Affiliation: University of Toronto
- Epidemic pathogenic selection: an explanation for hereditary hemochromatosis?Sharon Moalem
Department of Physiology, University of Toronto, Neurogenetics Laboratory, Surrey Place Centre, Toronto, Canada
Med Hypotheses 59:325-9. 2002..Furthermore, the C282Y mutation might have been selected for during the European plagues caused by Yersinia spp. and other pathogens because of the conferred resistance to infection, i.e., by epidemic pathogenic selection...
- Does female ejaculation serve an antimicrobial purpose?Sharon Moalem
Mount Sinai School of Medicine, Mail Box 1007, 1 Gustave Levy Place, New York, NY 10029, USA
Med Hypotheses 73:1069-71. 2009....
- The quandary of reductionism: relevance to Alzheimer disease researchSharon Moalem
Neurogenetics Laboratory, Surrey Place Centre, Toronto, Canada
J Alzheimers Dis 4:531-7. 2002..The time has come to reconsider and seriously question our most basic assumptions and beliefs surrounding what we believe Alzheimer disease to be, without which we run the risk of missed opportunities and failure...
- Hemochromatosis and the enigma of misplaced iron: implications for infectious disease and survivalSharon Moalem
Department of Physiology, University of Toronto, Surrey Place Centre, Toronto, Canada
Biometals 17:135-9. 2004..Iron supplementation may adversely affect the health of individuals who have mounted an acute phase response to infection, injury or stress, or who carry genes predisposing them to iron overload disorders...
- Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario populationMaire Percy
Surrey Place Centre and Departments of Physiology and Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada
J Alzheimers Dis 14:69-84. 2008..However, folate levels in the lowest population quartile did not affect the risk of AD. A model is presented to explain the experimental findings...
- Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndromeMaire E Percy
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet A 120:191-8. 2003..There was no evidence for an ApoE allele effect on HBV status, or for an HBV status effect on thyroid status. As thyroid status can affect cognitive function, ApoE allele effects in DAT may, in part, be thyroid effects...
- Aluminum and Alzheimer's disease, a personal perspective after 25 yearsDaniel P Perl
Mount Sinai School of Medicine, Department of Pathology, Neuropathology Division, USA
J Alzheimers Dis 9:291-300. 2006....