A J Sandford

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
  2. pmc Recent advances in asthma genetics
    Jian Zhang
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, B, C, V6Z 1Y6
    Respir Res 9:4. 2008
  3. pmc Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
    Alison M Wallace
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Respir Res 7:76. 2006
  4. pmc Selection of reference genes for gene expression studies in human neutrophils by real-time PCR
    Xiaozhu Zhang
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Vancouver, Canada
    BMC Mol Biol 6:4. 2005
  5. pmc Lack of association of TIM3 polymorphisms and allergic phenotypes
    Jian Zhang
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, BC, Canada
    BMC Med Genet 10:62. 2009
  6. pmc Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction
    A J Sandford
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Thorax 57:736-41. 2002
  7. ncbi request reprint Homing in on the asthma gene
    Andrew Sandford
    McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Lancet 360:422-3. 2002
  8. ncbi request reprint Candidate genetic polymorphisms for asthma in Chinese schoolchildren from Hong Kong
    A J Sandford
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Tuberc Lung Dis 8:519-27. 2004
  9. ncbi request reprint Genetic risk factors for chronic obstructive pulmonary disease
    Andrew J Sandford
    University of British Columbia Pulmonary Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 8:87-94. 2002
  10. ncbi request reprint Vitamin D binding protein variants and the risk of COPD
    D Schellenberg
    Respiratory Health Network of Centres of Excellence, University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
    Am J Respir Crit Care Med 157:957-61. 1998

Collaborators

Detail Information

Publications55

  1. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  2. pmc Recent advances in asthma genetics
    Jian Zhang
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, B, C, V6Z 1Y6
    Respir Res 9:4. 2008
    ..Some important genes such as filaggrin, interleukin-13, interleukin-17 and the cysteinyl leukotriene receptor-1 which not only were replicated by independent association studies but also have functional data are reviewed in this article...
  3. pmc Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
    Alison M Wallace
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Respir Res 7:76. 2006
    ....
  4. pmc Selection of reference genes for gene expression studies in human neutrophils by real-time PCR
    Xiaozhu Zhang
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Vancouver, Canada
    BMC Mol Biol 6:4. 2005
    ..Thus the selection of reference gene(s) is critical for gene expression studies. For this purpose, 10 commonly used housekeeping genes were investigated in isolated human neutrophils...
  5. pmc Lack of association of TIM3 polymorphisms and allergic phenotypes
    Jian Zhang
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, BC, Canada
    BMC Med Genet 10:62. 2009
    ..The aims of this study were to examine whether genetic variation in the promoter region of TIM3 influenced transcription of the gene and risk for allergic phenotypes...
  6. pmc Chronic obstructive pulmonary disease. 1: Susceptibility factors for COPD the genotype-environment interaction
    A J Sandford
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Thorax 57:736-41. 2002
    ..Candidate gene association studies in COPD are reviewed. Efforts to identify interactions between genetic factors and environmental determinants such as smoking may lead to improved understanding of the pathogenesis of the disease...
  7. ncbi request reprint Homing in on the asthma gene
    Andrew Sandford
    McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Lancet 360:422-3. 2002
  8. ncbi request reprint Candidate genetic polymorphisms for asthma in Chinese schoolchildren from Hong Kong
    A J Sandford
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Tuberc Lung Dis 8:519-27. 2004
    ..In this study we tested for associations of 11 polymorphisms with wheeze and asthma in 10-year-old Chinese schoolchildren...
  9. ncbi request reprint Genetic risk factors for chronic obstructive pulmonary disease
    Andrew J Sandford
    University of British Columbia Pulmonary Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 8:87-94. 2002
    ..Thus, the genetic basis for chronic obstructive pulmonary disease has begun to be elucidated, and it is likely that several genes will be implicated in the pathogenesis of this disease...
  10. ncbi request reprint Vitamin D binding protein variants and the risk of COPD
    D Schellenberg
    Respiratory Health Network of Centres of Excellence, University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
    Am J Respir Crit Care Med 157:957-61. 1998
    ..We found no difference among genotypes with respect to neutrophil chemotaxis suggesting that the protective effect of the Gc2 allele is mediated through a different mechanism...
  11. ncbi request reprint Polymorphisms of interleukin-10 and its receptor and lung function in COPD
    J Q He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 29:1120-6. 2007
    ....
  12. ncbi request reprint Susceptibility genes for rapid decline of lung function in the lung health study
    A J Sandford
    The University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 163:469-73. 2001
    ..9, p = 0.04). The alpha1-antitrypsin S and 3' polymorphisms, vitamin D-binding protein isoforms, and tumor necrosis factor (TNF-alpha G-308A and TNF-beta A252G) polymorphisms were not associated with rate of decline of lung function...
  13. doi request reprint Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Eur Respir J 32:25-34. 2008
    ..No association was found for CSF2 SNPs and lung function, nor was there evidence of epistasis. In conclusion, genetic variation in colony-stimulating factor 3 is associated with cross-sectionally measured lung function in smokers...
  14. pmc Polymorphisms in the beta2 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers
    L Joos
    UBC McDonald Research Laboratories iCAPTURE Center, Vancouver, BC, Canada
    Thorax 58:703-7. 2003
    ..Based on these associations, we hypothesised that ADRB2 polymorphisms would be associated with NSBH and BDR as well as an accelerated rate of decline in lung function among smokers...
  15. pmc Lack of association of group specific component haplotypes with lung function in smokers
    I Kasuga
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Thorax 58:790-3. 2003
    ..Several reports have described associations between GC haplotypes and COPD but these remain controversial. In addition, most of these studies were based on a small number of subjects...
  16. ncbi request reprint Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers
    G Tanaka
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Eur Respir J 29:34-41. 2007
    ..In conclusion, these results support the findings of previous studies in late-onset chronic obstructive pulmonary disease in Caucasian populations...
  17. pmc Associations of IL6 polymorphisms with lung function decline and COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Thorax 64:698-704. 2009
    ..There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers...
  18. pmc Genetic association between human chitinases and lung function in COPD
    F Aminuddin
    James Hogg Research Centre, Providence Heart and Lung Institute, St Paul s Hospital, The University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Hum Genet 131:1105-14. 2012
    ..Although a significant effect of chitinase gene alleles was found on lung function level and decline in the LHS, we were unable to replicate the associations with COPD affection status in the other COPD study groups...
  19. ncbi request reprint Recent developments in the genetics of asthma
    J Q He
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Pharmacogenomics 2:329-39. 2001
    ..In the future, knowledge of an individual's genotype may help us tailor treatment to make it the most appropriate form for that asthmatic individual...
  20. ncbi request reprint beta(2)-Adrenergic receptor polymorphisms and asthma
    L Joos
    University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 7:69-74. 2001
    ..It is the aim of this chapter to summarize the latest developments in this interesting field of research...
  21. ncbi request reprint Association study between the CX3CR1 gene and asthma
    K Tremblay
    Department of Medicine, University of Montreal Community Genomic Medicine Centre, Chicoutimi University Hospital, Saguenay, Quebec, Canada
    Genes Immun 7:632-9. 2006
    ..007) and dominant model (P=0.059). These results suggest an asthma protective effect of the minor alleles in healthy control carriers. Further functional studies of CX3CR1 are needed to document its role in the pathophysiology of asthma...
  22. ncbi request reprint Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children
    J Q He
    McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, University of British Columbia, Canada
    Genes Immun 4:385-9. 2003
    ..006) and with atopy (P=0.009). Our data suggest that the IL13 Arg130Gln polymorphism and haplotypes consisting of IL13 Arg130Gln and IL4 C-589 T were associated with the development of atopy and atopic dermatitis at 24 months of age...
  23. pmc Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers
    L Joos
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada V6Z 1Y6
    Thorax 56:863-6. 2001
    ..The IL-1beta (IL1B) gene contains a promoter polymorphism (C-511T) that has been associated with inflammatory diseases and is in linkage disequilibrium with the IL1RN polymorphism...
  24. ncbi request reprint PMN degranulation in relation to CD63 expression and genetic polymorphisms in healthy individuals and COPD patients
    X Z Zhang
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Int J Mol Med 19:817-22. 2007
    ..It is likely that genetic variants have limited effect on CD63 expression and MPO release in the context of COPD but their role in other diseases has yet to be determined...
  25. doi request reprint Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 32:755-62. 2008
    ....
  26. ncbi request reprint alpha1-antitrypsin genotypes and the acute-phase response to open heart surgery
    A J Sandford
    University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver
    Am J Respir Crit Care Med 159:1624-8. 1999
    ..However, a deficient acute-phase rise in alpha1-AT may contribute to the susceptibility to COPD associated with the Z mutation...
  27. ncbi request reprint Alpha 1-antichymotrypsin mutations in patients with chronic obstructive pulmonary disease
    A J Sandford
    Respiratory Health Network of Centres of Excellence, University of British Columbia Pulmonary, Vancouver, Canada
    Dis Markers 13:257-60. 1998
    ..The prevalence of the Pro227-->Ala mutation was 0.9% and it was not associated with impaired lung function. None of the subjects had the Leu55-->Pro mutation...
  28. ncbi request reprint Stability of housekeeping genes in alveolar macrophages from COPD patients
    T Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver BC, V6Z 1Y6, Canada
    Eur Respir J 27:300-6. 2006
    ....
  29. doi request reprint Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection
    J E Park
    James Hogg Research Centre, Providence Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Genes Immun 12:370-7. 2011
    ..However, because of the multiple comparisons made, further studies are required to confirm the interaction between these modifying genes and CFTR...
  30. doi request reprint Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype
    C C K Hui
    Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
    Mucosal Immunol 8:993-9. 2015
    ..Identifying functional consequences of SNPs in genes with previously reported clinical associations is critical in understanding and targeting allergic inflammation...
  31. ncbi request reprint The role of the C-C chemokine receptor-5 Delta32 polymorphism in asthma and in the production of regulated on activation, normal T cells expressed and secreted
    A J Sandford
    UBC McDonald Research Laboratories, St Paul s Hospital, and the Respiratory Division, Vancouver General Hospital, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 108:69-73. 2001
    ..RANTES is a chemokine that is known to play an important role in the pathogenesis of allergic asthma...
  32. ncbi request reprint The E237G polymorphism of the high-affinity IgE receptor beta chain and asthma
    Xiaozhu Zhang
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia
    Ann Allergy Asthma Immunol 93:499-503. 2004
    ..The beta chain of high-affinity IgE receptor (FcepsilonRI beta) has been proposed as a candidate gene for asthma and atopic diseases...
  33. doi request reprint A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness
    Jian Qing He
    James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 124:222-9. 2009
    ..Association of genetic variation in thymic stromal lymphopoietin with IgE levels has been reported for human subjects...
  34. doi request reprint Analyses of associations with asthma in four asthma population samples from Canada and Australia
    Denise Daley
    James Hogg iCAPTURE Center, University of British Columbia UBC, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Hum Genet 125:445-59. 2009
    ..To aid in future replication studies of asthma genes a comprehensive database was compiled and is available to the scientific community at http://genapha.icapture.ubc.ca/...
  35. ncbi request reprint Promoter polymorphism and expression of beta-arrestin 2 in neutrophils
    Xiaozhu Zhang
    Clin Chim Acta 385:79-80. 2007
  36. doi request reprint Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues
    Karine Tremblay
    Hopital Laval, Universite Laval, Quebec, Canada
    J Allergy Clin Immunol 122:529-36.e17. 2008
    ..Eight genes in the immune signaling pathway shown to be differentially expressed in asthmatic lung biopsy specimens in a previous microarray experiment were selected as candidate genes for asthma susceptibility...
  37. ncbi request reprint Genetic polymorphisms of matrix metalloproteinases: functional importance in the development of chronic obstructive pulmonary disease?
    Alison M Wallace
    University of British Columbia McDonald Research Laboratories iCAPTURE Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Pharmacogenomics 2:167-75. 2002
    ..Understanding the role of genetic polymorphisms in MMP1, MMP9 and MMP12 may help in the discovery of new and more effective therapies...
  38. ncbi request reprint Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers
    Emiko Ogawa
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Respir Med 101:938-43. 2007
    ..04). These data suggest that the T-C polymorphism at position +869 in the TGF-beta1 gene contributes to airway hyperresponsiveness, but not to rapid decline of lung function...
  39. ncbi request reprint Association of Hck genetic polymorphisms with gene expression and COPD
    Xiaozhu Zhang
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Room 166, Vancouver, BC, Canada
    Hum Genet 120:681-90. 2007
    ..These data suggest that the insertion/deletion polymorphism could be a functional polymorphism of the Hck gene, may contribute to COPD pathogenesis and modify COPD-related phenotypes...
  40. ncbi request reprint Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 166:323-8. 2002
    ..20; p = 0.01). However, due to the multiple comparisons that were made, these associations may represent type 1 error. There was no association between HMOX1 (GT)n alleles and the rate of decline in lung function in smokers...
  41. ncbi request reprint Genotype predictors of response to asthma medications
    Ladina Joos
    Pulmonary Cell Research Laboratory, Research Department, University of Basel, Basel, Switzerland
    Curr Opin Pulm Med 8:9-15. 2002
    ..To date, no polymorphisms have been identified that influence response to anticholinergics or are involved in steroid resistance...
  42. ncbi request reprint Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 28:379-85. 2003
    ..Haplotypes consisting of alleles from the IL13 polymorphisms or from the IL4RA polymorphisms were not associated with rate of decline in lung function in smokers...
  43. ncbi request reprint Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Chest 123:438S. 2003
  44. ncbi request reprint Alpha 1-antitrypsin deficiency alleles in cystic fibrosis lung disease
    Despina D Frangolias
    McDonald Research Laboratories iCAPTURE Centre, Division of Biochemical Diseases, Department of Pediatrics, University of British Columbia, B C Children s Hospital, Vancouver, Canada
    Am J Respir Cell Mol Biol 29:390-6. 2003
    ..Body mass index was a significant predictor of alpha1-AT levels during exacerbations. alpha1-AT genotype is not a major contributor to the variability of pulmonary disease severity in CF...
  45. ncbi request reprint The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
    ..0007). These data suggest that polymorphisms in the MMP1 and MMP12 genes, but not MMP9, are either causative factors in smoking-related lung injury or are in linkage disequilibrium with causative polymorphisms...
  46. ncbi request reprint Glutathione S-transferase variants and their interaction with smoking on lung function
    Jian Qing He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 170:388-94. 2004
    ..49 (95% CI, 1.48-8.39, p = 0.005) in mild smokers (< or = 25 pack years). We conclude that GST genotypes are risk factors for rapid decline or low lung function in smokers with mild to moderate airflow obstruction...
  47. ncbi request reprint Therapeutic response to asthma medications: genotype predictors
    Alison M Wallace
    University of British Columbia, James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, British Columbia, Canada
    Treat Respir Med 3:161-71. 2004
    ..To date, single nucleotide polymorphism and limited haplotype analysis have provided inconclusive evidence as to how genotype predictors can be used to optimize current asthma therapies based on each patient's genetic profile...
  48. ncbi request reprint Genetic modifiers of lung disease in cystic fibrosis
    Mitchell L Drumm
    Department of Pediatrics, Case Western Reserve University, Cleveland, USA
    N Engl J Med 353:1443-53. 2005
    ..Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis...
  49. ncbi request reprint Lack of association of human leukocyte antigen-B7 with COPD and rate of decline in lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Respir Med 99:1528-33. 2005
    ..The aim of this study was to investigate the contribution of the HLA-B7 allele to COPD and to rate of decline of lung function...
  50. ncbi request reprint Interferon gamma polymorphisms and their interaction with smoking are associated with lung function
    Jian Qing He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Hum Genet 119:365-75. 2006
    ..No association was found in the rate of decline study. There was an association between IFNG genotype and baseline of lung function and this association was modified by cigarette smoking...
  51. pmc Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease
    Edward F McKone
    Department of Environmental and Occupational Health Sciences, University of Washington Mail Box 354695, Seattle, WA 98195, USA
    Am J Respir Crit Care Med 174:415-9. 2006
    ..Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury...
  52. ncbi request reprint Genetic risk factors of chronic obstructive pulmonary disease
    Ladina Joos
    Departement Innere Medizin, Kantonsspital Basel, Switzerland
    Swiss Med Wkly 132:27-37. 2002
    ..Family and twin studies suggest that genetic factors also contribute to the development of COPD. We present a detailed literature review of the genes which have been investigated as potential risk factors for this disease...
  53. ncbi request reprint Reconcilable differences: a cross-sectional study of the relationship between socioeconomic status and the magnitude of short-acting beta-agonist use in asthma
    Larry D Lynd
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    Chest 126:1161-8. 2004
    ..To assess the association between socioeconomic status (SES) and short-acting (SA) beta-agonist use, controlling for asthma severity...
  54. doi request reprint Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema
    Alison M Wallace
    University of British Columbia UBC James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, BC, Canada
    COPD 5:13-23. 2008
    ..Furthermore, these data provide evidence to support the concept that multiple proteinases, causing both elastin and collagen degradation, are important in the pathogenesis of pulmonary emphysema...
  55. ncbi request reprint Relationship of matrix metalloproteinase mRNA expression and genetic polymorphisms to emphysema
    Raja T Abboud
    Division of Respiratory Medicine, University of British Columbia, 2775 Heather Street, Vancouver, BC, V5Z 3J5 Canada
    Proc Am Thorac Soc 3:475. 2006