Cheng Han Lee

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 4:e7314. 2009
  2. doi request reprint The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Canada
    Adv Anat Pathol 17:222-32. 2010
  3. doi request reprint Histotype-genotype correlation in 36 high-grade endometrial carcinomas
    Lien N Hoang
    Departments of Pathology and Laboratory Medicine Gynecology and Obstetrics, University of British Columbia Genetic Pathology Evaluation Center, Vancouver General Hospital, Vancouver, BC Department of Pathology, University of Calgary, Calgary, AB Department of Pathology, University of Toronto, Toronto, ON, Canada Department of Pathology, Faculty of Medicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway Department of Pathology, Massachusetts General Hospital Department of Pathology, Brigham and Women s Hospital, Boston, MA Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
    Am J Surg Pathol 37:1421-32. 2013
  4. ncbi request reprint Calyculin-A disrupts subplasmalemmal junction and recurring Ca2+ waves in vascular smooth muscle
    Cheng Han Lee
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Room 166 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Cell Calcium 37:9-16. 2005
  5. doi request reprint Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis
    Melissa K McConechy
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital and BC Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 22:2865-73. 2016
  6. doi request reprint Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment
    Aline Talhouk
    Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, Vancouver, British Columbia, Canada
    Gynecol Oncol 143:46-53. 2016
  7. doi request reprint Immunophenotypic features of dedifferentiated endometrial carcinoma - insights from BRG1/INI1-deficient tumours
    Lien N Hoang
    Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
    Histopathology 69:560-9. 2016
  8. ncbi request reprint Organellar junctions promote targeted Ca2+ signaling in smooth muscle: why two membranes are better than one
    Damon Poburko
    The Department of Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
    Trends Pharmacol Sci 25:8-15. 2004
  9. pmc Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
    Melissa K McConechy
    Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada
    Mod Pathol 27:128-34. 2014
  10. pmc Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation
    Manohar Pradhan
    Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada
    BMC Cancer 10:493. 2010

Detail Information

Publications44

  1. pmc MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 4:e7314. 2009
    ..Little is known regarding the miRNA expression profiles of high grade serous carcinoma in relation to BRCA1/2 status, and compared to normal tubal epithelium, the putative tissue of origin for high grade serous carcinomas...
  2. doi request reprint The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Canada
    Adv Anat Pathol 17:222-32. 2010
    ..When used in combination with KIT, this panel of diagnostic biomarkers can help pathologists and clinicians to identify more patients who may benefit from targeted therapies...
  3. doi request reprint Histotype-genotype correlation in 36 high-grade endometrial carcinomas
    Lien N Hoang
    Departments of Pathology and Laboratory Medicine Gynecology and Obstetrics, University of British Columbia Genetic Pathology Evaluation Center, Vancouver General Hospital, Vancouver, BC Department of Pathology, University of Calgary, Calgary, AB Department of Pathology, University of Toronto, Toronto, ON, Canada Department of Pathology, Faculty of Medicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway Department of Pathology, Massachusetts General Hospital Department of Pathology, Brigham and Women s Hospital, Boston, MA Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
    Am J Surg Pathol 37:1421-32. 2013
    ..Judicious use and interpretation of p53 immunohistochemistry in selected scenarios can improve histotype-genotype concordance. ..
  4. ncbi request reprint Calyculin-A disrupts subplasmalemmal junction and recurring Ca2+ waves in vascular smooth muscle
    Cheng Han Lee
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Room 166 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Cell Calcium 37:9-16. 2005
    ..These findings offer support for the hypothesis that the presence of the PM-SR junctions is required for the generation of asynchronous recurring Ca2+ waves, which underlie excitation-contraction coupling in the VSMC of the rabbit IVC...
  5. doi request reprint Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis
    Melissa K McConechy
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital and BC Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 22:2865-73. 2016
    ..The aim of this study was to confirm the prognostic significance of POLE exonuclease domain mutations (EDM) in endometrial carcinoma patients. In addition, the effect of treatment on POLE-mutated tumors was assessed...
  6. doi request reprint Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: Earlier prognostic information to guide treatment
    Aline Talhouk
    Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, Vancouver, British Columbia, Canada
    Gynecol Oncol 143:46-53. 2016
    ....
  7. doi request reprint Immunophenotypic features of dedifferentiated endometrial carcinoma - insights from BRG1/INI1-deficient tumours
    Lien N Hoang
    Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
    Histopathology 69:560-9. 2016
    ..The aim of this study was to characterize the immunophenotypic features of DDECs, particularly in cases with prototypical histological and molecular features (BRG1/INI1 deficiency)...
  8. ncbi request reprint Organellar junctions promote targeted Ca2+ signaling in smooth muscle: why two membranes are better than one
    Damon Poburko
    The Department of Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
    Trends Pharmacol Sci 25:8-15. 2004
    ....
  9. pmc Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
    Melissa K McConechy
    Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Centre for Translational and Applied Genomics, Vancouver, BC, Canada
    Mod Pathol 27:128-34. 2014
    ..Understanding the distinct mutation patterns found in the PI3K and Wnt pathways of ovarian and endometrial endometrioid carcinomas may provide future opportunities for stratifying patients for targeted therapeutics. ..
  10. pmc Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation
    Manohar Pradhan
    Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada
    BMC Cancer 10:493. 2010
    ..The loss of BRCA1 function due to either germline/somatic mutation or epigenetic silencing is observed in most high-grade serous carcinomas of the ovary...
  11. doi request reprint Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy
    Salwa Bakhsh
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Histopathology 68:916-24. 2016
    ..To characterize the histomorphological features of endometrial carcinomas (ECs) harbouring polymerase ε (POLE) mutations...
  12. doi request reprint Immunohistochemical characterization of prototypical endometrial clear cell carcinoma--diagnostic utility of HNF-1β and oestrogen receptor
    Lien N Hoang
    Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Centre, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
    Histopathology 64:585-96. 2014
    ....
  13. ncbi request reprint Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma
    Cheng Han Lee
    Genetic Pathology Evaluation Centre, Vancouver General Hospital and University of BC, Vancouver, BC, Canada
    Int J Gynecol Pathol 24:147-52. 2005
    ..These results indicated that few patients with ovarian carcinoma have tumors that would benefit from therapy targeted specifically against Her-1, Her-2, or Her-3...
  14. doi request reprint Interobserver Agreement in Endometrial Carcinoma Histotype Diagnosis Varies Depending on The Cancer Genome Atlas (TCGA)-based Molecular Subgroup
    Lien N Hoang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital, University of British Columbia Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, BC Department of Pathology, Saskatoon City Hospital, Saskatoon, SK Department of Pathology, Laval University, Quebec City Department of Human Genetics, McGill University, Research Institute of the McGill University Health Network, Montreal, QC Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital, University of Alberta, Edmonton Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Calgary, AB, Canada
    Am J Surg Pathol 41:245-252. 2017
    ..The limitations in the precise histologic classification of endometrial carcinomas highlights the importance of an ancillary molecular-based classification scheme...
  15. doi request reprint Frequent Mismatch Repair Protein Deficiency in Mixed Endometrioid and Clear Cell Carcinoma of the Endometrium
    Martin Köbel
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary M K Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton C H L, AB Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia B T C, J L, L N H, C B G Department of Pathology, British Columbia Cancer Agency C H L, Vancouver, BC, Canada Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY R A S, D D Department of Histopathology, King Edward Memorial Hospital and School for Women s and Infants Health, University of Western Australia, Perth, WA, Australia C J R S
    Int J Gynecol Pathol . 2017
    ..This finding has implications both for our understanding of its tumor biology and for the identification of patients with potential Lynch syndrome...
  16. doi request reprint Outcomes of Incidental Fallopian Tube High-Grade Serous Carcinoma and Serous Tubal Intraepithelial Carcinoma in Women at Low Risk of Hereditary Breast and Ovarian Cancer
    Wen Yee Chay
    Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada National Cancer Centre Singapore, Singapore Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital, University of Alberta, Edmonton Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta Department of Pathology, Royal Jubilee Hospital and the University of British Columbia, Victoria, British Columbia, Canada Department of Oncology, NI Cancer Centre, Belfast Health and Social Care Trust, Belfast, United Kingdom and Department of Pathology, Vancouver General Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Int J Gynecol Cancer 26:431-6. 2016
    ....
  17. pmc Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas
    Anthony N Karnezis
    Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
    Mod Pathol 29:302-14. 2016
    ..The observed spatial association between SWI/SNF protein loss and histologic dedifferentiation suggests that inactivation of these core SWI/SNF proteins may contribute to the development of dedifferentiated endometrial carcinoma. ..
  18. pmc Molecular Analysis of Mixed Endometrial Carcinomas Shows Clonality in Most Cases
    Martin Köbel
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, AB Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
    Am J Surg Pathol 40:166-80. 2016
    ..Less commonly, mixed endometrial carcinomas are the result of early molecular divergence from a common progenitor clone or are synchronous biologically unrelated tumors (collision tumors). ..
  19. doi request reprint A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada
    Mod Pathol 22:1519-31. 2009
    ..Although ER positivity can be used to support the gynecologic origin of a leiomyosarcomas, nuclear WT1 immunostaining is of little use...
  20. doi request reprint Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers
    Alireza Heravi-Moussavi
    British Columbia Cancer Research Centre, Vancouver, BC, Canada
    N Engl J Med 366:234-42. 2012
    ..Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors...
  21. doi request reprint Diagnosis of Ovarian Carcinoma Histotype Based on Limited Sampling: A Prospective Study Comparing Cytology, Frozen Section, and Core Biopsies to Full Pathologic Examination
    Lien N Hoang
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, Canada L N H, S Z, D H, C B G Department of Histopathology, King Edward Memorial Hospital, Perth, Western Australia, Australia A S Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Canada M K Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital and University of Alberta, Edmonton, Canada C H L Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, BC, Canada J N M, D H Department of Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada D H, T T, D V N Department of Cellular Pathology, Barts and The London NHS Trust, London, United Kingdom N S
    Int J Gynecol Pathol 34:517-27. 2015
    ..Recognition of these scenarios can help improve diagnostic accuracy as we move forward with histotype-specific therapeutic strategies. ..
  22. doi request reprint Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma
    Lien N Hoang
    Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital University of British Columbia, Vancouver Department of Pathology and Laboratory Medicine, Calgary Laboratory Services University of Calgary, Calgary, Canada Department of Gynecology and Obstetrics, Tubingen University, Tubingen, Germany Department of Laboratory Medicine and Pathology, Royal Alexandra Hospital University of Alberta Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada Department of Public Health Sciences, Medical University of South Carolina Hollings Cancer Center, Charleston, SC and Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, Canada
    Int J Gynecol Cancer 25:1187-93. 2015
    ..These POLE mutated endometrial tumors were almost exclusively of the endometrioid histotype. The prevalence and patterns of POLE mutated tumors in endometrioid carcinomas of the ovary, however, have not been studied in detail...
  23. doi request reprint Targeted mutation analysis of endometrial clear cell carcinoma
    Lien N Hoang
    Department of Pathology and Laboratory Medicine, Genetic Pathology Evaluation Center, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
    Histopathology 66:664-74. 2015
    ..Endometrial clear cell carcinomas (CCC) constitute fewer than 5% of all carcinomas of the endometrium. Currently, little is known regarding the genetic basis of endometrial CCC...
  24. doi request reprint Immunohistochemical survey of mismatch repair protein expression in uterine sarcomas and carcinosarcomas
    Lien N Hoang
    Department of Pathology and Laboratory Medicine L N H, S L, C B G, C H L, University of British Columbia, Genetic Pathology Evaluation Centre, Vancouver, British Columbia, Canada Department of Laboratory Medicine and Pathology C H L, Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, Canada Department of Pathology R H A, Faculty of Medicine, Health Sciences Center, Kuwait University, Kuwait
    Int J Gynecol Pathol 33:483-91. 2014
    ..These observations provide a basis for MMR protein screening in uterine carcinosarcomas and leiomyosarcomas but not in other types of uterine mesenchymal or mixed epithelial/mesenchymal malignancies. ..
  25. ncbi request reprint Relationship between the sarcoplasmic reticulum and the plasma membrane
    Cheng Han Lee
    The iCAPTUR4E Center, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Novartis Found Symp 246:26-41; discussion 41-7, 48-51. 2002
    ..It is proposed that the above Ca2+ transport between the SR lumen and the extracellular space takes place at PM-SR junctions across a narrow junctional space...
  26. doi request reprint YWHAE-FAM22 endometrial stromal sarcoma: diagnosis by reverse transcription-polymerase chain reaction in formalin-fixed, paraffin-embedded tumor
    Anna Isphording
    Department of Pathology and Laboratory Medicine, and Genetic Pathology Evaluation Center, Vancouver General Hospital, Vancouver, British Columbia, Canada V5Z 4E3
    Hum Pathol 44:837-43. 2013
    ....
  27. pmc Use of mutation profiles to refine the classification of endometrial carcinomas
    Melissa K McConechy
    Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer Agency, Vancouver, BC, Canada
    J Pathol 228:20-30. 2012
    ..If used in practice, it may lead to improved diagnostic reproducibility and may also serve to stratify patients for targeted therapeutics...
  28. doi request reprint The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor
    Cheng Han Lee
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Surg Pathol 36:641-53. 2012
    ..Thus, their distinction from typical JAZF1 ESS is important for prognostic and therapeutic purposes...
  29. pmc Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada
    Am J Surg Pathol 36:1562-70. 2012
    ..When evaluating high-grade uterine sarcomas, cyclin D1 can be included in the immunohistochemical panel as an indicator of YWHAE-FAM22 ESS...
  30. doi request reprint IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype
    Martin Köbel
    Department of Pathology, Genetic Pathology Evaluation Centre of the Prostate Research Centre, Vancouver General Hospital and British Columbia Cancer Agency, Vancouver, BC, Canada
    Mod Pathol 22:469-75. 2009
    ..We conclude that IGF2BP3 is the first biomarker of prognostic significance in ovarian clear cell carcinoma that has been validated in an independent case series...
  31. ncbi request reprint Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models
    Cheng Han Lee
    Department of Pathology, Genetic Pathology Evaluation Centre of the Prostate Centre, Vancouver General Hospital, BC Cancer Agency and University of British Columbia, Vancouver, BC, Canada V5Z 4E6
    Gynecol Oncol 96:48-55. 2005
    ..To evaluate subrenal capsule xenografting of primary ovarian tumor tissues in mice for development of new ovarian cancer models...
  32. doi request reprint Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss
    Blaise Clarke
    Genetic Pathology Evaluation Center of the Prostate Research Center, Department of Pathology, Vancouver General Hospital and British Columbia Cancer Agency, Vancouver, BC, Canada
    Mod Pathol 22:393-402. 2009
    ..The presence of intraepithelial CD8(+) T cells also significantly correlates with loss of BRCA1...
  33. doi request reprint Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations
    Julie A Irving
    Department of Laboratory Medicine, Pathology, and Medical Genetics, Royal Jubilee Hospital, Victoria Department of Pathology, University of British Columbia Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC Department of Laboratory Medicine and Pathology, University of Alberta and Royal Alexandra Hospital, Edmonton, AB, Canada James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom
    Am J Surg Pathol 39:1420-6. 2015
    ....
  34. doi request reprint Metastatic small cell osteosarcoma to the liver: a diagnostic pitfall for fine-needle aspiration cytology
    Rola H Ali
    Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Diagn Cytopathol 42:161-4. 2014
    ..This is a potential diagnostic pitfall, particularly if interpreted without the knowledge of a suspected primary bone tumor...
  35. ncbi request reprint Relationship between asynchronous Ca2+ waves and force development in intact smooth muscle bundles of the porcine trachea
    Kuo Hsing Kuo
    St Paul s Hospital, The iCAPTURE Center, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 285:L1345-53. 2003
    ....
  36. doi request reprint Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institut of Biomedical Research IIB Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 37:514-21. 2013
    ..008). In our series, all ESSs showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation...
  37. doi request reprint FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma
    Anna F Lee
    Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Appl Immunohistochem Mol Morphol 19:233-8. 2011
    ..FLI-1 is therefore useful in the differential diagnosis of small round blue cell tumors of the bone...
  38. doi request reprint Duodenal epithelioid gastrointestinal stromal tumor with prominent granular cell features
    Anna Adamiak
    Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, BC, Canada
    Hum Pathol 40:599-602. 2009
    ..The current case illustrates the importance of considering gastrointestinal stromal tumor in the differential diagnosis of any epithelioid tumors in the gastrointestinal tract or the abdominal-pelvic cavity...
  39. doi request reprint ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors
    Ali H Alassiri
    Department of Pathology, Vancouver General Hospital Genome Sciences Center British Columbia Cancer Agency British Columbia Children s Hospital Department of Pathology, University of British Columbia, Vancouver, BC Department of Pathology, Royal Alexandra Hospital, Edmonton, AB, Canada Department of Pathology, King Abdulaziz Medical City, Riyadh, Saudi Arabia Department of Pathology, Kuwait University, Kuwait
    Am J Surg Pathol 40:1051-61. 2016
    ..Our data also further expand the growing spectrum of tumor types expressing the ETV6-NTRK3 fusion. ..
  40. ncbi request reprint Synchronous Ovarian and Appendiceal Mucinous Neoplasms in the Absence of Pseudomyxoma Peritonei
    Xianyong Gui
    Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary and Calgary Laboratory Services, Calgary and Department of Pathology, University of Alberta, Edmonton, Alberta, Canada
    Int J Gynecol Cancer . 2016
    ..Synchronous ovarian/appendiceal mucinous neoplasms sometimes occur in the absence of clinical pseudomyxoma peritonei (PMP), which raises a question about whether the 2 tumors could be independent...
  41. pmc An Immunohistochemical Algorithm for Ovarian Carcinoma Typing
    Martin Köbel
    Calgary Laboratory Services Alberta Health Services M K, P F R, C N, S L, Department of Pathology and Laboratory Medicine, Foothill Medical Center, University of Calgary, Calgary Department of Laboratory Medicine and Pathology X L, C A E, C H L, University of Alberta, Edmonton, AB Centre de recherche du K R, C L P, L M, M D L, D P, A M M M, Centre hospitalier de l Université de Montréal CRCHUM Departments of Pathology K R Obstetric Gynecology D P Medicine A M M M, Université de Montréal Institut du cancer de Montréal C L P, L M, M D L, D P, A M M M, Montreal, QC Department of Pathology S L, D H, C B G, University of British Columbia, Vancouver, BC Department of Cellular and Molecular Medicine B V, University of Ottawa, ON, Canada Department of Pathology P F R, Catholic University of Health and Allied Sciences Bugando, Mwanza, France
    Int J Gynecol Pathol 35:430-41. 2016
    ..This study provides statistically validated, inexpensive IHC algorithms, which have versatile applications in research, clinical practice, and clinical trials. ..
  42. doi request reprint Molecular Genetics of Mesenchymal Tumors of the Female Genital Tract
    Cheng Han Lee
    Department of Pathology and Laboratory Medicine, University of British Columbia, 1st floor JPPN, Vancouver General Hospital, 920 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Surg Pathol Clin 2:823-34. 2009
    ..This article focuses on current understanding of the molecular genetics of mesenchymal tumors of the female genital tract, with emphasis on diagnostic and prognostic molecular features. ..
  43. ncbi request reprint Sequential opening of IP(3)-sensitive Ca(2+) channels and SOC during alpha-adrenergic activation of rabbit vena cava
    Cheng Han Lee
    The iCAPTURE Center, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Heart Circ Physiol 282:H1768-77. 2002
    ..These new data suggest that the activation of both the IP(3)R channels and the SOC are required for PE-mediated [Ca(2+)](i) oscillations and constriction of the rabbit IVC...
  44. ncbi request reprint The role of the fallopian tube in ovarian cancer
    Alicia A Tone
    University of British Columbia, Vancouver, British Columbia, Canada
    Clin Adv Hematol Oncol 10:296-306. 2012
    ..The implementation of salpingectomy therefore promises to significantly impact ovarian cancer incidence and outcomes...