Affiliation: University of Toronto
- Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgeryMarcin Wasowicz
Department of Anesthesia and Pain Management, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
Can J Anaesth 59:14-20. 2012..We also investigated the use of automated SPME with the aim of improving the technique so it could be used efficiently for measuring plasma TXA levels...
- Early complications and immediate postoperative outcomes of paravalvular leaks after valve replacement surgeryMarcin Wasowicz
Department of Anesthesia and Pain Management, Toronto General Hospital University Health Network, Toronto, Ontario, Canada
J Cardiothorac Vasc Anesth 25:610-4. 2011..To evaluate the incidence of perivalvular leaks (PVLs) after valve replacement and assess its impact on immediate postoperative outcomes...
- Technical report: analysis of citrated blood with thromboelastography: comparison with fresh blood samplesMarcin Wasowicz
Department of Anesthesia, Toronto General Hospital, University Health Network, and Department of Health Policy, Management and Evaluation, University of Toronto, 200 Elizabeth St, EN3 424, Toronto, Ontario M5G 2C4, Canada
Can J Anaesth 55:284-9. 2008....
- The utility of thromboelastography for guiding recombinant activated factor VII therapy for refractory hemorrhage after cardiac surgeryMarcin Wasowicz
Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada
J Cardiothorac Vasc Anesth 23:828-34. 2009..In this study, the authors assessed the ability of thromboelastography (TEG) in guiding rFVIIa therapy in this setting...
- The incremental value of thrombelastography for prediction of excessive blood loss after cardiac surgery: an observational studyMarcin Wasowicz
Toronto General Hospital, 200 Elizabeth St, 3EN 402 Toronto, ON, Canada M5G 2C4
Anesth Analg 111:331-8. 2010..Accurate risk stratification may help reduce the burden of excessive blood loss after cardiac surgery. We measured the incremental value of thrombelastography to an existing risk prediction model for excessive blood loss in cardiac surgery...
- Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgeryKeyvan Karkouti
University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
Can J Anaesth 53:802-9. 2006..Recombinant factor VIIa (rFVIIa) is being used for refractory, excessive blood loss (EBL) after cardiac surgery, but its safety for this indication is not known...
- Therapeutic monitoring of tranexamic acid concentration: high-throughput analysis with solid-phase microextractionBarbara Bojko
Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada
Ther Drug Monit 34:31-7. 2012....
- Delirium following vascular surgery: increased incidence with preoperative beta-blocker administrationRita Katznelson
Department of Anesthesia and Pain Management, University of Toronto, Toronto, ON, Canada
Can J Anaesth 56:793-801. 2009..To determine if there is an association between perioperative administration of beta-blockers and postoperative delirium in patients undergoing vascular surgery...
- Hospital administrative database underestimates delirium rate after cardiac surgeryRita Katznelson
Department of Anesthesiology, Toronto General Hospital, Eaton North 3 453, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
Can J Anaesth 57:898-902. 2010....
- Determination of tranexamic acid concentration by solid phase microextraction and liquid chromatography-tandem mass spectrometry: first step to in vivo analysisBarbara Bojko
Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada
J Chromatogr B Analyt Technol Biomed Life Sci 879:3781-7. 2011..Another advantage of SPME over conventional techniques was the easy automation and feasibility of in vivo analysis; this advantage makes it possible to use the proposed method for an on-site analysis in clinical practice...
- Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgeryKeyvan Karkouti
Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can J Anaesth 53:279-87. 2006..To determine the independent relationship between leukoreduced platelet transfusions and adverse events in cardiac surgery...
- Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective TrialsAngela Jerath
From the Department of Anesthesia and Pain Medicine, Toronto General Hospital, Toronto, Ontario, Canada Department of Anesthesia and Pain Medicine, Middlemore Hospital, Auckland, New Zealand and Interdepartmental Division of Critical Care, University of Toronto, Ontario, Canada
Anesth Analg . 2016..We performed a systematic review and meta-analysis of prospective randomized controlled trials, which compared the use of volatile agents versus intravenous midazolam or propofol in critical care units...
- Volatile Anesthetics. Is a New Player Emerging in Critical Care Sedation?Angela Jerath
1 Department of Anesthesia and Pain Medicine, Toronto General Hospital, Toronto, Ontario, Canada and
Am J Respir Crit Care Med 193:1202-12. 2016..This review seeks to critically appraise current volatile use in critical care medicine including current research, technical consideration of their use, contraindications, areas of controversy, and proposed future research topics. ..
- Isocapnic hyperpnoea shortens postanesthetic care unit stay after isoflurane anesthesiaRita Katznelson
Department of Anesthesia, Toronto General Hospital, Eaton North 3 453, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
Anesth Analg 111:403-8. 2010..5 to 3 hours of isoflurane anesthesia...
- A derived and validated score to predict prolonged mechanical ventilation in patients undergoing cardiac surgeryVivek Sharma
Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, Ontario, Canada Electronic address
J Thorac Cardiovasc Surg . 2016..We undertook a retrospective analysis of 2 prospectively collected databases developed in tertiary cardiac care centers to derive and validate a risk index predicting prolonged mechanical ventilation after cardiac surgery...
- Early versus late tracheostomy in cardiovascular intensive care patientsWilfredo Puentes
Department of Anesthesia and Pain Management, Toronto General Hospital University Health Network Department of Anesthesia, Faculty of Medicine, University of Toronto, Canada
Anaesthesiol Intensive Ther 48:89-94. 2016..This retrospective cohort aims to assess the potential benefits of early tracheostomy on post-operative outcomes, length of stay and post-tracheostomy complications within cardiac surgical population...
- Volatile-based short-term sedation in cardiac surgical patients: a prospective randomized controlled trialAngela Jerath
1Department Anesthesia and Pain Management, Toronto General Hospital, Toronto, ON, Canada 2Department Anesthesia and Pain Management, Christian Medical College, Vellore, India 3Divison of Cardiac Surgery, Toronto General Hospital, Toronto, ON, Canada
Crit Care Med 43:1062-9. 2015..To evaluate the differences in extubation times in a group of cardiac surgical patients who were anesthetized and sedated with either IV propofol or inhaled volatile anesthetic agents...
- Type of anesthesia and postoperative delirium after vascular surgeryLouise Ellard
Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, Canada
J Cardiothorac Vasc Anesth 28:458-61. 2014..The role of LA with respect to postoperative delirium in vascular surgery patients previously has not been reported...
- The scavenging of volatile anesthetic agents in the cardiovascular intensive care unit environment: a technical reportThomas Pickworth
Department of Anesthesia and Pain Management, Toronto General Hospital University Health Network, ON, Canada
Can J Anaesth 60:38-43. 2013....
- The interaction of carbon dioxide and hypoxia in the control of cerebral blood flowAlexandra Mardimae
Department of Physiology, University of Toronto, Toronto, ON, Canada, M5S 1A8
Pflugers Arch 464:345-51. 2012....
- Risk of elective major noncardiac surgery after coronary stent insertion: a population-based studyDuminda N Wijeysundera
Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
Circulation 126:1355-62. 2012..Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year after drug-eluting stent implantation...
- Intraoperative Transesophageal Echocardiographic Diagnosis of Acute Budd-Chiari Syndrome After Extended Right HepatectomyGabriela Alcaraz
From the Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
A A Case Rep 7:13-5. 2016..TEE constituted a stepped-up level of monitoring, prompting an immediate surgical reexploration, and resolution of hemodynamic instability. ..
- Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairmentQi Joy Yang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada, M5S 3M2
Biopharm Drug Dispos 36:294-307. 2015..Our proposed dosing regimen, with consideration of renal function, is predicted to maintain effective target plasma concentrations below those associated with toxicity for patients with renal failure for CPB...
- The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trialAngela Jerath
Department Anesthesia and Pain Medicine, Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario, M5G 2C4, Canada
Trials 16:560. 2015..This pilot randomized controlled trial aims to assess the safety and feasibility of delivering volatile agents for long-term patient sedation in the ICU with limited or no experience of this technique...
- Bivalirudin anticoagulation for cardiopulmonary bypass in a patient with heparin-induced thrombocytopeniaMarcin Wasowicz
Department of Anesthesia, Toronto General Hospital, Ontario M5G 2C4, Canada
Can J Anaesth 52:1093-8. 2005..The patient underwent high-risk cardiac re-operation with the use of the alternative anticoagulant, bivalirudin...
- Air-blood barrier injury during cardiac operations with the use of cardiopulmonary bypass (CPB). An old story? A morphological studyMarcin Wasowicz
John Paul II Hospital, Department of Cardiovascular Surgery, Cracow, Poland
Scand Cardiovasc J 37:216-21. 2003..The purpose of this study is to morphologically analyze the structure of air-blood barriers in patients who underwent coronary artery bypass grafting (CABG) with use of CPB...