B Kolb

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. ncbi request reprint Recovery from infant medial frontal cortical lesions in rats is reversed by cortical lesions in adulthood
    Agnes Dallison
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4
    Behav Brain Res 146:57-63. 2003
  2. ncbi request reprint Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats
    Bryan Kolb
    Department of Psychology, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    J Cereb Blood Flow Metab 27:983-97. 2007
  3. doi request reprint Searching for the principles of brain plasticity and behavior
    Bryan Kolb
    Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada Electronic address
    Cortex 58:251-60. 2014
  4. doi request reprint Brain plasticity in the developing brain
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada Electronic address
    Prog Brain Res 207:35-64. 2013
  5. pmc Experience and the developing prefrontal cortex
    Bryan Kolb
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Proc Natl Acad Sci U S A 109:17186-93. 2012
  6. ncbi request reprint Embryonic pretreatment with bromodeoxyuridine blocks regeneration and functional recovery from perinatal medial frontal lesions in rats
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
    Dev Neurosci 34:228-39. 2012
  7. doi request reprint Age, experience, injury, and the changing brain
    Bryan Kolb
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Dev Psychobiol 54:311-25. 2012
  8. doi request reprint Contrasting effects of motor and visual spatial learning tasks on dendritic arborization and spine density in rats
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta T1K3M4, Canada
    Neurobiol Learn Mem 90:295-300. 2008
  9. ncbi request reprint Cryoanethesia on postnatal day 1, but not day 10, affects adult behavior and cortical morphology in rats
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, T1K 3M4 Canada
    Brain Res Dev Brain Res 130:9-14. 2001
  10. ncbi request reprint Brain plasticity and recovery from early cortical injury
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Dev Psychobiol 49:107-18. 2007

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Recovery from infant medial frontal cortical lesions in rats is reversed by cortical lesions in adulthood
    Agnes Dallison
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4
    Behav Brain Res 146:57-63. 2003
    ..It thus appears that the tissue that filled in the mPFC lesions on day 10 was functional...
  2. ncbi request reprint Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats
    Bryan Kolb
    Department of Psychology, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    J Cereb Blood Flow Metab 27:983-97. 2007
    ..These findings reveal that specific combinations of growth factors can mobilize endogenous adult neural stem cells to promote cortical tissue re-growth and functional recovery after stroke...
  3. doi request reprint Searching for the principles of brain plasticity and behavior
    Bryan Kolb
    Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada Electronic address
    Cortex 58:251-60. 2014
    ..Here we seek a synthesis of the multidisciplinary work on brain plasticity and behavior to identify some general principles on how the brain changes in response to a wide range of experiences over the lifetime. ..
  4. doi request reprint Brain plasticity in the developing brain
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada Electronic address
    Prog Brain Res 207:35-64. 2013
    ..Here, we review the phases of brain development, how factors influence brain, and behavioral development in both the normal and perturbed brain, and propose mechanisms that may underlie these effects. ..
  5. pmc Experience and the developing prefrontal cortex
    Bryan Kolb
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Proc Natl Acad Sci U S A 109:17186-93. 2012
    ..We begin with an overview of prefrontal functioning and development, and we conclude with a consideration of how early experiences influence prefrontal development and behavior...
  6. ncbi request reprint Embryonic pretreatment with bromodeoxyuridine blocks regeneration and functional recovery from perinatal medial frontal lesions in rats
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
    Dev Neurosci 34:228-39. 2012
    ..These results demonstrate a teratological effect of BrdU and are consistent with the claim that functional recovery after midline frontal removal on postnatal day 10 is supported by the generation of new midline frontal tissue...
  7. doi request reprint Age, experience, injury, and the changing brain
    Bryan Kolb
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Dev Psychobiol 54:311-25. 2012
    ..In this article, we review evidence we have collected from a rat model of normal development and the effects of brain injury, and comment on the general principals that may apply to human stroke and amblyopia...
  8. doi request reprint Contrasting effects of motor and visual spatial learning tasks on dendritic arborization and spine density in rats
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta T1K3M4, Canada
    Neurobiol Learn Mem 90:295-300. 2008
    ..Furthermore, changes in spine density and dendritic length and branching are not tightly correlated and can increase and/or decrease independently of one another in learning tasks...
  9. ncbi request reprint Cryoanethesia on postnatal day 1, but not day 10, affects adult behavior and cortical morphology in rats
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, T1K 3M4 Canada
    Brain Res Dev Brain Res 130:9-14. 2001
    ..It is important that all studies using cryoanesthesia have sham control animals exposed to the same degree of hypothermia...
  10. ncbi request reprint Brain plasticity and recovery from early cortical injury
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Dev Psychobiol 49:107-18. 2007
    ....
  11. ncbi request reprint Cortical plasticity and the development of behavior after early frontal cortical injury
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Dev Neuropsychol 18:423-44. 2000
    ..Finally, there is preliminary evidence in laboratory animals to suggest that it may be possible to induce neural regeneration in the injured brain and that the regenerated brain functions to support functional recovery...
  12. pmc Neural compensations after lesion of the cerebral cortex
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, Canada
    Neural Plast 8:1-16. 2001
    ..Factors that enhance dendritic change stimulate functional compensation, whereas factors that retard or block dendritic change block or retard compensation...
  13. pmc Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Proc Natl Acad Sci U S A 100:10523-8. 2003
    ....
  14. ncbi request reprint Is there an optimal age for recovery from motor cortex lesions? I. Behavioral and anatomical sequelae of bilateral motor cortex lesions in rats on postnatal days 1, 10, and in adulthood
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, AB T1K 3M4, Lethbridge, Canada
    Brain Res 882:62-74. 2000
    ..The widespread anatomical changes in all lesion groups versus the relatively better behavioral recovery after P10 lesions suggests that day 10 represents an optimal period for adapting to brain damage and subsequent brain reorganization...
  15. doi request reprint Effects of neonatal medial versus lateral temporal cortex injury: theoretical comment on Malkova et al. (2010)
    Bryan Kolb
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, AB, Canada
    Behav Neurosci 124:873-6. 2010
    ....
  16. ncbi request reprint Experience-dependent changes in dendritic arbor and spine density in neocortex vary qualitatively with age and sex
    Bryan Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Canada T1K 3M4
    Neurobiol Learn Mem 79:1-10. 2003
    ..These results may explain some of the apparent inconsistencies in reports of spine and dendrite changes in the literature...
  17. ncbi request reprint Overview of cortical plasticity and recovery from brain injury
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Phys Med Rehabil Clin N Am 14:S7-25, viii. 2003
    ..This article considers each level in turn and then briefly describes how an understanding of the principles of plasticity can be used to initiate treatments for cerebral injury...
  18. ncbi request reprint Environmental complexity has different effects on the structure of neurons in the prefrontal cortex versus the parietal cortex or nucleus accumbens
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada
    Synapse 48:149-53. 2003
    ..The data further suggest that it is prudent to measure both dendritic length and spine density in studies of experience-dependent effects on synaptic plasticity...
  19. ncbi request reprint Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats
    Bryan Kolb
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Synapse 60:429-36. 2006
    ..These results are similar to those evident in brains of rats sensitized to amphetamine, and support previous findings that cannabinoids promote DA activity in the mesolimbic DA system...
  20. ncbi request reprint Recovery from early cortical damage in rats. IX. Differential behavioral and anatomical effects of temporal cortex lesions at different ages of neural maturation
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 144:67-76. 2003
    ....
  21. ncbi request reprint Plasticity and functions of the orbital frontal cortex
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Brain Cogn 55:104-15. 2004
    ..It is proposed that both drug-induced and developmental abnormalities in the integrity of OFC neurons may lead to deficits in social behavior or other behavioral pathologies, possibly including depression...
  22. doi request reprint Searching for factors underlying cerebral plasticity in the normal and injured brain
    Bryan Kolb
    Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    J Commun Disord 44:503-14. 2011
    ..The goal of this review is to synthesize the multidisciplinary laboratory work on brain plasticity and behavior in the injured brain to inform the development of rehabilitation programs...
  23. doi request reprint Brain plasticity and recovery from early cortical injury
    Bryan Kolb
    Department of Neuroscience, University of Lethbridge, Alberta, Canada
    Dev Med Child Neurol 53:4-8. 2011
    ..All these factors influence cerebral development and influence recovery from brain injury during development...
  24. ncbi request reprint Does dendritic growth underly recovery from neonatal occipital lesions in rats
    B Kolb
    Department of Psychology, University of Lethbridge, Canada
    Behav Brain Res 77:125-33. 1996
    ..This arborization may be related to enhanced somatosensory function but does not support recovery of visually-guided behavior...
  25. doi request reprint Training on motor and visual spatial learning tasks in early adulthood produces large changes in dendritic organization of prefrontal cortex and nucleus accumbens in rats given nicotine prenatally
    A Muhammad
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada
    Neuroscience 252:178-89. 2013
    ....
  26. ncbi request reprint Recovery from early cortical damage in rats, VIII. Earlier may be worse: behavioural dysfunction and abnormal cerebral morphogenesis following perinatal frontal cortical lesions in the rat
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Canada
    Neuropharmacology 39:756-64. 2000
    ..The cortex of newborn rats appears to be especially vulnerable to even restricted injury. This contrasts to the effects of similar injury a week later when animals show extensive functional recovery and anatomical compensation...
  27. ncbi request reprint Experience-dependent amelioration of motor impairments in adulthood following neonatal medial frontal cortex injury in rats is accompanied by motor map expansion
    P T J Williams
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 141:1315-26. 2006
    ..The experience-induced expansion of the forelimb motor maps in adulthood provides a neural mechanism for the experience-dependent improvements in motor performance...
  28. ncbi request reprint FGF-2-induced cell proliferation stimulates anatomical, neurophysiological and functional recovery from neonatal motor cortex injury
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Eur J Neurosci 24:739-49. 2006
    ....
  29. ncbi request reprint Pre- and postnatal FGF-2 both facilitate recovery and alter cortical morphology following early medial prefrontal cortical injury
    Wendy L Comeau
    Canadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta T1K 3M4, Canada
    Behav Brain Res 180:18-27. 2007
    ....
  30. ncbi request reprint Sex differences in the effects of frontal cortex injury: role of differential hormonal experience in early development
    M L Forgie
    Department of Psychology and Neuroscience, The University of Lethbridge, Alberta, Canada
    Behav Neurosci 112:141-53. 1998
    ....
  31. ncbi request reprint Basic fibroblast growth factor stimulates functional recovery after neonatal lesions of motor cortex in rats
    M H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 134:1-8. 2005
    ..Our results suggest that FGF-2 may play an important role in recovery from early brain damage...
  32. ncbi request reprint Recovery of function is associated with increased spine density in cortical pyramidal cells after frontal lesions and/or noradrenaline depletion in neonatal rats
    B Kolb
    Department of Psychology, University of Lethbridge, AB, Canada
    Behav Brain Res 89:61-70. 1997
    ..These results suggest that recovery from neonatal cortical injury and from neonatal noradrenaline depletion may be supported by changes in both the dendritic arborization and the spine density in the remaining cortex...
  33. ncbi request reprint Possible regeneration of rat medial frontal cortex following neonatal frontal lesions
    B Kolb
    Department of Psychology, University of Lethbridge, Canada
    Behav Brain Res 91:127-41. 1998
    ..These results are discussed in relation to the proximity of the lesion to the stem cells in the lateral ventricle and their postnatal migrational activities...
  34. ncbi request reprint Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke
    G Silasi
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neuroscience 144:1160-8. 2007
    ..Based on these results we conclude that the plastic changes that are induced by long-term COX-2 inhibitor administration provide some benefit to functional outcome following ischemic cortical injury...
  35. ncbi request reprint Recovery from early cortical damage in rats, VII. Comparison of the behavioural and anatomical effects of medial prefrontal lesions at different ages of neural maturation
    B Kolb
    Department of Psychology, University of Lethbridge, Canada
    Behav Brain Res 79:1-14. 1996
    ..Thus although rats in all young lesion groups showed a milder behavioural syndrome than rats with comparable lesions in adulthood, the functional outcome was best for animals with lesions at 9 days of age...
  36. ncbi request reprint A golgi analysis of cortical pyramidal cells in the unilateral parkinson rat: absence of change in the affected hemisphere vs hypertrophy in the intact hemisphere
    Elena I Miklyaeva
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada
    Restor Neurol Neurosci 25:91-9. 2007
    ..The present study examined how DA depletion and the associated sensorimotor changes affect the morphology of the ipsilateral or contralateral neocortex neurons as assessed by dendritic morphology in Golgi-stained tissue...
  37. ncbi request reprint A comparison of different models of stroke on behaviour and brain morphology
    C L R Gonzalez
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Eur J Neurosci 18:1950-62. 2003
    ..These results suggest that: (i) different lesions to the motor cortex produce subtle differences in behaviour, and (ii) the method used to induce the lesion produces striking differences in cortical and subcortical plasticity...
  38. ncbi request reprint Unilateral lesions of the forelimb area of rat motor cortex: lack of evidence for use-dependent neural growth in the undamaged hemisphere
    M L Forgie
    Department of Psychology, University of Lethbridge, AB, Canada
    Brain Res 710:249-59. 1996
    ..Although the lesions produced significant behavioral asymmetry and enhanced glial response on the lesioned side, there was little evidence for use-dependent neural growth in the undamaged hemisphere in either sex...
  39. doi request reprint A comparison of the effects of days 1 and 10 unilateral lesions of medial prefrontal cortex on cerebral morphogenesis and behavior
    Nicole Sherren
    University of Lethbridge, Canada
    Behav Brain Res 214:108-14. 2010
    ..These results contrast with the effect of unilateral motor cortex injuries at the same ages...
  40. doi request reprint Tactile stimulation after frontal or parietal cortical injury in infant rats facilitates functional recovery and produces synaptic changes in adjacent cortex
    Bryan Kolb
    University of Lethbridge, Lethbridge, Canada
    Behav Brain Res 214:115-20. 2010
    ....
  41. ncbi request reprint Functional recovery and dendritic hypertrophy after posterior and complete cingulate lesions on postnatal day 10
    Claudia L R Gonzalez
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Canada T1K 3M4
    Dev Psychobiol 40:138-46. 2002
    ..It appears that there is something special about the reparative processes and subsequent functional recovery that follow midline neocortical lesions...
  42. doi request reprint Long-term alterations to dendritic morphology and spine density associated with prenatal exposure to nicotine
    R Mychasiuk
    Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Canada
    Brain Res 1499:53-60. 2013
    ..As changes were identified at P100, prenatal exposure to nicotine dramatically reorganized neuroanatomy in a persistent manner, likely altering the brain's response to normal and abnormal experiences...
  43. doi request reprint Tactile stimulation during development alters behaviour and neuroanatomical organization of normal rats
    S Richards
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Behav Brain Res 231:86-91. 2012
    ..These findings demonstrate that similar to early adversity, positive experiences early in development can dramatically alter neuroplasticity...
  44. ncbi request reprint Sex differences in cortical plasticity and behavior following anterior cortical kindling in rats
    G C Teskey
    Department of Psychology, University of Calgary, Alberta, Canada
    Cereb Cortex 9:675-82. 1999
    ..The differential gender effect suggests that males and females recruit similar plastic mechanisms although at different times in response to electrical kindling...
  45. ncbi request reprint Cerebral morphology and functional sparing after prenatal frontal cortex lesions in rats
    B Kolb
    Department of Psychology, University of Lethbridge, Canada
    Behav Brain Res 91:143-55. 1998
    ..The results are discussed in the context of a hypothesis regarding the optimal times for functional recovery from cortical injury...
  46. ncbi request reprint Nicotine improvement of Morris water task performance after fimbria-fornix lesion is blocked by mecamylamine
    R W Brown
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Alta, T1K 3M4, Lethbridge, Canada
    Behav Brain Res 119:185-92. 2001
    ..The compensatory effect of nicotine was blocked by mecamylamine. This study demonstrates that nicotine stimulates recovery from brain damage and the results are discussed in relation to neural mechanisms and potential applications...
  47. ncbi request reprint Social instability blocks functional restitution following motor cortex stroke in rats
    Gergely Silasi
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Behav Brain Res 188:219-26. 2008
    ....
  48. doi request reprint Juvenile play experience primes neurons in the medial prefrontal cortex to be more responsive to later experiences
    B T Himmler
    Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada Electronic address
    Neurosci Lett 556:42-5. 2013
    ..These findings suggest that juvenile play experiences enhance the plasticity of some neural systems. ..
  49. ncbi request reprint Effects of rat prenatal exposure to valproic acid on behaviour and neuro-anatomy
    R Mychasiuk
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
    Dev Neurosci 34:268-76. 2012
    ..Behavioural and anatomical findings from this study produced reliable results indicating that prenatal VPA exposure may be a viable model for the study of autism in rats...
  50. ncbi request reprint A cautionary note regarding drug and brain lesion studies that use swimming pool tasks: partial reinforcement impairs acquisition of place learning in a swimming pool but not on dry land
    C L Gonzalez
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, T1K 3M4, Alberta, Canada
    Behav Brain Res 112:43-52. 2000
    ..The results are discussed in relation to widespread applications of the Morris place task to neurobiological problems...
  51. ncbi request reprint Nicotine sensitization increases dendritic length and spine density in the nucleus accumbens and cingulate cortex
    R W Brown
    Department of Psychology and Neuroscience, University of Lethbridge, T1K 3M4, Lethbridge, Alb, Canada
    Brain Res 899:94-100. 2001
    ..The increase observed in the NAcc was significantly greater than what has been found with amphetamine or cocaine, and possible underlying mechanisms were discussed...
  52. doi request reprint Does prenatal nicotine exposure alter the brain's response to nicotine in adolescence? A neuroanatomical analysis
    R Mychasiuk
    Canadian Centre for Behavioural Neurosciences, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4
    Eur J Neurosci 38:2491-503. 2013
    ..Females showed additive effects in Par1, Cg3 and NAc whereas males demonstrated additive effects only in AID. Thus, the timing of nicotine exposure produced differential effects on cerebral organisation in a regionally specific manner...
  53. ncbi request reprint Nerve growth factor stimulates growth of cortical pyramidal neurons in young adult rats
    B Kolb
    Department of Psychology, University of Lethbridge, Canada
    Brain Res 751:289-94. 1997
    ....
  54. ncbi request reprint Brain plasticity and behavior
    B Kolb
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Annu Rev Psychol 49:43-64. 1998
    ..We discuss the important role that changes in dendritic arborization play in brain plasticity and behavior, and we consider these changes in the context of changing intrinsic circuitry of the cortex in processes such as learning...
  55. ncbi request reprint The modulation of play fighting in rats: role of the motor cortex
    Holly Kamitakahara
    Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Behav Neurosci 121:164-76. 2007
    ..It appears that different forms of cortical modulation of play fighting involve different cortical circuits...
  56. ncbi request reprint Differential effects of nicotine and complex housing on subsequent experience-dependent structural plasticity in the nucleus accumbens
    Derek A Hamilton
    Department of Psychology, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Behav Neurosci 119:355-65. 2005
    ..The findings indicate that there are important differences in the capacity of drugs and experience to influence subsequent modifications in dendritic structure...
  57. ncbi request reprint Differential expression of basic fibroblast growth factor-2 in the developing rat brain
    M H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Neuroscience 141:213-21. 2006
    ....
  58. doi request reprint Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex
    A Muhammad
    University of Lethbridge, AB, Canada
    Neuroscience 216:103-9. 2012
    ..The altered dendritic growth and spine density associated with stress during development could have potential impact on NAc and PFC related behaviors...
  59. ncbi request reprint Enriched environment improves motor function in intact and unilateral dopamine-depleted rats
    N M Jadavji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 140:1127-38. 2006
    ..These data are discussed in relation to possible mechanisms of experience-dependent modulation of the pathology of Parkinson's disease...
  60. ncbi request reprint Synaptic plasticity and the organization of behaviour after early and late brain injury
    B Kolb
    Department of Psychology and Neuroscience, University of Lethbridge
    Can J Exp Psychol 53:62-76. 1999
    ..Factors that retard recovery, such as depletion of neuromodulators, also block synaptic change. These results thus support Hebb's general idea that synaptic plasticity is related to behavioural change...
  61. ncbi request reprint Deficits in allothetic and idiothetic spatial behavior in rats with posterior cingulate cortex lesions
    I Q Whishaw
    Department of Psychology and Neuroscience, University of Lethbridge, T1K 3M4, Lethbridge, Alta, Canada
    Behav Brain Res 118:67-76. 2001
    ..The results demonstrate a role for posterior cingulate region in idiothetic navigation...
  62. ncbi request reprint Nicotine improves Morris water task performance in rats given medial frontal cortex lesions
    R W Brown
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, AB, Canada
    Pharmacol Biochem Behav 67:473-8. 2000
    ..These results demonstrate that nicotine has therapeutic effects in rats that have received cortical injury...
  63. ncbi request reprint Age, experience and the changing brain
    B Kolb
    Department of Psychology, University of Lethbridge, Alberta, Canada
    Neurosci Biobehav Rev 22:143-59. 1998
    ..Finally, we have attempted to reach some general conclusions that describe the effects of age, experience, sex, and injury on the cortex...
  64. ncbi request reprint FGF-2-induced functional improvement from neonatal motor cortex injury via corticospinal projections
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Exp Brain Res 185:453-60. 2008
    ..Our results demonstrate that FGF-2 treatment restores the connectivity of the filled region in neonatal rats. This provides a possible mechanism for FGF-2-induced functional recovery...
  65. doi request reprint Transient middle cerebral artery occlusion disrupts the forelimb movement representations of rat motor cortex
    Omar A Gharbawie
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Eur J Neurosci 28:951-63. 2008
    ..Thus, M1 dysfunction contributes to the impairments that ensue from proximal MCA occlusion, even when the infarct is limited to subcortical regions...
  66. ncbi request reprint Chronic low-dose administration of nicotine facilitates recovery and synaptic change after focal ischemia in rats
    Claudia L R Gonzalez
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada
    Neuropharmacology 50:777-87. 2006
    ..The results suggest that the behavioral enhancement in the stroke+nicotine group might be attributable to the enhanced dendritic growth in residual cortical motor regions...
  67. ncbi request reprint Neocortical kindling is associated with opposing alterations in dendritic morphology in neocortical layer V and striatum from neocortical layer III
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Alberta, Canada
    Synapse 59:1-9. 2006
    ..The differential effect between layer V pyramidal neurons and layer III pyramidal neurons suggests that these areas play different roles in the expression of seizures and the adaptation of the brain to the persistent effect of kindling...
  68. doi request reprint Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats
    B T Himmler
    Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Dev Psychobiol 56:1052-60. 2014
    ..It remains to be determined whether juvenile experience with play influences the rewarding properties of nicotine in social contexts as adults...
  69. ncbi request reprint Complete sparing of spatial learning following posterior and posterior plus anterior cingulate cortex lesions at 10 days of age in the rat
    C L R Gonzalez
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge T1K 3M4, AB, Canada
    Neuroscience 122:563-71. 2003
    ..Also discussed is evidence indicating that the neonatal brain, especially the day 10, has a special ability to compensate for injury...
  70. ncbi request reprint Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposal
    I Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge and NeuroDetective Inc, Lethbridge, Alberta, T1K 3M4
    Dev Psychobiol 39:151-70. 2001
    ..Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior...
  71. doi request reprint Motor cortex injury has different behavioral and anatomical effects in early and late adolescence
    Farshad Nemati
    Canadian Centre for Behavioural Neuroscience, Dept of Neuroscience, University of Lethbridge, Lethbridge, Alberta
    Behav Neurosci 124:612-22. 2010
    ....
  72. doi request reprint Juvenile peer play experience and the development of the orbitofrontal and medial prefrontal cortices
    Heather C Bell
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Behav Brain Res 207:7-13. 2010
    ..The results indicated that the neurons of the OFC responded to the number of peers present, not whether those peers engaged in play or not, whereas the neurons of the mPFC responded specifically to the experience of play...
  73. doi request reprint The hippocampus makes a significant contribution to experience-dependent neocortical plasticity
    Rob Sutherland
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 214:121-4. 2010
    ..The apical fields failed to show an effect of experience in either hemisphere. The hippocampus plays a crucial role in neocortical experience-dependent plasticity...
  74. ncbi request reprint Nicotine stimulates dendritic arborization in motor cortex and improves concurrent motor skill but impairs subsequent motor learning
    Claudia L R Gonzalez
    Department of Psychology and Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Synapse 55:183-91. 2005
    ..The results suggest that plasticity coincidence with skilled training is essential to skilled motor learning, but this expenditure can impair subsequent learning...
  75. ncbi request reprint Evidence for bilateral control of skilled movements: ipsilateral skilled forelimb reaching deficits and functional recovery in rats follow motor cortex and lateral frontal cortex lesions
    Claudia L R Gonzalez
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, AB T1K 3M4, Canada
    Eur J Neurosci 20:3442-52. 2004
    ....
  76. doi request reprint The role of the medial prefrontal cortex in the play fighting of rats
    Heather C Bell
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Neurosci 123:1158-68. 2009
    ..Thus, we have evidence for a triple dissociation of function between the MC, the OFC, and the mPFC with respect to social play behavior...
  77. ncbi request reprint A quantitative comparison of synaptic density following perfusion versus immersion fixation in the rat cerebral cortex
    Marie H Monfils
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada, T1K 3M4
    Microsc Res Tech 67:300-4. 2005
    ..Our results suggest that, despite suboptimal qualitative results, fixation by immersion allows for adequate quantification of synapses...
  78. ncbi request reprint The effects of orbital frontal cortex damage on the modulation of defensive responses by rats in playful and nonplayful social contexts
    Sergio M Pellis
    Canadian Centre for Behavioural NeuroscienceDepartment of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Behav Neurosci 120:72-84. 2006
    ..Rats that sustained bilateral damage at 3 days of age not only had deficits in partner-related modulation of defense but also exhibited hyperactivity in their play. The findings thus supported the proposed hypotheses...
  79. doi request reprint The problem of relating plasticity and skilled reaching after motor cortex stroke in the rat
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Behav Brain Res 192:124-36. 2008
    ..Whereas plasticity is usually proposed to be associated with improved performance it is suggested that future work should attempt to better relate plastic changes to the details of behavioral changes...
  80. ncbi request reprint Odor tracking in rats with orbital frontal lesions
    Douglas G Wallace
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Behav Neurosci 117:616-20. 2003
    ..Rats learned to track and discriminate between different odors reliably. These results suggest that other areas of the brain mediate odor-guided navigation following damage to the orbital frontal cortex...
  81. ncbi request reprint Neonatal handling alters brain organization but does not influence recovery from perinatal cortical injury
    Robbin Gibb
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Neurosci 119:1375-83. 2005
    ..The handling procedure led to a decrease in dendritic length in parietal cortex, but spine density was unchanged. No therapeutic advantage was observed following the preweaning handling of brain-injured rats...
  82. ncbi request reprint Neurophysiological properties of cells filling the neonatal medial prefrontal cortex lesion cavity
    Ira Driscoll
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Brain Res 1178:38-43. 2007
    ....
  83. ncbi request reprint Manipulation of gonadal hormones in neonatal rats alters the morphological response of cortical neurons to brain injury in adulthood
    Margaret L Forgie
    Department of Psychology and Neuroscience, The University of Lethbridge, Alberta, Canada
    Behav Neurosci 117:257-62. 2003
    ..Compensation after cortical injury is dependent on the rat's sex and history of exposure to gonadal steroids...
  84. ncbi request reprint Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females
    Greg Silasi
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Biochem Biophys Res Commun 325:1223-35. 2004
    ..We also present the first evidence of sex differences in radiation-induced signaling in the hippocampus and frontal cortex. We show the role of estrogens in brain radiation responses and discuss the implications of the observed changes...
  85. doi request reprint Acoustic tone or medial geniculate stimulation cue training in the rat is associated with neocortical neuroplasticity and reduced akinesia under haloperidol challenge
    Andrew R Brown
    Department of Neuroscience, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta, Canada T2N 4N1
    Behav Brain Res 214:85-90. 2010
    ..Results indicate that cue-training induces neuroplastic changes that may be related to improved sensorimotor function under dopaminergic antagonism...
  86. pmc Factors influencing frontal cortex development and recovery from early frontal injury
    Celeste Halliwell
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Canada
    Dev Neurorehabil 12:269-78. 2009
    ....
  87. doi request reprint Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid
    S Raza
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Canada Electronic address
    Behav Brain Res 282:25-36. 2015
    ..The results suggest that postnatal TS, during a critical period in development, acts as a powerful reorganization tool that can ameliorate the neuroanatomical consequences of prenatal VPA exposure. ..
  88. doi request reprint Are 50-kHz calls used as play signals in the playful interactions of rats? I. Evidence from the timing and context of their use
    B T Himmler
    Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada Electronic address
    Behav Processes 106:60-6. 2014
    ..However, calls were not more frequent in attacks leading to wrestling than in attacks leading to withdrawal. The data provide qualified support for the hypothesis that 50-kHz vocalizations function as play signals. ..
  89. doi request reprint Intensity matters: brain, behaviour and the epigenome of prenatally stressed rats
    R Mychasiuk
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K3M4, Canada
    Neuroscience 180:105-10. 2011
    ..The data from this study provide evidence to support a dose-dependent effect of prenatal stress on multiple aspects of brain development, potentially contributing to long-term outcomes...
  90. ncbi request reprint Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1658-67. 2008
    ..Our data may provide a roadmap for further analysis of the role of microRNAome in genotoxic stress responses and may help us explain sex specificity of radiation-induced carcinogenesis...
  91. ncbi request reprint Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use
    Carrie R Ferrario
    Department of Psychology Biopsychology and Neuroscience Program, University of Michigan, Ann Arbor, MIichigan 48109 1109, USA
    Biol Psychiatry 58:751-9. 2005
    ..We asked here whether extended access to cocaine also produces drug-induced sensitization, a form of neurobehavioral plasticity implicated in addiction...
  92. ncbi request reprint Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons
    Cecilia Flores
    Departement of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Quebec, Canada, H4H 1R3
    Synapse 61:978-84. 2007
    ....
  93. ncbi request reprint The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen
    Yilin Li
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Neuropsychopharmacology 28:1082-5. 2003
    ....
  94. ncbi request reprint Role of the neocortex in the water maze task in the rat: a detailed behavioral and Golgi-Cox analysis
    Timothy E Hoh
    Department of Psychology, University of Western Ontario, London, Ont, Canada N6A 5C2
    Behav Brain Res 138:81-94. 2003
    ..any changes in neuronal morphology that occur as a consequence of the training may be subtle and widely distributed...
  95. ncbi request reprint A Golgi study of neuronal architecture in a genetic mouse model for Lesch-Nyhan disease
    Ivan Mikolaenko
    Department of Neurology, Meyer Room 6 181, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurobiol Dis 20:479-90. 2005
    ..These findings demonstrate that HPRT deficiency is associated with changes in neuronal architecture in the HPRT- mice. Similar abnormalities in the LND brain could underlie some of the clinical manifestations...
  96. ncbi request reprint Differential neuroplastic changes in neocortical movement representations and dendritic morphology in epilepsy-prone and epilepsy-resistant rat strains following high-frequency stimulation
    Corey Flynn
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1 N4
    Eur J Neurosci 19:2319-28. 2004
    ..The potentiated FAST rats also showed an increase in spine density. Our results suggest that differences in susceptibility to epileptogenesis may result in a differential response to stimulation-induced plasticity...
  97. ncbi request reprint Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine
    Alanna Grant
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada, H4H 1R3
    Eur J Neurosci 26:3215-28. 2007
    ..These findings demonstrate that reduced DCC during development results in a behavioural phenotype opposite to that observed in developmental models of schizophrenia and identify DCC as a critical factor in the development of DA function...
  98. doi request reprint Therapeutic effects of complex rearing or bFGF after perinatal frontal lesions
    Wendy Comeau
    Canadian Centre for Behavioural Neuroscience University of Lethbridge Lethbridge, AB Canada T1K 3M4
    Dev Psychobiol 50:134-46. 2008
    ..Experience thus can affect functional and anatomical outcome after early brain injury but the effects vary with age at experience and may be facilitated by treatment with bFGF...
  99. ncbi request reprint The rodent prefrontal cortex
    Bryan Kolb
    Behav Brain Res 146:1-2. 2003
  100. doi request reprint Effects of hypophysectomy on compulsive checking and cortical dendrites in an animal model of obsessive-compulsive disorder
    Anna Dvorkin
    Department of Zoology, Tel Aviv University, Tel Aviv, Israel
    Behav Pharmacol 19:271-83. 2008
    ..On the basis of the animal model findings, it is concluded that the presence of OCD checking compulsions is not dependent on pituitary axis hormones...