Vesna Sossi

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Cutting-edge brain imaging with positron emission tomography
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada
    Neuroimaging Clin N Am 17:427-40, viii. 2007
  2. doi Cutting-Edge Brain Imaging with Positron Emission Tomography
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada Electronic address
    PET Clin 2:91-104. 2007
  3. doi Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, Vancouver British Columbia, Canada
    Mov Disord 25:2717-23. 2010
  4. doi Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function
    Andre R Troiano
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Synapse 64:146-51. 2010
  5. doi Effects of expectation on placebo-induced dopamine release in Parkinson disease
    Sarah C Lidstone
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Arch Gen Psychiatry 67:857-65. 2010
  6. pmc The nature of progression in Parkinson's disease: an application of non-linear, multivariate, longitudinal random effects modelling
    Lisa Kuramoto
    Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    PLoS ONE 8:e76595. 2013
  7. ncbi PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation
    John R Adams
    Pacific Parkinson s Research Centre, TRIUMF, Vancouver, BC, Canada
    Brain 128:2777-85. 2005
  8. ncbi Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies
    Kaveh M Koochesfahani
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mov Disord 21:970-5. 2006
  9. doi Age-specific progression of nigrostriatal dysfunction in Parkinson's disease
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, BC, Canada
    Ann Neurol 69:803-10. 2011
  10. doi Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease
    Ramachandiran Nandhagopal
    Pacific Parkinson s Research Centre, University of British Columbia and Vancouver Coastal Health, Vancouver, BC V6T 2B5, Canada
    Brain 134:3290-8. 2011

Detail Information

Publications62

  1. ncbi Cutting-edge brain imaging with positron emission tomography
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada
    Neuroimaging Clin N Am 17:427-40, viii. 2007
    ..PET findings must be evaluated in the context of clinical observations and complemented by other imaging modalities whenever possible to ensure a proper interpretation of the data...
  2. doi Cutting-Edge Brain Imaging with Positron Emission Tomography
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada Electronic address
    PET Clin 2:91-104. 2007
    ..PET findings must be evaluated in the context of clinical observations and complemented by other imaging modalities whenever possible to ensure a proper interpretation of the data. ..
  3. doi Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, Vancouver British Columbia, Canada
    Mov Disord 25:2717-23. 2010
    ..These results support a compensatory role of increased DA turnover in presymptomatic disease and indicate that at this stage, in contrast to the symptomatic PD phase, increased turnover is not related to DAT...
  4. doi Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function
    Andre R Troiano
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Synapse 64:146-51. 2010
    ..To determine the impact of age-related decline in dopamine transporter (DAT) expression on motor function in the elderly...
  5. doi Effects of expectation on placebo-induced dopamine release in Parkinson disease
    Sarah C Lidstone
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Arch Gen Psychiatry 67:857-65. 2010
    ..In Parkinson disease (PD), the placebo effect is associated with release of endogenous dopamine in both nigrostriatal and mesoaccumbens projections, yet the factors that control this dopamine release are undetermined...
  6. pmc The nature of progression in Parkinson's disease: an application of non-linear, multivariate, longitudinal random effects modelling
    Lisa Kuramoto
    Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    PLoS ONE 8:e76595. 2013
    ..In this paper, we demonstrate the usefulness of such methodology for studying the temporal and spatial aspects of the progression of PD. Extending this methodology further, we also explore the presymptomatic course of this disease...
  7. ncbi PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation
    John R Adams
    Pacific Parkinson s Research Centre, TRIUMF, Vancouver, BC, Canada
    Brain 128:2777-85. 2005
    ..Furthermore, we suggest that compensatory changes including downregulation of the DAT and upregulation of decarboxylase activity may delay the onset of parkinsonian symptoms...
  8. ncbi Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies
    Kaveh M Koochesfahani
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mov Disord 21:970-5. 2006
    ..Our data provide in vivo neurochemical support for the lack of clinical efficacy following MP in PD patients and are also in keeping with reduced DA release following amphetamine in PD subjects...
  9. doi Age-specific progression of nigrostriatal dysfunction in Parkinson's disease
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, BC, Canada
    Ann Neurol 69:803-10. 2011
    ..To investigate in vivo the impact of age on nigrostriatal dopamine dysfunction in Parkinson's disease (PD)...
  10. doi Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease
    Ramachandiran Nandhagopal
    Pacific Parkinson s Research Centre, University of British Columbia and Vancouver Coastal Health, Vancouver, BC V6T 2B5, Canada
    Brain 134:3290-8. 2011
    ..Our data suggest that compensatory mechanisms decline as Parkinson's disease progresses. This breakdown of compensatory strategies in the putamen could contribute to the progression of motor symptoms in advanced disease...
  11. pmc In-vivo measurement of LDOPA uptake, dopamine reserve and turnover in the rat brain using [18F]FDOPA PET
    Matthew D Walker
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada
    J Cereb Blood Flow Metab 33:59-66. 2013
    ..18)F]fluoro-3,4-dihydroxyphenyl-L-alanine PET enables measurements of DA turnover in the rat, which is useful for developing novel therapies for PD...
  12. doi Visualizing vesicular dopamine dynamics in Parkinson's disease
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Synapse 63:713-6. 2009
    ..Endogenous dopamine and exogenously derived dopamine seem to follow the same vesicular dynamics...
  13. ncbi Age-related differences in levodopa dynamics in Parkinson's: implications for motor complications
    Vesna Sossi
    University of British Columbia, Vancouver, Canada
    Brain 129:1050-8. 2006
    ..These results provide one possible explanation for the age-dependent occurrence of complications and support the existence of a pre-synaptic contribution to the occurrence of motor complications...
  14. doi Brain serotonin-2 receptors in acute mania
    Lakshmi N Yatham
    Mood Disorders Program, University of British Columbia, Vancouver, Canada
    Br J Psychiatry 196:47-51. 2010
    ..Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive...
  15. ncbi Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: their relation to disease-compensatory mechanisms
    Vesna Sossi
    Departments of Physics and Astronomy and Neurology, University of British Columbia, Vancouver, Canada
    J Cereb Blood Flow Metab 24:869-76. 2004
    ....
  16. ncbi Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson's disease: implications for dyskinesias
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, BC, Canada
    Brain 127:2747-54. 2004
    ..Large levodopa-induced increases in synaptic dopamine concentration can lead to dramatic changes in receptor occupancy, which may be responsible for the emergence of peak-dose dyskinesias in Parkinson's disease...
  17. doi Dopamine transporter relation to levodopa-derived synaptic dopamine in a rat model of Parkinson's: an in vivo imaging study
    Vesna Sossi
    Pacific Parkinson s Research Centre, Wesbrook Mall, Vancouver, British Columbia, Canada
    J Neurochem 109:85-92. 2009
    ....
  18. ncbi PET study of the effects of valproate on dopamine D(2) receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania
    Lakshmi N Yatham
    Mood Disorders Clinical Research Unit, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1
    Am J Psychiatry 159:1718-23. 2002
    ..The purpose of this study was to further examine D(2) receptor density in a larger sample of nonpsychotic manic patients by using positron emission tomography (PET) and [(11)C]raclopride...
  19. ncbi In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada
    J Cereb Blood Flow Metab 27:1407-15. 2007
    ..Quantitative PET results can thus be obtained even for severely lesioned animals with the striatum on one side not clearly visible provided accurate image analysis methods are used...
  20. doi Positron emission tomography kinetic modeling algorithms for small animal dopaminergic system imaging
    Geoffrey J Topping
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada
    Synapse 64:200-8. 2010
    ..The modified graphical method was found to be effectively unbiased by target tissue noise and has advantages for parametric imaging, while all tested methods were equivalent for ROI-averaged data...
  21. doi Levodopa and pramipexole effects on presynaptic dopamine PET markers and estimated dopamine release
    Vesna Sossi
    University of British Columbia, Vancouver, Canada
    Eur J Nucl Med Mol Imaging 37:2364-70. 2010
    ....
  22. doi An analytical scatter correction for singles-mode transmission data in PET
    Eric Vandervoort
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, V6T 1Z1 BC Canada
    IEEE Trans Med Imaging 27:402-12. 2008
    ..This extra calculation time does not seem unreasonable considering that, without scatter corrections, errors in the reconstructed mu-values were between 18%-45% depending on the phantom size and transmission source used...
  23. ncbi Dopamine transporter relation to dopamine turnover in Parkinson's disease: a positron emission tomography study
    Vesna Sossi
    University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 62:468-74. 2007
    ..To investigate the role of the dopamine transporter (DAT) in the regulation of synaptic dopamine (DA) levels in Parkinson's disease and its role in the preservation of DA in presynaptic terminals...
  24. ncbi Age and severity of nigrostriatal damage at onset of Parkinson's disease
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, and TRIUMF, University of British Columbia, Vancouver, BC, Canada V6T 2B5
    Synapse 47:152-8. 2003
    ..Age-related differences in [(18)F]-dopa uptake may be related to changes in dopamine turnover...
  25. ncbi Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography
    Elissa M Strome
    Pacific Parkinson s Research Centre, University of British Columbia, Purdy Pavilion M36, 2221 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    Mol Imaging Biol 8:292-9. 2006
    ..This evaluation can be performed in vivo, through evaluation of dopamine (DA)-dependent motor function or with small animal positron emission tomography (microPET), or at postmortem, by examining markers for DA neurons...
  26. ncbi [11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson's disease
    Ajit Kumar
    Pacific Parkinson s Research Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada
    Brain 126:2648-55. 2003
    ..Therefore, our study suggests that both levodopa treatment and DA terminal loss contribute to the pathogenesis of motor fluctuations...
  27. ncbi Dopamine release in human ventral striatum and expectation of reward
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, Vancouver Hospital and Health Sciences Center, University of British Columbia, Purdy Pavilion, 2221 Westbrook Mall, Vancouver, BC, Canada V6T 2B5
    Behav Brain Res 136:359-63. 2002
    ..These observations have potential implications for the treatment of drug addiction...
  28. ncbi A scatter-corrected list-mode reconstruction and a practical scatter/random approximation technique for dynamic PET imaging
    Ju Chieh Cheng
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
    Phys Med Biol 52:2089-106. 2007
    ..The precision of the scatter fraction was also demonstrated for the conventional and the approximate approach using phantom studies...
  29. doi In vivo dopamine transporter imaging in a unilateral 6-hydroxydopamine rat model of Parkinson disease using 11C-methylphenidate PET
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada
    J Nucl Med 53:813-22. 2012
    ..Here we investigate the characteristics of the (11)C-methylphenidate-derived quantification of DAT in rodents using the 6-hydroxydopamine Parkinson disease rat model...
  30. doi Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
    Br J Psychiatry 196:474-9. 2010
    ..Positron emission tomography (PET) studies in individuals with depression confirmed that antidepressant medications reduce brain 5-HT(2) receptors, but the effects of ECT on these receptors in individuals with depression are unknown...
  31. pmc A scan without evidence is not evidence of absence: Scans without evidence of dopaminergic deficit in a symptomatic leucine-rich repeat kinase 2 mutation carrier
    Daryl J Wile
    University of British Columbia, Vancouver, BC, Canada
    Mov Disord 31:405-9. 2016
    ..The basis for SWEDD is unclear, with most cases representing PD mimics but some later developing PD with a dopaminergic deficit...
  32. pmc In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers
    Andre C Felicio
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, BC, Canada
    Mov Disord 29:1197-201. 2014
    ..We used positron emission tomography (PET) to assess dopaminergic and serotonergic terminal density in three subjects carrying a mutation in the DCT1 gene, two clinically affected with Perry syndrome...
  33. doi Novel spatial analysis method for PET images using 3D moment invariants: applications to Parkinson's disease
    Marjorie E Gonzalez
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Rd, Vancouver, Canada BC V6T 1Z1
    Neuroimage 68:11-21. 2013
    ....
  34. doi Positron emission tomography study of the effects of tryptophan depletion on brain serotonin(2) receptors in subjects recently remitted from major depression
    Lakshmi N Yatham
    Mood Disorders Program, Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    Arch Gen Psychiatry 69:601-9. 2012
    ..We hypothesized that downregulation of brain serotonin(2) receptors might be a compensatory mechanism that prevents some patients from becoming depressed with tryptophan depletion...
  35. pmc Measuring dopaminergic function in the 6-OHDA-lesioned rat: a comparison of PET and microdialysis
    Matthew D Walker
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada
    EJNMMI Res 3:69. 2013
    ..We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microdialysis to aid in the interpretation of data from both techniques...
  36. pmc [11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat
    Matthew D Walker
    Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada
    J Cereb Blood Flow Metab 35:1331-8. 2015
    ..The intraclass correlation coefficient for SUV was 0.53, but was effectively zero for VT. These data show that [(11)C]PBR28 brain uptake increases with age, implying increased microglial activation in the aged brain...
  37. doi Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism
    Silke Appel-Cresswell
    Pacific Parkinson s Research Center, Division of Neurology, University of British Columbia, Vancouver, BC, Canada
    Mov Disord 29:1684-7. 2014
    ..Families of Dutch-German-Russian Mennonite descent with multi-incident parkinsonism have been identified as harboring a pathogenic DNAJC13 p.N855S mutation and are awaiting clinical and pathophysiological characterization...
  38. ncbi PET study of [(18)F]6-fluoro-L-dopa uptake in neuroleptic- and mood-stabilizer-naive first-episode nonpsychotic mania: effects of treatment with divalproex sodium
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Am J Psychiatry 159:768-74. 2002
    ....
  39. ncbi Monte Carlo modelling of singles-mode transmission data for small animal PET scanners
    Eric Vandervoort
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, V6T 1Z1, Canada
    Phys Med Biol 52:3169-84. 2007
    ..5% and 2.5% of experimental values for background-corrected 68Ge and 57Co transmission data, respectively. This new simulation tool accurately models the photon interactions and data acquisition for singles-mode transmission scans...
  40. ncbi The influence of measurement uncertainties on the evaluation of the distribution volume ratio and binding potential in rat studies on a microPET R4: a phantom study
    Vesna Sossi
    Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Rd, Vancouver V6T 1Z1, Canada
    Phys Med Biol 50:2859-69. 2005
    ..With measured attenuation correction, the COVs were on average 100% higher. The presented method can be used to examine the contribution of a variety of imaging conditions to the uncertainty of biologically meaningful parameters...
  41. doi Manganese-52 positron emission tomography tracer characterization and initial results in phantoms and in vivo
    Geoffrey J Topping
    Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Med Phys 40:042502. 2013
    ..In this work, (52)MnCl2 is produced and characterized as a PET tracer in phantoms and in rats...
  42. doi Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats
    Paul J Cocker
    Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    J Neurosci 32:15450-7. 2012
    ....
  43. ncbi Positron emission tomography after fetal transplantation in Huntington's disease
    Sarah Furtado
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 58:331-7. 2005
    ..These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation...
  44. doi Impact of contamination from scattered photons in singles-mode transmission data on quantitative small-animal PET imaging
    Eric Vandervoort
    Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada
    J Nucl Med 49:1852-61. 2008
    ..In the current work, we investigated the impact that our method has on the quantitative accuracy of small-animal PET...
  45. doi Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging
    Matthew D Walker
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada
    J Parkinsons Dis 4:483-98. 2014
    ..G2019S mutation. Examination of the effects of this mutation is necessary to determine the etiology of PD and to guide therapeutic development...
  46. pmc Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers
    Claudia Jacova
    From the Division of Neurology, Department of Medicine C J, G Y R H, I T, H L, P S, P B K, A J S, H H F, Department of Physics and Astronomy K D, S M, M G, V S, and Department of Pathology and Laboratory Medicine I R M, University of British Columbia, Vancouver, Canada and Department of Neuroscience M B, R R, Mayo Clinic, Jacksonville, FL
    Neurology 81:1322-31. 2013
    ..In this prospective cohort study, we investigated cerebral glucose metabolism reductions on [(18)F]-fluorodeoxyglucose (FDG)-PET in progranulin (GRN) mutation carriers prior to frontotemporal dementia (FTD) onset...
  47. doi Scanning rats on the high resolution research tomograph (HRRT): a comparison study with a dedicated micro-PET
    Stephan A L Blinder
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Med Phys 39:5073-83. 2012
    ..This study investigates the feasibility of using the HRRT for quantitative small animal brain studies...
  48. doi Trials of neuroprotective therapies for Parkinson's disease: problems and limitations
    Raul de la Fuente-Fernandez
    Pacific Parkinson s Research Centre, University of British Columbia, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, B C, Canada V6T 2B5
    Parkinsonism Relat Disord 16:365-9. 2010
    ..This can lead to unequally-distributed placebo responses during phase 2, and is also a potential source of raters' biases. None of the trials on neuroprotective therapies for PD has yet provided solid evidence for neuroprotection...
  49. doi Advances in imaging in Parkinson's disease
    A Jon Stoessl
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, BC, Canada
    Lancet Neurol 10:987-1001. 2011
    ..Furthermore, these techniques can be applied to animal models, to help validate these models and allow their use in the study of potential disease-modifying therapies...
  50. doi Performance assessment of a preclinical PET scanner with pinhole collimation by comparison to a coincidence-based small-animal PET scanner
    Matthew D Walker
    Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada
    J Nucl Med 55:1368-74. 2014
    ..Pinhole collimation strongly departs from traditional electronic collimation achieved via coincidence detection in PET. We investigated the potential of such a design by direct comparison to a traditional PET scanner...
  51. pmc Exploring the use of shape and texture descriptors of positron emission tomography tracer distribution in imaging studies of neurodegenerative disease
    Ivan S Klyuzhin
    Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada
    J Cereb Blood Flow Metab 36:1122-34. 2016
    ..Such metrics may provide an alternate and complementary data analysis approach to traditional kinetic modeling. ..
  52. doi Interpreting DTBZ binding data in rodent: Inherent variability and compensation
    Miguel Mejias
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Synapse 70:147-52. 2016
    ....
  53. pmc Exploring the effects of coexisting amyloid in subcortical vascular cognitive impairment
    Elizabeth Dao
    Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6S 0A9, Canada
    BMC Neurol 15:197. 2015
    ..The purpose of this study was to understand whether individual differences in amyloid pathology might explain variations in cognitive impairment among individuals with clinical subcortical VCI (SVCI)...
  54. doi 188Re image performance assessment using small animal multi-pinhole SPECT/PET/CT system
    Pedro L Esquinas
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada Electronic address
    Phys Med . 2016
    ..The goal of this study was to investigate the performance of a pre-clinical SPECT/PET/CT system for 188Re imaging...
  55. doi Commentary: an eye on PET quantification
    Matthew D Walker
    Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada
    Mol Imaging Biol 17:1-3. 2015
    ..The approach is a useful complement to standard phantom tests such as those prescribed by NEMA, but the resulting data are more difficult to interpret. ..
  56. ncbi Increase in dopamine turnover occurs early in Parkinson's disease: evidence from a new modeling approach to PET 18 F-fluorodopa data
    Vesna Sossi
    University of British Columbia TRIUMF, University of British Columbia, Vancouver, Canada
    J Cereb Blood Flow Metab 22:232-9. 2002
    ....
  57. ncbi Statistical dynamic image reconstruction in state-of-the-art high-resolution PET
    Arman Rahmim
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Phys Med Biol 50:4887-912. 2005
    ....
  58. pmc Accurate event-driven motion compensation in high-resolution PET incorporating scattered and random events
    Arman Rahmim
    Department of Radiology, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD 21205, USA
    IEEE Trans Med Imaging 27:1018-33. 2008
    ..The proposed approach has been extensively validated using phantom experiments as well as realistic simulations of a new mathematical brain phantom developed in this work, and the results for a dynamic patient study are also presented...
  59. pmc System matrix modelling of externally tracked motion
    Arman Rahmim
    Department of Radiology, School of Medicine, Johns Hopkins University, Baltimore, USA
    Nucl Med Commun 29:574-81. 2008
    ....
  60. ncbi Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  61. ncbi Lack of regional selectivity during the progression of Parkinson disease: implications for pathogenesis
    Chong S Lee
    Pacific Parkinson s Research Centre, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Purdy Pavilion Room M36, Vancouver, British Columbia, Canada V6T 2B5
    Arch Neurol 61:1920-5. 2004
    ..Dopamine terminal loss in the putamen of patients with Parkinson disease (PD) shows a regional heterogeneity, reflecting selective vulnerability of degenerating neurons to mechanisms of cell death...
  62. ncbi PET performance measurements using the NEMA NU 2-2001 standard
    Margaret E Daube-Witherspoon
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Nucl Med 43:1398-409. 2002
    ..In addition, the updated measurements strive toward being more representative of clinical studies, in particular, whole-body imaging...