Haibo Zhang

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Is there a place for N-acetylcysteine in the treatment of septic shock?
    Lorenzo Del Sorbo
    Department of Anaesthesia and Department of Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care 8:93-5. 2004
  2. pmc High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study
    Jan Willem Kuiper
    From the Department of Paediatric Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Anesthesiol 11:26. 2011
  3. pmc Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 10:6. 2010
  4. ncbi request reprint Effects of albumin and Ringer's lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats
    Haibo Zhang
    Department of Anaesthesia, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, Canada
    Crit Care Med 31:1515-22. 2003
  5. ncbi request reprint Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants
    H Zhang
    Division of Respiratory Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Toronto, Ontario, Canad
    Am J Respir Crit Care Med 160:1703-10. 1999
  6. ncbi request reprint Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion
    H Zhang
    Departments of Anaesthesia and Critical Care Medicine, St Michael s Hospital, Toronto M5B 1W8, Ontario M5G 2C4, Canada
    Am J Physiol Lung Cell Mol Physiol 280:L947-54. 2001
  7. ncbi request reprint Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats
    Ettore Crimi
    Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 174:178-86. 2006
  8. pmc Activating transcription factor 3 confers protection against ventilator-induced lung injury
    Ali Akram
    Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 182:489-500. 2010
  9. doi request reprint Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury
    Lukas Brander
    Interdepartmental Division of Critical Care Medicine, Department of Critical Care Medicine, University of Toronto, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
    Intensive Care Med 35:1979-89. 2009
  10. ncbi request reprint Intercellular adhesion molecule-1 mediates cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization
    Jin Hwa Lee
    Departments of Anaesthesia and Critical Care Medicine, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    J Immunol 172:608-16. 2004

Collaborators

Detail Information

Publications69

  1. pmc Is there a place for N-acetylcysteine in the treatment of septic shock?
    Lorenzo Del Sorbo
    Department of Anaesthesia and Department of Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care 8:93-5. 2004
    ..These clinical observations may lead us to examine further the role of antioxidant agents in developing novel therapies for septic shock...
  2. pmc High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study
    Jan Willem Kuiper
    From the Department of Paediatric Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Anesthesiol 11:26. 2011
    ..To examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses...
  3. pmc Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients
    Rogier M Determann
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 10:6. 2010
    ..In the present study we investigated whether plasma levels of lung-specific biological markers can be used to evaluate lung injury in patients with ALI/ARDS and patients without lung injury at onset of mechanical ventilation...
  4. ncbi request reprint Effects of albumin and Ringer's lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats
    Haibo Zhang
    Department of Anaesthesia, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, Canada
    Crit Care Med 31:1515-22. 2003
    ..We tested the hypothesis that the types of fluids used during early resuscitation have an important effect on the evolution of lung injury...
  5. ncbi request reprint Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants
    H Zhang
    Division of Respiratory Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Toronto, Ontario, Canad
    Am J Respir Crit Care Med 160:1703-10. 1999
    ....
  6. ncbi request reprint Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion
    H Zhang
    Departments of Anaesthesia and Critical Care Medicine, St Michael s Hospital, Toronto M5B 1W8, Ontario M5G 2C4, Canada
    Am J Physiol Lung Cell Mol Physiol 280:L947-54. 2001
    ....
  7. ncbi request reprint Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats
    Ettore Crimi
    Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 174:178-86. 2006
    ..Hypothesis: HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury...
  8. pmc Activating transcription factor 3 confers protection against ventilator-induced lung injury
    Ali Akram
    Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 182:489-500. 2010
    ..Understanding the molecular basis for response to cyclic stretch (CS) and its derangement during high-volume ventilation is of high priority...
  9. doi request reprint Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury
    Lukas Brander
    Interdepartmental Division of Critical Care Medicine, Department of Critical Care Medicine, University of Toronto, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
    Intensive Care Med 35:1979-89. 2009
    ....
  10. ncbi request reprint Intercellular adhesion molecule-1 mediates cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization
    Jin Hwa Lee
    Departments of Anaesthesia and Critical Care Medicine, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    J Immunol 172:608-16. 2004
    ..This may provide an explanation for the failure of anti-LPS therapies in sepsis trials...
  11. ncbi request reprint Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes
    Rosanna Vaschetto
    Department of Anaesthesia, University of Toronto, St Michael s Hospital, Room 7 007, Queen Wing, 30 Bond St, Toronto, ON M5B 1W8, Canada
    J Leukoc Biol 81:1022-31. 2007
    ..We conclude that HNP play an important role in linking innate to acquired immunity by activation of costimulatory molecules in lung epithelial cells and CD4+ lymphocytes...
  12. pmc Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates ventilator-induced lung injury
    Rosanna Vaschetto
    The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 108:261-8. 2008
    ..Therefore, the authors hypothesized that the pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase by PJ-34 would attenuate ventilator-induced lung injury...
  13. doi request reprint Cerebral cortical gene expression in acutely anemic rats: a microarray analysis
    Francoise Briet
    Department of Anaesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Can J Anaesth 56:921-34. 2009
    ..This study assesses whether hemodilutional anemia up-regulated inflammatory cerebral gene expression (microarray) to help define the mechanism...
  14. doi request reprint Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury
    Bing Han
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Intensive Care Med 37:334-42. 2011
    ..However, the role of PTX3 in the pathogenesis of ALI is not fully understood. We hypothesized that PTX3, as an important immune modulator, may determine the severity of ALI...
  15. pmc Differential signaling mechanisms of HNP-induced IL-8 production in human lung epithelial cells and monocytes
    Farisa Syeda
    The Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ont, Canada
    J Cell Physiol 214:820-7. 2008
    ..We conclude that the activation of ERK1/2 and PI3K/Akt pathways is required for HNP-induced IL-8 release which occurs in a Src-independent manner in lung epithelial cells, while is Src-dependent in monocytes...
  16. ncbi request reprint Effect of mechanical ventilation on cytokine response to intratracheal lipopolysaccharide
    Thomas C Whitehead
    Departments of Anesthesia and Critical Care Medicine, St Michael s Hospital, University of Toronto, Canada
    Anesthesiology 101:52-8. 2004
    ..The authors tested the hypothesis that intratracheal lipopolysaccharide amplifies the cytokine response to mechanical ventilation...
  17. pmc Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury
    Spyridon Fortis
    Keenan Research Center, Li Ka Shing Knowledge Institute of St Michael s Hospital, University of Toronto, Room 619 LKSKI, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Intensive Care Med 38:1548-55. 2012
    ..We hypothesized that the volatile anesthetic sevoflurane (SEVO) attenuates lung inflammation through activation of lung epithelial GABA(A) receptors...
  18. pmc Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition
    Nuria E Cabrera-Benítez
    Keenan Research Center at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Canada
    Crit Care Med 40:510-7. 2012
    ..g., damage the alveolar epithelium, biotrauma). The objective of this study was t test the hypothesis that mechanical ventilation plays an important role in the pathogenesis of lung fibrosis...
  19. ncbi request reprint Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDS
    Haibo Zhang
    Department of Anaesthesia and Critical Care Program, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesthesiology 97:1426-33. 2002
    ....
  20. pmc Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome
    Nuria E Cabrera-Benítez
    From the Keenan Research Centre in Biomedical Science, St Michael s Hospital, Toronto, Ontario, Canada N E C B, J G L, J V, H Z, A S S CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain N E C B, J V Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Spain N E C B, J V Departments of Anesthesia and Physiology, University of Toronto, Toronto, Ontario, Canada J G L, H Z Department of Medicine, Unit of Anesthesiology and Intensive Care, Medical School, University of Padua, Azienda Ospedaliera di Padova, Padua, Italy M P Department of Anesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany P M S and Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada H Z, A S S
    Anesthesiology 121:189-98. 2014
    ..The authors critically appraise possible mechanisms underlying the mechanical stress-induced lung fibrosis and highlight potential therapeutic strategies to mitigate this fibrosis. ..
  21. pmc Circadian rhythms: from basic mechanisms to the intensive care unit
    Ming Cheng Chan
    Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care Med 40:246-53. 2012
    ....
  22. pmc Bench-to-bedside review: Biotrauma and modulation of the innate immune response
    Claudia C dos Santos
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care 9:280-6. 2005
    ..In this paper, we explore the pertinent evidence implicating biotrauma caused by cyclic MV and its effect on innate immune responses...
  23. pmc Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs
    Stefanos Voglis
    The Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 180:159-66. 2009
    ..The mechanisms remain unknown...
  24. pmc Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases
    Kieran Quinn
    The Keenan Research Centre in the Li Ka Shing Knowledge Institute of Saint Michael s Hospital, Toronto, ON, Canada
    Am J Physiol Heart Circ Physiol 295:H1817-24. 2008
    ....
  25. ncbi request reprint Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway
    Aye Aye Khine
    Department of Anaesthesia, St Michael s Hospital, Rm 7 007, Queen Wing, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    Blood 107:2936-42. 2006
    ..Transfection of lung epithelial cells with antisense oligonucleotides targeting specific purinergic P2Y receptors revealed that the P2Y6 (ligand of UDP) signaling pathway plays a predominant role in mediating HNP-induced IL-8 production...
  26. ncbi request reprint Ventilation with negative airway pressure induces a cytokine response in isolated mouse lung
    Kuo Chen Cheng
    Departments of Anaesthesia and Critical Care Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 94:1577-82, table of contents. 2002
    ..Atelectatic lung during repeated collapse and reopening of lung units accentuates the lung cytokine response that may contribute to lung injury even during relatively low VT mechanical ventilation...
  27. ncbi request reprint Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia--a review
    Marcus J Schultz
    Department of Intensive Care Medicine, University of Amsterdam, Netherlands, and the Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, ON, Canada
    Crit Care Med 34:871-7. 2006
    ..To review the involvement of coagulation and fibrinolysis in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pulmonary infection, and ventilator-induced lung injury (VILI)...
  28. doi request reprint Differential gene profiling in acute lung injury identifies injury-specific gene expression
    Claudia C dos Santos
    Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Crit Care Med 36:855-65. 2008
    ..Physiologic and morphologic manifestations of disparate forms of injury are often indistinguishable. We sought to demonstrate that acute lung injury resulting from distinct insults may lead to different gene expression profiles...
  29. pmc Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation
    Kieran L Quinn
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 31:2070-9. 2011
    ..Human neutrophil peptides (HNPs) released from activated neutrophils exert immune modulating properties. We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis...
  30. ncbi request reprint Effects of alpha - and beta -adrenergic stimulation on hepatosplanchnic perfusion and oxygen extraction in endotoxic shock
    H Zhang
    Division of Respiratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Crit Care Med 29:581-8. 2001
    ..In addition, alpha-adrenergic stimulation can increase tumor necrosis factor levels...
  31. ncbi request reprint Modulation of bacterial growth by tumor necrosis factor-alpha in vitro and in vivo
    Jin Hwa Lee
    Department of Anaesthesia, St Michael s Hospital, Toronto, ON, M5B 1W8 Canada
    Am J Respir Crit Care Med 168:1462-70. 2003
    ..coli growth in vitro and in vivo. However, in vivo, this effect becomes only apparent in neutropenic animals. The relevance of these findings for immune compromised patients remains to be investigated...
  32. pmc The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis
    Weijuan Shao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Diabetes 62:789-800. 2013
    ....
  33. ncbi request reprint XB130, a novel adaptor protein for signal transduction
    Jing Xu
    Division of Cellular and Molecular Biology, University Health Network Toronto General Research Institute, and Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 282:16401-12. 2007
    ..These data suggest that XB130 as an adaptor may play an important role in the regulation of signal transduction and cellular functions...
  34. pmc From bench to bedside: bacterial growth and cytokines
    Claudia C dos Santos
    University of Toronto, Ontario, Canada
    Crit Care 6:4-6. 2002
  35. doi request reprint Ventilator-induced coagulopathy in experimental Streptococcus pneumoniae pneumonia
    J J Haitsma
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Queen Wing 4 042, Toronto, ON, M5B 1W8 Canada
    Eur Respir J 32:1599-606. 2008
    ..Mechanical ventilation causing ventilator-induced lung injury increases pulmonary coagulopathy in an animal model of Streptococcus pneumoniae pneumonia and results in systemic coagulopathy...
  36. ncbi request reprint Direct and indirect bacterial killing functions of neutrophil defensins in lung explants
    G A Porro
    Respiratory Division, Department of Anaesthesia, St. Michael's Hospital, Toronto M5B 1W8, Canada
    Am J Physiol Lung Cell Mol Physiol 281:L1240-7. 2001
    ..We conclude that defensins exert a significant antimicrobial effect under physiological conditions and that this effect is enhanced in the presence of lung tissue by a mechanism that involves the production of reactive oxygen species...
  37. doi request reprint Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1
    Vito Fanelli
    From the Department of Anesthesia and Critical Care, University of Turin, AOU Città della Salute e della Scienza di Torino Ospedale Molinette, Torino, Italy V F, V M R Critical Care Program, The Keenan Research Centre for Biomedical Science of St Michael s Hospital, Toronto, Ontario, Canada Y M, M G, B S, J B, H Z, A S S Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy P C Department of Pathology, AOU Città della Salute e della Scienza di Torino Ospedale Molinette, Torino, Italy L D Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada H Z, A S S and Departments of Anesthesia and Physiology, University of Toronto, Toronto, Ontario, Canada H Z
    Anesthesiology 124:132-40. 2016
    ..Thus, the author hypothesized that the use of NMBA mitigates lung injury by improving ventilator synchrony and decreasing inflammatory responses...
  38. pmc Host immune response in returning travellers infected with malaria
    Gregory Macmullin
    Public Health Ontario, Toronto, ON, Canada
    Malar J 11:148. 2012
    ..A more detailed understanding of the profiles of cytokines, chemokines, and endothelial activation may be useful in developing biomarkers and novel therapeutic approaches for malaria...
  39. pmc Year in review 2008: Critical Care--respirology
    Haibo Zhang
    Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Bond Street, Toronto, ON, Canada
    Crit Care 13:225. 2009
    ....
  40. doi request reprint Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1
    Dingyan Wang
    St Michael s Hospital, 30 Bond St, Queen Wing, Rm 8 019, Toronto, ON, Canada M5B 1W8
    FASEB J 24:947-56. 2010
    ..Wang, D., Stewart, A. K., Zhuang, L., Zhu, Y., Wang, Y., Shi, C., Keating, A., Slutsky, A., Zhang, H., Wen, X.-Y. Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1...
  41. pmc Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality
    Hwee Teoh
    Div of Cardiovascular and Thoracic Surgery, St Michael s Hospital, Toronto, ON, Canada M5B 1W8
    Am J Physiol Endocrinol Metab 295:E658-64. 2008
    ..These data suggest a critical role of adiponectin as a modulator of survival and endothelial inflammation in experimental sepsis and a potential mechanistic link between adiposity and increased sepsis...
  42. doi request reprint A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution
    Anya T McLaren
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 56:502-9. 2009
    ..This study assessed the effects of acute hemodilution on inducible NOS (iNOS) and systemic inflammatory cytokines...
  43. ncbi request reprint Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 124:1137-44. 2002
    ..This study was undertaken to examine the effect of 2 ventilatory strategies on the development of ischemia-reperfusion injury after lung transplantation...
  44. doi request reprint Acute lung injury: a yellow card for engineered nanoparticles?
    Mingyao Liu
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    J Mol Cell Biol 1:6-7. 2009
    ..To translate nanotechnology into nanomedicine, it is important to understand any potential mechanisms of toxicity caused by nanomaterials, and to design approaches to mitigate any detrimental effects...
  45. doi request reprint Biotrauma and Ventilator-Induced Lung Injury: Clinical Implications
    Gerard F Curley
    Department of Anesthesia, St Michael s Hospital, and the Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science of St Michael s Hospital, Toronto, Ontario, Canada Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
    Chest 150:1109-1117. 2016
    ..We will assess evidence that ventilatory and other "adjunctive" strategies that decrease biotrauma offer great potential to minimize the adverse consequences of VILI and to improve the outcomes of patients with respiratory failure...
  46. pmc The Tie2-agonist Vasculotide rescues mice from influenza virus infection
    Michael G Sugiyama
    1 Keenan Research Centre for Biomedical Science, St Michael s Hospital, Toronto, ON 2 Department of Laboratory Medicine and Pathobiology, University of Toronto
    Sci Rep 5:11030. 2015
    ..Thus, Vasculotide may represent a novel and practical therapy for severe infections with influenza. ..
  47. pmc Monocyte interaction accelerates HCl-induced lung epithelial remodeling
    Qiuhua Chen
    Keenan Research Center for Biomedical Science of St, Michael s Hospital, Toronto, Ontario, Canada
    BMC Pulm Med 14:135. 2014
    ..We hypothesized that leukocyte infiltration during the inflammatory response modulates epithelial remodeling through a mechanism of epithelial-mesenchymal transition (EMT)...
  48. pmc GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes
    Nepton Soltani
    Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada M5B 1W8
    Proc Natl Acad Sci U S A 108:11692-7. 2011
    ..The β-cell regenerative and immunoinhibitory effects of GABA provide insights into the role of GABA in regulating islet cell function and glucose homeostasis, which may find clinical application...
  49. doi request reprint Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury
    S C Ko
    The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    Acta Anaesthesiol Scand 52:514-21. 2008
    ..Different levels of positive end-expiratory pressure (PEEP) with and without a recruitment maneuver (RM) may have a significant impact on ventilator-induced lung injury but this issue has not been well addressed...
  50. ncbi request reprint Pressure-time curve predicts minimally injurious ventilatory strategy in an isolated rat lung model
    V M Ranieri
    Division of Respiratory Medicine, Samuel Lunenfeld Research Institute, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 93:1320-8. 2000
    ..We tested the hypothesis that the pressure-time (P-t) curve during constant flow ventilation can be used to set a noninjurious ventilatory strategy...
  51. pmc Ventilator-induced lung injury. Similarity and differences between children and adults
    Martin C J Kneyber
    1 Keenan Research Centre for Biomedical Science of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 190:258-65. 2014
    ..This Critical Care Perspective analyzes the relevance of VILI to the pediatric population, and addresses why pediatric patients might be less susceptible than adults to VILI. ..
  52. doi request reprint α1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death
    Wenxi Gao
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 33:309-15. 2014
    ..On the basis of a literature review, we hypothesize that A1AT may have the potential to reduce IR-induced lung injury through its anti-inflammatory and anti-apoptotic effects...
  53. pmc Intensive care unit-acquired bacteremia in mechanically ventilated patients: clinical features and outcomes
    Hsin Kuo Ko
    Institute of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan, ROC Department of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, Taiwan, ROC The Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e83298. 2013
    ..The clinical features related to IAB and clinical characteristics of IAB based on specific bacterial species identified in our study may be utilized to refine the management of IAB. ..
  54. doi request reprint The effects of chemotherapy on cognitive function in a mouse model: a prospective study
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Ontario, Canada
    Clin Cancer Res 18:3112-21. 2012
    ..The present study used a prospective longitudinal design to assess short- and long-term effects of commonly used anticancer drugs on cognitive performance in a mouse model...
  55. pmc Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysis
    Karen E A Burns
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    PLoS ONE 6:e14623. 2011
    ..We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing pressure and volume-limited (PVL) ventilation strategies with more traditional mechanical ventilation in adults with ALI and ARDS...
  56. doi request reprint Cytokines and their relationship to the symptoms and outcome of cancer
    Bostjan Seruga
    Division of Medical Oncology, Princess Margaret Hospital, St Michael s Hospital, University of Toronto, Toronto, Canada
    Nat Rev Cancer 8:887-99. 2008
    ..However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis...
  57. ncbi request reprint Bradyrhizobium japonicum mutants with enhanced sensitivity to genistein resulting in altered nod gene regulation
    H Ip
    Department of Biology, University of Waterloo, Ontario, Canada
    Mol Plant Microbe Interact 14:1404-10. 2001
    ..Some of these strains may be useful in mitigating the low root zone temperature-associated delay in soybean nodulation at the northern extent of soybean cultivation...
  58. pmc Tumor necrosis factor receptor p55-deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance
    Y X Zhao
    Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Infect Immun 68:1243-51. 2000
    ....
  59. ncbi request reprint Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats
    Pradip P Kamat
    Atlanta Veterans Administration Medical Center and the Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 29:1457-65. 2005
    ....
  60. ncbi request reprint Autologous lung used as a substitute of oxygenator in cardiopulmonary bypass can preserve postoperative respiratory function
    Huimin Huang
    Department of Cardiothoracic Surgery, Shanghai Children s Medical Center, Xinhua Hospital, Medical College, Shanghai Jiaotong University, Shanghai, China
    ASAIO J 53:456-9. 2007
    ..Autologous lung may tolerate nonpulsatile perfusion and be used clinically as a substitute for the artificial oxygenator to reduce lung injury after CPB...
  61. ncbi request reprint Mechanical ventilation may increase susceptibility to the development of bacteremia
    Chang Yi Lin
    Department of Medicine, Mackay Memorial Hospital, Taiwan
    Crit Care Med 31:1429-34. 2003
    ..We examined the hypothesis that mechanical ventilation with a potentially injurious strategy would predispose animals to the detrimental effects of subsequent instillation of bacteria...
  62. doi request reprint Year in review in Intensive Care Medicine, 2007. II. Haemodynamics, pneumonia, infections and sepsis, invasive and non-invasive mechanical ventilation, acute respiratory distress syndrome
    Massimo Antonelli
    Department of Intensive Care and Anaesthesiology, Policlinico Universitario A Gemelli, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Intensive Care Med 34:405-22. 2008
  63. pmc Functional cloning, sorting, and expression profiling of nucleic acid-binding proteins
    Y Ramanathan
    Center for Applied Genomics, Public Health Research Institute, International Center for Public Health W420M, Newark, New Jersey 07103, USA
    Genome Res 12:1175-84. 2002
    ....
  64. ncbi request reprint Hemodynamic effects of glibenclamide during endotoxemia: contrasting findings in vitro versus in vivo
    Jean Charles Preiser
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Shock 19:223-8. 2003
    ..As different effects of glibenclamide were observed in vivo, the importance of the opening of KATP channels in endotoxic shock may be limited...
  65. ncbi request reprint Comparison of polyacrylonitrile (AN69) and polysulphone membrane during hemofiltration in canine endotoxic shock
    Peter Rogiers
    Department of Intensive Care, Middelheim General Hospital, Antwerp, Belgium
    Crit Care Med 31:1219-25. 2003
    ....
  66. pmc Biased alternative polyadenylation in human tissues
    Haibo Zhang
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07101 1709, USA
    Genome Biol 6:R100. 2005
    ..Previous studies of individual genes have indicated that alternative polyadenylation could occur in a tissue-specific manner...
  67. ncbi request reprint Role of oxidative stress in experimental sepsis and multisystem organ dysfunction
    Ettore Crimi
    Department of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara, Italy
    Free Radic Res 40:665-72. 2006
    ..Based on this experimental evidence, we could improve the rationale of supplementation of antioxidants alone or in combination with standard therapies aimed to reduce oxidative stress as novel adjunct treatment in critical care...
  68. pmc Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology
    Massimo Antonelli
    Universita Cattolica del Sacro Cuore, Department of Intensive Care and Anesthesiology, Policlinico Universitario A Gemelli, Largo A Gemelli, 8, 00168 Rome, Italy
    Intensive Care Med 34:229-42. 2008
  69. ncbi request reprint 3D computerized segmentation of lung volume with computed tomography
    Xuejun Sun
    MRC231D, CANCONT, H Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, College of Medicine, University of South Florida, Tampa, 33612 9497, USA
    Acad Radiol 13:670-7. 2006
    ..In addition, this approach can be integrated into a picture archiving and communication system serving as a visualization tool for radiologists' reading and interpretation...