Eduardo Candelario-Jalil

Summary

Publications

  1. pmc Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Havana 10600, Cuba
    J Neuroinflammation 2:3. 2005
  2. ncbi request reprint Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 1007:98-108. 2004
  3. ncbi request reprint The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 927:212-5. 2002
  4. ncbi request reprint Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, 10600, Havana City, Cuba
    Eur J Pharmacol 453:189-95. 2002
  5. ncbi request reprint Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats
    Armando González-Falcón
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 990:1-7. 2003
  6. ncbi request reprint Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Neurosci Res 47:245-53. 2003
  7. pmc Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    BMC Pharmacol 3:7. 2003
  8. pmc Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia
    Eduardo Candelario-Jalil
    Brain Injury Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurochem 86:545-55. 2003
  9. ncbi request reprint Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 100:1108-20. 2007
  10. pmc Detrimental effects of tropisetron on permanent ischemic stroke in the rat
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstr, 5, D 79104 Freiburg, Germany
    BMC Neurosci 9:19. 2008

Collaborators

  • Rohit R Sood
  • Gregorio Martinez-Sanchez
  • Harsharan S Bhatia
  • Bernd L Fiebich
  • Antonio Carlos Pinheiro de Oliveira
  • Klaus Lieb
  • Michael Hull
  • Ravi Shankar Akundi
  • Armando González-Falcón
  • Olumayokun A Olajide
  • Antonio C Pinheiro de Oliveira
  • Peter J Gebicke-Haerter
  • Sandra Hess
  • Olga Sonia Leon
  • Michel García-Cabrera

Detail Information

Publications17

  1. pmc Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Havana 10600, Cuba
    J Neuroinflammation 2:3. 2005
    ..These findings have important implications for the therapeutic potential of using COX-2 inhibitors in the treatment of stroke...
  2. ncbi request reprint Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 1007:98-108. 2004
    ....
  3. ncbi request reprint The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 927:212-5. 2002
    ..These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury...
  4. ncbi request reprint Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, 10600, Havana City, Cuba
    Eur J Pharmacol 453:189-95. 2002
    ..The present study confirms the ability of cyclooxygenase-2 inhibitors to reduce brain damage induced by cerebral ischemia and indicates that nimesulide can provide protection when administered for up to 24 h post-ischemia...
  5. ncbi request reprint Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats
    Armando González-Falcón
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 990:1-7. 2003
    ....
  6. ncbi request reprint Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Neurosci Res 47:245-53. 2003
    ..These results suggest that nimesulide may protect neurons by attenuating oxidative stress and reperfusion injury following the ischemic insult with a wide therapeutic window of protection...
  7. pmc Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    BMC Pharmacol 3:7. 2003
    ..Here we investigate if this effect is mediated by the direct antioxidant properties of nimesulide using a well-characterized in vitro model of kainate toxicity...
  8. pmc Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia
    Eduardo Candelario-Jalil
    Brain Injury Research Center, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurochem 86:545-55. 2003
    ....
  9. ncbi request reprint Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 100:1108-20. 2007
    ....
  10. pmc Detrimental effects of tropisetron on permanent ischemic stroke in the rat
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstr, 5, D 79104 Freiburg, Germany
    BMC Neurosci 9:19. 2008
    ....
  11. doi request reprint Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Pharmacol Res 57:266-73. 2008
    ....
  12. doi request reprint Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
    Antonio Carlos Pinheiro de Oliveira
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 56:844-55. 2008
    ....
  13. pmc Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroinflammation 4:25. 2007
    ..The aim of this study was to examine whether resveratrol is able to reduce prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2alpha (8-iso-PGF2 alpha) production by lipopolysaccharide (LPS)-activated primary rat microglia...
  14. pmc Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain
    Rohit R Sood
    Department of Neurology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 28:431-8. 2008
    ....
  15. ncbi request reprint Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Neuroimmunol 174:39-51. 2006
    ....
  16. ncbi request reprint Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  17. doi request reprint Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells
    Harsharan S Bhatia
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Arch Biochem Biophys 477:253-8. 2008
    ..These data suggest that modulation of microglial activation might contribute to the mechanism of cerebral protection by mangiferin...