I Q Whishaw

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. doi request reprint Dissociation of the Reach and the Grasp in the destriate (V1) monkey Helen: a new anatomy for the dual visuomotor channel theory of reaching
    Ian Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada
    Exp Brain Res 234:2351-62. 2016
  2. pmc The structure of skilled forelimb reaching in the rat: a movement rating scale
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge
    J Vis Exp . 2008
  3. pmc Use of rotorod as a method for the qualitative analysis of walking in rat
    Ian Q Whishaw
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge
    J Vis Exp . 2008
  4. pmc A video demonstration of preserved piloting by scent tracking but impaired dead reckoning after fimbria-fornix lesions in the rat
    Ian Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge
    J Vis Exp . 2009
  5. ncbi request reprint Rats alternate on a dry-land but not swimming-pool (Morris task) place task: implications for spatial processing
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Neurosci 114:442-6. 2000
  6. ncbi request reprint Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Canada
    Neuropharmacology 39:788-805. 2000
  7. ncbi request reprint Calibrating space: exploration is important for allothetic and idiothetic navigation
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Hippocampus 9:659-67. 1999
  8. ncbi request reprint Did a change in sensory control of skilled movements stimulate the evolution of the primate frontal cortex?
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada, T1K 3M4
    Behav Brain Res 146:31-41. 2003
  9. pmc Complete and partial lesions of the pyramidal tract in the rat affect qualitative measures of skilled movements: impairment in fixations as a model for clumsy behavior
    Ian Q Whishaw
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neural Plast 10:77-92. 2003
  10. ncbi request reprint Spatial mapping takes time
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Hippocampus 8:122-30. 1998

Detail Information

Publications119 found, 100 shown here

  1. doi request reprint Dissociation of the Reach and the Grasp in the destriate (V1) monkey Helen: a new anatomy for the dual visuomotor channel theory of reaching
    Ian Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada
    Exp Brain Res 234:2351-62. 2016
    ..The finding that extrastriate pathways can direct the hand toward extrinsic target properties (location) but not intrinsic target properties (size and shape) is discussed as a novel addition to dual visuomotor channel theory. ..
  2. pmc The structure of skilled forelimb reaching in the rat: a movement rating scale
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge
    J Vis Exp . 2008
    ..4. The reaching act is then replayed using frame by frame replay. 5. The movements are described in the accompanying video...
  3. pmc Use of rotorod as a method for the qualitative analysis of walking in rat
    Ian Q Whishaw
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge
    J Vis Exp . 2008
    ..The results of this study indicate that the rotorod task, in addition to providing quantitative measures of motor impairments, can also provide insights into the qualitative impairments [corrected]...
  4. pmc A video demonstration of preserved piloting by scent tracking but impaired dead reckoning after fimbria-fornix lesions in the rat
    Ian Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge
    J Vis Exp . 2009
    ....
  5. ncbi request reprint Rats alternate on a dry-land but not swimming-pool (Morris task) place task: implications for spatial processing
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Neurosci 114:442-6. 2000
    ..It is proposed that rats treat escape (swimming) and search (walking) tasks in different ways, and this difference is discussed with respect to the possibility that different central processes may be used in the task solutions...
  6. ncbi request reprint Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Canada
    Neuropharmacology 39:788-805. 2000
    ..The results are discussed in relation to the idea that true recovery from motor cortex injury will require that damaged neurons and their connections be rescued or replaced...
  7. ncbi request reprint Calibrating space: exploration is important for allothetic and idiothetic navigation
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Hippocampus 9:659-67. 1999
    ..That exploration is equally important for allothetic and idiothetic navigation, suggests that both navigation strategies require a calibrated representation of the environment...
  8. ncbi request reprint Did a change in sensory control of skilled movements stimulate the evolution of the primate frontal cortex?
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada, T1K 3M4
    Behav Brain Res 146:31-41. 2003
    ..Correspondingly, along with many other anatomical changes, the primate frontal cortex became relatively larger and move complex under visual influence...
  9. pmc Complete and partial lesions of the pyramidal tract in the rat affect qualitative measures of skilled movements: impairment in fixations as a model for clumsy behavior
    Ian Q Whishaw
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neural Plast 10:77-92. 2003
    ..The finding that complete and partial pyramidal tract lesions produce chronic impairment in fixations provides insight for understanding clumsy behavior in humans and its potential remediation via specific training in making fixations...
  10. ncbi request reprint Spatial mapping takes time
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Hippocampus 8:122-30. 1998
    ..The results are discussed in relation to their relevance to spatial mapping theory, hippocampal function, and the evolution of foraging strategies...
  11. ncbi request reprint Long-Evans and Sprague-Dawley rats have similar skilled reaching success and limb representations in motor cortex but different movements: some cautionary insights into the selection of rat strains for neurobiological motor research
    Ian Q Whishaw
    The Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 145:221-32. 2003
    ....
  12. ncbi request reprint Deficits in allothetic and idiothetic spatial behavior in rats with posterior cingulate cortex lesions
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, T1K 3M4, Lethbridge, Alta, Canada
    Behav Brain Res 118:67-76. 2001
    ..The results demonstrate a role for posterior cingulate region in idiothetic navigation...
  13. ncbi request reprint Distinct forelimb and hind limb stepping impairments in unilateral dopamine-depleted rats: use of the rotorod as a method for the qualitative analysis of skilled walking
    Ian Q Whishaw
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Alberta, Lethbridge, Canada T1K 3M4
    J Neurosci Methods 126:13-23. 2003
    ..These findings not only reveal new deficits secondary to unilateral DA-depletion, but also show that the rotorod can provide a robust tool for the qualitative analysis of movement...
  14. ncbi request reprint On the origins of autobiographical memory
    Ian Q Whishaw
    Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 138:113-9. 2003
    ..Thus, it may be homologous to, and an antecedent of, autobiographical memory in humans...
  15. ncbi request reprint Dead reckoning (path integration) requires the hippocampal formation: evidence from spontaneous exploration and spatial learning tasks in light (allothetic) and dark (idiothetic) tests
    I Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 127:49-69. 2001
    ..These, tests of spontaneous exploration and foraging suggest a role for the hippocampal formation in dead reckoning...
  16. ncbi request reprint Absence of impairments or recovery mediated by the uncrossed pyramidal tract in the rat versus enduring deficits produced by the crossed pyramidal tract
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 134:323-36. 2002
    ....
  17. ncbi request reprint Posterior neocortical (visual cortex) lesions in the rat impair matching-to-place navigation in a swimming pool: a reevaluation of cortical contributions to spatial behavior using a new assessment of spatial versus nonspatial behavior
    Ian Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 155:109-116. 2004
    ..This definitive demonstration that appropriate testing methods can reveal a failure in spatial behavior following visual cortex lesions is consistent with the idea that primary visual cortex is required in spatial navigation...
  18. ncbi request reprint Posterior neocortical (visual cortex) lesions in the rat impair matching-to-place navigation in a swimming pool: a reevaluation of cortical contributions to spatial behavior using a new assessment of spatial versus non-spatial behavior
    Ian Q Whishaw
    Canadian Center for Behavioral Neuroscience, Lethbridge, Alta, Canada
    Behav Brain Res 155:177-84. 2004
    ..This definitive demonstration that appropriate testing methods can reveal a failure in spatial behavior following visual cortex lesions is consistent with the idea that primary visual cortex is required in spatial navigation...
  19. ncbi request reprint Impairment of pronation, supination, and body co-ordination in reach-to-grasp tasks in human Parkinson's disease (PD) reveals homology to deficits in animal models
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive, Alberta, Canada T1K 3M4
    Behav Brain Res 133:165-76. 2002
    ..These results are discussed in terms of a homology to impairments displayed animal models of PD...
  20. doi request reprint The problem of relating plasticity and skilled reaching after motor cortex stroke in the rat
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Behav Brain Res 192:124-36. 2008
    ..Whereas plasticity is usually proposed to be associated with improved performance it is suggested that future work should attempt to better relate plastic changes to the details of behavioral changes...
  21. ncbi request reprint Neurotoxic lesions of the caudate-putamen on a reaching for food task in the rat: acute sensorimotor neglect and chronic qualitative motor impairment follow lateral lesions and improved success follows medial lesions
    I Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 146:86-97. 2007
    ....
  22. ncbi request reprint The exploratory behavior of rats in an open environment optimizes security
    Ian Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, Lethbridge, Alta, Canada
    Behav Brain Res 171:230-9. 2006
    ..The results are discussed in relation to the advantages of investigating the influence of neural processes on exploration in terms optimization theory versus motivational theory...
  23. doi request reprint Hind limb stepping over obstacles in the horse guided by place-object memory
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, Alberta, T1K 3M4 Canada
    Behav Brain Res 198:372-9. 2009
    ....
  24. ncbi request reprint Unilateral frontal lobe contusion and forelimb function: chronic quantitative and qualitative impairments in reflexive and skilled forelimb movements in rats
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    J Neurotrauma 21:1584-600. 2004
    ....
  25. doi request reprint The functional origins of speech-related hand gestures
    Ian Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada
    Behav Brain Res 214:206-15. 2010
    ..These findings are further discussed in relation to the idea that speech-related gestures reflect forelimb motor cortex contributions to embodied language...
  26. doi request reprint Hand shaping in the rat: conserved release and collection vs. flexible manipulation in overground walking, ladder rung walking, cylinder exploration, and skilled reaching
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Behav Brain Res 206:21-31. 2010
    ..Conserved release and collection vs. the variability of manipulation is discussed in relation to the evolution, neural control, and neural commitment underlying hand movements...
  27. ncbi request reprint Home bases formed to visual cues but not to self-movement (dead reckoning) cues in exploring hippocampectomized rats
    Dustin J Hines
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Eur J Neurosci 22:2363-75. 2005
    ..This result is discussed in relation to the idea that the hippocampus contributes to spatial behavior that is dependent upon guidance (dead reckoning) derived from self-movement cues...
  28. ncbi request reprint Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
    Evelyn F Field
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 174:39-48. 2006
    ....
  29. ncbi request reprint Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats
    G A Metz
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4
    Eur J Neurosci 14:27-37. 2001
    ..The results are discussed in relationship to the idea that the restoration of some skilled movements may require normal synaptic function...
  30. ncbi request reprint A novel skilled-reaching impairment in paw supination on the "good" side of the hemi-Parkinson rat improved with rehabilitation
    Patricia Vergara-Aragon
    The Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada, T1K 3M4
    J Neurosci 23:579-86. 2003
    ..The results are discussed in relation to possible causes of the ipsilateral impairment, its treatment, and to relevant research on human Parkinson patients, indicating that they display bilateral improvements after unilateral treatments...
  31. ncbi request reprint A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere
    Elena I Miklyaeva
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada
    Restor Neurol Neurosci 25:91-9. 2007
    ..The present study examined how DA depletion and the associated sensorimotor changes affect the morphology of the ipsilateral or contralateral neocortex neurons as assessed by dendritic morphology in Golgi-stained tissue...
  32. doi request reprint Compensation aids skilled reaching in aging and in recovery from forelimb motor cortex stroke in the rat
    M Alaverdashvili
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Neuroscience 167:21-30. 2010
    ..Thus, this study demonstrates that the neural plasticity that mediates compensatory movements after stroke in young adults is preserved prior to and following stroke in aging...
  33. ncbi request reprint Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood
    E Castaneda
    Department of Psychology, University of Lethbridge, Alta, Canada
    Brain Res 508:30-9. 1990
    ..This presynaptic compensatory response may play a role in the sparing of behavioral function seen following neonatal damage...
  34. ncbi request reprint Middle cerebral artery (MCA) stroke produces dysfunction in adjacent motor cortex as detected by intracortical microstimulation in rats
    O A Gharbawie
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 130:601-10. 2005
    ..Anterograde and retrograde tract tracing suggest that M1 efferents were intact. Although M1 appears to be in the main anatomically spared after MCA stroke its function as assessed electrophysiologically and behaviorally is disrupted...
  35. ncbi request reprint Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size
    E Castaneda
    Department of Psychology, University of Lethbridge, Alberta, Canada
    J Neurosci 10:1847-54. 1990
    ..abstract truncated at 250 words)..
  36. ncbi request reprint Hippocampal modulation of nucleus accumbens: behavioral evidence from amphetamine-induced activity profiles
    I Q Whishaw
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Behav Neural Biol 55:289-306. 1991
    ..Together these findings suggest that the hippocampus may participate in the control of locomotion by projections that modulate the activity of the nucleus accumbens...
  37. ncbi request reprint Impaired spatial performance in rats with retrosplenial lesions: importance of the spatial problem and the rat strain in identifying lesion effects in a swimming pool
    K Troy Harker
    Canadian Center for Behavioral Neuroscience, Lethbridge, Alberta, T1K 3M4, Canada
    J Neurosci 22:1155-64. 2002
    ....
  38. ncbi request reprint NMDA lesions of Ammon's horn and the dentate gyrus disrupt the direct and temporally paced homing displayed by rats exploring a novel environment: evidence for a role of the hippocampus in dead reckoning
    Douglas G Wallace
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, T1K 3M4 Canada
    Eur J Neurosci 18:513-23. 2003
    ..These results are discussed in relation to the ideas that dead reckoning is used in the homing of exploring rats and that this form of navigation involves the hippocampus...
  39. ncbi request reprint Limits on recovery in the corticospinal tract of the rat: partial lesions impair skilled reaching and the topographic representation of the forelimb in motor cortex
    Dionne M Piecharka
    Department of Psychology and Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada
    Brain Res Bull 66:203-11. 2005
    ..The incomplete recovery, as measured both behaviorally and electrophysiologically, demonstrates that plasticity within the corticospinal system is limited even with lesions that permit substantial sparing of pyramidal tract fibers...
  40. ncbi request reprint Is there an optimal age for recovery from motor cortex lesions? I. Behavioral and anatomical sequelae of bilateral motor cortex lesions in rats on postnatal days 1, 10, and in adulthood
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, AB T1K 3M4, Lethbridge, Canada
    Brain Res 882:62-74. 2000
    ..The widespread anatomical changes in all lesion groups versus the relatively better behavioral recovery after P10 lesions suggests that day 10 represents an optimal period for adapting to brain damage and subsequent brain reorganization...
  41. ncbi request reprint Skilled reaching an action pattern: stability in rat (Rattus norvegicus) grasping movements as a function of changing food pellet size
    G A Metz
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta T1K 3M4, Canada
    Behav Brain Res 116:111-22. 2000
    ....
  42. ncbi request reprint Food wrenching and dodging: a neuroethological test of cortical and dopaminergic contributions to sensorimotor behavior in the rat
    I Q Whishaw
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Behav Neurosci 102:110-23. 1988
    ....
  43. ncbi request reprint The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats
    E I Miklyaeva
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Behav Brain Res 88:143-52. 1997
    ..Measures of ground reaction forces confirm that DA-depleted rats can support posture but cannot initiate postural adjustments with their impaired limbs...
  44. ncbi request reprint Quantitative and qualitative impairments in skilled reaching in the mouse (Mus musculus) after a focal motor cortex stroke
    Tracy D Farr
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    Stroke 33:1869-75. 2002
    ..The purpose of this study was to document skilled movements in mice before and after a focal motor cortex stroke for the purpose of developing a mouse model of human stroke...
  45. ncbi request reprint Attempt-dependent decrease in skilled reaching characterizes the acute postsurgical period following a forelimb motor cortex lesion: an experimental demonstration of learned nonuse in the rat
    Crystal A Erickson
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta T1K 3M4, Canada
    Behav Brain Res 179:208-18. 2007
    ....
  46. ncbi request reprint Long-Evans rats have a larger cortical topographic representation of movement than Fischer-344 rats: a microstimulation study of motor cortex in naïve and skilled reaching-trained rats
    Penny M VandenBerg
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alta, Lethbridge, Canada
    Brain Res Bull 59:197-203. 2002
    ..The results are discussed in relation to using strain differences as a way of examining the behavioral, the physiological, and the anatomical organization of the motor system...
  47. doi request reprint Both compensation and recovery of skilled reaching following small photothrombotic stroke to motor cortex in the rat
    Seong Keun Moon
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada, T1K 3M4
    Exp Neurol 218:145-53. 2009
    ..The results demonstrate the utility of a small lesion model for studying post-stroke neural and behavioral change and support the view that optimal post-stroke treatment should be directed toward limiting tissue loss...
  48. ncbi request reprint Perseveration on place reversals in spatial swimming pool tasks: further evidence for place learning in hippocampal rats
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Hippocampus 7:361-70. 1997
    ..The results are discussed in relation to the idea that the hippocampus mediates spatial mapping and/or uses self-movement cues to solve spatial problems...
  49. ncbi request reprint Analysis of limb use by control rats and unilateral DA-depleted rats in the Montoya staircase test: movements, impairments and compensatory strategies
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Brain Res 89:167-77. 1997
    ..The results confirm that the Staircase Test is a sensitive measure for motor system damage and demonstrate that when movement analysis is combined with end point measures, the test can dissociate impairment, recovery, and compensation...
  50. doi request reprint Acute but not chronic differences in skilled reaching for food following motor cortex devascularization vs. photothrombotic stroke in the rat
    M Alaverdashvili
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 157:297-308. 2008
    ..The findings are discussed in relation to the idea that whereas the course of recovery might be altered as a function of the type of stroke, chronic deficits are more closely related to the ensuing damage...
  51. ncbi request reprint The pasta matrix reaching task: a simple test for measuring skilled reaching distance, direction, and dexterity in rats
    M Ballermann
    Department of Psychology and Neuroscience and NeuroDetective Inc, University of Lethbridge, 4401 University Dr. AB, T1K 3M4, Lethbridge, Canada
    J Neurosci Methods 106:39-45. 2001
    ..The task can also be modified to investigate other features of limb use including skill adjustments, laterality, and force...
  52. ncbi request reprint A cautionary note regarding drug and brain lesion studies that use swimming pool tasks: partial reinforcement impairs acquisition of place learning in a swimming pool but not on dry land
    C L Gonzalez
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, T1K 3M4, Alberta, Canada
    Behav Brain Res 112:43-52. 2000
    ..The results are discussed in relation to widespread applications of the Morris place task to neurobiological problems...
  53. ncbi request reprint Evidence for rodent-common and species-typical limb and digit use in eating, derived from a comparative analysis of ten rodent species
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Brain Res 96:79-91. 1998
    ....
  54. ncbi request reprint Sexually dimorphic postural adjustments are used in a skilled reaching task in the rat
    Evelyn F Field
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alta
    Behav Brain Res 163:237-45. 2005
    ..These results are discussed in relation to the dissociation of skilled movement from postural adjustments, sex-dependent alterations following CNS injury, and the neural and evolutionary basis of sex differences in movement organization...
  55. ncbi request reprint Recovery of skilled reaching following motor cortex stroke: do residual corticofugal fibers mediate compensatory recovery?
    Omar A Gharbawie
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, Canada
    Eur J Neurosci 26:3309-27. 2007
    ..The results are discussed in relation to the idea that the involvement of the neocortical areas in skilled reaching performance and its recovery is proportional to the region from which corticospinal projections originate...
  56. doi request reprint Transient middle cerebral artery occlusion disrupts the forelimb movement representations of rat motor cortex
    Omar A Gharbawie
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Eur J Neurosci 28:951-63. 2008
    ..Thus, M1 dysfunction contributes to the impairments that ensue from proximal MCA occlusion, even when the infarct is limited to subcortical regions...
  57. ncbi request reprint Quantification of a single exploratory trip reveals hippocampal formation mediated dead reckoning
    Douglas G Wallace
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 113:131-45. 2002
    ..Methods to quantify exploratory behavior in terms of velocity and angular components provide an assessment of control behavior and the assessment of the behavior of rats with hippocampal formation damage that is easy to implement...
  58. ncbi request reprint Drug-induced rotation intensity in unilateral dopamine-depleted rats is not correlated with end point or qualitative measures of forelimb or hindlimb motor performance
    G A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, AB, Canada T1K 3M4
    Neuroscience 111:325-36. 2002
    ....
  59. ncbi request reprint Reducing stability of support structure for a target does not alter reach kinematics among younger adults
    S A Cooper
    Balance Research Laboratory, Department of Kinesiology, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, AB, Canada
    Percept Mot Skills 100:831-8. 2005
    ..The results imply that stability of support structure does not influence transport kinematics among younger adults...
  60. ncbi request reprint Paw and limb use in skilled and spontaneous reaching after pyramidal tract, red nucleus and combined lesions in the rat: behavioral and anatomical dissociations
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Brain Res 93:167-83. 1998
    ..The results are discussed in relation to the possible distinctive contributions of the rubrospinal and corticospinal tract to the action patterns that comprise skilled movements in rats...
  61. ncbi request reprint Piloting and dead reckoning dissociated by fimbria-fornix lesions in a rat food carrying task
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Brain Res 89:87-97. 1997
    ..That FF lesions dissociated the two kinds of navigation suggests a role for the hippocampus in navigation based on ideothetic cues...
  62. ncbi request reprint Evidence for extrahippocampal involvement in place learning and hippocampal involvement in path integration
    I Q Whishaw
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Hippocampus 6:513-24. 1996
    ..Contrasts between conditions in which hippocampal rats acquire a place response and conditions in which they fail suggests that the hippocampus may serve as an on line system for monitoring movement and integrating movement paths...
  63. pmc Fimbria-fornix lesions disrupt the dead reckoning (homing) component of exploratory behavior in mice
    Joanna H Gorny
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 4N6, Canada
    Learn Mem 9:387-94. 2002
    ..The results also show that the home-bedding methodology facilitates the establishment of a home base by mice, thus providing a useful methodology for studies with mice...
  64. ncbi request reprint Motor deficits in Parkinsonian reaching: dopa-sensitivity influenced by real-world task constraint
    Jon Doan
    Department of Kinesiology, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    J Mot Behav 38:45-59. 2006
    ....
  65. doi request reprint Visual guidance for hand advance but not hand withdrawal in a reach-to-eat task in adult humans: reaching is a composite movement
    Natalie de Bruin
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada
    J Mot Behav 40:337-46. 2008
    ..The dependence on visual control of advance but not withdrawal suggests that the reach-to-eat movement is a composite of 2 basic movements under visual and tactile/proprioceptive guidance, respectively...
  66. ncbi request reprint Possible regeneration of rat medial frontal cortex following neonatal frontal lesions
    B Kolb
    Department of Psychology, University of Lethbridge, Canada
    Behav Brain Res 91:127-41. 1998
    ..These results are discussed in relation to the proximity of the lesion to the stem cells in the lateral ventricle and their postnatal migrational activities...
  67. ncbi request reprint Brain plasticity and behavior
    B Kolb
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Annu Rev Psychol 49:43-64. 1998
    ..We discuss the important role that changes in dendritic arborization play in brain plasticity and behavior, and we consider these changes in the context of changing intrinsic circuitry of the cortex in processes such as learning...
  68. ncbi request reprint Complete sparing of spatial learning following posterior and posterior plus anterior cingulate cortex lesions at 10 days of age in the rat
    C L R Gonzalez
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge T1K 3M4, AB, Canada
    Neuroscience 122:563-71. 2003
    ..Also discussed is evidence indicating that the neonatal brain, especially the day 10, has a special ability to compensate for injury...
  69. ncbi request reprint Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposal
    I Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge and NeuroDetective Inc, Lethbridge, Alberta, T1K 3M4
    Dev Psychobiol 39:151-70. 2001
    ..Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior...
  70. ncbi request reprint Hippocampal lesions and path integration
    I Q Whishaw
    Department of Psychology and Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Curr Opin Neurobiol 7:228-34. 1997
    ..Path integration may underlie the forms of place learning that are impaired by hippocampal damage. It remains a challenge to determine whether path integration is the central function of the hippocampus or but one of many...
  71. ncbi request reprint Nicotine improvement of Morris water task performance after fimbria-fornix lesion is blocked by mecamylamine
    R W Brown
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Alta, T1K 3M4, Lethbridge, Canada
    Behav Brain Res 119:185-92. 2001
    ..The compensatory effect of nicotine was blocked by mecamylamine. This study demonstrates that nicotine stimulates recovery from brain damage and the results are discussed in relation to neural mechanisms and potential applications...
  72. doi request reprint Posterior hypothalamic nucleus deep brain stimulation restores locomotion in rats with haloperidol-induced akinesia but not skilled forelimb use in pellet reaching and lever pressing
    C K Young
    Behavioural Neuroscience Group, Department of Psychology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Neuroscience 192:452-8. 2011
    ....
  73. doi request reprint Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis
    J M Karl
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neuroscience 170:123-37. 2010
    ....
  74. ncbi request reprint Subcortical middle cerebral artery ischemia abolishes the digit flexion and closing used for grasping in rat skilled reaching
    O A Gharbawie
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 137:1107-18. 2006
    ..The paradigm should prove useful for further studies of rehabilitation in relation to the idea that digit closure may be controlled by the joint action of a number of neural systems that converge in the basal ganglia...
  75. ncbi request reprint Bilateral alteration in stepping pattern after unilateral motor cortex injury: a new test strategy for analysis of skilled limb movements in neurological mouse models
    Tracy D Farr
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    J Neurosci Methods 153:104-13. 2006
    ..The findings demonstrate that this test strategy provides comprehensive assessment of motor impairments in mice and that qualitative movement analysis is a valuable tool for elaborating subtle motor disturbances...
  76. ncbi request reprint Impaired dodging in food-conflict following fimbria-fornix transection in rats: a novel hippocampal formation deficit
    Scott D Oddie
    Department of Humanities and Social Sciences, Red Deer College, Box 5005, Red Deer, Alberta, Canada
    Brain Res Bull 57:565-73. 2002
    ..The finding of this novel deficit underscores the importance of considering both loss as well as release phenomena in the analysis of hippocampal formation function...
  77. ncbi request reprint Place learning in hippocampal rats and the path integration hypothesis
    I Q Whishaw
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Neurosci Biobehav Rev 22:209-20. 1998
    ..An ability to recalibrate external cues may provide the tuning that allows control rats to quickly acquire place responses while hippocampal rats are constrained by the processes of associative learning...
  78. ncbi request reprint Visual modulation of air righting by rats involves calculation of time-to-impact, but does not require the detection of the looming stimulus of the approaching ground
    S M Pellis
    Department of Psychology, University of Lethbridge, Canada
    Behav Brain Res 74:207-11. 1996
    ..These findings suggest that the rats' ability to calculate the time-to-impact when falling involves a more complex calculation than simply detecting the presence of a looming stimulus...
  79. ncbi request reprint THC does not affect striatal dopamine release: microdialysis in freely moving rats
    E Castaneda
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Pharmacol Biochem Behav 40:587-91. 1991
    ..There were also no behavioral differences between groups during any of these treatments...
  80. ncbi request reprint Food carrying: a new method for naturalistic studies of spontaneous and forced alternation
    I Q Whishaw
    Department of Psychology, University of Lethbridge, Alberta Canada
    J Neurosci Methods 61:139-43. 1995
    ..The procedure can be modified for forced and other alternation paradigms and allows collection of a variety of psychophysical measures. The strength of the task is that it provides an analogue of natural foraging behavior...
  81. doi request reprint Intact intracortical microstimulation (ICMS) representations of rostral and caudal forelimb areas in rats with quinolinic acid lesions of the medial or lateral caudate-putamen in an animal model of Huntington's disease
    Jenni M Karl
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada
    Brain Res Bull 77:42-8. 2008
    ..Therefore, the impairments that follow striatal cell loss are due either to alterations in circuitry that is independent of motor cortex or to alterations in circuitry afferent to the motor cortex projections...
  82. doi request reprint Cineradiographic (video X-ray) analysis of skilled reaching in a single pellet reaching task provides insight into relative contribution of body, head, oral, and forelimb movement in rats
    Mariam Alaverdashvili
    Department of Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Behav Brain Res 192:232-47. 2008
    ....
  83. doi request reprint Bilateral impairments of skilled reach-to-eat in early Parkinson's disease patients presenting with unilateral or asymmetrical symptoms
    Jon B Doan
    Department of Kinesiology and Physical Education, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Behav Brain Res 194:207-13. 2008
    ..These findings suggest that functional qualitative reaching evaluation is a sensitive test in early PD, and that significant bilateral abnormalities in reach function are present even in pre-clinical stages of the disease...
  84. ncbi request reprint Odor tracking in rats with orbital frontal lesions
    Douglas G Wallace
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Behav Neurosci 117:616-20. 2003
    ..Rats learned to track and discriminate between different odors reliably. These results suggest that other areas of the brain mediate odor-guided navigation following damage to the orbital frontal cortex...
  85. ncbi request reprint The topography of three-dimensional exploration: a new quantification of vertical and horizontal exploration, postural support, and exploratory bouts in the cylinder test
    Omar A Gharbawie
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 151:125-35. 2004
    ..The results are discussed in relation to the use of the cylinder test for analyzing a number of behaviors including exploration, locomotion, and supporting reactions...
  86. doi request reprint Nicotine does not improve recovery from learned nonuse nor enhance constraint-induced therapy after motor cortex stroke in the rat
    Diana H Lim
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 198:411-9. 2009
    ..The results are discussed in relation to the problem of identifying pharmacotherapeutic agents that augment rehabilitation following stroke...
  87. ncbi request reprint Parkinsonian deficits in context-dependent regulation of standing postural control
    Lesley A Brown
    Balance Research Laboratory, Department of Kinesiology, University of Lethbridge, Canada
    Neurosci Lett 418:292-7. 2007
    ..Our results extend the current understanding of Parkinsonian deficits in the context-dependent regulation of postural control to include upright standing...
  88. ncbi request reprint Vestibular information is required for dead reckoning in the rat
    Douglas G Wallace
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci 22:10009-17. 2002
    ..The vestibular animals were also impaired in learning a new piloting task. This is the first unambiguous demonstration that vestibular information is used in dead reckoning and also contributes to piloting...
  89. ncbi request reprint Independent digit movements and precision grip patterns in 1-5-month-old human infants: hand-babbling, including vacuous then self-directed hand and digit movements, precedes targeted reaching
    Patricia S Wallace
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, T1K 3M4, Lethbridge, Alta, Canada
    Neuropsychologia 41:1912-8. 2003
    ..It is also suggested that hand babbling, consisting of first vacuous and then self-directed movements, is preparatory to targeted reaching...
  90. doi request reprint Similar hand shaping in reaching-for-food (skilled reaching) in rats and humans provides evidence of homology in release, collection, and manipulation movements
    Lori Ann R Sacrey
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Behav Brain Res 204:153-61. 2009
    ..Homologous hand shaping in the rodent clade and the primate clade and within the primate lineage is discussed in relation to its possible derivation from hand shaping movements associated with stepping...
  91. ncbi request reprint Place and matching-to-place spatial learning affected by rat inbreeding (Dark-Agouti, Fischer 344) and albinism (Wistar, Sprague-Dawley) but not domestication (wild rat vs. Long-Evans, Fischer-Norway)
    K Troy Harker
    Canadian Center for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada
    Behav Brain Res 134:467-77. 2002
    ..In general, although nonspatial and spatial deficits were associated with both inbreeding and albinism, impaired spatial performance is not a necessary result of domestication...
  92. doi request reprint Development of collection precedes targeted reaching: resting shapes of the hands and digits in 1-6-month-old human infants
    Lori Ann R Sacrey
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive W, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 214:125-9. 2010
    ..The results are discussed in relation to the idea that the development of collection is an important antecedent to other hand shaping movements, especially skilled movements of grasping and reaching...
  93. doi request reprint Challenging context affects standing reach kinematics among Parkinson's disease patients
    Jon B Doan
    Department of Kinesiology Physical Education, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada
    Behav Brain Res 214:135-41. 2010
    ..These behaviours, in combination with the bradykinetic motor control observed in PD patients, could contribute to the frequent falls observed among the PD population...
  94. ncbi request reprint Rats can track odors, other rats, and themselves: implications for the study of spatial behavior
    Douglas G Wallace
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Alberta, T1K 3M4, Lethbridge, Canada
    Behav Brain Res 131:185-92. 2002
    ..The results are discussed in relation to their implications for experimental methodology and olfactory contributions to spatial navigation in general and dead reckoning in particular...
  95. ncbi request reprint "Learned baduse" limits recovery of skilled reaching for food after forelimb motor cortex stroke in rats: a new analysis of the effect of gestures on success
    Mariam Alaverdashvili
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Behav Brain Res 188:281-90. 2008
    ..This description of "learned baduse" furthers the understanding of MtCx contributions to skilled movements and could potentially contribute to the modification of rehabilitative strategies for the treatment of stroke...
  96. ncbi request reprint Impaired place navigation in place and matching-to-place swimming pool tasks follows both retrosplenial cortex lesions and cingulum bundle lesions in rats
    K Troy Harker
    Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 14:224-31. 2004
    ..The results are discussed in relation to the anatomical organization of CG and RG projections to the hippocampus and with respect to their possible separate/conjoint contributions to spatial behavior...
  97. ncbi request reprint Parkinsonian deficits in sensory integration for postural control: temporal response to changes in visual input
    Lesley A Brown
    Balance Research Laboratory, Department of Kinesiology, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Parkinsonism Relat Disord 12:376-81. 2006
    ..These results indicate a PD-associated deficit with the reorganization of sensory priorities for postural control, and may implicate the basal ganglia as being critical for integration of sensory information for postural control...
  98. ncbi request reprint Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4, Canada
    Brain Res 1026:126-35. 2004
    ....
  99. ncbi request reprint Motor activity (exploration) and formation of home bases in mice (C57BL/6) influenced by visual and tactile cues: modification of movement distribution, distance, location, and speed
    Benjamin J Clark
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 4N6
    Physiol Behav 87:805-16. 2006
    ..That the exploratory behavior of mice is affected by experience and context provides insights into performance variability and may prove useful in investigating the genetic and neural influences on mouse behavior...
  100. ncbi request reprint Skilled reaching impairments from the lateral frontal cortex component of middle cerebral artery stroke: a qualitative and quantitative comparison to focal motor cortex lesions in rats
    Omar A Gharbawie
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, AB, Canada T1K 3M4
    Behav Brain Res 156:125-37. 2005
    ..The results are discussed in relation to the contribution of lateral frontal cortex injury to MCA stroke sensorimotor syndromes...
  101. ncbi request reprint Play fighting in androgen-insensitive tfm rats: evidence that androgen receptors are necessary for the development of adult playful attack and defense
    Evelyn F Field
    University of Lethbridge, Lethbridge Alberta, Canada
    Dev Psychobiol 48:111-20. 2006
    ..These data suggest that the development of play fighting and defense in males is dependent on both androgen- and estrogen-receptor-mediated effects...