U I Schwarz
Affiliation: University of Western Ontario
- Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinololU I Schwarz
Medical Faculty, Institute of Clinical Pharmacology, Technical University Dresden, Dresden, Germany
Clin Pharmacol Ther 81:669-78. 2007..Interestingly, the magnitude of induction appeared to be affected by MDR1 genotype...
- Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humansU I Schwarz
Institute of Clinical Pharmacology, Faculty of Medicine, University of Technology, Dresden, Germany
Clin Pharmacol Ther 65:283-90. 1999..To quantitate the effect of verapamil administered orally, a calcium channel blocker and potent inhibitor of P-glycoprotein on oral pharmacokinetics of the beta1-adrenergic receptor antagonist talinolol, a substrate of P-glycoprotein...
- Intestinal drug transporter expression and the impact of grapefruit juice in humansH Glaeser
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Clin Pharmacol Ther 81:362-70. 2007..Although short-term grapefruit juice ingestion was associated with reduced fexofenadine availability, OATP1A2 or MDR1 expression was unaffected...
- Identification of functionally variant MDR1 alleles among European Americans and African AmericansR B Kim
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Clin Pharmacol Ther 70:189-99. 2001..Thus allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P-glycoprotein function...