Esteban J Parra

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc SOD2 gene Val16Ala polymorphism is associated with macroalbuminuria in Mexican type 2 diabetes patients: a comparative study and meta-analysis
    Iván de Jesús Ascencio-Montiel
    Biochemistry Research Unit, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico DF, Mexico
    BMC Med Genet 14:110. 2013
  2. ncbi request reprint Human pigmentation variation: evolution, genetic basis, and implications for public health
    Esteban J Parra
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada L5L 1C6
    Am J Phys Anthropol . 2007
  3. pmc Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas
    E J Parra
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, Canada, L5L 1C6
    Diabetologia 54:2038-46. 2011
  4. doi request reprint Technical note: quantitative measures of iris color using high resolution photographs
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Ontario, Canada
    Am J Phys Anthropol 147:141-9. 2012
  5. pmc Analysis of iris surface features in populations of diverse ancestry
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Toronto, Ontario, Canada
    R Soc Open Sci 3:150424. 2016
  6. pmc Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry
    Jessica L Hider
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    BMC Evol Biol 13:150. 2013
  7. doi request reprint Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements
    Kendra A Ross
    Department of Anthropology, University of Toronto, Toronto, Ontario, Canada
    J Hum Genet 55:582-9. 2010
  8. doi request reprint Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    J Steroid Biochem Mol Biol 127:405-12. 2011
  9. doi request reprint Association study confirms the role of two OCA2 polymorphisms in normal skin pigmentation variation in East Asian populations
    Katherine Eaton
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Am J Hum Biol 27:520-5. 2015
  10. doi request reprint Iris pigmentation as a quantitative trait: variation in populations of European, East Asian and South Asian ancestry and association with candidate gene polymorphisms
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Mississauga, ON, Canada
    Pigment Cell Melanoma Res 29:141-62. 2016

Collaborators

Detail Information

Publications32

  1. pmc SOD2 gene Val16Ala polymorphism is associated with macroalbuminuria in Mexican type 2 diabetes patients: a comparative study and meta-analysis
    Iván de Jesús Ascencio-Montiel
    Biochemistry Research Unit, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico DF, Mexico
    BMC Med Genet 14:110. 2013
    ..Several studies in type 2 diabetes patients have shown significant associations between the SOD2 gene Val16Ala polymorphism and albuminuria, but this association has not been explored in the Mexican population...
  2. ncbi request reprint Human pigmentation variation: evolution, genetic basis, and implications for public health
    Esteban J Parra
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada L5L 1C6
    Am J Phys Anthropol . 2007
    ....
  3. pmc Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas
    E J Parra
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, Canada, L5L 1C6
    Diabetologia 54:2038-46. 2011
    ..The top signals observed in this meta-analysis were followed up in the Diabetes Genetics Replication and Meta-analysis Consortium (DIAGRAM) and DIAGRAM+ datasets...
  4. doi request reprint Technical note: quantitative measures of iris color using high resolution photographs
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Ontario, Canada
    Am J Phys Anthropol 147:141-9. 2012
    ..High-resolution pictures of the iris will also make it possible to study the genetic variation involved in iris textural patterns, which show substantial heritability in human populations...
  5. pmc Analysis of iris surface features in populations of diverse ancestry
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Toronto, Ontario, Canada
    R Soc Open Sci 3:150424. 2016
    ..The study of iris surface features in diverse populations may provide valuable information of forensic, biomedical and ophthalmological interest. ..
  6. pmc Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry
    Jessica L Hider
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    BMC Evol Biol 13:150. 2013
    ..Based on the results obtained from a genome wide analysis of 25 kb windows, we constructed an empirical distribution for each statistic across all windows, and identified pigmentation genes that are outliers in the distribution...
  7. doi request reprint Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements
    Kendra A Ross
    Department of Anthropology, University of Toronto, Toronto, Ontario, Canada
    J Hum Genet 55:582-9. 2010
    ..Understanding the worldwide distribution of markers determining warfarin dosing is important for the future application of pharmacogenomic-based algorithms to different population groups...
  8. doi request reprint Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    J Steroid Biochem Mol Biol 127:405-12. 2011
    ..Vitamin D intake was also significantly predictive of serum 25(OHD) concentrations, and similarly to what was observed for the GC polymorphisms, the relative strength of the association was influenced by ancestry and season...
  9. doi request reprint Association study confirms the role of two OCA2 polymorphisms in normal skin pigmentation variation in East Asian populations
    Katherine Eaton
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Am J Hum Biol 27:520-5. 2015
    ....
  10. doi request reprint Iris pigmentation as a quantitative trait: variation in populations of European, East Asian and South Asian ancestry and association with candidate gene polymorphisms
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Mississauga, ON, Canada
    Pigment Cell Melanoma Res 29:141-62. 2016
    ..We also observed that the marker HERC2 rs12913832, which is the main determinant of 'blue' versus 'brown' iris colour in European populations, is also significantly associated with central heterochromia in the European sample...
  11. pmc JBASE: Joint Bayesian Analysis of Subphenotypes and Epistasis
    Recep Colak
    Department of Computer Science, University of Toronto, M5S 2E4, Toronto, ON, Canada, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, M5S 3E1, Toronto, ON, Canada
    Bioinformatics 32:203-10. 2016
    ..JBASE explores two major reasons of missing heritability: interactions between genetic variants, a phenomenon known as epistasis and phenotypic heterogeneity, addressed via subphenotyping...
  12. pmc Evaluation of the imputation performance of the program IMPUTE in an admixed sample from Mexico City using several model designs
    S Krithika
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, Canada
    BMC Med Genomics 5:12. 2012
    ..two-step (phasing and imputation) approaches; (c) the effect of different INFO score thresholds on imputation performance and (d) imputation performance in common vs. rare markers...
  13. pmc Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation
    Melissa Edwards
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    PLoS Genet 6:e1000867. 2010
    ..Our results are consistent with previous research indicating that evolution to lightly-pigmented skin occurred, at least in part, independently in Europe and East Asia...
  14. pmc Low wintertime vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area: associations with vitamin D intake and skin pigmentation
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    BMC Public Health 8:336. 2008
    ..The main goal of this study was to examine the vitamin D status and vitamin D intake of young Canadian adults of diverse ancestry during the winter months...
  15. doi request reprint Single nucleotide polymorphism coverage and inference of N-acetyltransferase-2 acetylator phenotypes in wordwide population groups
    Guilherme Suarez-Kurtz
    aCoordenação de Pesquisa, Instituto Nacional de Câncer bPrograma de Computacão Científica, Fundacao Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil cDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Pharmacogenet Genomics 26:363-9. 2016
    ....
  16. pmc Genome-wide association study of warfarin maintenance dose in a Brazilian sample
    Esteban J Parra
    Department of Anthropology, University of Toronto at Mississauga, ON, Canada
    Pharmacogenomics 16:1253-63. 2015
    ..Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians...
  17. doi request reprint Serum 25-hydroxyvitamin D concentrations fluctuate seasonally in young adults of diverse ancestry living in Toronto
    Agnes Gozdzik
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    J Nutr 140:2213-20. 2010
    ..001), and with study year (r(2) = 0.02; P = 0.009). Our study confirms that serum 25(OH)D concentrations undergo strong seasonal variation at high latitudes and are influenced by vitamin D intake, skin pigmentation, and sun exposure...
  18. ncbi request reprint Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors
    Veronica L Martinez-Marignac
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Rd Room 4026, South Bldg, L5L 1C6, Mississauga, ON, Canada
    Hum Genet 120:807-19. 2007
    ..Sample sizes of about 2,000 cases will be required to detect any locus that contributes an ancestry risk ratio of at least 1.5...
  19. ncbi request reprint Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
    ..The implications and applications of ancestry estimates in biomedical research are discussed...
  20. ncbi request reprint Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city
    Carolina Bonilla
    National Human Genome Center, Howard University, Washington, DC 20060, USA
    Hum Genet 115:57-68. 2004
    ..065, P=0.042), but no such correlation was evident with BMI or the remaining body composition measurements. We discuss the implications of our findings for the potential use of this Hispanic population for admixture mapping...
  21. ncbi request reprint Characterization of admixture in an urban sample from Buenos Aires, Argentina, using uniparentally and biparentally inherited genetic markers
    Veronica L Martinez Marignac
    Multidisciplinary Institute of Cell Biology, Department of Population Molecular Genetics, La Plata, CP 1900, Buenos Aires, Argentina
    Hum Biol 76:543-57. 2004
    ..The results of this study emphasize the need to use both uniparentally and biparentally inherited genetic markers to understand the history of admixed populations...
  22. ncbi request reprint Comparing quantitative measures of erythema, pigmentation and skin response using reflectometry
    Jennifer K Wagner
    Department of Anthropology, The Pennsylvania State University, University Park, PA, USA
    Pigment Cell Res 15:379-84. 2002
    ..Diffuse reflectance spectroscopy can be used to quantify the constitutive pigmentation, melanogenic dose-response at 7 d and erythemal dose-response at both 24 h and 7 d postexposure...
  23. ncbi request reprint Admixture analysis of a rural population of the state of Guerrero, Mexico
    Carolina Bonilla
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Phys Anthropol 128:861-9. 2005
    ..We suggest that heterogeneity is a major characteristic of Mexican populations and, as a consequence, should not be disregarded when designing epidemiological studies of Mexican and Mexican American populations...
  24. ncbi request reprint SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  25. ncbi request reprint Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Adv Exp Med Biol 588:89-100. 2006
    ..There is great promise that together these methods will facilitate the discovery of genes influencing hypoxic response...
  26. pmc A genomewide admixture mapping panel for Hispanic/Latino populations
    Xianyun Mao
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16801, USA
    Am J Hum Genet 80:1171-8. 2007
    ..This genomewide AM panel will make it possible to apply AM approaches in many admixed populations throughout the Americas...
  27. ncbi request reprint Skin responses to ultraviolet radiation: effects of constitutive pigmentation, sex, and ancestry
    Jennifer K Wagner
    Department of Anthropology, The Pennsylvania State University, PA 16802, USA
    Pigment Cell Res 15:385-90. 2002
    ....
  28. pmc Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua
    Abigail W Bigham
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania, USA
    High Alt Med Biol 9:167-78. 2008
    ..001). This suggests that the I-allele effect on Sa(O(2)) is not mediated by the peripheral control of breathing, but rather by some other central cardiopulmonary effect of the ACE gene on the renin-angiotensin-aldosterone system (RAAS)...
  29. ncbi request reprint Spanish genetic admixture is associated with larger V(O2) max decrement from sea level to 4338 m in Peruvian Quechua
    Tom D Brutsaert
    Department of Anthropology, The University at Albany, Albany, NY 12222, USA
    J Appl Physiol (1985) 95:519-28. 2003
    ..The results of this study are consistent with the evolutionary hypothesis and point to a better gas-exchange system in Quechua...
  30. ncbi request reprint Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives
    Tom D Brutsaert
    Department of Anthropology, 1400 Washington Ave, University at Albany, State University of New York, Albany, NY 12222, USA
    Am J Physiol Regul Integr Comp Physiol 289:R225-34. 2005
    ..On the basis of these ancestry associations and on the fact that developmental effects were completely controlled by study design, we suggest both a genetic basis and an evolutionary origin for these traits in Quechua...
  31. pmc Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 2:81-9. 2005
    ....
  32. ncbi request reprint Melting curve SNP (McSNP) genotyping: a useful approach for diallelic genotyping in forensic science
    Jian Ye
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    J Forensic Sci 47:593-600. 2002
    ..As such, McSNP is one of the least expensive genotyping methods available and can and should be useful in forensic science...