Ming Gao Zhao

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
  2. pmc Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 3:36. 2007
  3. pmc Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 2:29. 2006
  4. pmc Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice
    Ming Gao Zhao
    School of Pharmacy, Fourth Military Medical University, 17 Changle West Road, Xi an 710032, Shaanxi, PR China
    Mol Brain 2:11. 2009
  5. doi request reprint Neuroprotective effects of oxymatrine against excitotoxicity partially through down-regulation of NR2B-containing NMDA receptors
    Kun Zhang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Phytomedicine 20:343-50. 2013
  6. doi request reprint G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors
    Shui Bing Liu
    Department of Pharmacology, School of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    J Neurosci 32:4887-900. 2012
  7. doi request reprint Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress
    Zhen Tian
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an 710032, China
    Psychoneuroendocrinology 38:2218-33. 2013
  8. pmc Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
    Zhao hui Xu
    Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 17 Changle West Road, Xi an, 710032, China
    Mol Neurodegener 7:24. 2012
  9. doi request reprint The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors
    Le Yang
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, PR China
    Toxicol In Vitro 27:908-14. 2013
  10. doi request reprint Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors
    Yu Jiao Li
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, PR China
    Neurotoxicology 34:219-25. 2013

Collaborators

Detail Information

Publications42

  1. pmc Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
    ..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC...
  2. pmc Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 3:36. 2007
    ..Thus, our study suggests that the MAPK signaling pathway is involved in the induction of cingulate LTP and plays a critical role in physiological conditions...
  3. pmc Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 2:29. 2006
    ..GluR5-containing KARs are thus important for spinal sensory transmission/modulation in the spinal cord...
  4. pmc Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice
    Ming Gao Zhao
    School of Pharmacy, Fourth Military Medical University, 17 Changle West Road, Xi an 710032, Shaanxi, PR China
    Mol Brain 2:11. 2009
    ..Our findings provide the first evidence that NMDA NR2B receptors play an important role in experience-dependent synaptic potentiation within the ACC in wild mice as previously reported in laboratory mice...
  5. doi request reprint Neuroprotective effects of oxymatrine against excitotoxicity partially through down-regulation of NR2B-containing NMDA receptors
    Kun Zhang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Phytomedicine 20:343-50. 2013
    ..Our results provide new insights into the development of natural therapeutic anti-oxidants against ischemia...
  6. doi request reprint G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors
    Shui Bing Liu
    Department of Pharmacology, School of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    J Neurosci 32:4887-900. 2012
    ..The modulation of DAPK1 activity by GPR30 may be an important mediator of estradiol-dependent neuroprotection...
  7. doi request reprint Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress
    Zhen Tian
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an 710032, China
    Psychoneuroendocrinology 38:2218-33. 2013
    ....
  8. pmc Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
    Zhao hui Xu
    Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 17 Changle West Road, Xi an, 710032, China
    Mol Neurodegener 7:24. 2012
    ..However, the contribution of Grp1 mGluR to the facilitation of synaptic plasticity by D1 receptor stimulation in the prefrontal cortex has been less extensively studied...
  9. doi request reprint The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors
    Le Yang
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, PR China
    Toxicol In Vitro 27:908-14. 2013
    ..These findings suggest that Pra-C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family...
  10. doi request reprint Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors
    Yu Jiao Li
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, PR China
    Neurotoxicology 34:219-25. 2013
    ..These findings suggest that CYT protects cortical neurons, at least partially, by inhibiting the level of GluN2B-containing NMDA receptors and regulating Bcl-2 family...
  11. ncbi request reprint Anti-apoptotic effects of hyperoside via inhibition of NR2B-containing NMDA receptors
    Xiao nan Zhang
    Department of Pharmacology, School of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi an 710032, China
    Pharmacol Rep 62:949-55. 2010
    ..Our results demonstrate that the neuroprotective effect of Hyp owes, at least partially, to its differential modulation of NR2A- and NR2B-containing NMDA receptors...
  12. doi request reprint Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro
    Tian Yao Shi
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Neurotox Res 21:358-67. 2012
    ..This gives a new insight into the development of therapeutic natural antioxidants against oxidative stress...
  13. doi request reprint Anxiolytic actions of motilin in the basolateral amygdala
    Bin Feng
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an 710032, China
    Mol Neurobiol 47:892-902. 2013
    ..The present data demonstrate the importance of motilin in anxiety and the development of motilin receptor non-peptide agonist as a clear target for the potential treatment of anxiety disorders...
  14. pmc Excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome
    Qi Yang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    PLoS Genet 8:e1003172. 2012
    ..This study indicates that excessive NT-3 from astrocytes contributes to the abnormal neuronal dendritic development and that astrocytes could be a potential therapeutic target for FXS...
  15. pmc Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome
    Zhao hui Xu
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    PLoS ONE 7:e48741. 2012
    ..These findings suggested that FMRP was involved in serotonin receptor signaling and contributed in GluR1 surface expression induced by 5-HT2AR inactivation...
  16. doi request reprint Neuroprotective effects of curculigoside against NMDA-induced neuronal excitoxicity in vitro
    Zhen Tian
    Department of Pharmacology, School of Pharmacy and Fourth Military Medical University, Xi an 710032, Shaanxi, China
    Food Chem Toxicol 50:4010-5. 2012
    ..These findings give a new insight into the development of natural anti-excitotoxicity agents...
  17. doi request reprint Increased coupling of caveolin-1 and estrogen receptor α contributes to the fragile X syndrome
    Qi Yang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    Ann Neurol 77:618-36. 2015
    ..Interaction between estrogen receptor (ER) and lipid raft caveolae is critical for the estrogen signaling. Here, we tested the hypothesis that impaired ER-caveolae coupling contributes to the mental retardation of FXS...
  18. pmc A role of periaqueductal grey NR2B-containing NMDA receptor in mediating persistent inflammatory pain
    Jing Hu
    School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Mol Pain 5:71. 2009
    ..Our findings provide strong evidence that up-regulation of NR2B-containing NMDA receptors in the PAG involves in the modulation to the peripheral persistent inflammatory pain...
  19. ncbi request reprint Sinomenine attenuates chronic inflammatory pain in mice
    Shuo Li
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, 710032, China
    Metab Brain Dis . 2016
    ..In conclusion, results indicated that sinomenine reduced the chronic inflammatory pain induced by CFA, at least partially by regulating the GluN2B receptors and mTOR signals in the ACC...
  20. doi request reprint Neuroprotective effects of a novel translocator protein (18 kDa) ligand, ZBD-2, against focal cerebral ischemia and NMDA-induced neurotoxicity
    Xu bo Li
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    Clin Exp Pharmacol Physiol 42:1068-74. 2015
    ..These findings provide direct evidence that neuroprotection by ZBD-2 is partially mediated by inhibiting GluN2B-containing NMDA receptor-mediated excitotoxicity. ..
  21. doi request reprint Activation of GPR30 attenuates chronic pain-related anxiety in ovariectomized mice
    Shui Bing Liu
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an 710032, China
    Psychoneuroendocrinology 53:94-107. 2015
    ..The anxiolytic effects of GPR30 were partially due to maintaining the balance between excitatory and inhibitory transmissions in the BLA. ..
  22. doi request reprint Neuroprotective effects of daphnetin against NMDA receptor-mediated excitotoxicity
    Le Yang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Molecules 19:14542-55. 2014
    ..The findings suggest that Dap prevents the excitotoxicity through inhibiting the NR2B-containing NMDA receptors and the subsequent calcium overload in cultured cortical neurons. ..
  23. doi request reprint Neuroprotective effects of formononetin against NMDA-induced apoptosis in cortical neurons
    Zhen Tian
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, 710032, China
    Phytother Res 27:1770-5. 2013
    ..These findings demonstrate that FMNT is capable of protecting neurons from NMDA-evoked excitotoxic injury and has a potential perspective to the clinical treatment for neurodegenerative disorders in central nervous system...
  24. doi request reprint Anxiolytic effects of sesamin in mice with chronic inflammatory pain
    Hong Liang Guo
    a Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Nutr Neurosci 19:231-6. 2016
    ..However, little is known about the role of sesamin in the development of emotional disorders. Here we investigated persistent inflammatory pain hypersensitivity and anxiety-like behaviors in the mouse suffering chronic pain...
  25. doi request reprint Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death
    Xin Shang Wang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, 710032, China
    Phytother Res 30:386-96. 2016
    ..Furthermore, gastrodin blocked the down-regulation of glutamine synthetase induced by LPS exposure in astrocytes. Our results suggest that gastrodin can be used as a preventive agent for the excessive autophagy induced by LPS...
  26. pmc A new chiral pyrrolyl α-nitronyl nitroxide radical attenuates β-amyloid deposition and rescues memory deficits in a mouse model of Alzheimer disease
    Tian Yao Shi
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, 710032, China
    Neurotherapeutics 10:340-53. 2013
    ..These results proved that the newly synthesized L-NNNBP was an effective therapeutic agent for the prevention and treatment of AD...
  27. pmc Analgesic effects of NB001 on mouse models of arthralgia
    Zhen Tian
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, 710032, China
    Mol Brain 8:60. 2015
    ..Results indicated that NB001 exhibited an analgesic effect on the animal models of arthritis but was not caused by anti-inflammatory activities...
  28. pmc Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala
    Yan Yan Guo
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    J Physiol 590:875-86. 2012
    ..These data demonstrate, for the first time, that restraint stress-induced anxiety-like behaviour could at least partly be explained by alterations in the functional BKCa channels in the LA...
  29. doi request reprint Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons
    Le Yang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, 710032, China
    Mol Cell Biochem 386:251-8. 2014
    ..The neuroprotective effects of Vit are related to inhibiting the activities of NR2B-containing NMDA receptors and reducing the calcium influx in cultured cortical neurons...
  30. doi request reprint Blocking α4β2 and α7 nicotinic acetylcholine receptors inhibits the reinstatement of morphine-induced CPP by drug priming in mice
    Bin Feng
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Behav Brain Res 220:100-5. 2011
    ..The data suggest that specific nAChR subtypes, i.e., α(4)β(2) and α(7), may contribute to the reinstatement of morphine-induced CPP by drug priming in mice...
  31. pmc Cytisine, a Partial Agonist of α4β2 Nicotinic Acetylcholine Receptors, Reduced Unpredictable Chronic Mild Stress-Induced Depression-Like Behaviors
    Jing Han
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an 710032, China
    Biomol Ther (Seoul) 24:291-7. 2016
    ..CYT significantly reversed the decreases of 5-HT1A, BDNF, and mTOR levels in the hippocampus and amygdala. These results imply that CYT may act as a potential anti-depressant in the animals under chronic stress. ..
  32. doi request reprint Neuroprotective effect of estrogen: role of nonsynaptic NR2B-containing NMDA receptors
    Shui Bing Liu
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    Brain Res Bull 93:27-31. 2013
    ..This article is part of a Special Issue entitled 'Extrasynaptic ionotropic receptors'...
  33. doi request reprint Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled receptor 30 receptor
    Shui Bing Liu
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    Clin Exp Pharmacol Physiol 38:577-85. 2011
    ..In addition, the anti-apoptotic activity of GPR30 was dependent on the expression of Bcl-2 and pro-caspase-3. GPR30 might be a potential therapeutic target for neuroprotection and oxidative stress...
  34. doi request reprint Gastrodin relieved complete Freund's adjuvant-induced spontaneous pain by inhibiting inflammatory response
    Ting Sun
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, P R China Department of Natural Medicine, Institute of Materia Medica, School of Pharmacy, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, P R China
    Int Immunopharmacol 41:66-73. 2016
    ....
  35. doi request reprint Effect of Praeruptorin C on 3-nitropropionic acid induced Huntington's disease-like symptoms in mice
    Lu Wang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, 710032 Xi an, China
    Biomed Pharmacother 86:81-87. 2016
    ..These results taken together suggest that Pra-C may have therapeutic potential with respect to the movement, psychiatric, and cognitive symptoms of HD...
  36. pmc Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus
    Zi Lin Li
    Department of Cardiovascular Surgery, Xijing Hospital, School of Pharmacy, Fourth Military Medical University, Xi an, China
    PLoS ONE 7:e38787. 2012
    ..These findings provide preliminary evidence that GPR30 activation leads to eNOS activation, as well as vasodilation, to a certain degree and has beneficial effects on vascular function in diabetic OVX rats...
  37. doi request reprint Protective effects of hyperoside against human umbilical vein endothelial cell damage induced by hydrogen peroxide
    Zi Lin Li
    Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Ethnopharmacol 139:388-94. 2012
    ..This study investigated the action of Hyp in an endothelial injury model induced by hydrogen peroxide (H(2)O(2)), as well as its possible mechanisms...
  38. pmc Corosolic acid inhibits the proliferation of glomerular mesangial cells and protects against diabetic renal damage
    Xiao Qiang Li
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Sci Rep 6:26854. 2016
    ..These findings suggest that CA exert the protective effect on DN by anti-proliferation resulted from inhibition of p38 MAPK- and NADPH-mediated inactivation of ERK1/2. ..
  39. pmc Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats
    Ya Ting Deng
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    PLoS ONE 10:e0136572. 2015
    ..In conclusion, EA could prevent reduction of bone mass and strength and improve the cancellous bone structure and biochemical properties in OVX rats. Hence, EA may serve as a new candidate or a leading compound for anti-osteoporosis. ..
  40. doi request reprint Potential pharmacological treatment of fragile X syndrome during adulthood
    Zhao hui Xu
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Neurosci Bull 25:296-300. 2009
    ..Here we outline our recent studies and initial clinical trials that may provide an approach to treat FXS in the adulthood...
  41. doi request reprint Neuroprotective effects of hydroxysafflor yellow A against excitotoxic neuronal death partially through down-regulation of NR2B-containing NMDA receptors
    Q Yang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an, China
    Neurochem Res 35:1353-60. 2010
    ..These finding suggest that HSYA protects cortical neurons, at least partially, from inhibiting the expression NR2B-containing NMDA receptors and by regulating Bcl-2 family...
  42. ncbi request reprint TNF-alpha involves in altered prefrontal synaptic transmission in mice with persistent inflammatory pain
    Dong Jia
    Department of Neurosurgery, Tangdu Hospital, and Department of Pharmacology, Fourth Military Medical University, Xi an 710032, China
    Neurosci Lett 415:1-5. 2007
    ..Our findings provide evidence that presynaptic alterations caused by peripheral inflammation is partly attributable to the up-regulation of TNF-alpha in the ACC...