Meaghan A O'Reilly

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Ultrasound enhanced drug delivery to the brain and central nervous system
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Canada
    Int J Hyperthermia 28:386-96. 2012
  2. pmc Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller
    Meaghan A O'Reilly
    Physical Science Platform, Sunnybrook Research Institute, Toronto, ON, Canada M4N 3M5
    Radiology 263:96-106. 2012
  3. pmc A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy
    Meaghan A O'Reilly
    Department of Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON M4N3M5, Canada
    IEEE Trans Biomed Eng 57:2286-94. 2010
  4. pmc The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model
    Meaghan A O'Reilly
    Department of Imaging Research, Sunnybrook Research Institute, Toronto, Canada
    Phys Med Biol 55:5251-67. 2010
  5. pmc Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Ultrasound Med Biol 37:587-94. 2011
  6. pmc Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Ultrasound Med Biol 37:1930-7. 2011
  7. pmc A super-resolution ultrasound method for brain vascular mapping
    Meaghan A O'Reilly
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada
    Med Phys 40:110701. 2013
  8. pmc Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study
    Ryan M Jones
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
    Phys Med Biol 58:4981-5005. 2013
  9. doi request reprint MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption
    Yuexi Huang
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Methods Mol Biol 711:579-93. 2011
  10. ncbi request reprint Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006

Collaborators

Detail Information

Publications36

  1. pmc Ultrasound enhanced drug delivery to the brain and central nervous system
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Canada
    Int J Hyperthermia 28:386-96. 2012
    ..Cellular and physical mechanisms of disruption are discussed, as well as treatment technique, safety and monitoring...
  2. pmc Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller
    Meaghan A O'Reilly
    Physical Science Platform, Sunnybrook Research Institute, Toronto, ON, Canada M4N 3M5
    Radiology 263:96-106. 2012
    ..To determine if focused ultrasound disruption of the blood-brain barrier (BBB) can be safely controlled by using real-time modulation of treatment pressures on the basis of acoustic emissions from the exposed microbubbles...
  3. pmc A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy
    Meaghan A O'Reilly
    Department of Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON M4N3M5, Canada
    IEEE Trans Biomed Eng 57:2286-94. 2010
    ..Future work will focus on developing a multi-element array for transcranial treatment monitoring...
  4. pmc The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model
    Meaghan A O'Reilly
    Department of Imaging Research, Sunnybrook Research Institute, Toronto, Canada
    Phys Med Biol 55:5251-67. 2010
    ....
  5. pmc Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Ultrasound Med Biol 37:587-94. 2011
    ..Increased burst PRF combined with infusion improved T1w enhancement but without statistical significance, whereas a decrease in burst PRF showed a statistically significant decrease in enhancement...
  6. pmc Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Ultrasound Med Biol 37:1930-7. 2011
    ..Preclinical transcranial ultrasound studies in rats may be improved by scaling applied powers according to body mass to produce more consistent in situ pressures...
  7. pmc A super-resolution ultrasound method for brain vascular mapping
    Meaghan A O'Reilly
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada
    Med Phys 40:110701. 2013
    ..The authors present a method for transcranial ultrasound imaging of single micrometer-size bubbles within a tube phantom...
  8. pmc Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study
    Ryan M Jones
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
    Phys Med Biol 58:4981-5005. 2013
    ....
  9. doi request reprint MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption
    Yuexi Huang
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Methods Mol Biol 711:579-93. 2011
    ..In this chapter, a detailed protocol of MR-guided focused ultrasound for brain thermal ablation and BBB disruption in an animal research setting is presented...
  10. ncbi request reprint Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006
    ....
  11. pmc Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound
    David E Goertz
    Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ultrasound Med Biol 36:916-24. 2010
    ....
  12. doi request reprint Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International Journal of Hyperthermia 1987;3:21-35
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, and Sunnybrook Health Sciences Centre, Imaging Research, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Int J Hyperthermia 26:12-5. 2010
    ..The impact of the research presented in the paper on the development of the current image-guided noninvasive surgery and treatments will also be discussed...
  13. doi request reprint MRI-guided focused ultrasound treatments
    Kullervo Hynynen
    Sunnybrook Health Sciences Centre, Imaging Research, Department of Medical Biophysics, University of Toronto, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5
    Ultrasonics 50:221-9. 2010
    ..This paper will review the current technical and clinical status of MRI-guided focused ultrasound therapy and discuss future research and development opportunities...
  14. pmc Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy
    Junho Song
    Focused Ultrasound Laboratory, Imaging Research, Sunnybrook Health Science Centre, Toronto, ON M4N 3M5, Canada
    IEEE Trans Biomed Eng 57:124-33. 2010
    ..5 MPa at 306 kHz and 3.7 MPa at 840 kHz for RF power of 1 W on each element. This is the first study demonstrating the feasibility of using cylindrical transducer elements and lateral coupling in construction of ultrasound phased arrays...
  15. pmc MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking
    Yuexi Huang
    Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Med Phys 36:2016-20. 2009
    ..96 and R2=0.67). The temporal information by the ultrasound measurement indicates that the parameters in MR ARF imaging should be optimized according to the tissue type, acoustic power, and envelope and frequency of the ARF modulation...
  16. ncbi request reprint Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada
    Expert Opin Drug Deliv 4:27-35. 2007
    ..However, effective clinical devices and methods need to be developed further and the clinical feasibility demonstrated...
  17. ncbi request reprint Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study
    Samuel Pichardo
    Imaging Research Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room C713, Toronto, Ontario, Canada
    Phys Med Biol 52:4923-42. 2007
    ....
  18. ncbi request reprint Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study
    Samuel Pichardo
    Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Ave Rm C713 Toronto, ON M4N 3M5, Canada
    Phys Med Biol 52:7313-32. 2007
    ..In conclusion, shear waves provide a useful method for trans-cranial focusing in regions close to the skull surface...
  19. pmc Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging
    Laura Curiel
    Imaging Research Department at Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
    IEEE Trans Med Imaging 26:1740-6. 2007
    ..This demonstration of technical feasibility and the development of a prototype system open up the potential to investigate the promising clinical applications of this combined technology...
  20. pmc Ultrasound for drug and gene delivery to the brain
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada
    Adv Drug Deliv Rev 60:1209-17. 2008
    ..Most notably, the delivery of the chemotherapy agents (liposomal Doxorubicin and Herceptin) has been shown in a rat model...
  21. pmc In vivo monitoring of focused ultrasound surgery using local harmonic motion
    Laura Curiel
    Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ultrasound Med Biol 35:65-78. 2009
    ..LHM measurements were also used to perform a spatial scan of the tissues across the exposure region and the thermal lesions could be detected as a reduction in the maximum motion amplitude value at the sonication region...
  22. doi request reprint Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques
    Ali Yousefi
    Electrical Engineering Department, University of Toronto, Toronto, ON M4N 3M5 Canada
    IEEE Trans Med Imaging 28:763-74. 2009
    ..The results are an important step towards enhancing the quality of transcranial sonography...
  23. pmc An MRI-compatible system for focused ultrasound experiments in small animal models
    Rajiv Chopra
    Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Med Phys 36:1867-74. 2009
    ..Initial results suggest that this is a robust and precise apparatus for use in the investigation of novel ultrasound-based therapeutic strategies in small animal preclinical models...
  24. pmc Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays
    Kullervo Hynynen
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    IEEE Trans Ultrason Ferroelectr Freq Control 56:557-64. 2009
    ..Acoustic intensity (averaged over the cylinder diameter) over 10 W / cm(2) (a therapeutically relevant intensity) was measured from these elements...
  25. doi request reprint Localised drug release using MRI-controlled focused ultrasound hyperthermia
    Robert Staruch
    Centre for Research in Image Guided Therapeutics, Sunnybrook Health Sciences Centre, Toronto, Canada
    Int J Hyperthermia 27:156-71. 2011
    ..The objective of this study was to evaluate the feasibility of using MRI-controlled focused ultrasound (FUS) and thermosensitive liposomes to achieve thermally mediated localised drug delivery in vivo...
  26. pmc Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice
    Tiffany Scarcelli
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada
    Brain Stimul 7:304-7. 2014
    ..This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease...
  27. pmc Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections
    Ryan M Jones
    Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
    Med Phys 42:4385-400. 2015
    ..Phys. Med. Biol. 58, 4981-5005 (2013)]...
  28. pmc Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors
    Roberto Jose Diaz
    The Hospital for Sick Children, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Nanomedicine 10:1075-87. 2014
    ..Thus, nanoparticles with SERS imaging capability can be delivered across the BBB non-invasively using TcMRgFUS and have the potential to be used as optical tracking agents at the invasive front of malignant brain tumors...
  29. pmc Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound
    Arnold B Etame
    The Hospital for Sick Children Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada
    Nanomedicine 8:1133-42. 2012
    ..These results suggest a role for MRgFUS in the delivery of AuNPs with therapeutic potential into the CNS for targeting neurological diseases...
  30. doi request reprint Macromolecular delivery across the blood-brain barrier
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada
    Methods Mol Biol 480:175-85. 2009
    ..A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery...
  31. pmc Emerging non-cancer applications of therapeutic ultrasound
    Meaghan A O'Reilly
    Physical Sciences, Sunnybrook Research Institute, Toronto
    Int J Hyperthermia 31:310-8. 2015
    ....
  32. doi request reprint Quantitative MRI in a non-surgical model of cervical spinal cord injury
    Wendy Oakden
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    NMR Biomed 28:925-36. 2015
    ..No significant changes in diffusivity parameters were observed. Pathologies were often co-occurring, with opposite effects on the average T2 in a given voxel, reducing the visibility of injured tissue on standard T2 -weighted MR images...
  33. pmc Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound
    Emmanuel Thévenot
    Brain Sciences Sunnybrook Research Institute, Toronto, ON, Canada
    Hum Gene Ther 23:1144-55. 2012
    ..Transcranial focused ultrasound applications could fulfill a long-term goal of gene therapy: delivering vectors to diseased brain areas directly from the circulation, in a noninvasive manner...
  34. pmc Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease
    Jessica F Jordão
    Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada
    PLoS ONE 5:e10549. 2010
    ..In conclusion, this is the first report to demonstrate that MRIgFUS delivery of anti-Abeta antibodies provides the combined advantages of using a low dose of antibody and rapidly reducing plaque pathology...
  35. doi request reprint Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion
    Laura Curiel
    Imaging Res, Sunnybrook Health Sciences Centre, 2075 Bayview Av, Toronto, ON, M4N 3M5, Canada High Intensity Focused Ultrasound HIFU Lab, Thunder Bay Regional Research Institute, 980 Oliver Rd, Thunder Bay, ON, P7C 1M5, Canada
    Phys Med Biol 54:3405-19. 2009
    ..The control was generally successful, but sudden change or noise in the acquired echo signal caused failure. Coagulation after exposure could be validated by comparing amplitudes before and after exposure...
  36. doi request reprint In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy
    Kelly C Schad
    Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada
    Phys Med Biol 55:4933-47. 2010
    ..9, 4.4 and 5.3 MPa for 0.578, 1736 and 2.855 MHz, respectively. In summary, we have demonstrated that droplet conversion is feasible for clinically relevant sized droplets and acoustic exposures...