargo Cancer Center, Sao Paulo, Brazil
    Cancer . 2016
    ..Infections with multiple human papillomavirus (HPV) types (mHPV) in Papanicolaou tests have been reported but the histologic correlation and clinical meaning remains debatable...
  12. pmc Poly (A)+ transcriptome assessment of ERBB2-induced alterations in breast cell lines
    Dirce Maria Carraro
    Centro Internacional de Ensino e Pesquisa, Hospital AC Camargo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 6:e21022. 2011
    ....
  13. doi request reprint Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma
    Mariana Rezende Alves
    International Center of Research in Cancer CIPE, A C Camargo Cancer Center, Rua Taguá, 440 Liberdade, 01508 010, Sao Paulo, SP, Brazil
    Virchows Arch 465:321-30. 2014
    ..We found 32 novel mutations in the VHL gene in ccRCC. The presence of mutations was not concordant with mRNA or protein expression. Nonsense mutations of the VHL gene appear to be related with poorer prognosis and survival...
  14. pmc The human cell surfaceome of breast tumors
    Julia Pinheiro Chagas da Cunha
    Ludwig Institute for Cancer Research, São Paulo 01308 050, SP, Brazil Center for Applied Toxinology, Butantan Institute, Sao Paulo 05503 900, SP, Brazil
    Biomed Res Int 2013:976816. 2013
    ..Cell surface proteins are ideal targets for cancer therapy and diagnosis. We have identified a set of more than 3700 genes that code for transmembrane proteins believed to be at human cell surface...
  15. pmc P53 and expression of immunological markers may identify early stage thyroid tumors
    Marjory Alana Marcello
    Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences FCM, University of Campinas UNICAMP, Rua Tessalia Vieira de Camargo 126, Cidade Universitaria Zeferino Vaz, Campinas 13083 887, SP, Brazil
    Clin Dev Immunol 2013:846584. 2013
    ..We aimed to investigate p53 and immune cell markers utility as diagnostic and prognostic markers of differentiated thyroid cancer (DTC)...
  16. pmc Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression
    Rosângela Portilho Costa Santos
    Departamento de Radiologia e Oncologia, LIM24, Faculdade de Medicina, Universidade de Sao Paulo, Avenida Dr Arnaldo, 455, 4º andar, sala 4124, CEP 01246 903 Sao Paulo, SP, Brazil
    Tumour Biol 32:145-57. 2011
    ..However, fibroblasts effects are distinct in each one of the breast cancer lineages, suggesting that the inter-relationships between stromal and malignant cells are dependent on the intrinsic subtype of the tumor...
  17. doi request reprint Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis
    Alice Muglia Thomaz da Silva Amancio
    Department of Anatomic Pathology, A C Camargo Cancer Center, Sao Paulo, Brazil
    Hum Pathol . 2016
    ..Altered FISH (polysomy and gene amplification) was an independent risk factor for dying of cancer. Only one patient of 107 presented KRAS mutations, and no mutations of EGFR or BRAF were observed...
  18. doi request reprint Genome-wide DNA methylation profile of leukocytes from melanoma patients with and without CDKN2A mutations
    Erica Sara Souza de Araújo
    International Center for Research, A C Camargo Cancer Center, Sao Paulo, Brazil
    Exp Mol Pathol 97:425-32. 2014
    ..Thus, further studies are required to elucidate the impact of these findings on melanoma predisposition and their possible effect on the penetrance of CDKN2A mutations. ..
  19. pmc MicroRNAs discriminate familial from sporadic non-BRCA1/2 breast carcinoma arising in patients ≤35 years
    Elen Pereira Bastos
    Oncology and Radiology Department, Laboratory of Medical Investigation 24 LIM 24, University of Sao Paulo, Medical School, Sao Paulo, Brazil
    PLoS ONE 9:e101656. 2014
    ..MiR-mRNA co-expression analysis allowed us to identify changes in the miR-mRNA regulation that were able to distinguish tumors from familial and sporadic young BC patients non-carriers of BRCA mutations. ..
  20. doi request reprint Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma
    Alexandre Leon Ribeiro de Ávila
    Department of Skin Câncer, AC Camargo Cancer Center, Sao Paulo, Brazil
    Fam Cancer 13:645-9. 2014
    ..This consideration should be taken into account when referring patients for genetic screening in a setting of limited budget, such as in developing countries...
  21. pmc A novel SYBR-based duplex qPCR for the detection of gene dosage: detection of an APC large deletion in a familial adenomatous polyposis patient with an unusual phenotype
    Giovana Tardin Torrezan
    CIPE International Center of Research and Training A, C, Camargo Hospital, Rua Taguá, Sao Paulo, Brazil
    BMC Med Genet 13:55. 2012
    ..Large deletions in APC are a common cause of FAP; despite the existence of a variety of gene dosage detection methodologies, most are labor intensive and time and resource consuming...
  22. pmc Estrogen-responsive genes overlap with triiodothyronine-responsive genes in a breast carcinoma cell line
    Nancy Bueno Figueiredo
    Department of Internal Medicine, Botucatu School of Medicine, University of Sao Paulo State Unesp, 18618 000 Botucatu, SP, Brazil
    ScientificWorldJournal 2014:969404. 2014
    ..0, pFDR < 0.05). We confirmed our microarray results by real-time PCR. Our findings reveal that certain genes in MCF-7 cells can be regulated by both E₂ and T₃...
  23. doi request reprint Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas
    Sabrina Daniela da Silva
    Department of Oral Diagnosis, School of Dentistry of Piracicaba, State University of Campinas UNICAMP, Av Limeira 901, CP52, Areão, Piracicaba, CEP 13414 018, Sao Paulo, Brazil
    Oral Oncol 45:e134-9. 2009
    ..0001, respectively). Taken together, the results presented here suggest a molecular connection among FASN, ErbB2, and USP2a in OSCC since their mRNA and protein levels were associated with tumor progression and poor prognosis...
  24. pmc A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease
    Elisa Napolitano Ferreira
    International Research Center CIPE, A C Camargo Cancer Center, Sao Paulo, SP, Brazil
    Hum Genomics 10:36. 2016
    ..Here, we present a comprehensive genomic profiling of one DSRCT affecting a 26-year-old male, who achieved an excellent outcome...
  25. doi request reprint Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts
    Patricia Bortman Rozenchan
    Disciplina de Oncologia, Departamento de Radiologia, Faculdade de Medicina da Universidade de Sao Paulo, Hospital A C Camargo, Av Dr Arnaldo, 455, Sala 4112, Sao Paulo, SP CEP 01246 903, Brazil
    Int J Cancer 125:2767-77. 2009
    ..Our data indicate that interactions between breast fibroblasts and basal epithelial cells resulted in alterations in the genomic profiles of both cell types which may help to clarify some aspects of this heterotypic signaling...
  26. ncbi request reprint Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy
    Maria Aparecida Azevedo Koike Folgueira
    Faculdade de Medicina da Universidade de Sao Paulo, Departamento de Radiologia, Disciplina de Oncologia, Sao Paulo, SP, Brasil
    Oncol Rep 22:805-13. 2009
    ..CTGF and DUSP1 overexpression in residual samples may be a reflection of resistance to further administration of AC regimen...
  27. pmc Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in Brazil
    Simone Maistro
    Departamento de Radiologia e Oncologia, Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    BMC Cancer 16:934. 2016
    ..The aim of this study was to evaluate BRCA1/2 mutations, through entire gene sequencing, in a Brazilian population of women with epithelial ovarian cancer...
  28. pmc Clinical and Molecular Characterization of Brazilian Patients Suspected to Have Lynch Syndrome
    Felipe Carneiro da Silva
    Laboratory of Genomics and Molecular Biology, International Research Center CIPE A C Camargo Cancer Center, Sao Paulo, Brazil
    PLoS ONE 10:e0139753. 2015
    ....
  29. doi request reprint Mutational Profile and New IASLC/ATS/ERS Classification Provide Additional Prognostic Information about Lung Adenocarcinoma: A Study of 125 Patients from Brazil
    Andréia Cristina de Melo
    Department of Pathology, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Oncology 89:175-86. 2015
    ....
  30. doi request reprint Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports
    Mariana Petaccia Macedo
    Department of Pathology, Hospital A C Camargo, Sao Paulo, Brazil
    Int J Colorectal Dis 26:1241-8. 2011
    ..Few data exist on MMs with regard to their frequency and the codons and amino acids that are affected. We report two cases of Kras double mutations in codons 12 and 13 and review Kras MMs in primary CRC in PubMed databases...
  31. doi request reprint Association of melanoma with intraepithelial neoplasia of the pancreas in three patients
    Felipe Fidalgo
    International Research Center, AC Camargo Cancer Center, Sao Paulo, Brazil
    Exp Mol Pathol 97:144-7. 2014
    ..Our data pinpoint that rare germline CNVs harboring genes can contribute to the cancer predisposition of melanoma and intraepithelial neoplasia of the pancreas...
  32. ncbi request reprint The value of a tumor bank in the development of cancer research in Brazil: 13 years of experience at the a C camargo hospital
    Antônio Hugo José Fróes Marques Campos
    1 A C Camargo Hospital Biobank, A C Camargo Hospital Antonio Prudente Foundation, Sao Paulo, SP, Brazil
    Biopreserv Biobank 10:168-73. 2012
    ..We conclude that biobanking should be part of the strategy employed by scientists and research institutions dedicated to the study of human diseases. ..
  33. pmc Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast
    Carolina Sens-Abuázar
    Laboratory of Genomics and Molecular Biology, International Center of Research and Teaching, A C Camargo Hospital, Sao Paulo, SP, Brazil
    Transl Oncol 5:113-23. 2012
    ..1-1q32.1), 8q, and 17q (17q24.2), regions that display common imbalances in breast tumors, suggesting that down-regulation of ANAPC13 contributes to genomic instability in this disease...
  34. doi request reprint A clinical, pathologic, and molecular study of p53 and murine double minute 2 in penile carcinogenesis and its relation to prognosis
    Rafael Malagoli Rocha
    Department of Pathology, Hospital do Cancer A C Camargo Fundação Antônio Prudente, Sao Paulo, Brazil
    Hum Pathol 43:481-8. 2012
    ..Examining p53 is helpful in identifying patients with more aggressive tumors and may be crucial in selecting the most suitable surgical procedure...