Eduardo Candelario Jalil

Summary

Publications

  1. ncbi request reprint The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 927:212-5. 2002
  2. ncbi request reprint Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, 10600, Havana City, Cuba
    Eur J Pharmacol 453:189-95. 2002
  3. ncbi request reprint Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Neurosci Res 47:245-53. 2003
  4. pmc Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    BMC Pharmacol 3:7. 2003
  5. ncbi request reprint Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 1007:98-108. 2004
  6. doi request reprint Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Pharmacol Res 57:266-73. 2008
  7. ncbi request reprint Cyclooxygenase inhibition in ischemic brain injury
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Curr Pharm Des 14:1401-18. 2008
  8. pmc Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia
    Eduardo Candelario-Jalil
    Brain Injury Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurochem 86:545-55. 2003
  9. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
  10. pmc Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroinflammation 4:25. 2007

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 927:212-5. 2002
    ..These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury...
  2. ncbi request reprint Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, 10600, Havana City, Cuba
    Eur J Pharmacol 453:189-95. 2002
    ..The present study confirms the ability of cyclooxygenase-2 inhibitors to reduce brain damage induced by cerebral ischemia and indicates that nimesulide can provide protection when administered for up to 24 h post-ischemia...
  3. ncbi request reprint Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Neurosci Res 47:245-53. 2003
    ..These results suggest that nimesulide may protect neurons by attenuating oxidative stress and reperfusion injury following the ischemic insult with a wide therapeutic window of protection...
  4. pmc Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    BMC Pharmacol 3:7. 2003
    ..Here we investigate if this effect is mediated by the direct antioxidant properties of nimesulide using a well-characterized in vitro model of kainate toxicity...
  5. ncbi request reprint Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 1007:98-108. 2004
    ....
  6. doi request reprint Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Pharmacol Res 57:266-73. 2008
    ....
  7. ncbi request reprint Cyclooxygenase inhibition in ischemic brain injury
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Curr Pharm Des 14:1401-18. 2008
    ..Finally, we will provide a critical evaluation of the therapeutic potential of COX inhibitors in cerebral ischemia and discuss new targets downstream of COX with potential neuroprotective ability...
  8. pmc Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia
    Eduardo Candelario-Jalil
    Brain Injury Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurochem 86:545-55. 2003
    ....
  9. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
    ..Modulation of COX in brain injury by COX inhibitors or agents modulating prostaglandin E(2) formation/signaling may be useful in clinical settings associated with BBB disruption...
  10. pmc Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroinflammation 4:25. 2007
    ..The aim of this study was to examine whether resveratrol is able to reduce prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2alpha (8-iso-PGF2 alpha) production by lipopolysaccharide (LPS)-activated primary rat microglia...
  11. ncbi request reprint Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats
    Armando González-Falcón
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 990:1-7. 2003
    ....