John Robert O'Kusky

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
    J R O'Kusky
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9
    J Neurosci 20:8435-42. 2000
  2. ncbi request reprint Increased expression of insulin-like growth factor I augments the progressive phase of synaptogenesis without preventing synapse elimination in the hypoglossal nucleus
    John Robert O'Kusky
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada
    J Comp Neurol 464:382-91. 2003
  3. pmc A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development
    William H Lagarde
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Int J Dev Neurosci 25:95-105. 2007
  4. pmc Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice
    Ping Ye
    Division of Endocrinology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:712-22. 2007
  5. ncbi request reprint Lack of spontaneous ocular neovascularization and attenuated laser-induced choroidal neovascularization in IGF-I overexpression transgenic mice
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Vision Res 47:776-82. 2007
  6. ncbi request reprint Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling
    Ramón Jiménez Moreno
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    J Membr Biol 212:147-61. 2006
  7. pmc Developmental expression of histone deacetylase 11 in the murine brain
    Hedi Liu
    Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 86:537-43. 2008
  8. ncbi request reprint Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 78:472-84. 2004
  9. ncbi request reprint In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system
    Gregory J Popken
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Eur J Neurosci 19:2056-68. 2004
  10. ncbi request reprint Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 80:481-90. 2005

Collaborators

  • P Ye
  • O Delbono
  • W Wang
  • Jin Zhong
  • Jonathan R Seckl
  • William H Lagarde
  • Jihui Zhang
  • A JOSEPH D'ERCOLE
  • Gregory J Popken
  • Hedi Liu
  • Martha Zeger
  • Wenzheng Hu
  • Wenfeng An
  • Ramón Jiménez Moreno
  • Qichen Hu
  • Amanda Kaufman
  • Shouhong Xuan
  • Wei Hua Lee
  • Greg Popken
  • Q Richard Lu
  • David Rowitch
  • Weiguo Yao
  • Klaus Armin Nave
  • Hua Gao
  • Xiaoxi Qiao
  • Markus H Schwab
  • Wen Liu
  • Billie M Moats-Staats
  • Candice E Coombes
  • Joseph A D'Ercole
  • Edward S Davis
  • Sarah J Wheelan
  • Zhong Min Wang
  • Maria Laura Messi
  • Jef D Boeke
  • Jeffrey S Han
  • Christina Triplett
  • Zhenlin Zheng
  • Winnie Ng
  • Rebecca D Hodge

Detail Information

Publications28

  1. ncbi request reprint Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
    J R O'Kusky
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9
    J Neurosci 20:8435-42. 2000
    ....
  2. ncbi request reprint Increased expression of insulin-like growth factor I augments the progressive phase of synaptogenesis without preventing synapse elimination in the hypoglossal nucleus
    John Robert O'Kusky
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada
    J Comp Neurol 464:382-91. 2003
    ..Our results demonstrated that IGF-I can stimulate a persistent increase in the number of hypoglossal synapses, thereby augmenting the progressive phase of synaptogenesis without preventing synapse elimination during the regressive phase...
  3. pmc A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development
    William H Lagarde
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Int J Dev Neurosci 25:95-105. 2007
    ..This non-immortalized oligodendrocyte precursor cell line, therefore, exhibits behavior consistent with the in vivo development of oligodendrocytes and provides an excellent model for the study of developing oligodendrocytes...
  4. pmc Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice
    Ping Ye
    Division of Endocrinology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:712-22. 2007
    ..Our results indicate that IGF-I is capable of protecting myelin and oligodendrocytes from TNF-alpha-induced damage in vivo...
  5. ncbi request reprint Lack of spontaneous ocular neovascularization and attenuated laser-induced choroidal neovascularization in IGF-I overexpression transgenic mice
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Vision Res 47:776-82. 2007
    ..The transgene was also associated with an attenuated laser-induced choroidal neovascularization. Differential expression levels and pattern of IGF-I gene may underlie the different retinal phenotypes in different transgenic lines...
  6. ncbi request reprint Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling
    Ramón Jiménez Moreno
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    J Membr Biol 212:147-61. 2006
    ..Our results raise questions about the timing and cell location of CNS IGF-I overexpression necessary to prevent or to ameliorate age-dependent alterations in the structure and function of skeletal muscle...
  7. pmc Developmental expression of histone deacetylase 11 in the murine brain
    Hedi Liu
    Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 86:537-43. 2008
    ..These findings support a role for HDAC11 in CNS histone deacetylation and the development of oligodendrocytes and neurons during postnatal development...
  8. ncbi request reprint Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 78:472-84. 2004
    ..Our data also suggest that IGF-I's actions in CNS depend in part on the location of its expression and cellular microenvironment and that continuous presence of IGF-I expression is necessary for brain overgrowth...
  9. ncbi request reprint In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system
    Gregory J Popken
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Eur J Neurosci 19:2056-68. 2004
    ..Our results demonstrate that IGF-I can both promote proliferation of neural cells in the embryonic central nervous system in vivo and inhibit their apoptosis during postnatal life...
  10. ncbi request reprint Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 80:481-90. 2005
    ..These results confirm our previous suggestion that a lack of IGF-I activity contributes to apoptosis of weaver granule neurons in vivo and supports IGF-I's potential therapeutic use in neurodegenerative disease...
  11. ncbi request reprint Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice
    Ping Ye
    Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 71:721-31. 2003
    ..Our data indicate that TNF-alpha alters the expression of IGF-I system proteins in vivo, and suggest that altered expression of IGF-I system proteins may in part explain TNF-alpha deleterious actions on brain growth...
  12. ncbi request reprint Mutant mouse models of insulin-like growth factor actions in the central nervous system
    A JOSEPH D'ERCOLE
    Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, North Carolina 27599 7220, USA
    Neuropeptides 36:209-20. 2002
    ..Evidence from experiments in these mouse models also indicates that IGF-I has a role in recovery from neural injury...
  13. ncbi request reprint Down-regulation of 14-3-3 eta gene expression by IGF-I in mouse cerebellum during postnatal development
    Jihui Zhang
    Department of Pediatrics, Division of Endocrinology, CB 7039, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Brain Res Dev Brain Res 143:199-206. 2003
    ..e. limit Purkinje cell number, and/or (b) function as part of a distinct signaling mechanism, perhaps one that augments the capacity of Purkinje cells to promote granule cell survival...
  14. ncbi request reprint Myelination is altered in insulin-like growth factor-I null mutant mice
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7220, USA
    J Neurosci 22:6041-51. 2002
    ..These data suggest that IGF-I plays a significant role in myelination during normal early development and that IGF-II can compensate in part for IGF-I actions on myelination...
  15. ncbi request reprint Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res Dev Brain Res 136:111-21. 2002
    ..Nonetheless, the finding that IGF-I stimulates brain growth less well in the absence of IRS-1 suggests that IRS-1-mediated signaling may be more central to IGF-I action in cells other than glia and oligodendrocytes...
  16. ncbi request reprint Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II
    Ping Ye
    Medical Research Council Blood Pressure Group, Western Infirmary, Glasgow, Scotland G11 6NT, United Kingdom
    Endocrinology 144:3321-8. 2003
    ..To summarize, we have identified a local CYP11B2 response to sodium depletion in the hippocampus and cerebellum. This is the first such regulation of CYP11B2 transcription to be identified in the CNS...
  17. ncbi request reprint Reevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants
    Ping Ye
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    J Immunol 168:4968-79. 2002
    ..Therefore, we suggest that T cell turnover should be examined together with TREC concentration as a measure of RTE. If peripheral T cell division remains relatively unchanged, then TREC concentration indeed reflects thymic output...
  18. pmc Pitfalls of PCR-based strategy for genotyping cre-loxP mice
    Jihui Zhang
    Biotechniques 42:281, 283. 2007
  19. pmc Expression of insulin-like growth factor system genes during the early postnatal neurogenesis in the mouse hippocampus
    Jihui Zhang
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:1618-27. 2007
    ..Our data support a role for IGF in hippocampal neurogenesis and provide evidence that IGF actions are regulated within a defined in vivo milieu...
  20. pmc Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination
    Martha Zeger
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Glia 55:400-11. 2007
    ..These data also provide a fundamental basis for developing strategies with the potential to target IGF-IGF1R signaling pathways in oligodendrocyte lineage cells for the treatment of demyelinating disorders...
  21. pmc Active retrotransposition by a synthetic L1 element in mice
    Wenfeng An
    High Throughput Biology Center and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:18662-7. 2006
    ..The results suggest that ORFeus may be developed into useful tools for in vivo mutagenesis...
  22. ncbi request reprint Effect of aging on the expression of peroxisome proliferator-activated receptor gamma and the possible relation to insulin resistance
    Ping Ye
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Gerontology 52:69-75. 2006
    ..The morbidity of insulin resistance tends to increase with aging. However, studies on molecular mechanisms underlying insulin resistance in aging process is still in paucity...
  23. ncbi request reprint Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, 27599 7220, USA
    J Neurosci Res 83:1-6. 2006
    ..IGF-I actions, however, likely depend on cell type, developmental stage, and microenvironmental milieu...
  24. ncbi request reprint Age-related decrease in expression of peroxisome proliferator-activated receptor alpha and its effects on development of dyslipidemia
    Ping Ye
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    Chin Med J (Engl) 118:1093-8. 2005
    ..To investigate potential molecular mechanisms, the effects of age and fibrate administration on peroxisome proliferator-activated receptor alpha (PPARalpha) expression in livers of young and old rats were studied...
  25. ncbi request reprint Measuring emigration of human thymocytes by T-cell receptor excision circles
    Ping Ye
    Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI, USA
    Crit Rev Immunol 22:483-97. 2002
    ..Our findings suggest that T-cell dynamics are key to the accuracy of TREC concentrations as a useful measurement of human RTEs...
  26. ncbi request reprint Mouse NG2+ oligodendrocyte precursors express mRNA for proteolipid protein but not its DM-20 variant: a study of laser microdissection-captured NG2+ cells
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7220, USA
    J Neurosci 23:4401-5. 2003
    ..This work also shows that LCM is a valuable tool to define and analyze gene expression in the cells of the oligodendrocyte lineage...
  27. ncbi request reprint Cosegregation analysis of natriuretic peptide genes and blood pressure in the spontaneously hypertensive rat
    Ping Ye
    Department of Medicine, The University of Queensland, Prince Charles Hospital, Brisbane, Queensland, Australia
    Clin Exp Pharmacol Physiol 30:930-6. 2003
    ..It provides a strong foundation for further detailed genetic studies in congenic strains, which may help to narrow down the location of this gene and lead to positional cloning...
  28. ncbi request reprint Effect of peroxisome proliferator-activated receptor activators on tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes
    Ping Ye
    Department of Geriatric Cardiology, Chinese People s Liberation Army General Hospital, Beijing 100853
    Chin Med Sci J 19:243-7. 2004
    ..To investigate the effect of peroxisome proliferator-activated receptor-alpha (PPAR alpha) and PPAR gamma activators on tumor necrosis factor-alpha (TNFalpha) expression in neonatal rat cardiac myocytes...