Magdy Younes

Summary

Country: Canada

Publications

  1. ncbi request reprint Hypoxic respiratory response during acute stable hypocapnia
    Stephen Corne
    Department of Respiratory Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 167:1193-9. 2003
  2. ncbi request reprint Role of arousals in the pathogenesis of obstructive sleep apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 169:623-33. 2004
  3. ncbi request reprint A method for monitoring and improving patient: ventilator interaction
    Magdy Younes
    Intensive Care Med 33:1337-46. 2007
  4. doi request reprint Genioglossus activity available via non-arousal mechanisms vs. that required for opening the airway in obstructive apnea patients
    Magdy Younes
    Sleep Center, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 112:249-58. 2012
  5. ncbi request reprint Response of ventilator-dependent patients to delayed opening of exhalation valve
    Magdy Younes
    Section of Respiratory and Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 166:21-30. 2002
  6. doi request reprint Immediate postarousal sleep dynamics: an important determinant of sleep stability in obstructive sleep apnea
    Magdy Younes
    Sleep Disorders Centre, University of Manitoba, Winnipeg, and Sleep Center, Foothills Medical Centre, University of Calgary, Canada
    J Appl Physiol (1985) 120:801-8. 2016
  7. ncbi request reprint Pentobarbital sedation increases genioglossus respiratory activity in sleeping rats
    Magdy Younes
    Department of Medicine, University of Toronto, ON, Canada
    Sleep 30:478-88. 2007
  8. ncbi request reprint Mechanisms of breathing instability in patients with obstructive sleep apnea
    Magdy Younes
    Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 103:1929-41. 2007
  9. doi request reprint Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders
    Magdy Younes
    Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 105:1389-405. 2008
  10. pmc Response of genioglossus muscle to increasing chemical drive in sleeping obstructive apnea patients
    Andrea H S Loewen
    Sleep Center, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    Sleep 34:1061-73. 2011

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Hypoxic respiratory response during acute stable hypocapnia
    Stephen Corne
    Department of Respiratory Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 167:1193-9. 2003
    ..We conclude that when apnea occurs under conditions in which central PCO2 is well below the CO2 setpoint, subjects are at risk of developing dangerous hypoxemia due to absence of a hypoxic ventilatory response...
  2. ncbi request reprint Role of arousals in the pathogenesis of obstructive sleep apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 169:623-33. 2004
    ..They are not needed to initiate opening or to obtain adequate flow and they likely increase the severity of the disorder by promoting greater ventilatory instability...
  3. ncbi request reprint A method for monitoring and improving patient: ventilator interaction
    Magdy Younes
    Intensive Care Med 33:1337-46. 2007
    ..To evaluate a new approach for monitoring and improving patient-ventilator interaction that utilizes a signal generated by the equation of motion, using improvised values for resistance and elastance obtained noninvasively...
  4. doi request reprint Genioglossus activity available via non-arousal mechanisms vs. that required for opening the airway in obstructive apnea patients
    Magdy Younes
    Sleep Center, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 112:249-58. 2012
    ..Arousals occur in most cases just before non-arousal mechanisms manage to increase activity above GG Opening Threshold. Measures to reduce GG Opening Threshold even slightly may help stabilize breathing in many patients...
  5. ncbi request reprint Response of ventilator-dependent patients to delayed opening of exhalation valve
    Magdy Younes
    Section of Respiratory and Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 166:21-30. 2002
    ..10 +/- 0.08 L, p = 2E-10). We conclude that acute compensatory responses to delays in opening of exhalation value are weak in ventilator-dependent patients. As a result, such nonsynchrony tends to exacerbate DH...
  6. doi request reprint Immediate postarousal sleep dynamics: an important determinant of sleep stability in obstructive sleep apnea
    Magdy Younes
    Sleep Disorders Centre, University of Manitoba, Winnipeg, and Sleep Center, Foothills Medical Centre, University of Calgary, Canada
    J Appl Physiol (1985) 120:801-8. 2016
    ..We conclude that postarousal sleep dynamics are highly variable among patients with sleep-disordered breathing and largely determine average sleep depth and continuity...
  7. ncbi request reprint Pentobarbital sedation increases genioglossus respiratory activity in sleeping rats
    Magdy Younes
    Department of Medicine, University of Toronto, ON, Canada
    Sleep 30:478-88. 2007
    ..Intermittently, inspired CO2 was increased gradually until arousal occurred...
  8. ncbi request reprint Mechanisms of breathing instability in patients with obstructive sleep apnea
    Magdy Younes
    Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 103:1929-41. 2007
    ....
  9. doi request reprint Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders
    Magdy Younes
    Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 105:1389-405. 2008
    ....
  10. pmc Response of genioglossus muscle to increasing chemical drive in sleeping obstructive apnea patients
    Andrea H S Loewen
    Sleep Center, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    Sleep 34:1061-73. 2011
    ..We wished to determine, in obstructive apnea patients, the response of the genioglossus to increasing chemical drive and the contribution of mechanoreceptor feedback to this response...
  11. pmc Determinants of ventilatory instability in obstructive sleep apnea: inherent or acquired?
    Andrea Loewen
    Sleep Center, Foothills Medical Centre, University of Calgary, Calgary, Canada
    Sleep 32:1355-65. 2009
    ..We wished to determine whether these characteristics are inherent or are acquired during untreated OSA...
  12. pmc Systemic vs. central administration of common hypnotics reveals opposing effects on genioglossus muscle activity in rats
    Eileen Park
    Department of Medicine, University of Toronto, Toronto, Canada
    Sleep 31:355-65. 2008
    ..We also determined effects on GG activity with local application to the hypoglossal motor nucleus (HMN)...
  13. pmc Contribution of arousal from sleep to postevent tachycardia in patients with obstructive sleep apnea
    Ali Azarbarzin
    Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, Manitoba, Canada
    Sleep 36:881-9. 2013
    ..Our objective was to determine the contribution of these physiologic responses to postevent tachycardia...
  14. ncbi request reprint Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea
    Magdy Younes
    Department of Medicine, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 168:645-58. 2003
    ..Severity is largely due to factors other than mechanical load. Compensatory effectiveness is impaired in the supine position and in REM sleep, but not by age, sex, or body mass index...
  15. ncbi request reprint Model based analysis of sleep disordered breathing in congestive heart failure
    Zbigniew L Topor
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alta, Canada
    Respir Physiol Neurobiol 155:82-92. 2007
    ..We conclude that development of CSB is the result of a complex interaction between CCR and PCR loops which may, in turn, interact with decreased cardiac output and cardiomegaly...
  16. doi request reprint Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography
    Jaime M Beecroft
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Intensive Care Med 34:2076-83. 2008
    ....
  17. pmc Relationship between arousal intensity and heart rate response to arousal
    Ali Azarbarzin
    YRT Ltd, Winnipeg, Manitoba, Canada
    Sleep 37:645-53. 2014
    ....
  18. pmc Odds ratio product of sleep EEG as a continuous measure of sleep state
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    Sleep 38:641-54. 2015
    ..To develop and validate an algorithm that provides a continuous estimate of sleep depth from the electroencephalogram (EEG)...
  19. pmc Short-term potentiation in the control of pharyngeal muscles in obstructive apnea patients
    Magdy Younes
    Sleep Disorders Centre, Misericordia Health Centre, Winnipeg, Manitoba, Canada Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, Canada
    Sleep 37:1833-49. 2014
    ..To determine if activation of the genioglossus (GG) muscle during obstructive apnea events involves short-term potentiation (STP) and is followed by sustained activation beyond the obstructive phase (after-discharge)...
  20. pmc Staging Sleep in Polysomnograms: Analysis of Inter-Scorer Variability
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    J Clin Sleep Med 12:885-94. 2016
    ..To determine the reasons for inter-scorer variability in sleep staging of polysomnograms (PSGs)...
  21. pmc Arousal Responses during Overnight Polysomnography and their Reproducibility in Healthy Young Adults
    Ali Azarbarzin
    YRT Ltd, Winnipeg, Manitoba, Canada
    Sleep 38:1313-21. 2015
    ..Our objective was to determine the range of these arousal characteristics in healthy young adults and whether they are consistent on repeated testing...
  22. pmc Accuracy of Automatic Polysomnography Scoring Using Frontal Electrodes
    Magdy Younes
    Sleep Disorders Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Sleep Med 12:735-46. 2016
    ..We wished to determine if MSS' accuracy is maintained if frontal derivations are used instead. If confirmed, home sleep monitoring would not require home setup or lengthy manual scoring by technologists...
  23. pmc Enhancements to the multiple sleep latency test
    Sonia Meza-Vargas
    Sleep Disorders Centre, University of Manitoba, Winnipeg, MB, Canada
    Nat Sci Sleep 8:145-58. 2016
    ..0, and 2.5 reflecting very deep sleep, light sleep, and full wakefulness, respectively. We determined the time course of sleep depth during MSLT naps expecting that this would enhance the test's clinical utility...
  24. pmc Minimizing Interrater Variability in Staging Sleep by Use of Computer-Derived Features
    Magdy Younes
    YRT Ltd, Winnipeg, MB, Canada
    J Clin Sleep Med 12:1347-1356. 2016
    ..We hypothesized that providing digitally derived information about these variables to PSG scorers may reduce inter-scorer variability...
  25. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
  26. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
  27. pmc Why does airway pressure rise sometimes near the end of inflation during pressure support?
    Magdy Younes
    Intensive Care Med 34:1-3. 2008
  28. ncbi request reprint Pharyngeal anatomy and severity of obstructive apnea
    Magdy Younes
    Am J Respir Crit Care Med 170:716. 2004
  29. ncbi request reprint Measurement of the CO2 apneic threshold
    Magdy Younes
    Am J Respir Crit Care Med 167:472; author relpy 472-3. 2003