Andres M Lozano

Summary

Affiliation: University Health Network
Country: Canada

Publications

  1. doi request reprint Probing and regulating dysfunctional circuits using deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Krembil Neuroscience Center, University of Toronto, Toronto, ON M5T 2S8, Canada
    Neuron 77:406-24. 2013
  2. doi request reprint A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Canada
    J Neurosurg 116:315-22. 2012
  3. doi request reprint The Wilson films--hemiballism
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:2469-70. 2011
  4. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
  5. doi request reprint Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
    Hippocampus 21:1348-62. 2011
  6. doi request reprint Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 20:1549-53. 2009
  7. pmc Stimulation of the subthalamic nucleus and impulsivity: release your horses
    Benedicte Ballanger
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:817-24. 2009
  8. doi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
  9. doi request reprint A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
    Adrian W Laxton
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 68:521-34. 2010
  10. ncbi request reprint Involvement of human thalamus in the preparation of self-paced movement
    Guillermo Paradiso
    The Krembil Neuroscience Centre and Toronto Western Research Institute, Toronto, Ontario, Canada
    Brain 127:2717-31. 2004

Detail Information

Publications75

  1. doi request reprint Probing and regulating dysfunctional circuits using deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Krembil Neuroscience Center, University of Toronto, Toronto, ON M5T 2S8, Canada
    Neuron 77:406-24. 2013
    ..Here we review recent advances in the DBS field and discuss potential future directions in targeted intracranial neuromodulation...
  2. doi request reprint A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Canada
    J Neurosurg 116:315-22. 2012
    ..They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression...
  3. doi request reprint The Wilson films--hemiballism
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:2469-70. 2011
    ..Classical teaching dictates that this patient has a lesion in the subthalamic nucleus. Here then is a prime example where classical teaching is wrong!..
  4. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
    ..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
  5. doi request reprint Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
    Hippocampus 21:1348-62. 2011
    ....
  6. doi request reprint Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 20:1549-53. 2009
    ..These findings confirm and extend earlier findings suggesting that in PD there are marked changes in basal ganglia oscillatory activity and that these can be reversed after dopaminergic therapy...
  7. pmc Stimulation of the subthalamic nucleus and impulsivity: release your horses
    Benedicte Ballanger
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:817-24. 2009
    ....
  8. doi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
    ..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
  9. doi request reprint A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
    Adrian W Laxton
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 68:521-34. 2010
    ..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits...
  10. ncbi request reprint Involvement of human thalamus in the preparation of self-paced movement
    Guillermo Paradiso
    The Krembil Neuroscience Centre and Toronto Western Research Institute, Toronto, Ontario, Canada
    Brain 127:2717-31. 2004
    ..Different cortico-subcortical circuits may mediate alpha and beta oscillations. During movement preparation, the motor thalamus and the supplementary motor area predominantly interact in the beta band...
  11. doi request reprint Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease
    Akihiro Yugeta
    Division of Neurology, Toronto Western Research Institute, and the Edmond J Safra Program in Parkinson s Disease, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 33:6895-904. 2013
    ..Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction...
  12. doi request reprint Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Biol Psychiatry 64:461-7. 2008
    ..We now report the results of these and an additional 14 patients with extended follow-up...
  13. doi request reprint Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  14. doi request reprint High-frequency microstimulation in human globus pallidus and substantia nigra
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Medical Sciences Building Room 3302, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Exp Brain Res 205:251-61. 2010
    ..The findings suggest that high-frequency microstimulation of the GPi and SNr depresses local neuronal activity and synaptic transmission, and such mechanisms may contribute to the therapeutic effects of DBS...
  15. ncbi request reprint Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
    ..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
  16. doi request reprint Neuronal coding of implicit emotion categories in the subcallosal cortex in patients with depression
    Adrian W Laxton
    Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina Department of Surgery, Toronto Western Hospital, Institute of Medical Science, University of Toronto, Toronto, Canada Electronic address
    Biol Psychiatry 74:714-9. 2013
    ..On the basis of imaging studies, it is unclear whether the SCC predominantly processes 1) negatively valenced affective content, 2) affective arousal, or 3) category-specific affective information...
  17. ncbi request reprint Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans
    Jamie Purzner
    The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8
    J Neurosci 27:6029-36. 2007
    ..The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements...
  18. doi request reprint Event-related desynchronization of motor cortical oscillations in patients with multiple system atrophy
    Ron Levy
    Division of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Calgary, Foothills Medical Centre, Calgary, AB, T2N 2T9, Canada
    Exp Brain Res 206:1-13. 2010
    ....
  19. doi request reprint Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movements
    Eric W Tsang
    Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
    J Neurol Neurosurg Psychiatry 83:91-7. 2012
    ..To study internal globus pallidus (GPi) activities and the interactions among the bilateral GPi and motor cortical areas during voluntary movements...
  20. doi request reprint Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study
    Benedicte Ballanger
    Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 30:3901-9. 2009
    ..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements...
  21. doi request reprint Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease
    Bogdan Neagu
    Toronto Western Research Institute, University Health Network, University of Toronto, Canada
    Exp Neurol 250:221-7. 2013
    ..These results demonstrate a functional connection between the STN and the PPNR. It likely involves direct projections between the STN and PPNR or polysynaptic pathways with thalamic or cortical relays. ..
  22. doi request reprint Frequency-dependent effects of electrical stimulation in the globus pallidus of dystonia patients
    Liu D Liu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:5-17. 2012
    ....
  23. doi request reprint Unilateral subdural motor cortex stimulation improves essential tremor but not Parkinson's disease
    Elena Moro
    Movement Disorders Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, ON M5T2S8, Canada
    Brain 134:2096-105. 2011
    ..These findings suggest that unilateral subdural motor cortex stimulation may be useful for contralateral hand tremor in selected patients with essential tremor but was not effective in improving parkinsonian signs in our series...
  24. doi request reprint The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease
    Renju Kuriakose
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    Cereb Cortex 20:1926-36. 2010
    ..Cortical activation may be related to the clinical effects of STN DBS in PD...
  25. doi request reprint Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
    ..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
  26. doi request reprint Spatial extent of β oscillatory activity in and between the subthalamic nucleus and substantia nigra pars reticulata of Parkinson's disease patients
    Mahan Alavi
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 245:60-71. 2013
    ....
  27. pmc Direct demonstration of inhibitory interactions between long interval intracortical inhibition and short interval intracortical inhibition
    Zhen Ni
    7MC 411, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    J Physiol 589:2955-62. 2011
    ..We conclude that decreased SICI in the presence of LICI is not due to changes in I-wave content induced by LICI and is caused by their interactions at the cortical level...
  28. doi request reprint Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region
    I Jin Yeh
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Mov Disord 25:2076-83. 2010
    ..Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins...
  29. ncbi request reprint Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease
    Panida Piboolnurak
    Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:990-7. 2007
    ..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
  30. ncbi request reprint Subdural motor cortex stimulation in Parkinson's disease does not modify movement-related rCBF pattern
    Antonio P Strafella
    Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 22:2113-6. 2007
    ..We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD...
  31. doi request reprint Neurosurgical treatment of anorexia nervosa: review of the literature from leucotomy to deep brain stimulation
    Nir Lipsman
    Division of Neurosurgery, University Health Network, University of Toronto, Toronto, ON, Canada
    Eur Eat Disord Rev 21:428-35. 2013
    ..This has translated into the development of novel, focused therapeutic options for patients with treatment-refractory AN...
  32. doi request reprint Enhanced synchronization of thalamic theta band local field potentials in patients with essential tremor
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 217:171-6. 2009
    ....
  33. ncbi request reprint Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Epilepsia 47:1958-62. 2006
    ..The hippocampal inhibition was clearly related to the voltage (> or =7 V) and frequency (> or =70 Hz) of the thalamic stimulus and occurred with a delay of approximately 60 s after stimulus onset...
  34. doi request reprint Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosurg 111:724-8. 2009
    ..The presence of inhibition in the SNr but not in the STN could be used as an additional criterion to help identify the location of the border between the STN and SNr...
  35. doi request reprint Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystonia
    Moran Weinberger
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Clin Neurophysiol 123:358-68. 2012
    ....
  36. ncbi request reprint Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulation
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, UHN, Toronto, Canada
    Adv Neurol 96:130-47. 2005
    ..The paucity of the literature underscores the need for well-designed studies on psychiatric issues investigating both pathophysiology and clinical outcomes...
  37. doi request reprint Unilateral pedunculopontine stimulation improves falls in Parkinson's disease
    Elena Moro
    Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
    Brain 133:215-24. 2010
    ..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required...
  38. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005
    ..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
  39. ncbi request reprint Eye movement-related responses of neurons in human subthalamic nucleus
    Adrian P Fawcett
    Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Brain Res 162:357-65. 2005
    ....
  40. ncbi request reprint Bursting activity of neurons in the human anterior thalamic nucleus
    Mojgan Hodaie
    Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada
    Brain Res 1115:1-8. 2006
    ..This study describes for the first time the properties of this nucleus in humans and may be important in furthering our knowledge of thalamic mechanisms of epileptogenesis...
  41. ncbi request reprint Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia
    Joyce K H Tang
    Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Exp Neurol 204:845-8. 2007
    ..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
  42. ncbi request reprint Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus procedures
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto, ON M5T 2S8, Canada
    Surg Neurol 63:249-53; discussion 253. 2005
    ..Little is known about the correlation between the position of the STN as seen on MRI and that as determined by MER mapping. We compared these in 10 patients with Parkinson's disease...
  43. ncbi request reprint Dual microelectrode technique for deep brain stereotactic surgery in humans
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Neurosurgery 60:277-83; discussion 283-4. 2007
    ..To improve functional stereotactic microelectrode localization of small deep brain structures by developing and evaluating a recording system with two closely separated independently controlled microelectrodes...
  44. ncbi request reprint Saccade-related potentials recorded from human subthalamic nucleus
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Clin Neurophysiol 118:155-63. 2007
    ..To investigate an ocular motor role for the STN in Parkinson's disease (PD) patients...
  45. doi request reprint The dominant-STN phenomenon in bilateral STN DBS for Parkinson's disease
    Anna Castrioto
    Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada
    Neurobiol Dis 41:131-7. 2011
    ..In our sample 50% of the patients presented with a dominant-STN, suggesting that a non-negligible part of PD patients might not need bilateral STN-DBS surgery...
  46. doi request reprint rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: a PET study
    Antonio P Strafella
    Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1051-4. 2008
    ....
  47. doi request reprint Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
    Lili Naz Hazrati
    Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Mov Disord 27:1304-7. 2012
    ..However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP)...
  48. doi request reprint Basal ganglia physiology and deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada
    Mov Disord 25:S71-5. 2010
    ..In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease...
  49. ncbi request reprint New movement in Parkinson's
    Andres M Lozano
    Toronto Western Hospital, University of Toronto
    Sci Am 293:68-75. 2005
  50. doi request reprint Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years
    Sidney H Kennedy
    Department of Psychiatry, Division of Neurosurgery, University Health Network, Toronto, Canada
    Am J Psychiatry 168:502-10. 2011
    ..This report represents an extended follow-up of 20 patients with treatment-resistant depression who received DBS to the subcallosal cingulate gyrus (Brodmann's area 25)...
  51. ncbi request reprint Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
    ....
  52. ncbi request reprint Comparison of 2-dimensional magnetic resonance imaging and 3-planar reconstruction methods for targeting the subthalamic nucleus in Parkinson disease
    Yuri M Andrade-Souza
    Division of Neurosurgery, Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8, Canada
    Surg Neurol 63:357-62; discussion 362-3. 2005
    ....
  53. doi request reprint Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
    J Neurosurg 111:1209-15. 2009
    ..Based on the location of the active contacts used for long-term stimulation in responders, the authors suggest a standardized method of targeting the SCG in patients with MDD...
  54. doi request reprint The contemporary practice of psychiatric surgery: results from a global survey of functional neurosurgeons
    Daniel Mendelsohn
    Division of Neurosurgery, Vancouver General Hospital, University of British Columbia, Vancouver, B C, Canada
    Stereotact Funct Neurosurg 91:306-13. 2013
    ..We previously reported the results of a survey of North American functional neurosurgeons that evaluated general attitudes towards NPD and the future directions of the field...
  55. ncbi request reprint Subthalamic nucleus stimulation: improvements in outcome with reprogramming
    Elena Moro
    Movement Disorders Center and Department of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario
    Arch Neurol 63:1266-72. 2006
    ..Even when the electrode is well positioned in the target, the optimization of clinical results depends on careful programming of electrical parameters and changes in antiparkinsonian drug dosages...
  56. ncbi request reprint Subthalamic nucleus deep brain stimulation for parkinson's disease after successful pallidotomy: clinical and electrophysiological observations
    Galit Kleiner-Fisman
    Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1209-14. 2004
    ..017, 0.005). There were no side-to-side differences clinically or in the STN neuronal firing rates and patterns. Bilateral STN DBS is safe and efficacious in improving motor symptoms in patients with prior pallidotomy...
  57. ncbi request reprint Depth electrode recorded cerebral responses with deep brain stimulation of the anterior thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ont, Canada M5T 2S8
    Clin Neurophysiol 117:1602-9. 2006
    ....
  58. ncbi request reprint The dopaminergic nigrostriatal system and Parkinson's disease: molecular events in development, disease, and cell death, and new therapeutic strategies
    Mojgan Hodaie
    Division of Neurosurgery, Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Canada
    Neurosurgery 60:17-28; discussion 28-30. 2007
    ..These advancements are used as a template to review emerging therapeutic techniques, including neuroprotection strategies, surgical treatment of trophic factors, gene therapy, and neural transplantation...
  59. pmc Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
    Sleep 30:823-7. 2007
    ..We sought to identify and characterize human PGO waves...
  60. doi request reprint The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
    Hiroki Toda
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 108:132-8. 2008
    ..To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model...
  61. ncbi request reprint Neuronal activity in the globus pallidus of multiple system atrophy patients
    Luiz C M Pereira
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1485-92. 2004
    ....
  62. ncbi request reprint Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 20:371-7. 2005
    ..Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control...
  63. doi request reprint Memory enhancement induced by hypothalamic/fornix deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 63:119-23. 2008
    ..This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions...
  64. doi request reprint Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 months
    Heather E McNeely
    Schizophrenia Services, Neuropsychology Service, St Joseph s Healthcare, Hamilton, Ontario, Canada
    J Nerv Ment Dis 196:405-10. 2008
    ..Though the sample size is small, these results support cognitive safety of Cg25 DBS for TRD...
  65. doi request reprint The subcallosal cingulate gyrus in the context of major depression
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Biol Psychiatry 69:301-8. 2011
    ..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region...
  66. ncbi request reprint Dissociation of thalamic high frequency oscillations and slow component of sensory evoked potentials following damage to ascending pathways
    Ritsuko Hanajima
    Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, ONT Canada
    Clin Neurophysiol 117:906-11. 2006
    ..In this study, we examined how lesions in the sensory afferent pathway affect these components...
  67. doi request reprint Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosis
    Cristina V Torres
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Neurosurgery 67:646-51; discussion 651. 2010
    ..Tremor is an important cause of disability in patients with multiple sclerosis (MS). Deep brain stimulation (DBS) in the ventral intermediate nucleus (VIM) of the thalamus is said to be beneficial for MS tremor...
  68. ncbi request reprint Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's disease
    Yuri M Andrade-Souza
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 56:360-8; discussion 360-8. 2005
    ....
  69. doi request reprint Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Exp Neurol 232:100-4. 2011
    ....
  70. doi request reprint Location of active contacts in patients with primary dystonia treated with globus pallidus deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Neurosurgery 62:217-23; discussion 223-5. 2008
    ..We compared the location of the contacts being used for stimulation (active contacts) in patients with cervical dystonia, generalized dystonia, and Parkinson's disease and correlated the results with clinical outcome...
  71. ncbi request reprint Rhythmic cortical EEG synchronization with low frequency stimulation of the anterior and medial thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Canada
    Clin Neurophysiol 117:2272-8. 2006
    ..To investigate the neurophysiological characteristics and prognostic impact of EEG synchronization with low frequency thalamic stimulation in patients with intractable epilepsy...
  72. ncbi request reprint Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgery
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    J Neurosurg 103:246-51. 2005
    ..In the present study, preoperative psychiatric symptoms were systematically assessed in patients with PD presenting for routine preoperative psychiatric assessment...
  73. ncbi request reprint How does DBS work?
    Andres M Lozano
    Toronto Western Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
    Suppl Clin Neurophysiol 57:733-6. 2004
    ..This simplistic proposal has supporting and detracting evidence. In the present work we consider the mechanism of action of DBS and provide arguments for and against the stimulation or inhibition of target neural structures...
  74. doi request reprint Bilateral pallidal stimulation for x-linked dystonia parkinsonism
    Pettarusp M Wadia
    Movement Disorders Centre, Toronto Western Hospital, 399 Bathurst St, McL7 402, Toronto, Ontario, Canada, M5T 2S8
    Arch Neurol 67:1012-5. 2010
    ..To report the clinical benefits of bilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) in a patient with X-linked dystonia parkinsonism (XDP)...
  75. doi request reprint The pedunculopontine nucleus as a target for deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street WW 4 447, Toronto, ON, M5T2S8, Canada
    J Neural Transm (Vienna) 118:1461-8. 2011
    ..In this article, we review some of the basic aspects of the PPN as a target and the outcome of the recently published clinical trials...