Rosalind S Labow

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. ncbi request reprint Neutrophil-mediated biodegradation of medical implant materials
    R S Labow
    Cardiovascular Devices Division, University of Ottawa Heart Institute, ON, Canada
    J Cell Physiol 186:95-103. 2001
  2. ncbi request reprint Hydrolytic degradation of poly(carbonate)-urethanes by monocyte-derived macrophages
    R S Labow
    Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Biomaterials 22:3025-33. 2001
  3. ncbi request reprint The biodegradation of poly(urethane)s by the esterolytic activity of serine proteases and oxidative enzyme systems
    R S Labow
    University of Ottawa Heart Institute, ON, Canada
    J Biomater Sci Polym Ed 10:699-713. 1999
  4. ncbi request reprint Human macrophage-mediated biodegradation of polyurethanes: assessment of candidate enzyme activities
    Rosalind S Labow
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa Heart Institute, Ont, Canada
    Biomaterials 23:3969-75. 2002
  5. ncbi request reprint The effect of oxidation on the enzyme-catalyzed hydrolytic biodegradation of poly(urethane)s
    Rosalind S Labow
    University of Ottawa Heart Institute, ON, Canada
    J Biomater Sci Polym Ed 13:651-65. 2002
  6. ncbi request reprint Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation
    Rosalind S Labow
    University of Ottawa Heart Institute, University of Ottawa, ON, Canada
    J Biomater Sci Polym Ed 16:1167-77. 2005
  7. ncbi request reprint The human macrophage response during differentiation and biodegradation on polycarbonate-based polyurethanes: dependence on hard segment chemistry
    Rosalind S Labow
    University of Ottawa Heart Institute, Ottawa, Ont, Canada K1Y 4W7
    Biomaterials 26:7357-66. 2005
  8. doi request reprint Differentiation of monocytes on a degradable, polar, hydrophobic, ionic polyurethane: Two-dimensional films vs. three-dimensional scaffolds
    Joanne E McBane
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, ON, Canada
    Acta Biomater 7:115-22. 2011
  9. ncbi request reprint Cyclic biaxial strain affects U937 macrophage-like morphology and enzymatic activities
    Loren A Matheson
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
    J Biomed Mater Res A 76:52-62. 2006
  10. doi request reprint The effects of phorbol ester activation and reactive oxygen species scavengers on the macrophage-mediated foreign body reaction to polyurethanes
    Joanne E McBane
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Biomed Mater Res A 91:1150-9. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Neutrophil-mediated biodegradation of medical implant materials
    R S Labow
    Cardiovascular Devices Division, University of Ottawa Heart Institute, ON, Canada
    J Cell Physiol 186:95-103. 2001
    ..05). This study has shown that it is possible to find out the differences in PMN activation through the PLA2 pathway when exposed to different material surfaces, making this a model system worthy of further investigation...
  2. ncbi request reprint Hydrolytic degradation of poly(carbonate)-urethanes by monocyte-derived macrophages
    R S Labow
    Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Biomaterials 22:3025-33. 2001
    ....
  3. ncbi request reprint The biodegradation of poly(urethane)s by the esterolytic activity of serine proteases and oxidative enzyme systems
    R S Labow
    University of Ottawa Heart Institute, ON, Canada
    J Biomater Sci Polym Ed 10:699-713. 1999
    ..The process of biodegradation as assessed by radiolabel release appears to be a specific hydrolytic process, while the role of oxidative enzymes remains less clear...
  4. ncbi request reprint Human macrophage-mediated biodegradation of polyurethanes: assessment of candidate enzyme activities
    Rosalind S Labow
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa Heart Institute, Ont, Canada
    Biomaterials 23:3969-75. 2002
    ..The results of these studies point to both esterases as being candidates. However, the current methods were unable to determine the relative contribution of each one to the observed biodegradation...
  5. ncbi request reprint The effect of oxidation on the enzyme-catalyzed hydrolytic biodegradation of poly(urethane)s
    Rosalind S Labow
    University of Ottawa Heart Institute, ON, Canada
    J Biomater Sci Polym Ed 13:651-65. 2002
    ..Both in vitro oxidation by HOCl and the release of HOCI by PMN were associated with the inhibition of RR and suggest perturbations between oxidative and hydrolytic mechanisms of biodegradation...
  6. ncbi request reprint Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation
    Rosalind S Labow
    University of Ottawa Heart Institute, University of Ottawa, ON, Canada
    J Biomater Sci Polym Ed 16:1167-77. 2005
    ..This may be related to both the substrate specificity of each esterase, as well as by the relative amount of each esterase that the specific biomaterial substrates induce the cells to synthesize and secrete...
  7. ncbi request reprint The human macrophage response during differentiation and biodegradation on polycarbonate-based polyurethanes: dependence on hard segment chemistry
    Rosalind S Labow
    University of Ottawa Heart Institute, Ottawa, Ont, Canada K1Y 4W7
    Biomaterials 26:7357-66. 2005
    ....
  8. doi request reprint Differentiation of monocytes on a degradable, polar, hydrophobic, ionic polyurethane: Two-dimensional films vs. three-dimensional scaffolds
    Joanne E McBane
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, ON, Canada
    Acta Biomater 7:115-22. 2011
    ....
  9. ncbi request reprint Cyclic biaxial strain affects U937 macrophage-like morphology and enzymatic activities
    Loren A Matheson
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
    J Biomed Mater Res A 76:52-62. 2006
    ....
  10. doi request reprint The effects of phorbol ester activation and reactive oxygen species scavengers on the macrophage-mediated foreign body reaction to polyurethanes
    Joanne E McBane
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Biomed Mater Res A 91:1150-9. 2009
    ..Manipulation of signaling pathways may provide insight surrounding the mechanism of activation for oxidative and/or hydrolytic degradative pathways in the MDM response to material surface chemistry...
  11. ncbi request reprint Biodegradation of polycarbonate-based polyurethanes by the human monocytes-derived macrophage and U937 cell systems
    Loren A Matheson
    University of Ottawa Heart Institute, University of Ottawa, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Biomed Mater Res 61:505-13. 2002
    ..Once established with U937s, the pathways can then be validated with the more physiologically relevant human MDM cell system...
  12. ncbi request reprint Intracellular phospholipase A2 expression and location in human macrophages: influence of synthetic material surface chemistry
    Donna Lee M Dinnes
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Cell Physiol 214:136-44. 2008
    ....
  13. ncbi request reprint Changes in macrophage function and morphology due to biomedical polyurethane surfaces undergoing biodegradation
    Loren A Matheson
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Cell Physiol 199:8-19. 2004
    ....
  14. ncbi request reprint The functional response of U937 macrophage-like cells is modulated by extracellular matrix proteins and mechanical strain
    Loren A Matheson
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, ON, Canada
    Biochem Cell Biol 84:763-73. 2006
    ..Using this approach with an in vitro cell system may help to unravel the complex function of MDMs in the foreign-body reaction...
  15. ncbi request reprint The interaction between hydrolytic and oxidative pathways in macrophage-mediated polyurethane degradation
    Joanne E McBane
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Biomed Mater Res A 82:984-94. 2007
    ..The findings highlight that both oxidative and hydrolytic mechanisms need to be understood in order to tailor material chemistry to produce desired cell responses for in vivo applications...
  16. ncbi request reprint Human monocyte adhesion onto RGD and PHSRN peptides delivered to the surface of a polycarbonate polyurethane using bioactive fluorinated surface modifiers
    Mark J Ernsting
    Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    J Biomed Mater Res A 83:759-69. 2007
    ..This was specifically highlighted for human blood monocytes, a key cell involved in the early stages of wound healing...
  17. ncbi request reprint Is cell culture stressful? Effects of degradable and nondegradable culture surfaces on U937 cell function
    Loren A Matheson
    University of Ottawa, Ottawa, ON, Canada
    Biotechniques 42:744, 746-50. 2007
    ....
  18. ncbi request reprint Phospholipase A2 pathway association with macrophage-mediated polycarbonate-urethane biodegradation
    Donna Lee M Dinnes
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ont, K1Y 4W7, Canada
    Biomaterials 26:3881-9. 2005
    ..Understanding PCNU activation of intracellular pathways, such as PLA2, will allow the design of materials optimized for their intended use...
  19. doi request reprint Differences in protein binding and cytokine release from monocytes on commercially sourced tissue culture polystyrene
    Kyle G Battiston
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Acta Biomater 8:89-98. 2012
    ....
  20. ncbi request reprint Differential effects of uniaxial and biaxial strain on U937 macrophage-like cell morphology: influence of extracellular matrix type proteins
    Loren A Matheson
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario, Canada
    J Biomed Mater Res A 81:971-81. 2007
    ..The combination of these parameters caused changes in U937 macrophage-like cells that should be considered in the outcome of the desired performance in the tissue-material constructs...
  21. ncbi request reprint Influence of biodegradable and non-biodegradable material surfaces on the differentiation of human monocyte-derived macrophages
    Donna Lee M Dinnes
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada
    Differentiation 76:232-44. 2008
    ....
  22. ncbi request reprint Material surfaces affect the protein expression patterns of human macrophages: A proteomics approach
    Donna Lee M Dinnes
    Department of Surgery, Faculty of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Biomed Mater Res A 80:895-908. 2007
    ....
  23. ncbi request reprint Generation of cell adhesive substrates using peptide fluoralkyl surface modifiers
    Mark J Ernsting
    Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ont, Canada
    Biomaterials 26:6536-46. 2005
    ..The generation of a peptide substrate points to the possibility of producing complex bioactive surfaces using various peptide BFSMs or pharmaceuticals simultaneously to manipulate cell functions...
  24. ncbi request reprint Tissue engineering a small diameter vessel substitute: engineering constructs with select biomaterials and cells
    Joanne E McBane
    University of Toronto, Toronto, ON, Canada
    Curr Vasc Pharmacol 10:347-60. 2012
    ..The discussion of these significant research challenges constitutes the focus of this review...
  25. doi request reprint Use of monocyte/endothelial cell co-cultures (in vitro) and a subcutaneous implant mouse model (in vivo) to evaluate a degradable polar hydrophobic ionic polyurethane
    Sarah M McDonald
    University of Ottawa, Ottawa, Ontario, Canada
    J Cell Biochem 112:3762-72. 2011
    ....
  26. doi request reprint Characterization of a degradable polar hydrophobic ionic polyurethane with circulating angiogenic cells in vitro
    Eva Mathieu
    a Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    J Biomater Sci Polym Ed 25:1159-73. 2014
    ....
  27. doi request reprint Synthesis and characterization of degradable polar hydrophobic ionic polyurethane scaffolds for vascular tissue engineering applications
    Soroor Sharifpoor
    Institute of Biomaterials and Biomedical Engineering, Faculty of Dentistry, University of Toronto, Room 461, Ontario, Canada
    Biomacromolecules 10:2729-39. 2009
    ..The versatility of the D-PHI properties may allow for the tailoring of cell-material interaction and ultimately functional tissue regeneration...
  28. ncbi request reprint Characterization of the Flexcell Uniflex cyclic strain culture system with U937 macrophage-like cells
    Loren A Matheson
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada
    Biomaterials 27:226-33. 2006
    ..These data indicate that cyclic mechanical strain applied by the Uniflex strain system modulates U937 cell function leading to selective increases in enzymatic activities as well as orientation in a favored direction...
  29. doi request reprint Changes in collagen with aging maintain molecular stability after overload: evidence from an in vitro tendon model
    Thomas L Willett
    Bone Biology Laboratory, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    J Biomech Eng 132:031002. 2010
    ..As techniques develop and improve, this new information may lead to important future studies concerning improved detection, prediction, and modeling of mechanical damage at much finer levels of tissue hierarchy than currently possible...
  30. doi request reprint Co-culturing monocytes with smooth muscle cells improves cell distribution within a degradable polyurethane scaffold and reduces inflammatory cytokines
    Joanne E McBane
    Institute of Biomaterials and Biomedical Engineering, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada M5G 1G6
    Acta Biomater 8:488-501. 2012
    ....