Hansen Wang

Summary

Affiliation: University of Toronto
Location: Toronto, Canada
Summary:
Neuroscience, neurobiology of disease

Publications

  1. ncbi request reprint [The 9th International Child Neurology Congress and the 7th Asian and Oceanian Congress of Child Neurology held in Beijing]
    Xin hua Bao
    Zhonghua Er Ke Za Zhi 41:65-6. 2003
  2. doi request reprint FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
  3. pmc Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:18953-62. 2009
  4. doi request reprint Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice
    Yuze Shang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurochem 111:635-46. 2009
  5. pmc DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Brain 3:3. 2010
  6. pmc Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
  7. doi request reprint Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
  8. doi request reprint Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
  9. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
  10. pmc Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurosci 28:7445-53. 2008

Detail Information

Publications26

  1. ncbi request reprint [The 9th International Child Neurology Congress and the 7th Asian and Oceanian Congress of Child Neurology held in Beijing]
    Xin hua Bao
    Zhonghua Er Ke Za Zhi 41:65-6. 2003
  2. doi request reprint FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
    ..Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome...
  3. pmc Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:18953-62. 2009
    ..Our study has provided strong evidence for CaMKIV as a molecular link between Group I mGluRs and FMRP in ACC neurons and may help us to elucidate the pathogenesis of fragile X syndrome...
  4. doi request reprint Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice
    Yuze Shang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurochem 111:635-46. 2009
    ....
  5. pmc DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Brain 3:3. 2010
    ..By contrast, sensory responses to noxious stimuli were not affected. Our results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory...
  6. pmc Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
    ..Our study thus provides further insights into FMRP involvement in DA modulation and may help to reveal the molecular mechanisms underlying impaired learning and memory in fragile X syndrome...
  7. doi request reprint Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  8. doi request reprint Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
    ..Our study thus shows that AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain...
  9. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
    ..These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders...
  10. pmc Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurosci 28:7445-53. 2008
    ..AC1 thus may serve as a potential therapeutic target for treating neuropathic pain...
  11. doi request reprint Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 28:4385-97. 2008
    ..Our study has provided the first evidence for a molecular link between group I mGluRs and FMRP in ACC neurons and may help us to understand the pathogenesis of fragile X syndrome...
  12. doi request reprint Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Eur J Neurosci 27:1923-32. 2008
    ..Our results provide strong evidence that forebrain CaMKIV contributes to trace fear memory by enhancing synaptic potentiation in the ACC...
  13. ncbi request reprint [Helper-virus-free herpes simplex virus-1 vector mediated LacZ gene expression in cultured cortical neurons]
    Han sen Wang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 37:172-4. 2005
    ....
  14. pmc Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases
    Kunjumon I Vadakkan
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, ON, Canada
    Mol Pain 2:7. 2006
    ..Muscle pain is different from cutaneous pain in its characteristics as well as conducting fibers. Therefore, we conducted the present work to test the role of AC1 and AC8 in both acute persistent and chronic muscle pain...
  15. ncbi request reprint Gene delivery into primary cerebral cortical neurons by lentiviral vector
    Yuzhi Zhang
    Department of Pediatrics, Peking University First Hospital, No 8 Xi An Men Street, West District, Beijing 100034, PR China
    Cell Biol Int 30:777-83. 2006
    ..o.i.) of 20. The results show that lentiviral vectors are not only good prospects for in vivo gene delivery, but are also good candidates for in vitro studies of the function of gene products in primary cerebral cortical neurons...
  16. ncbi request reprint [Knocking down rat Mecp2 expression by RNAi]
    Yu zhi Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 38:529-32. 2006
    ..To find the valid siRNA (small interference RNA) sequence to knock down rat Mecp2 expression for the analysis of Mecp2 function by RNA interference (RNAi)...
  17. ncbi request reprint Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 282:1507-17. 2007
    ..Our findings provide direct evidence that AC1 plays an important role in neuronal excitotoxicity and may serve as a therapeutic target for preventing excitotoxicity in stroke and neurodegenerative diseases...
  18. ncbi request reprint Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons
    Bo Gong
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Eur J Neurosci 26:275-88. 2007
    ..AC1 plays a subtype selective role in this process by coupling signals from L-type Ca(2+) channels to downstream signalling pathways...
  19. pmc Neurabin contributes to hippocampal long-term potentiation and contextual fear memory
    Long Jun Wu
    Department of Physiology, University of Toronto, Toronto, Onatrio, Canada
    PLoS ONE 3:e1407. 2008
    ..Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons...
  20. doi request reprint RNAi-induced down-regulation of Mecp2 expression in the rat brain
    Jing Jin
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Int J Dev Neurosci 26:457-65. 2008
    ..Bdnf mRNA expression decreased in the hippocampus, supporting the hypothesis that Bdnf may be a target gene of MeCP2 in the CNS...
  21. pmc Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Mol Brain 5:27. 2012
    ....
  22. pmc Overcoming barriers and thresholds - signaling of oligomeric Aβ through the prion protein to Fyn
    Hansen Wang
    Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2, Canada
    Mol Neurodegener 8:24. 2013
    ....
  23. pmc Induced pluripotent stem cells to model and treat neurogenetic disorders
    Hansen Wang
    Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
    Neural Plast 2012:346053. 2012
    ....