Magdy Younes

Summary

Country: Canada

Publications

  1. ncbi Response of ventilator-dependent patients to delayed opening of exhalation valve
    Magdy Younes
    Section of Respiratory and Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 166:21-30. 2002
  2. ncbi Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 168:645-58. 2003
  3. ncbi Role of arousals in the pathogenesis of obstructive sleep apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 169:623-33. 2004
  4. pmc Systemic vs. central administration of common hypnotics reveals opposing effects on genioglossus muscle activity in rats
    Eileen Park
    Department of Medicine, University of Toronto, Toronto, Canada
    Sleep 31:355-65. 2008
  5. pmc Contribution of arousal from sleep to postevent tachycardia in patients with obstructive sleep apnea
    Ali Azarbarzin
    Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, Manitoba, Canada
    Sleep 36:881-9. 2013
  6. ncbi Pentobarbital sedation increases genioglossus respiratory activity in sleeping rats
    Magdy Younes
    Department of Medicine, University of Toronto, ON, Canada
    Sleep 30:478-88. 2007
  7. pmc Relationship between arousal intensity and heart rate response to arousal
    Ali Azarbarzin
    YRT Ltd, Winnipeg, Manitoba, Canada
    Sleep 37:645-53. 2014
  8. ncbi Hypoxic respiratory response during acute stable hypocapnia
    Stephen Corne
    Department of Respiratory Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 167:1193-9. 2003
  9. pmc Staging Sleep in Polysomnograms: Analysis of Inter-Scorer Variability
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    J Clin Sleep Med 12:885-94. 2016
  10. pmc Arousal Responses during Overnight Polysomnography and their Reproducibility in Healthy Young Adults
    Ali Azarbarzin
    YRT Ltd, Winnipeg, Manitoba, Canada
    Sleep 38:1313-21. 2015

Detail Information

Publications24

  1. ncbi Response of ventilator-dependent patients to delayed opening of exhalation valve
    Magdy Younes
    Section of Respiratory and Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 166:21-30. 2002
    ..10 +/- 0.08 L, p = 2E-10). We conclude that acute compensatory responses to delays in opening of exhalation value are weak in ventilator-dependent patients. As a result, such nonsynchrony tends to exacerbate DH...
  2. ncbi Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 168:645-58. 2003
    ..Severity is largely due to factors other than mechanical load. Compensatory effectiveness is impaired in the supine position and in REM sleep, but not by age, sex, or body mass index...
  3. ncbi Role of arousals in the pathogenesis of obstructive sleep apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 169:623-33. 2004
    ..They are not needed to initiate opening or to obtain adequate flow and they likely increase the severity of the disorder by promoting greater ventilatory instability...
  4. pmc Systemic vs. central administration of common hypnotics reveals opposing effects on genioglossus muscle activity in rats
    Eileen Park
    Department of Medicine, University of Toronto, Toronto, Canada
    Sleep 31:355-65. 2008
    ..We also determined effects on GG activity with local application to the hypoglossal motor nucleus (HMN)...
  5. pmc Contribution of arousal from sleep to postevent tachycardia in patients with obstructive sleep apnea
    Ali Azarbarzin
    Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, Manitoba, Canada
    Sleep 36:881-9. 2013
    ..Our objective was to determine the contribution of these physiologic responses to postevent tachycardia...
  6. ncbi Pentobarbital sedation increases genioglossus respiratory activity in sleeping rats
    Magdy Younes
    Department of Medicine, University of Toronto, ON, Canada
    Sleep 30:478-88. 2007
    ..Intermittently, inspired CO2 was increased gradually until arousal occurred...
  7. pmc Relationship between arousal intensity and heart rate response to arousal
    Ali Azarbarzin
    YRT Ltd, Winnipeg, Manitoba, Canada
    Sleep 37:645-53. 2014
    ....
  8. ncbi Hypoxic respiratory response during acute stable hypocapnia
    Stephen Corne
    Department of Respiratory Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 167:1193-9. 2003
    ..We conclude that when apnea occurs under conditions in which central PCO2 is well below the CO2 setpoint, subjects are at risk of developing dangerous hypoxemia due to absence of a hypoxic ventilatory response...
  9. pmc Staging Sleep in Polysomnograms: Analysis of Inter-Scorer Variability
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    J Clin Sleep Med 12:885-94. 2016
    ..To determine the reasons for inter-scorer variability in sleep staging of polysomnograms (PSGs)...
  10. pmc Arousal Responses during Overnight Polysomnography and their Reproducibility in Healthy Young Adults
    Ali Azarbarzin
    YRT Ltd, Winnipeg, Manitoba, Canada
    Sleep 38:1313-21. 2015
    ..Our objective was to determine the range of these arousal characteristics in healthy young adults and whether they are consistent on repeated testing...
  11. pmc Short-term potentiation in the control of pharyngeal muscles in obstructive apnea patients
    Magdy Younes
    Sleep Disorders Centre, Misericordia Health Centre, Winnipeg, Manitoba, Canada Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Canada
    Sleep 37:1833-49. 2014
    ..To determine if activation of the genioglossus (GG) muscle during obstructive apnea events involves short-term potentiation (STP) and is followed by sustained activation beyond the obstructive phase (after-discharge)...
  12. pmc Odds ratio product of sleep EEG as a continuous measure of sleep state
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    Sleep 38:641-54. 2015
    ..To develop and validate an algorithm that provides a continuous estimate of sleep depth from the electroencephalogram (EEG)...
  13. doi Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography
    Jaime M Beecroft
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Intensive Care Med 34:2076-83. 2008
    ....
  14. pmc Accuracy of Automatic Polysomnography Scoring Using Frontal Electrodes
    Magdy Younes
    Sleep Disorders Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Sleep Med 12:735-46. 2016
    ..We wished to determine if MSS' accuracy is maintained if frontal derivations are used instead. If confirmed, home sleep monitoring would not require home setup or lengthy manual scoring by technologists...
  15. pmc Enhancements to the multiple sleep latency test
    Sonia Meza-Vargas
    Sleep Disorders Centre, University of Manitoba, Winnipeg, MB, Canada
    Nat Sci Sleep 8:145-58. 2016
    ..0, and 2.5 reflecting very deep sleep, light sleep, and full wakefulness, respectively. We determined the time course of sleep depth during MSLT naps expecting that this would enhance the test's clinical utility...
  16. pmc Minimizing Interrater Variability in Staging Sleep by Use of Computer-Derived Features
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    J Clin Sleep Med 12:1347-1356. 2016
    ..We hypothesized that providing digitally derived information about these variables to PSG scorers may reduce inter-scorer variability...
  17. doi Immediate postarousal sleep dynamics: an important determinant of sleep stability in obstructive sleep apnea
    Magdy Younes
    Sleep Disorders Centre, University of Manitoba, Winnipeg, and Sleep Center, Foothills Medical Centre, University of Calgary, Canada
    J Appl Physiol (1985) 120:801-8. 2016
    ..We conclude that postarousal sleep dynamics are highly variable among patients with sleep-disordered breathing and largely determine average sleep depth and continuity...
  18. ncbi Mechanisms of breathing instability in patients with obstructive sleep apnea
    Magdy Younes
    Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 103:1929-41. 2007
    ....
  19. doi Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
  20. pmc Why does airway pressure rise sometimes near the end of inflation during pressure support?
    Magdy Younes
    Intensive Care Med 34:1-3. 2008
  21. ncbi Model based analysis of sleep disordered breathing in congestive heart failure
    Zbigniew L Topor
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alta, Canada
    Respir Physiol Neurobiol 155:82-92. 2007
    ..We conclude that development of CSB is the result of a complex interaction between CCR and PCR loops which may, in turn, interact with decreased cardiac output and cardiomegaly...
  22. ncbi Pharyngeal anatomy and severity of obstructive apnea
    Magdy Younes
    Am J Respir Crit Care Med 170:716. 2004
  23. ncbi Measurement of the CO2 apneic threshold
    Magdy Younes
    Am J Respir Crit Care Med 167:472; author relpy 472-3. 2003
  24. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...