Heather N Reich

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus
    Heather N Reich
    Division of Nephrology, Department of Medicine, University Health Network and University of Toronto, Toronto, ON, Canada
    Kidney Int 79:914-20. 2011
  2. doi request reprint Individuals of Pacific Asian origin with IgA nephropathy have an increased risk of progression to end-stage renal disease
    Sean J Barbour
    1 Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 2 British Columbia Provincial Renal Agency, Vancouver, British Columbia, Canada 3 Toronto Glomerulonephritis Registry, University Health Network, Toronto, Ontario, Canada
    Kidney Int 84:1017-24. 2013
  3. doi request reprint Validation of the Oxford classification of IgA nephropathy
    Andrew M Herzenberg
    Division of Nephrology, Toronto General Hospital, University of Toronto, Ontario, Canada
    Kidney Int 80:310-7. 2011
  4. doi request reprint Age is a determinant of acute hemodynamic responses to hyperglycemia and angiotensin II in humans with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R206-14. 2010
  5. doi request reprint Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Can J Physiol Pharmacol 90:113-21. 2012
  6. doi request reprint Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital and Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 84:1246-53. 2013
  7. doi request reprint The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes
    David Z I Cherney
    Division of Nephrology, University Health Network Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Diabetologia 56:2308-17. 2013
  8. doi request reprint Glomerular filtration rate predicts arterial events in women with systemic lupus erythematosus
    Wendy Zhang
    Arthritis Centre of Excellence, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada
    Rheumatology (Oxford) 50:799-805. 2011
  9. doi request reprint Have we changed the outcome in membranous nephropathy? A propensity study on the role of immunosuppressive therapy
    Daniel C Cattran
    Department of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Clin J Am Soc Nephrol 6:1591-8. 2011
  10. doi request reprint The urinary inflammatory profile in gluten free diet-adherent adolescents with type 1 diabetes and celiac disease
    Emilia N De Melo
    Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada
    J Diabetes Complications 30:295-9. 2016

Collaborators

Detail Information

Publications26

  1. doi request reprint Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus
    Heather N Reich
    Division of Nephrology, Department of Medicine, University Health Network and University of Toronto, Toronto, ON, Canada
    Kidney Int 79:914-20. 2011
    ..Hence, as in idiopathic glomerular disease, persistent proteinuria and dyslipidemia (modifiable risks) are the major factors for CKD progression in lupus patients with renal involvement...
  2. doi request reprint Individuals of Pacific Asian origin with IgA nephropathy have an increased risk of progression to end-stage renal disease
    Sean J Barbour
    1 Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 2 British Columbia Provincial Renal Agency, Vancouver, British Columbia, Canada 3 Toronto Glomerulonephritis Registry, University Health Network, Toronto, Ontario, Canada
    Kidney Int 84:1017-24. 2013
    ..5) and an increased risk of a reduction in eGFR by half (hazard ratio 1.81, 95% CI 1.25, 2.62). Thus, in a large multiracial cohort of patients with IgAN, individuals of Pacific Asian origin have a higher risk of progression to ESRD...
  3. doi request reprint Validation of the Oxford classification of IgA nephropathy
    Andrew M Herzenberg
    Division of Nephrology, Toronto General Hospital, University of Toronto, Ontario, Canada
    Kidney Int 80:310-7. 2011
    ..Further studies are needed to determine the relationship to the impact of treatment and to define the value of the mesangial hypercellularity score...
  4. doi request reprint Age is a determinant of acute hemodynamic responses to hyperglycemia and angiotensin II in humans with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R206-14. 2010
    ....
  5. doi request reprint Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Can J Physiol Pharmacol 90:113-21. 2012
    ..The lack of effect on Ang II responses suggests that PKCβ inhibition may act through non-RAS pathways in humans with DM...
  6. doi request reprint Long-term hemodynamic and molecular effects persist after discontinued renin-angiotensin system blockade in patients with type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital and Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 84:1246-53. 2013
    ..Our findings suggest that sustained long-term protective effects of finite RAS inhibition requires further study. ..
  7. doi request reprint The effect of aliskiren on urinary cytokine/chemokine responses to clamped hyperglycaemia in type 1 diabetes
    David Z I Cherney
    Division of Nephrology, University Health Network Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Diabetologia 56:2308-17. 2013
    ....
  8. doi request reprint Glomerular filtration rate predicts arterial events in women with systemic lupus erythematosus
    Wendy Zhang
    Arthritis Centre of Excellence, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada
    Rheumatology (Oxford) 50:799-805. 2011
    ..To determine whether renal function predicts the development of cardiovascular disease and other arterial vascular events in patients with SLE...
  9. doi request reprint Have we changed the outcome in membranous nephropathy? A propensity study on the role of immunosuppressive therapy
    Daniel C Cattran
    Department of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Clin J Am Soc Nephrol 6:1591-8. 2011
    ..Given these important changes, we sought to determine whether implementation of IS has altered outcome...
  10. doi request reprint The urinary inflammatory profile in gluten free diet-adherent adolescents with type 1 diabetes and celiac disease
    Emilia N De Melo
    Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada
    J Diabetes Complications 30:295-9. 2016
    ....
  11. pmc The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes
    David Z I Cherney
    Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, Ontario, Canada
    Diabetes Care 35:2324-30. 2012
    ..Accordingly, our aim was to determine if direct renin inhibition alone, and in combination with an ACE inhibitor, corrects early hemodynamic abnormalities associated with type 1 diabetes...
  12. pmc Early changes in cardiovascular structure and function in adolescents with type 1 diabetes
    Timothy J Bradley
    Department of Paediatrics, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 15:31. 2016
    ..We assessed cardiovascular structure and function in adolescents with T1D compared with healthy controls and the relationships between peripheral vascular function and myocardial parameters...
  13. doi request reprint The angiotensin II receptor type 2 polymorphism influences haemodynamic function and circulating RAS mediators in normotensive humans
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto ON, Canada
    Nephrol Dial Transplant 25:4093-6. 2010
    ..An AT2R G1675A gene polymorphism has been described, but the functional effects of this polymorphism are unknown...
  14. doi request reprint Risk stratification of patients with IgA nephropathy
    Sean J Barbour
    Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Kidney Dis 59:865-73. 2012
    ....
  15. pmc Molecular markers of injury in kidney biopsy specimens of patients with lupus nephritis
    Heather N Reich
    University Health Network and University of Toronto, Toronto, Ontario, Canada
    J Mol Diagn 13:143-51. 2011
    ....
  16. doi request reprint The impact of sex in primary glomerulonephritis
    Daniel C Cattran
    Department of Nephrology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Nephrol Dial Transplant 23:2247-53. 2008
    ..Studies comparing the impact of sex in primary glomerular disease have reported conflicting results...
  17. doi request reprint Urinary ACE2 in healthy adults and patients with uncomplicated type 1 diabetes
    David Z I Cherney
    a Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Physiol Pharmacol 92:703-6. 2014
    ..Urinary ACE2 activity and protein expression are increased in T1D patients prior to the onset of clinical complications. Further work is required to determine the functional role of urinary ACE2 in early T1D. ..
  18. doi request reprint Disease-specific risk of venous thromboembolic events is increased in idiopathic glomerulonephritis
    Sean J Barbour
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Kidney Int 81:190-5. 2012
    ..Thus, in this large cohort, histologic diagnosis was an independent risk factor for venous thromboembolic events. Further studies are needed to discover mechanisms responsible for this high risk in patients with membranous nephropathy...
  19. pmc The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 34:177-80. 2011
    ..Our objective was to determine whether acute hyperglycemia affects urinary secretion of inflammatory cytokines/chemokines in humans with uncomplicated type 1 diabetes...
  20. pmc A molecular signature of proteinuria in glomerulonephritis
    Heather N Reich
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e13451. 2010
    ..Our findings support the hypothesis that albuminuria may directly promote injury in the tubulo-interstitial compartment of the kidney in patients with glomerulonephritis...
  21. doi request reprint Determinants of long-term graft outcome in transplant glomerulopathy
    Rohan John
    Department of Pathology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Transplantation 90:757-64. 2010
    ..We investigated several potentially prognostic clinical and pathologic factors in TG and evaluated estimated glomerular filtration rate (eGFR) slopes to assess graft function and early decline...
  22. doi request reprint The MEST score provides earlier risk prediction in lgA nephropathy
    Sean J Barbour
    Division of Nephrology, University of British Columbia, Vancouver, BC, Canada BC Provincial Renal Agency, Vancouver, BC, Canada Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, Vancouver, BC, Canada
    Kidney Int 89:167-75. 2016
    ..Thus, combining the MEST score with cross-sectional clinical data at biopsy provides earlier risk prediction in IgAN than our current best methods. ..
  23. pmc The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes
    Ron L H Har
    Division of Nephrology, University Health Network Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e111131. 2014
    ..Our second aim was to determine the relationship between urine and plasma levels of inflammatory biomarkers, to clarify the origin of these factors...
  24. doi request reprint Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
    Heather N Reich
    Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 74:1610-6. 2008
    ..Our results suggest that the kidney disease of patients with type 2 diabetes is associated with a reduction in ACE2 gene and protein expression and this may contribute to the progression of renal injury...
  25. pmc Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:361-5. 2010
    ..The recent development of direct renin inhibitors (DRIs) provides a new approach to block the RAS, but the effects of DRIs on renal and systemic vascular function in uncomplicated type 1 diabetes have not been elucidated...
  26. ncbi request reprint Remission of proteinuria improves prognosis in IgA nephropathy
    Heather N Reich
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Nephrol 18:3177-83. 2007
    ..These results underscore the relationship between proteinuria and prognosis in IgA nephropathy and establish the importance of remission...