Lauralyn A McIntyre
Affiliation: University of Ottawa
- Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic reviewLauralyn A McIntyre
Division of Intensive Care, Department of Medicine, The Ottawa Hospital, General Campus, University of Ottawa, Ottawa, Ontario, Canada
JAMA 289:2992-9. 2003..The benefits of therapeutic hypothermia as a treatment for traumatic brain injury (TBI) remain unclear...
- Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocolManoj M Lalu
Department of Medicine Division of Critical Care, University of Ottawa, Ottawa, ON, Canada
Syst Rev 3:48. 2014..Prior to a human clinical trial, our aim is to conduct a systematic review to compare the efficacy and safety of MSC therapy versus controls in preclinical models of acute lung injury that mimic some aspects of the human ARDS...
- Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trialsManoj M Lalu
Department of Anesthesiology, University of Ottawa, Ottawa, Canada
PLoS ONE 7:e47559. 2012..There is interest in using these cells in critical illness, however, the safety profile of these cells is not well known. We thus conducted a systematic review of clinical trials that examined the use MSCs to evaluate their safety...
- Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trialLauralyn A McIntyre
Department of Medicine Division of Critical Care, Ottawa Hospital Research Institute OHRI, University of Ottawa, Ottawa, Ontario, Canada
J Crit Care 27:317.e1-6. 2012..We describe the Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock (PRECISE) pilot trial study design and report feasibility of patient recruitment...
- Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trialLauralyn A McIntyre
University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
Can J Anaesth 55:819-26. 2008..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...
- Resuscitating patients with early severe sepsis: a Canadian multicentre observational studyLauralyn A McIntyre
Department of Medicine critical care, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Can J Anaesth 54:790-8. 2007..We sought to examine associations of the quantity and type of fluid administered in the first six hours after identification of severe sepsis and hospital mortality, intensive care unit (ICU) mortality, and organ failure...
- A survey of Canadian intensivists' resuscitation practices in early septic shockLauralyn A McIntyre
University of Ottawa Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit of the Ottawa Hospital, Ottawa Health Research Institute, 501 Smyth Rd Ottawa, Ontario, Canada K1H 8L6
Crit Care 11:R74. 2007..The objective of this survey was to characterize reported resuscitation practices of Canadian physicians caring for adult critically ill patients with early septic shock...
- Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injuryLauralyn A McIntyre
Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario
Neurocrit Care 5:4-9. 2006..To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs)...
- Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?Lauralyn McIntyre
Centre for Transfusion and Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario
J Trauma 57:563-8; discussion 568. 2004..An analysis from the prospective multicenter randomized controlled trial (Transfusion Requirements in Critical Care Trial) compared the use of restrictive and liberal transfusion strategies with resuscitated critically ill trauma patients...
- Inappropriate medication administration practices in Canadian adult ICUs: a multicenter, cross-sectional observational studySalmaan Kanji
The Ottawa Hospital, Associate Scientist, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Ann Pharmacother 47:637-43. 2013..Coadministration of multiple medications through the same port of a venous access device often is necessary but requires an assessment of compatibility...
- Can we safely restrict transfusion in trauma patients?Lauralyn A McIntyre
Department of Medicine, Division of Critical Care, Centre for Transfusion and Critical Care Research, Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
Curr Opin Crit Care 12:575-83. 2006..The question is how much and when? It is important to weigh the risks and benefits of red blood cell transfusions, as well alternatives to transfusion as these products are not benign...
- Reliability of point-of-care testing for glucose measurement in critically ill adultsSalmaan Kanji
Department of Pharmacy, The Ottawa Hospital, Ottawa, Canada
Crit Care Med 33:2778-85. 2005..Therefore, it is imperative that bedside glucose testing methods be safe and accurate...
- Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic ReviewLauralyn A McIntyre
Department of Medicine Division of Critical Care, University of Ottawa, Ottawa, Ontario, Canada
PLoS ONE 11:e0147170. 2016..The results from our meta-analysis support that MSCs substantially reduce the odds of death in animal models of ALI but important reporting elements were sub optimal and limit the strength of our conclusions. ..
- Treatment of new-onset atrial fibrillation in noncardiac intensive care unit patients: a systematic review of randomized controlled trialsSalmaan Kanji
Ottawa Hospital, Canada
Crit Care Med 36:1620-4. 2008..The objective of this systematic review was to evaluate the efficacy of pharmacologic rhythm control of new-onset atrial fibrillation in noncardiac, critically ill adults...
- Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adultsSalmaan Kanji
Department of Pharmacy, Ottawa Hospital, General Campus, 501 Smyth, Ottawa, Ontario K1H 8L6, Canada
Intensive Care Med 30:804-10. 2004..This study evaluates the efficiency and safety of a nurse-managed insulin protocol in critically ill adults...
- Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsisAlexis F Turgeon
Center for Transfusion and Critical Care Research, Ottawa Health Research Institute, the University of Ottawa and the Canadian Blood Service, Ottawa, Ontario, Cananda
Ann Intern Med 146:193-203. 2007..Intravenous immunoglobulin therapy has been proposed as an adjuvant treatment for sepsis. Yet, its benefit remains unclear, and its use is not currently recommended...
- Revisiting transfusion practices in critically ill patientsPaul C Hebert
Centre for Transfusion and Clinical Epidemiology Program, University of Ottawa, 501 Smyth Road, Box 201, Ottawa, Ontario, K1H 8L6, Canada
Crit Care Med 33:7-12; discussion 232-2. 2005..The objective of this study was to characterize contemporary red cell transfusion practice in the critically ill and to examine changes in practice over time...
- Transfusion rates vary significantly amongst Canadian medical centresBrian Hutton
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Can J Anaesth 52:581-90. 2005..To document variation of transfusion practice following repair of hip fracture or cardiac surgery, as well as those requiring intensive care following a surgical intervention or multiple trauma (high risk patients)...
- Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysisEric Mercier
Centre de recherche du CHU de Québec Université Laval Mercier, Boutin, Shemilt, Lauzier, Moore, Archambault, Légaré, Turgeon, Population Health and Optimal Health Practices Research Unit Department of Social and Preventive Medicine Boutin, Moore Department of Anesthesiology and Critical Care Medicine Lauzier, Archambault, Turgeon, Division of Critical Care Medicine Department of Family Medicine and Emergency Medicine Archambault, Légaré, Faculty of Medicine Lauzier Department of Molecular Biology Rousseau, Nadeau, Medical Biochemistry and Pathology, Universite Laval, Quebec City, Que Department of Haematology and Medical Oncology Zarychanski, University of Manitoba, Winnipeg, Man Center for Transfusion and Critical Care Research Fergusson, McIntyre, Turgeon, Clinical Epidemiology Unit, Ottawa Health Research Institute, University of Ottawa Department of Critical Care Medicine Fergusson, McIntyre, Ottawa Hospital, University of Ottawa, Ottawa, Ont Centre de Recherche Étienne Lebel Lamontagne, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Pennsylvania 19010
CMAJ Open 4:E371-E382. 2016..Our objective was to determine the association between neuron-specific enolase and clinical outcomes, and the prognostic value of neuron-specific enolase after a moderate or severe traumatic brain injury...
- Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studiesPhilippe Desjardins
Department of Anesthesiology, Division of Critical Care Medicine, Faculty of Medicine, Universite Laval, 1050, Avenue de Médecine, Pavillon Ferdinand Vandry, Quebec, QC, G1V 0A6, Canada
Crit Care 16:R54. 2012..Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in neurocritically ill patients...