Fei Fei Liu

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy
    Joseph D Mocanu
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Ther 15:921-9. 2007
  2. pmc MicroRNAs in nasopharyngeal carcinoma
    Jeff P Bruce
    Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
    Chin J Cancer 33:539-44. 2014
  3. pmc Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway
    Nehad M Alajez
    Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Oncotarget 3:1641-52. 2012
  4. pmc Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
    N M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Cell Death Dis 1:e85. 2010
  5. pmc A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase
    Kenneth W Yip
    Ontario Cancer Institute Campbell Family Cancer Research Institute, University Health Network UHN, Toronto, Ontario, Canada
    PLoS ONE 9:e89889. 2014
  6. pmc Enhanced vesicular stomatitis virus (VSVΔ51) targeting of head and neck cancer in combination with radiation therapy or ZD6126 vascular disrupting agent
    Nehad M Alajez
    Ontario Cancer Institute, Toronto, ON, Canada
    Cancer Cell Int 12:27. 2012
  7. ncbi request reprint Nasopharyngeal cancer: new frontiers from the laboratory to the clinic
    Fei Fei Liu
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 69:S122-4. 2007
  8. ncbi request reprint Novel gene therapy approach for nasopharyngeal carcinoma
    Fei Fei Liu
    Department of Radiation Oncology, Princess Margaret Hospital University Health Networks, University of Toronto, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
    Semin Cancer Biol 12:505-15. 2002
  9. ncbi request reprint East-West Symposium on nasopharyngeal cancer
    Fei Fei Liu
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, Canada
    Int J Radiat Oncol Biol Phys 67:703-8. 2007
  10. ncbi request reprint Potential efficacy of p16 gene therapy for EBV-positive nasopharyngeal carcinoma
    Anna Aihua Li
    Ontario Cancer Institute, University Health Network, Ontario, Canada
    Int J Cancer 110:452-8. 2004

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy
    Joseph D Mocanu
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Ther 15:921-9. 2007
    ..This study reports the favorable modulation by STI571 of the biodistribution of adenoviral vectors, providing a potential approach to improving therapeutic outcome...
  2. pmc MicroRNAs in nasopharyngeal carcinoma
    Jeff P Bruce
    Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
    Chin J Cancer 33:539-44. 2014
    ..In this review, we describe the efforts to date to identify and characterize such miRNAs in the context of NPC. ..
  3. pmc Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway
    Nehad M Alajez
    Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Oncotarget 3:1641-52. 2012
    ....
  4. pmc Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
    N M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Cell Death Dis 1:e85. 2010
    ..In particular, miR-98 was underexpressed in relapsed patient samples, strongly suggesting an important role for the miR-98 and EZH2 axis in NPC biology...
  5. pmc A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase
    Kenneth W Yip
    Ontario Cancer Institute Campbell Family Cancer Research Institute, University Health Network UHN, Toronto, Ontario, Canada
    PLoS ONE 9:e89889. 2014
    ..This work presents the first known synthetic UROD inhibitor, and sets the foundation for the design, synthesis, and characterization of higher affinity and more effective UROD inhibitors...
  6. pmc Enhanced vesicular stomatitis virus (VSVΔ51) targeting of head and neck cancer in combination with radiation therapy or ZD6126 vascular disrupting agent
    Nehad M Alajez
    Ontario Cancer Institute, Toronto, ON, Canada
    Cancer Cell Int 12:27. 2012
    ..In this study, we evaluated the therapeutic potential of mutant vesicular stomatitis virus (VSVΔ51) against the human hypopharyngeal FaDu tumour model in vitro and in vivo...
  7. ncbi request reprint Nasopharyngeal cancer: new frontiers from the laboratory to the clinic
    Fei Fei Liu
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 69:S122-4. 2007
    ....
  8. ncbi request reprint Novel gene therapy approach for nasopharyngeal carcinoma
    Fei Fei Liu
    Department of Radiation Oncology, Princess Margaret Hospital University Health Networks, University of Toronto, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
    Semin Cancer Biol 12:505-15. 2002
    ....
  9. ncbi request reprint East-West Symposium on nasopharyngeal cancer
    Fei Fei Liu
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, Canada
    Int J Radiat Oncol Biol Phys 67:703-8. 2007
    ..To achieve greater understanding of the epidemiology, pathogenesis, molecular oncology, diagnostic, and therapeutic aspects of nasopharyngeal cancer (NPC), an international meeting was held in June 2005, Toronto, Canada...
  10. ncbi request reprint Potential efficacy of p16 gene therapy for EBV-positive nasopharyngeal carcinoma
    Anna Aihua Li
    Ontario Cancer Institute, University Health Network, Ontario, Canada
    Int J Cancer 110:452-8. 2004
    ..p16 gene therapy for NPC, mediated through multimodal mechanisms of cytotoxicity. Future evaluations will examine strategies to increase in vivo tumor transduction with a view towards future clinical applications...
  11. ncbi request reprint Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen
    Kenneth W Yip
    Department of Medical Biophysics, University of Toronto, and Department of Medical Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Clin Cancer Res 12:5557-69. 2006
    ..This study aims to identify a novel therapeutic agent for head and neck cancer and to evaluate its antitumor efficacy...
  12. ncbi request reprint Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer
    Kenneth W Yip
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada
    Clin Cancer Res 11:8131-44. 2005
    ..This current study evaluates the efficacy of combining systemically delivered Bcl-2 phosphorothioate antisense (Bcl-2 ASO) and radiation for nasopharyngeal cancer therapy...
  13. ncbi request reprint Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer
    Kenneth W Yip
    Department of Medical Biophysics, University of Toronto, and Division of Applied Molecular Oncology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada
    Clin Cancer Res 12:5726-32. 2006
    ..The latent presence of EBV affects the function of p53, Bcl-2, and survivin. We thus investigated the relationship between EBV status, p53, Bcl-2, and survivin in biopsy specimens from patients with primary NPC...
  14. ncbi request reprint Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling
    Wei Shi
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Int J Cancer 119:2467-75. 2006
    ..The role of survivin in resisting apoptosis in NPC was confirmed by RNA interference. Our data provide novel insights into the development and progression of NPC, and suggest survivin as a novel therapeutic target for NPC...
  15. doi request reprint Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer
    Wei Shi
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, ON, Canada
    Int J Cancer 126:2036-48. 2010
    ..Targeting Plk1 will cause mitotic catastrophe, with significant cytotoxicity both in vitro and in vivo, underscoring the important therapeutic opportunity of Plk1 in NPC...
  16. ncbi request reprint Tumor-targeted gene therapy for nasopharyngeal carcinoma
    Jian Hua Li
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, M5G 2M9 Canada
    Cancer Res 62:171-8. 2002
    ..This has now provided the tumor-specific expression system from which additional interventions can be evaluated in future treatment strategies for patients with nasopharyngeal cancers...
  17. ncbi request reprint Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent
    Kenneth W Yip
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Mol Cancer Ther 5:2234-40. 2006
    ..Thus, we have identified alexidine dihydrochloride as the first bisbiguanide compound with anticancer specificity...
  18. ncbi request reprint Potential utility of BimS as a novel apoptotic therapeutic molecule
    Kenneth W Yip
    Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2M9
    Mol Ther 10:533-44. 2004
    ..This vector appears to be safe and effectively cytotoxic to EBV-positive NPC cells both in vitro and in vivo, mediated primarily through the induction of apoptosis...
  19. doi request reprint Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Oral Oncol 49:79-85. 2013
    ..To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC)...
  20. doi request reprint Significance of dysregulated metadherin and microRNA-375 in head and neck cancer
    Angela B Y Hui
    Department of Pathology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Clin Cancer Res 17:7539-50. 2011
    ..Hence, further understanding of HNC biology, and in particular, the genes/pathways driving metastasis is essential to improve outcome...
  21. doi request reprint Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma
    Angela B Y Hui
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Clin Cancer Res 19:2154-62. 2013
    ..Hence, the objectives of this study were to determine whether miRNA expression differed as a function of HPV status and to assess whether such miRNAs provide prognostic value beyond HPV status...
  22. ncbi request reprint Efficacy of targeted FasL in nasopharyngeal carcinoma
    Jian Hua Li
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario MS 1A1, Canada
    Mol Ther 8:964-73. 2003
    ..These results demonstrate the efficacy of our EBV-specific targeting strategy, which allows the potentially safe and effective utilization of a highly potent membrane-based apoptotic gene...
  23. ncbi request reprint p16 gene therapy: a potentially efficacious modality for nasopharyngeal carcinoma
    Andrew Wing Cheong Lee
    Department of Experimental Therapeutics, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Mol Cancer Ther 2:961-9. 2003
    ..p16-treated CNE-2Z cells. In conclusion, adv.p16 gene transfer appears to be highly effective against NPC that lack functional p16, which is the situation in the majority of NPC patients...
  24. ncbi request reprint A conditionally replicating adenovirus for nasopharyngeal carcinoma gene therapy
    Marie C Chia
    Division of Experimental Therapeutics, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Ther 9:804-17. 2004
    ..We have successfully established a conditionally replicating adenovirus for EBV-positive NPC, which is both safe and efficacious, indicating a strategy that may be therapeutically applicable...
  25. doi request reprint Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma
    Angela B Y Hui
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University Health Network, University of Toronto, Canada
    Clin Cancer Res 15:3716-24. 2009
    ..Because most nasopharyngeal carcinoma patients harbor EBV, we proceeded to evaluate the cytotoxic effects of seliciclib in EBV-positive nasopharyngeal carcinoma models...
  26. pmc Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex
    Roxana I Sufan
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    EMBO Mol Med 1:66-78. 2009
    ..These findings introduce the concept and feasibility of 'bio-tailored' enzymes in the treatment of HIF-overexpressing tumours...
  27. doi request reprint Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    Brian O'Sullivan
    Room 5 624, Princess Margaret Hospital, 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    J Clin Oncol 31:543-50. 2013
    ..To define human papillomavirus (HPV) -positive oropharyngeal cancers (OPC) suitable for treatment deintensification according to low risk of distant metastasis (DM)...
  28. doi request reprint Targeting polo-like kinase 1 enhances radiation efficacy for head-and-neck squamous cell carcinoma
    Kate Gerster
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 77:253-60. 2010
    ..To investigate the efficacy of targeting polo-like kinase 1 (Plk1) combined with ionizing radiotherapy (RT) for head-and-neck squamous cell carcinoma (HNSCC)...
  29. pmc MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer
    Christine How
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e67846. 2013
    ....
  30. doi request reprint Nuclear factor-Y and Epstein Barr virus in nasopharyngeal cancer
    Marie C Chia
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Clin Cancer Res 14:984-94. 2008
    ..The process of switching from latency to replication is not well understood, particularly in response to DNA stress; hence, the focus of this study is on an EBV-positive NPC model...
  31. doi request reprint Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer
    Emma Ito
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Mol Pharmacol 76:969-83. 2009
    ..Thus, using an HTS approach, CTAB was identified as a potential apoptogenic quaternary ammonium compound possessing in vitro and in vivo efficacy against HNC models...
  32. ncbi request reprint Results of radiotherapy for primary subglottic squamous cell carcinoma
    Sonya Paisley
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 52:1245-50. 2002
    ..To retrospectively evaluate the outcome after radical radiotherapy (RT) and surgical salvage and assess the risk of late toxicity for patients with primary subglottic squamous cell carcinoma treated at our center...
  33. ncbi request reprint Molecular pathology parameters in human nasopharyngeal carcinoma
    Wei Shi
    Department of Research, Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    Cancer 94:1997-2006. 2002
    ....
  34. ncbi request reprint Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer
    Nancy Ma
    Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Cancer Gene Ther 11:52-60. 2004
    ....
  35. doi request reprint Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma
    Wei Shi
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, Canada, M5G 2M9
    J Clin Oncol 27:6213-21. 2009
    ..We compared a quantitative real-time polymerase chain reaction (qRT-PCR) assay for HPV16 mRNA to a DNA in situ hybridization (ISH) method, and evaluated their significance for overall (OS) and disease-free (DFS) survival...
  36. pmc MicroRNA-193b enhances tumor progression via down regulation of neurofibromin 1
    Michelle Lenarduzzi
    Ontario Cancer Institute, University Health Network, Toronto, Canada
    PLoS ONE 8:e53765. 2013
    ....
  37. doi request reprint The changing incidence of human papillomavirus-associated oropharyngeal cancer using multiple imputation from 2000 to 2010 at a Comprehensive Cancer Centre
    Steven Habbous
    Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, Ontario, Canada M5G2M9
    Cancer Epidemiol 37:820-9. 2013
    ..Human papillomavirus (HPV) is a risk and prognostic factor for oropharyngeal cancer (OPC). Determining whether the incidence of HPV-associated OPC is rising informs health policy...
  38. doi request reprint Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas
    Angela B Y Hui
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 16:1129-39. 2010
    ..The objective of this study is to investigate the significance of microRNAs (miRNA) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC)...
  39. ncbi request reprint Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity
    Barbara Bachtiary
    Department of Radiation Oncology, Clinical Study Coordination and Biostatistics, Division of Cancer Genomics and Proteomics, Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Cancer Res 12:5632-40. 2006
    ..To explore intratumor heterogeneity in gene expression profiles from patients with cervical cancer...
  40. pmc Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer
    Michelle Lenarduzzi
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e74075. 2013
    ..To address this challenge, we proceeded to evaluate the role of iron in HNSCC...
  41. ncbi request reprint Heat-directed suicide gene therapy for breast cancer
    Anthony M Brade
    Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    Cancer Gene Ther 10:294-301. 2003
    ....
  42. doi request reprint Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 103:49-56. 2012
    ..To report outcome of HPV-related [HPV(+)] oropharyngeal cancer (OPC) managed predominantly by altered-fractionation radiotherapy-alone (RT-alone)...
  43. doi request reprint Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:276-83. 2012
    ..To report atypical clinical behavior observed in human papillomavirus (HPV)-related oropharyngeal carcinoma (OPC) treated with radiotherapy...
  44. doi request reprint MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway
    Nehad M Alajez
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Cancer Res 71:2381-91. 2011
    ..008, HR=6.0). Our findings define an integrative tumor suppressor function for miR-218 in NPC and further suggest that restoring miR-218 expression in NPC might be useful for its clinical management...
  45. ncbi request reprint Dysregulated PTEN-PKB and negative receptor status in human breast cancer
    Wei Shi
    Department of Experimental Therapeutics, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario
    Int J Cancer 104:195-203. 2003
    ..These observations support the contention that dysregulation in PTEN-PKB contributes to disease progression and hormone resistance of human breast cancer...
  46. ncbi request reprint Heat-directed tumor cell fusion
    Anthony M Brade
    Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Hum Gene Ther 14:447-61. 2003
    ..Heat-directed tumor cell fusion may prove to be a highly beneficial adjunct to existing cancer treatment strategies that take advantage of the synergistic interaction between mild hyperthermia and radiation or chemotherapeutic drugs...
  47. doi request reprint MicroRNA-301 mediates proliferation and invasion in human breast cancer
    Wei Shi
    Department of Medical Biophysics, Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Canada
    Cancer Res 71:2926-37. 2011
    ..In summary, our findings define miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses...
  48. doi request reprint Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma
    Hisayuki Kato
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Clin Cancer Res 16:898-911. 2010
    ..GMX1777, which inhibits nicotinamide phosphoribosyltransferase, was evaluated in two human head and neck cancer models in combination with radiotherapy...
  49. pmc Chromosomal instability as a prognostic marker in cervical cancer
    Christine How
    Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
    BMC Cancer 15:361. 2015
    ....
  50. doi request reprint Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas
    Shao Hui Huang
    Shao Hui Huang, Wei Xu, John Waldron, Lillian Siu, Xiaowei Shen, Li Tong, Jolie Ringash, Andrew Bayley, John Kim, Andrew Hope, John Cho, Meredith Giuliani, Aaron Hansen, Jonathan Irish, Ralph Gilbert, Patrick Gullane, Bayardo Perez Ordonez, Ilan Weinreb, Fei Fei Liu, and Brian O Sullivan, Princess Margaret Cancer Centre, University of Toronto and Fei Fei Liu and Brian O Sullivan, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    J Clin Oncol 33:836-45. 2015
    ..To refine stage and prognostic group for human papillomavirus (HPV) -related nonmetastatic (M0) oropharyngeal cancer (OPC)...
  51. pmc Developing a prognostic micro-RNA signature for human cervical carcinoma
    Christine How
    Ontario Cancer Institute, University Health Network, Toronto, ON, Canada Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    PLoS ONE 10:e0123946. 2015
    ..Our observations provide an important cautionary tale for future miRNA signature studies for cervical cancer, which can also be potentially applicable to miRNA profiling studies involving other types of human malignancies. ..
  52. ncbi request reprint Imaging and modulating antisense microdistribution in solid human xenograft tumor models
    Joseph D Mocanu
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Canada
    Clin Cancer Res 13:5935-41. 2007
    ..Antisense oligodeoxynucleotides (ASO) are a class of therapeutics where limited information is available about their distribution within a solid tumor environment...
  53. doi request reprint Comorbidity and prognosis in head and neck cancers: Differences by subsite, stage, and human papillomavirus status
    Steven Habbous
    Department of Medicine, Medical Biophysics, and Epidemiology, Ontario Cancer Institute, Princess Margaret Hospital University Health Network, Toronto, Ontario, Canada Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, Canada
    Head Neck 36:802-10. 2014
    ..The prognostic utility of comorbidity on head and neck cancer may differ by subsite, stage, and human papillomavirus (HPV) status...
  54. pmc Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma
    Justin P Williams
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 9:e98557. 2014
    ..These effects were further enhanced when combined with IR, both in vitro and in vivo. The preclinical data support the further evaluations of Dacomitinib combined with IR for the future management of patients with SCCHN. ..
  55. ncbi request reprint Five year results of a randomized trial comparing hyperfractionated to conventional radiotherapy over four weeks in locally advanced head and neck cancer
    Bernard Cummings
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Radiother Oncol 85:7-16. 2007
    ....
  56. doi request reprint A dose escalation study of hyperfractionated accelerated radiation delivered with integrated neck surgery (HARDWINS) for the management of advanced head and neck cancer
    John Waldron
    Department of Radiation Oncology, Princess Margaret Hospital and the University of Toronto, Canada
    Radiother Oncol 87:173-80. 2008
    ..To determine toxicity and outcome of radiation dose escalation with hyperfractionated accelerated radiation delivered with neck surgery (HARDWINS) for head and neck cancer...
  57. pmc The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer
    Ryunosuke Kogo
    Ontario Cancer Institute, University Health Network UHN, Toronto, Ontario, Canada
    Oncotarget 6:1090-100. 2015
    ....
  58. pmc Prognostic microRNAs modulate the RHO adhesion pathway: A potential therapeutic target in undifferentiated pleomorphic sarcomas
    Philip Wong
    Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
    Oncotarget 6:39127-39. 2015
    ..46 (p < 0.001). A prognostic miRNA biomarker for clinical validation was thus identified along with a functional pathway that modulates UPS metastatic phenotype. ..
  59. pmc Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma
    Jeff P Bruce
    Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
    Oncotarget 6:4537-50. 2015
    ..MicroRNAs (miRNAs) play many important roles in human cancers; hence, we proceeded to address the primary hypothesis that there is a miRNA expression signature capable of predicting DM for NPC patients...
  60. pmc Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus (HPV)-dependent regulation of the activator protein 1 (AP-1) pathway
    Lusia Sepiashvili
    From the Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7 Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada M5T 2M9
    Mol Cell Proteomics 13:3572-84. 2014
    ....
  61. doi request reprint Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma
    Nehad M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario, Canada
    Clin Cancer Res 14:4891-7. 2008
    ..We evaluated the therapeutic potential of a mutant vesicular stomatitis virus (VSVDelta51) as single treatment modality or in combination with ionizing radiation (RT) in NPC...
  62. ncbi request reprint The potential role of breast conservation surgery and adjuvant breast radiation for adenoid cystic carcinoma of the breast
    Barbara Ann M Millar
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, University Health Network, Ont, Canada
    Breast Cancer Res Treat 87:225-32. 2004
    ..A review of this unusual tumour was performed at our Institution, to assess the role of breast conservation in the management of this disease...
  63. ncbi request reprint Limitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma
    John Waldron
    Department of Radiation Oncology, The Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ont M5G 2M9, Canada
    Radiother Oncol 68:153-61. 2003
    ..To assess the adequacy of coverage of gross tumor volume (GTV) with traditional two dimensional (2D) radiation therapy (RT) planning in patients with nasopharyngeal cancer (NPC)...
  64. ncbi request reprint DJ-1, a novel regulator of the tumor suppressor PTEN
    Raymond H Kim
    Advanced Medical Discovery Institute, The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada M5G 2C1
    Cancer Cell 7:263-73. 2005
    ..DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer...
  65. pmc Potentially novel candidate biomarkers for head and neck squamous cell carcinoma identified using an integrated cell line-based discovery strategy
    Lusia Sepiashvili
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Mol Cell Proteomics 11:1404-15. 2012
    ..Furthermore, as demonstrated using ELISAs, circulating levels of PLAU and IGFBP7 were significantly higher in the plasma of HNSCC patients compared with healthy individuals...
  66. doi request reprint Rapid automated treatment planning process to select breast cancer patients for active breathing control to achieve cardiac dose reduction
    Wei Wang
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 82:386-93. 2012
    ....
  67. doi request reprint Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Cancer Centre University of Toronto, Toronto, Canada
    Cancer 121:545-55. 2015
    ....
  68. pmc Evaluation of copolymers of N-isopropylacrylamide and 2-dimethyl(aminoethyl)methacrylate in nonviral and adenoviral vectors for gene delivery to nasopharyngeal carcinoma
    Jim Moselhy
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Int J Nanomedicine 2:461-78. 2007
    ..PDMAEM and PNIPAM/DMAEM demonstrate both transfection and transduction enhancement activity of modified vectors in nasopharyngeal cancer cells in culture...
  69. doi request reprint miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1
    Xiaoyong Huang
    Authors Affiliations Sunnybrook Research Institute, Sunnybrook Health Sciences Centre Departments of Medicine, Medical Biophysics, and Radiation Oncology, University of Toronto and Ontario Cancer Institute, University Health Network, Toronto, Canada
    Cancer Res 73:6972-86. 2013
    ..Finally, miR-95 expression was increased in human prostate and breast cancer specimens compared with normal tissue. Together, our work reveals miR-95 expression as a critical determinant of radiation resistance in cancer cells...
  70. doi request reprint Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening
    David Katz
    University of Toronto, Canada
    Biotechniques 44:ix-xiv. 2008
    ..These data indicate that the 96-well CFA can be adopted as an efficient alternative assay to the 6-well CFA in evaluating single and combination therapies in vitro, providing a possible readout that could be used on a HTS platform...
  71. doi request reprint The effect of local breast radiotherapy on circulating CD34(+) cells
    Nehad M Alajez
    Ontario Cancer Institute, Toronto, Canada
    Radiother Oncol 100:304-7. 2011
    ..These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications...
  72. pmc Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies
    Angela Hui
    Ontario Cancer Institute Campbell Family Cancer Research Institute, University Health Network, Toronto, ON, Canada
    BMC Cancer 11:500. 2011
    ..Nonetheless, well-conducted miR profiling studies should contribute important insights into the molecular aberrations driving human cancer development and progression...
  73. doi request reprint Concomitant intensity modulated boost during whole breast hypofractionated radiotherapy--a feasibility and toxicity study
    Amy Yuen Meei Teh
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Radiother Oncol 102:89-95. 2012
    ....
  74. pmc Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma
    Nirojini Sivachandran
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Virol 86:60-8. 2012
    ..Therefore, PML disruption by EBNA1 is one mechanism by which EBV may contribute to the development of gastric cancer...
  75. pmc Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins
    Perry L Howard
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 100:11267-72. 2003
    ..These hybrid adaptors can be used to selectively kill oncogenic cells in which RTK activity is deregulated...
  76. ncbi request reprint Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression
    Mindy A Maynard
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 6:2810-6. 2007
    ....
  77. pmc NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data
    Daryl Waggott
    Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Bioinformatics 28:1546-8. 2012
    ..However, systematic inter-sample technical artifacts caused by variability in sample preservation, bio-molecular extraction and platform fluctuations must be removed to ensure robust data...
  78. ncbi request reprint A Phase III placebo-controlled trial of oral pilocarpine in patients undergoing radiotherapy for head-and-neck cancer
    Padraig Warde
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, 610 University Avenue, 5th Floor, Toronto, Ontario M5G 2M9, Canada
    Int J Radiat Oncol Biol Phys 54:9-13. 2002
    ..To test the hypothesis that the use of oral pilocarpine during and after radiotherapy (RT) for head-and-neck cancer would reduce the symptoms of post-RT xerostomia...
  79. doi request reprint Excellence in Radiation Research for the 21st Century (EIRR21): description of an innovative research training program
    Christine P'ng
    Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 83:e563-70. 2012
    ....
  80. pmc Spinal cord stimulators and radiotherapy: first case report and practice guidelines
    Lorraine Walsh
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto M5G2M9, Ontario, Canada
    Radiat Oncol 6:143. 2011
    ..We also provide useful practical recommendations on the management of this scenario within a radiation oncology department...
  81. pmc Characterization of complexation of poly (N-isopropylacrylamide-co-2-(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA
    Jim Moselhy
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada M5S 3M2
    Int J Nanomedicine 4:153-64. 2009
    ..The findings demonstrate that stable TCNGs can be prepared with controllable responsive properties determined by the nature of the cationic charge incorporated and may have potential as vehicles for DNA delivery...
  82. ncbi request reprint The oncogene PDGF-B provides a key switch from cell death to survival induced by TNF
    P Y Billie Au
    AMDI cFIFBCR, University Health Network, Department of Medical Biophysics, University of Toronto, 620 University Ave Suite 7 706, Toronto, Ontario, Canada M5G 2C1
    Oncogene 24:3196-205. 2005
    ..Our results suggest that while normal cells contain multiple TNF-induced survival signals, tumor cells may favor a specific survival gene that is abnormally upregulated in order to evade death signals...
  83. ncbi request reprint Local radiotherapy induces homing of hematopoietic stem cells to the irradiated bone marrow
    Carlo Bastianutto
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 67:10112-6. 2007
    ..Our data also suggest some opportunities for leukemia prevention in breast cancer patients undergoing RT...
  84. pmc A spectrum of basaloid morphology in a subset of EBV-associated "lymphoepithelial carcinomas" of major salivary glands
    Jeppe Friborg
    Department of Radiation Oncology, University Health Network, Toronto, ON, Canada
    Head Neck Pathol 6:445-50. 2012
    ..A basaloid variant of LEC in major salivary gland should be recognized, especially in highly prone populations, to avoid misdiagnosis of other more common salivary tumors...
  85. doi request reprint p53 Arg72Pro polymorphism, HPV status and initiation, progression, and development of cervical cancer: a systematic review and meta-analysis
    Steven Habbous
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada
    Clin Cancer Res 18:6407-15. 2012
    ..There were no associations of this variant with overall risk or initiation of cancer in either HPV-positive or HPV-negative patients. Clin Cancer Res; 18(23); 6407-15...
  86. doi request reprint On the path to seeking novel radiosensitizers
    David Katz
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:988-96. 2009
    ....
  87. doi request reprint Nasopharyngeal carcinoma: the next challenges
    Albiruni R A Razak
    Division of Medical Oncology and Haematology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Eur J Cancer 46:1967-78. 2010
    ....
  88. ncbi request reprint Radiotherapy management for squamous cell carcinoma of the nasal skin: the Princess Margaret Hospital experience
    May N Tsao
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 52:973-9. 2002
    ..To evaluate the outcome of radiotherapy (RT) for squamous cell carcinoma (SCC) of the nasal skin...
  89. doi request reprint Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues
    Angela B Y Hui
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Lab Invest 89:597-606. 2009
    ....
  90. doi request reprint Tumor-derived exosomes and microvesicles in head and neck cancer: implications for tumor biology and biomarker discovery
    Simona Principe
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Proteomics 13:1608-23. 2013
    ..We also highlight the importance of saliva as a proximal and easily accessible bio-fluid for HNC detection, and propose that salivary vesicles might serve as an alternative model in the discovery of novel HNC biomarkers...
  91. doi request reprint Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer
    Emma Ito
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Sci Transl Med 3:67ra7. 2011
    ..Thus, our study has revealed UROD as a potent tumor-selective sensitizer for both radiation and chemotherapy, with potential relevance to many human malignancies...
  92. ncbi request reprint Radiotherapy alone in patients with advanced nasopharyngeal cancer: comparison with an intergroup study. Is combined modality treatment really necessary?
    Edward Chow
    Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    Radiother Oncol 63:269-74. 2002
    ..To examine the outcome of radiotherapy (RT) alone in patients with advanced nasopharyngeal cancer (NPC) and to compare the results with those reported by the Intergroup study 0099 (IGS) comparing RT to combined modality therapy (CMT)...
  93. ncbi request reprint Loss of p16 expression has prognostic significance in human nasopharyngeal carcinoma
    Antti A Makitie
    Department of Otolaryngology, Princess Margaret Hospital Ontario Cancer Institute, Toronto M5G 2M9, Canada
    Clin Cancer Res 9:2177-84. 2003
    ..Our objective was to determine whether there was a correlation between these parameters and clinical outcome in NPC...