Genomes and Genes
Ian C G Weaver
Affiliation: University of Toronto
- Shaping adult phenotypes through early life environmentsIan C G Weaver
Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto Medical Discovery East Tower, Medical and Related Sciences MaRS CentreToronto, Ontario, Canada M5G 1X8
Birth Defects Res C Embryo Today 87:314-26. 2009....
- Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing offIan C G Weaver
The Hospital for Sick Children, Department of Developmental Biology, Toronto, Ontario, Canada
Epigenetics 2:22-8. 2007..Accordingly, epigenetic modifications of specific genomic regions in response to variations in environmental conditions might serve as a major source of variation in biological and behavioral phenotypes...
- From maternal care to gene expression: DNA methylation and the maternal programming of stress responsesIan C G Weaver
Douglas Hospital Research Centre, McGill University, Montreal, PQ, Canada
Endocr Res 28:699. 2002
- Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspringFrances A Champagne
Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
Endocrinology 147:2909-15. 2006....
- The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genesIan C G Weaver
Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
J Neurosci 27:1756-68. 2007..The data are consistent with the hypothesis that NGFI-A participates in epigenetic programming of GR expression...
- Epigenetic effects of glucocorticoidsIan C G Weaver
Developmental Biology Program, Hospital for Sick Children, Toronto Medical Discovery East Tower, Medical and Related Sciences MaRS Centre, Toronto, Ontario, M5G 1X8, Canada
Semin Fetal Neonatal Med 14:143-50. 2009..Accordingly, epigenetic modifications in target gene promoters in response to environmental demand may ensure stable yet dynamic regulation that mediates persistent changes in biological and behavioral phenotype over the lifespan...
- TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursorsMasashi Fujitani
Cell Biology, Hospital for Sick Children, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
Curr Biol 20:2058-65. 2010..Moreover, we show that TAp73 does this by transcriptionally regulating the bHLH Hey2, which itself promotes neural precursor maintenance by preventing premature differentiation...
- CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brainJing Wang
Developmental and Stem Cell Biology Program, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada
Dev Cell 18:114-25. 2010....
- GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processesMichael O Poulter
Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 64:645-52. 2008..Epigenetic mechanisms may be involved in the reprogramming of gene expression in response to stressful stimuli. This investigation determined whether epigenetic phenomena might similarly be associated with suicide/depression...
- Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthoodIan C G Weaver
Douglas Hospital Research Center, Montreal, QC, Canada
Proc Natl Acad Sci U S A 103:3480-5. 2006..These results suggest that early-life experience has a stable and broad effect on the hippocampal transcriptome and anxiety-mediated behavior, which is potentially reversible in adulthood...
- Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in lifeIan C G Weaver
Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
J Neurosci 25:11045-54. 2005..These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain...
- Maternal programming of steroid receptor expression and phenotype through DNA methylation in the ratMoshe Szyf
McGill Program for the Study of Behavior, Genes and Environment, McGill University, Montreal, Canada
Front Neuroendocrinol 26:139-62. 2005..These findings demonstrate that an epigenomic state of a gene can be established through a behavioral mode of programming and that in spite of the inherent stability of this epigenomic mark, it is dynamic and potentially reversible...
- Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sitesIan C G Weaver
McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Ann N Y Acad Sci 1024:182-212. 2004..This paper summarizes the evidence in favor of these pathways as well as recent studies describing regulatory targets within the chromatin structure of the promoter region of the rat hippocampal glucocorticoid receptor gene...
- Epigenetic programming by maternal behaviorIan C G Weaver
Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
Nat Neurosci 7:847-54. 2004..Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible...
- Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic areaFrances A Champagne
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Canada H4H 1R3
Endocrinology 144:4720-4. 2003..These findings suggest that natural variations in maternal care are associated with differences in ER alpha expression in the MPOA and that such differences are transmitted from the mother to her female offspring...
- Maternal behavior regulates long-term hippocampal expression of BAX and apoptosis in the offspringIan C G Weaver
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center and Program for the Study of Behavior, Genes, and Environment, McGill University, Montreal, Canada
J Neurochem 82:998-1002. 2002..In conclusion, we propose that hippocampal neurons in the offspring of low-level LG mothers may be more vulnerable to loss through apoptosis...