Arno G Siraki

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis
    Arno G Siraki
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chem Res Toxicol 23:880-7. 2010
  2. doi request reprint The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 91:228-35. 2013
  3. doi request reprint Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Biochem Pharmacol 106:46-55. 2016
  4. doi request reprint The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical
    Naif Aljuhani
    a University of Alberta, Faculty of Pharmacy and Pharmaceutical Sciences, Edmonton, AB T6G 2E1, Canada
    Can J Physiol Pharmacol 91:783-90. 2013
  5. doi request reprint Cytoprotective effect of isoniazid against H2O2 derived injury in HL-60 cells
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Chem Biol Interact 244:37-48. 2016
  6. doi request reprint Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada
    Chem Biol Interact 239:129-38. 2015
  7. doi request reprint Scavenging of free-radical metabolites of aniline xenobiotics and drugs by amino acid derivatives: toxicological implications of radical-transfer reactions
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Chem Res Toxicol 26:1872-83. 2013
  8. doi request reprint Post-trapping derivatization of radical-derived EPR-silent adducts: application to free radical detection by HPLC/UV in chemical, biochemical, and biological systems and comparison with EPR spectroscopy
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Anal Chem 84:6739-46. 2012
  9. doi request reprint 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites
    Pratik Arvadia
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Arch Biochem Biophys 515:120-6. 2011
  10. doi request reprint Current status and future prospects of toxicogenomics in drug discovery
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Drug Discov Today 19:562-78. 2014

Collaborators

  • Karim Michail
  • Jose L Medina-Franco
  • Badreldin H Ali
  • Ayman O S El-Kadi
  • Ronald P Mason
  • Saifur R Khan
  • Naif Aljuhani
  • Argishti Baghdasarian
  • Pratik Arvadia
  • Malyaj Narwaley
  • Andrew G M Morgan
  • Fahad S Aldawsari
  • Richard P Fahlman
  • Randy M Whittal
  • Mohamed A M El Gendy
  • Nutan Srivastava
  • Rafael Pazinatto Aguiar
  • Luiz Alexandre Marques Wiirzler
  • Carlos A Velázquez-Martínez
  • Roberto Kenji Nakamura Cuman
  • Rodrigo Aguayo-Ortiz
  • Prarthna H Nagar
  • Richard Fahlman
  • Paul Jurasz
  • Zubeida Karapetyan

Detail Information

Publications13

  1. pmc Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis
    Arno G Siraki
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chem Res Toxicol 23:880-7. 2010
    ..Interestingly, we found that only those aniline derivatives that produced a phenyl radical also formed MPO*. We propose that the phenyl radical is the reactive free radical metabolite responsible for generating the MPO*...
  2. doi request reprint The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 91:228-35. 2013
    ..In conclusion, di- and poly-amines are capable of enhancing the formation of aromatic-amine-derived free radicals, a fact that is expected to have toxicological consequences...
  3. doi request reprint Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Biochem Pharmacol 106:46-55. 2016
    ..This adduct was confirmed to be isonicotinyl-NAD(+) using LC-MS analysis where the intact adduct was detected (m/z=769). The findings of this study suggest that neutrophil MPO may also play a role in INH pharmacological activity. ..
  4. doi request reprint The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical
    Naif Aljuhani
    a University of Alberta, Faculty of Pharmacy and Pharmaceutical Sciences, Edmonton, AB T6G 2E1, Canada
    Can J Physiol Pharmacol 91:783-90. 2013
    ..These findings demonstrate the importance of NaHCO3 in menadione redox cycling and cytotoxicity. ..
  5. doi request reprint Cytoprotective effect of isoniazid against H2O2 derived injury in HL-60 cells
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Chem Biol Interact 244:37-48. 2016
    ..Unexpectedly, these covalent protein adducts were correlated with INH-induced cytoprotection in HL-60 cells. Further studies are needed to determine whether the INH-protein adducts were causative in the mechanism of cytoprotection. ..
  6. doi request reprint Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada
    Chem Biol Interact 239:129-38. 2015
    ..This response correlated with the intensity of AG-induced protein radical formation in HL-60 cells, which may play a role in cell death signaling mechanisms. ..
  7. doi request reprint Scavenging of free-radical metabolites of aniline xenobiotics and drugs by amino acid derivatives: toxicological implications of radical-transfer reactions
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Chem Res Toxicol 26:1872-83. 2013
    ..These findings may have significant implications for the biological fate of arylamine xenobiotic and drug free-radical metabolites. ..
  8. doi request reprint Post-trapping derivatization of radical-derived EPR-silent adducts: application to free radical detection by HPLC/UV in chemical, biochemical, and biological systems and comparison with EPR spectroscopy
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Anal Chem 84:6739-46. 2012
    ..We believe the proposed methodology could represent a valuable tool to probe free radical metabolites in vivo using DMPO, the least toxic spin trap...
  9. doi request reprint 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites
    Pratik Arvadia
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Arch Biochem Biophys 515:120-6. 2011
    ..We conclude that the 4-ABAH free radical metabolites which were bound to MP-11 were involved in the catalytic inhibition and were scavenged by DMPO...
  10. doi request reprint Current status and future prospects of toxicogenomics in drug discovery
    Saifur R Khan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada
    Drug Discov Today 19:562-78. 2014
    ..In this review, we describe the various components of holistic toxicogenomics with examples of applications, and discuss the various analytical tools and platforms to illustrate the current status and prospects of next-generation DDD. ..
  11. doi request reprint Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites
    Malyaj Narwaley
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Chem Res Toxicol 24:1031-9. 2011
    ....
  12. doi request reprint Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog
    Fahad S Aldawsari
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada Electronic address
    Bioorg Med Chem Lett 26:1411-5. 2016
    ..Because of the proven association between cancer, inflammation, and oxidative stress, we believe that C10 is a promising chemopreventive molecule. ..
  13. doi request reprint Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism
    Mohamed A M El Gendy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Ethnopharmacol 144:416-24. 2012
    ..Rhazya stricta has been used traditionally to treat several diseases including tumors; however, the underlying mechanism is still not fully elucidated...