Eytan Wine

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. doi request reprint Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis
    Eytan Wine
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Electronic address
    J Crohns Colitis 7:916-22. 2013
  2. pmc Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Microbiol 9:180. 2009
  3. pmc Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions
    Eytan Wine
    Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 177:1320-32. 2010
  4. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
  5. doi request reprint Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    FEMS Microbiol Lett 300:146-52. 2009
  6. pmc A balanced IL-1β activity is required for host response to Citrobacter rodentium infection
    Misagh Alipour
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e80656. 2013
  7. pmc The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury
    Marilyn Gordon
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e75483. 2013
  8. ncbi request reprint Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
  9. doi request reprint Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells
    Juan C Ossa
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 15:446-57. 2013
  10. doi request reprint Bacterial infections: new and emerging enteric pathogens
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 26:1-4. 2010

Collaborators

Detail Information

Publications23

  1. doi request reprint Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis
    Eytan Wine
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Electronic address
    J Crohns Colitis 7:916-22. 2013
    ..Predicting response to IVCS to initiate early salvage therapy remains challenging. The aim of this study was to evaluate the role of serum inflammatory cytokines in ASC and determine their predictive utility with IVCS treatment failure...
  2. pmc Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Microbiol 9:180. 2009
    ..Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial monolayers as a contributor to intestinal injury in IBD...
  3. pmc Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions
    Eytan Wine
    Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 177:1320-32. 2010
    ..rodentium infection, indicating that OPN impacts disease pathogenesis through bacterial attachment and altered host immune responses...
  4. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
    ..Whether intestinal events, such as enteric bacterial infections and bacterial colonisation, exert a reciprocal effect on stress-associated behaviour is not well established...
  5. doi request reprint Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    FEMS Microbiol Lett 300:146-52. 2009
    ..The data support the concept of probiotic strain selectivity, which is dependent on the setting in which it is being evaluated and tested...
  6. pmc A balanced IL-1β activity is required for host response to Citrobacter rodentium infection
    Misagh Alipour
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e80656. 2013
    ..Together, these findings highlight the importance of balanced cytokine responses as IL-1β improved bacterial clearance in Nlrp3(-/-) mice but increased tissue damage when given to WT mice. ..
  7. pmc The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury
    Marilyn Gordon
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e75483. 2013
    ..Failure to restrict NFκB resulted in the inflammation-induced DNA damage driven tyrosine phosphorylation of YAP, subsequent p53 accumulation and loss of intestinal epithelial homeostasis. ..
  8. ncbi request reprint Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
    ..We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis...
  9. doi request reprint Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells
    Juan C Ossa
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 15:446-57. 2013
    ..We conclude that the suppression of epithelial cell STAT1 signal transduction by AIEC strains isolated from patients with Crohn disease represents a novel mechanism by which the pathogen evades host immune responses to the infection...
  10. doi request reprint Bacterial infections: new and emerging enteric pathogens
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 26:1-4. 2010
    ....
  11. ncbi request reprint Increased Epithelial Gap Density in the Noninflamed Duodenum of Children With Inflammatory Bowel Diseases
    Deenaz Zaidi
    Department of Pediatrics Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR Department of Physiology Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada University of Arkansas for Medical Sciences, Little Rock, AR
    J Pediatr Gastroenterol Nutr 63:644-650. 2016
    ..Our objectives were to compare epithelial gaps in the duodenum of IBD and non-IBD pediatric patients, to study the correlation between epithelial gaps, inflammation, and disease activity, and identify potential mechanisms...
  12. doi request reprint Epithelial cell extrusion leads to breaches in the intestinal epithelium
    Julia J Liu
    Gastroenterology Division, University of Alberta, Edmonton, Alberta, Canada
    Inflamm Bowel Dis 19:912-21. 2013
    ..In this study, we sought to determine the mechanism underlying the IEC extrusion that alters the permeability of the gut epithelium...
  13. doi request reprint Exposure to ingested airborne pollutant particulate matter increases mucosal exposure to bacteria and induces early onset of inflammation in neonatal IL-10-deficient mice
    Saad Y Salim
    Departments of Medicine, and Pediatrics, University of Alberta, Edmonton, AB, Canada Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada Environmental Health Directorate, Health Canada, Ottawa, ON, Canada Department of Lab Medicine and Pathology, University of Alberta, Edmonton, AB, Canada and Departments of Medicine, and Production Animal Health, University of Calgary, Calgary, AB, Canada
    Inflamm Bowel Dis 20:1129-38. 2014
    ..Our aim was to determine if exposure to airborne particulate matter (PM(10)) during the neonatal period would alter colitis in the interleukin (IL)-10(-/-) mouse model...
  14. doi request reprint Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific, time dependent, and correlates with bacterial invasion
    Eytan Wine
    Department of Paediatrics, University of Toronto, Toronto, Ontario, M5G 1X8, Canada
    Pediatr Res 64:599-604. 2008
    ..jejuni disruption of monolayers is mediated by invasion, provide new insights into C. jejuni-host epithelial barrier interactions, and offer potential mechanisms of intestinal injury and chronic immune stimulation...
  15. pmc Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome
    Lisa Kish
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e62220. 2013
    ..The aim of this study was to examine the effects of orally administered PM on the gut microbiome and immune function under normal and inflammatory conditions...
  16. pmc Pericentriolar Targeting of the Mouse Mammary Tumor Virus GAG Protein
    Guangzhi Zhang
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 10:e0131515. 2015
    ..Together, the data imply that MMTV Gag targets the pericentriolar region as a result of the MMTV cytoplasmic targeting and retention signal, possibly aided by the Y box protein-1 required for the assembly of centrosomal microtubules. ..
  17. pmc Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis
    Misagh Alipour
    Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Crohns Colitis 10:462-71. 2016
    ..Therefore, we sought to assess whether these features are inherently abrogated in the terminal ileum [TI] of UC patients, where inflammation is absent...
  18. pmc Increased epithelial gaps in the small intestine are predictive of hospitalization and surgery in patients with inflammatory bowel disease
    Jean Francois Turcotte
    Division of Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Clin Transl Gastroenterol 3:e19. 2012
    ..Cell-shedding events on CLE were found to be predictive of disease relapse. The aim of this study was to assess the prognostic value of epithelial gap densities for major clinical events (hospitalization or surgery) in follow-up...
  19. doi request reprint Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients are Increased and Unrelated to Inflammation
    Deenaz Zaidi
    Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 1C9, Canada Centre of Excellence for Gastrointestinal Inflammation and Immunity Research CEGIIR, University of Alberta, Edmonton, AB, T6G 2X8, Canada Department of Physiology, University of Alberta, Edmonton, AB, T6G 1C9, Canada
    J Pediatr Gastroenterol Nutr . 2016
    ..Assessing circulatory changes in typically unaffected sites in IBD (e.g., duodenum), when inflammation is absent, can identify vascular changes associated with pathogenesis...
  20. pmc Metagenomic analysis of microbiome in colon tissue from subjects with inflammatory bowel diseases reveals interplay of viruses and bacteria
    Weiwei Wang
    Center of Excellence in Gastrointestinal Inflammation and Immunity Research, Department of Medicine, University of Alberta, Edmonton, Canada and Beijing Genomics Institute, Shenzhen, China
    Inflamm Bowel Dis 21:1419-27. 2015
    ..This study provides a promising metagenomic approach to describe the colonic microbiome that can be used to better understand virus-host and phage-bacteria interactions in IBD. ..
  21. pmc Epithelial gaps in a rodent model of inflammatory bowel disease: a quantitative validation study
    Julia J Liu
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Clin Transl Gastroenterol 2:e3. 2011
    ..The goal of this study was to quantitatively validate the findings of epithelial gap density observed with CLE against confocal microscopy (CM) and light microscopy...
  22. ncbi request reprint Biliary atresia with choledochal cyst: implications for classification
    Aleixo M Muise
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Gastroenterol Hepatol 4:1411-4. 2006
    ..To illustrate the limitations of the embryonic and perinatal classification system of biliary atresia (BA), we present a child with an antenatal diagnosis of choledochal cyst (CC) associated with BA and review the published literature...
  23. doi request reprint Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Infect Dis 201:81-91. 2010
    ..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease severity...